The effects of using omega 3 in the treatment of patients with Alzheimer

Authors

DOI:

https://doi.org/10.33448/rsd-v10i15.22654

Keywords:

Alzheimer Disease; Omega-3 Fatty Acids; Therapeutics.

Abstract

Introduction: The aging process is a risk factor for neurological diseases such as Alzheimer's disease.  Omega 3 is a fatty acid present in neuronal membranes and plays a fundamental role in the metabolism of nervous tissue.  Objective: to describe the effects of using omega 3 in the treatment of patients with Alzheimer's Disease.  Method: this is an integrative review developed in LILACS, MEDLINE AND EMBASE databases using the descriptors: Alzheimer Disease, Omega-3 Fatty Acids, Therapeutics and Disease Prevention.  483 articles were found, but 476 did not meet the eligibility criteria and were excluded.  A comparative analysis of the data extracted from the articles selected for the final sample was carried out.  Results: The sample consisted of seven articles.  There was a prevalence of the use of capsules containing 800 mg of docosahexaenoic acid and 225 mg of eicosapentaenoic acid.  Fatty acids have been shown to have the potential to reduce the accumulation of beta amyloid proteins in cortical regions of the brain or even prevent formation, in addition to increasing cortical thickness.  Conclusion: Supplementation with omega 3 has beneficial effects in the treatment of patients with Alzheimer's, as it has neuroprotective characteristics in combating morphophysiological changes that normally occur in the pathological environment.

References

Abeysinghe, A. A. D. T., Deshapriya, R. D. U. S., & Udawatte, C. (2020). Alzheimer's disease; a review of the pathophysiological basis and therapeutic interventions. Life Sciences, 256, 117996.

Andrieu, S., Guyonnet, S., Coley, N., Cantet, C., Bonnefoy, M., Bordes, S., ... & Olivier-Abbal, P. (2017). Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial. The Lancet Neurology, 16(5), 377-389.

Ajith, T. A. (2018). A recent update on the effects of omega-3 fatty acids in Alzheimer's disease. Current clinical pharmacology, 13(4), 252-260.

Alzheimer's Association. (2019). 2019 Alzheimer's disease facts and figures. Alzheimer's & dementia, 15(3), 321-387.

Prince, M. J., Wimo, A., Guerchet, M. M., Ali, G. C., Wu, Y. T., & Prina, M. (2015). World Alzheimer Report 2015-The Global Impact of Dementia: An analysis of prevalence, incidence, cost and trends.

Anand, R., Gill, K. D., & Mahdi, A. A. (2014). Therapeutics of Alzheimer's disease: Past, present and future. Neuropharmacology, 76, 27-50.

Costa, I. B., Dantas, D. V., Dantas, R. A. N., Oliveira, S. P., Aiquoc, K. M., & Sarmento, S. D. G. (2019). Terapias não farmacológicas para o manejo da dor em vítima de queimaduras: uma revisão sistemática. Revista Inspirar: movimento e saúde, 19(2), 1-20.

Chaudhary, V., Nigam, A. K., Paliwal, A., Singh, M. K., Gour, J. K., & Sinha, V. B. (2021). Omega 3 PUFA. In Naturally Occurring Chemicals Against Alzheimer's Disease (pp. 65-82). Academic Press.

Engelhardt, E., Brucki, S. M., Cavalcanti, J. L. S., Forlenza, O. V., Laks, J., & Vale, F. A. (2005). Tratamento da Doença de Alzheimer: recomendações e sugestões do Departamento Científico de Neurologia Cognitiva e do Envelhecimento da Academia Brasileira de Neurologia. Arquivos de Neuro-psiquiatria, 63, 1104-1112.

Fiala, M., Lau, Y. C. C., Aghajani, A., Bhargava, S., Aminpour, E., Kaczor-Urbanowicz, K. E., ... & Pellegrini, M. (2020). Omega-3 Fatty Acids Increase Amyloid-β Immunity, Energy, and Circadian Rhythm for Cognitive Protection of Alzheimer’s Disease Patients Beyond Cholinesterase Inhibitors. Journal of Alzheimer's Disease, 75(3), 993-1002.

Giudici, K. V., Barreto, P. S., Beard, J., Cantet, C., de Carvalho, I. A., Rolland, Y., & Vellas, B. (2020). Effect of long-term omega-3 supplementation and a lifestyle multidomain intervention on intrinsic capacity among community-dwelling older adults: secondary analysis of a randomized, placebo-controlled trial (MAPT study). Maturitas, 141, 39-45.

Hooper, C., Coley, N., Barreto, P. D. S., Payoux, P., Salabert, A. S., Andrieu, S., ... & Vellas, B. (2020). Cortical β-Amyloid in Older Adults Is Associated with Multidomain Interventions with and without Omega 3 Polyunsaturated Fatty Acid Supplementation. The journal of prevention of Alzheimer's disease, 7(2), 128-134.

