Comparative analysis between treatments for alopecia: a systematic review

Authors

DOI:

https://doi.org/10.33448/rsd-v10i15.22770

Keywords:

Alopecia; Therapy; Systematic review.

Abstract

Introduction: Alopecia is the temporary or congenital absence of hair or hair and can be classified as scarred and non-scarred. This study focused on the comparative analysis of the treatments of androgenetic alopecia areata, which are non-scarring alopecia. Androgenetic alopecia is the most common form of hair loss in humans and alopecia areata has around 2% worldwide. Objective: The study aimed to know, correlate and compare the different forms of treatment for andeatetic alopecia areata in the most recent studies. Method: This is a systematic review of scientific articles published in the PUBMED database between 01/01/2018 and 12/31/2018. The keywords "alopecia areata and treatment" and "alopecia androgenetic and treatment" were used. First, the articles were analyzed by title and abstract by two reviewers (BMSS and TJ), and in case of disagreement, a third reviewer was consulted (RAN). Afterwards, there was a complete reading of the texts, and in case of disagreement, a last reviewer was consulted (RAN). Results: The search for "alopecia areata and treatment" resulted in 26 records, of which 14 were excluded. After reading the full articles, of the 12 articles, only seven were used. The search for "alopecia androgenetic and treatment" resulted in out of 84 records, of which 61 articles did not meet the inclusion criteria.After reading the 24 articles, only nine were selected.After the selection phase, 16 articles remained eligible. Conclusion: There is a wide range of treatments for alopecia, showing that the treatment should be individualized for each patient.Always remember to associate pharmacological therapy with psychological follow-up, since hair is also a communication tool.

References

Anderi, R., Makdissy, N., Azar, A., Rizk, F., & Hamade, A. (2018). Cellular therapy with human autologous adipose-derived adult cells of stromal vascular fraction for alopecia areata. Stem Cell Research & Therapy. 10.1186/s13287-018-0889-y

Arita, T., Nomiyama, T., Asai, J., & Katoh, N. (2018). Successful treatment of refractory alopecia universalis by persuading a patient not to sleep with her dog. Allergology International. 10.1016/j.alit.2017.06.011

Carvalho, L. T., & D’Acri, A. M. (2014). Alopecia Areata: Revisão Bibliográfica e Relato de Caso. Cad. Bras. Med. XXVII. http://www.seer.unirio.br/index.php/cadernosbrasileirosdemedicina/article/view/4422/3983

Darwin, E. (2018). Alopecia Areata: Review of Epidemiology, Clinical Features, Pathogenesis and New Treatment Options. Int. Jornaul of Trichology. 10.4103/ijt.ijt_99_17

Dawber, R., & Van Neste, D. (1996). Doenças dos Cabelos e do Couro Cabelo. Ed. Manole. p. 205-7

Dhaher, S. A., & Yacoub, A. A. (2018). Estimation of Zinc and Iron Levels in the Serum and Hair of Women with Androgenetic Alopecia: Case-control Study. Indian Journal of Dermatology. 10.4103/ijd.IJD_624_16

Ejjiyar, M., & Driss El Amrani, M. (2018). An unusual cause of alopecia on the scalp. The Pan African Medical Journal. 10.11604/pamj.2018.29.213.14533

Faghihi, G. (2018). The effectiveness of adding low-level light therapy to monoxidil 5% solution in the treatment of patients with androgenetic alopecia. Indian J. Dermatol Venereol Leprol. 10.4103/ijdvl.IJDVL_1156_16

Faghihi, G., Mozafarpoor, S., Asilian, A., Mokhtari, F., Esfahani, A. A., Bafandeh, B., Nouraei, S., Nilforoushzadeh, M. A., & Hosseini, S. M. (2018). The effectiveness of adding low-level light therapy to minoxidil 5% solution in the treatment of patients with androgenetic alopecia. Indian J Dermatol Venereol Leprol. 10.4103/ijdvl.IJDVL_1156_16

Ganzer, C. A., & Jacobs, A. R. (2018). Emotional Consequences of Finasteride: Fool’s Gold. American Journal of Men’s Health. 10.1177/1557988316631624

Gomez-Zubiaur, A., Saceda-Corralo, D., Velez-Velazquez, M. D., & Vano-Galvan, S. (2018). Tratamiento de la alopecia areata, um recorrido desde las opciones terapêuticas clásicas hasta los nuervos fármacos aparecidos em los últimos años. Dermatology Online Journal. https://escholarship.org/uc/item/4ft667kk