Köbe, T., Witte, A. V., Schnelle, A., Lesemann, A., Fabian, S., Tesky, V. A., ... & Flöel, A. (2016). Combined omega-3 fatty acids, aerobic exercise and cognitive stimulation prevents decline in gray matter volume of the frontal, parietal and cingulate cortex in patients with mild cognitive impairment. Neuroimage, 131, 226-238.

Macaron, T., Giudici, K. V., Bowman, G. L., Sinclair, A., Stephan, E., Vellas, B., & de Souto Barreto, P. (2021). Associations of Omega-3 fatty acids with brain morphology and volume in cognitively healthy older adults: A narrative review. Ageing Research Reviews, 67, 101300.

Medeiros Filho, F. C., dos Santos Nascimento, K., Santos, W. O., & Frazão, N. F. (2020). Estudo Da Inibição Da Acetilcolinesterase Por Docking Molecular: Aplicação No Tratamento Da Doença Do Alzheimer. Educação, Ciência E Saúde, 7(2), 18.

Pais, M., Martinez, L., Ribeiro, O., Loureiro, J., Fernandez, R., Valiengo, L., ... & Forlenza, O. V. (2020). Early diagnosis and treatment of Alzheimer’s disease: new definitions and challenges. Brazilian Journal of Psychiatry, 42, 431-441.

Sala-Vila, A., Arenaza-Urquijo, E. M., Sánchez-Benavides, G., Suárez-Calvet, M., Milà-Alomà, M., Grau-Rivera, O., ... & ALFA study. (2021). DHA intake relates to better cerebrovascular and neurodegeneration neuroimaging phenotypes in middle-aged adults at increased genetic risk of Alzheimer disease. The American journal of clinical nutrition, 113(6), 1627-1635.

Schwarz, C., Wirth, M., Gerischer, L., Grittner, U., Witte, A. V., Köbe, T., & Flöel, A. (2018). Effects of Omega-3 fatty acids on resting cerebral perfusion in patients with mild cognitive impairment: a randomized controlled trial. The journal of prevention of Alzheimer's disease, 5(1), 26-30.

Soares, N. M., Pereira, G. M., da Nóbrega Figueiredo, R. I., Soares, N. M., de Almeida, R. M. M., & da Silva Portela, A. (2017). Impacto econômico e prevalência da doença de Alzheimer em uma capital Brasileira. Ciência & Saúde, 10(3), 133-138.

Souza, M. T. D., Silva, M. D. D., & Carvalho, R. D. (2010). Integrative review: what is it? How to do it?. Einstein (São Paulo), 8, 102-106.

Sozańska, B., & Sikorska-Szaflik, H. (2021). Diet Modifications in Primary Prevention of Asthma. Where Do We Stand?. Nutrients, 13(1), 173.

Stillwell, S. B., Fineout-Overholt, E., Melnyk, B. M., & Williamson, K. M. (2010). Evidence-based practice, step by step: asking the clinical question: a key step in evidence-based practice. AJN The American Journal of Nursing, 110(3), 58-61.

Tchkonia, T., & Kirkland, J. L. (2018). Aging, cell senescence, and chronic disease: emerging therapeutic strategies. Jama, 320(13), 1319-1320.

Whittemore, R., & Knafl, K. (2005). The integrative review: updated methodology. Journal of advanced nursing, 52(5), 546-553.

Winblad, B., Amouyel, P., Andrieu, S., Ballard, C., Brayne, C., Brodaty, H., ... & Zetterberg, H. (2016). Defeating Alzheimer's disease and other dementias: a priority for European science and society. The Lancet Neurology, 15(5), 455-532.

Xu, Z. J., Li, Q., Ding, L., Shi, H. H., Xue, C. H., Mao, X. Z., ... & Zhang, T. T. (2021). A comparative study of the effects of phosphatidylserine rich in DHA and EPA on Aβ-induced Alzheimer's disease using cell models. Food & Function, 12(10), 4411-4423.

Zhou, M. M., Che, H. X., Huang, J. Q., Zhang, T. T., Xu, J., Xue, C. H., & Wang, Y. M. (2018). Comparative study of different polar groups of EPA‐enriched phospholipids on ameliorating memory loss and cognitive deficiency in aged SAMP8 mice. Molecular nutrition & food research, 62(7), 1700637.

Published

18/11/2021

How to Cite

COSTA, P. J. .; SILVA, M. M. da .; GUEDES, J. P. . The effects of using omega 3 in the treatment of patients with Alzheimer. Research, Society and Development, [S. l.], v. 10, n. 15, p. e239101522654, 2021. DOI: 10.33448/rsd-v10i15.22654. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/22654. Acesso em: 26 nov. 2024.

Issue

Section

Review Article