Gonul, M., Cemil, B. C., Ayvaz, H. H., Cankurtaran, E., Ergin, C., & Gurel, M. S. (2018). Comparision of quality of life in patients with androgenetic alopecia and alopecia areata. An. Bras. Dermatol. 10.1590/abd1806-4841.20186131

Hamed, F. N., McDonagh, A. J. G., Almaghrabi, S., Bakri, Y., Messenger, A.G., & Tazi-Ahnini, R. (2018). Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 MKG2D Lymphocytes of Alopecia Areata Patient. International Journal of Environmental Research and Public Health. 10.3390/ijerph15122882

Hawkshaw, N. J. (2018). Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles. PLOS Biology. 10.1371/journal.pbio.2003705

Kaliyadan, F., Alkhateeb, A., & Swaroop, K. (2018). Localized atrophy with surrounding hair growth in a case of alopecia areata treated with intralesional steroids, using a needle-less injector. Indian J Dermatol Venereol Leprol. 10.4103/ijdvl.IJDVL_297_17

Martinez-Jacobo, L., Villarreal-Villarreal, C. D., Ortiz-López, R. Ocampo-Candiani, J., & Rojas-Martínez, A. (2018). Genetic and molecular aspects of adrogenetic alopecia. Indian J Dermatol Venerol Leprol. 10.4103/ijdvl.IJDVL_262_17

Oliveira, I., & Machado, C. C. (2017). Calvície e alopecia: Revisão Bibliográfica. Universidade Lusófona de Humanidade e Tecnologias. Recuperado de http://recil.grupolusofona.pt/bitstream/handle/10437/8402/Calv%C3%ADcieeAlopecia_Revis%C3%A3oBibliografica.pdf?sequence=1

Pekmezci, E., Dundar, C., & Turkoglu, M. (2018). Proprietary Herbal Extract Downregulates the Gene Expression of IL-1α in HaCaT Cells: Possible Implications Against Nonscarring Alopecia. Med Arch. 10.5455/medarh.2018.72.136-140

Rodgers, A. R. (2018). Why finding a treatment for alopecia areata is important: a multifaceted perspective. Journal of Investigative Dermatology Symposium Proceedings. 10.1016/j.jisp.2017.10.008

Tenore, G. C., Caruso, D., Buonomo, G., D'Avino, M., Santamaria, R., Irace, C., Piccolo, M., Maisto, M., & Novellino, E. (2018). Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropismin a Randomized Clinical Trial. Journal of Medicinal Food. 10.1089/jmf.2017.0016

Thanomkitti, K., Kanlaya, R., Fong-ngern, K., Kapincharanon, C., Sueksakit, K., Chanchaem, P., Thuangtong, R., & Thongboonkerd, V. (2018). Differential proteomics of lesional vs. non-lesional biopsies revealed non-immune mechanisms of alopecia areata. Scientific Reports. 10.1038/s41598-017-18282-1

Tsai, T. F., Choi, G. S., Kim, B. J., Kim, M. B., Ng, C. F., Kochhar, P., Jasper, S., Brotherton, B., Orban, B., & Lulic, Z. (2018). Prospective randomized study of sexual function in men taking dutasteride for the treatment of androgenetic alopecia. The Journal of Dermatology. 10.1111/1346-8138.14329.

Wang, X., Xiong, C., Zhang, L., Yang, B., Wei, R., Cui, L., & Xing, X. (2018). Psychological assessment in 355 Chinese college students with androgenetic alopecia. Medicine. 10.1097/MD.0000000000011315

Zhang, Y., Xu, J., Jing, J., Wu, X., & Lv, Z. (2018). Serum Levels of Androgen-Associated Hormones Are Correlated with Curative Effect in Androgenic Alopecia in Young Men. Medical Science Monitor. 10.12659/MSM.913116

Published

21/11/2021

How to Cite

SOUSA, B. M. da S. .; NATAL, T. J. .; PEREIRA, T. B. .; DRUMMOND, M. V. M. S. .; NEVES, R. A. Comparative analysis between treatments for alopecia: a systematic review. Research, Society and Development, [S. l.], v. 10, n. 15, p. e134101522770, 2021. DOI: 10.33448/rsd-v10i15.22770. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/22770. Acesso em: 12 nov. 2024.

Issue

Section

Review Article