Ozonetherapy as a supporting in the treatment of periodontitis: literature review
DOI:
https://doi.org/10.33448/rsd-v10i15.22961Keywords:
Periodontitis; Ozone therapy; Ozone; Inflammation; Therapeutics.Abstract
Introduction: Periodontitis is characterized as a chronic and multifactorial inflammation that is related to biofilm imbalance. The gold standard in therapy is through periodontal scaling, generally supported by an association of common and systemic antibiotics. However, drugs can lead to the development of bacterial resistance or patient discomfort. Thus, ozone therapy has stood out as a form of adjuvant intervention for the disease and the inflammatory process. Objective: To demonstrate, based on the literature, the efficiency of ozone therapy as an adjunct in the treatment of periodontitis. Methodology: A search in Pubmed, Embase, Scopus, Web of Science (all databases), and Cochrane Library databases was performed using a search strategy based on the MeSH terms “periodontitis”, “ozone” and “inflammation” and their corresponding input terms. No additional search filters were added. Only articles with their full text published and dealing with periodontitis as the primary focus of the study were included. Data were obtained through a qualitative synthesis of the results. Results and Discussion: 21 articles were selected and similar designs varied. All articles are emphatic about the safe use of ozone therapy, however, they differ as to its real practical effect in the clinic. Studies are still not conclusive about the expected effect. Conclusion: Despite its anti-inflammatory effects, ozone therapy does not seem to have a significant effect as periodontal treatment, but it can be used as an auxiliary measure in difficult-to-control cases in which periodontal scaling alone does not present satisfactory results.
References
Ameyaroy, D. K., Ramabhadran, B. K., Emmatty, R., Paul, T. P., & Jose, P. (2020). Comparative evaluation of the effect of Ozone therapy and Photodynamic therapy in non-surgical management of Chronic periodontitis: A split mouth longitudinal study. Journal of Indian Society of Periodontology, 24(5), 447–453. https://doi.org/10.4103/jisp.jisp_381_19
Anzolin, A. P., da Silveira-Kaross, N. L., & Bertol, C. D. (2020). Ozonated oil in wound healing: what has already been proven?.
Medical gas research, 10(1), 54–59. https://doi.org/10.4103/2045-9912.279985
Deas, D. E., Moritz, A. J., Sagun, R. S., Jr, Gruwell, S. F., & Powell, C. A. (2016). Scaling and root planing vs. conservative surgery in the treatment of chronic periodontitis. Periodontology 2000, 71(1), 128–139. https://doi.org/10.1111/prd.12114
Deepthi, R., & Bilichodmath, S. (2020). Ozone Therapy in Periodontics: A Meta-analysis. Contemporary clinical dentistry, 11(2), 108–115. https://doi.org/10.4103/ccd.ccd_79_19
Domb W. C. (2014). Ozone therapy in dentistry. A brief review for physicians. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 20(5), 632–636. https://doi.org/10.15274/INR-2014- 10083
Fischer, R., Lira Junior, R., Retamal-Valdes, B., Figueiredo, L., Malheiros, Z., Stewart, B., & Feres, M. (2020). Periodontal disease and its impact on general health in Latin America. Section V: Treatment of periodontitis. Brazilian Oral Research, 34(suppl 1). doi: 10.1590/1807-3107bor-2020.vol34.0026
Graziani, F., Karapetsa, D., Alonso, B., & Herrera, D. (2017). Nonsurgical and surgical treatment of periodontitis: how many options for one disease?. Periodontology 2000, 75(1), 152–188. https://doi.org/10.1111/prd.12201
Gupta, G., & Mansi, B. (2012). Ozone therapy in periodontics. Journal of medicine and life, 5(1), 59–67.
Hayakumo, S., Arakawa, S., Mano, Y., & Izumi, Y. (2013). Clinical and microbiological effects of ozone nano-bubble water irrigation as an adjunct to mechanical subgingival debridement in periodontitis patients in a randomized controlled trial. Clinical oral investigations, 17(2), 379–388. https://doi.org/10.1007/s00784-012-0711-7
Herrera, D., Alonso, B., León, R., Roldán, S., & Sanz, M. (2008). Antimicrobial therapy in periodontitis: the use of systemic antimicrobials against the subgingival biofilm. Journal of clinical periodontology, 35(8 Suppl), 45–66. https://doi.org/10.1111/j.1600- 051X.2008.01260.x
Hiyari, S., Wong, R. L., Yaghsezian, A., Naghibi, A., Tetradis, S., Camargo, P. M., & Pirih, F. Q. (2018). Ligature-induced peri- implantitis and periodontitis in mice. Journal of clinical periodontology, 45(1), 89–99. https://doi.org/10.1111/jcpe.12817
Honório, H., & Santiago Júnior, J. (2021). Fundamentos das revisões sistemáticas em saúde (1st ed.). Santos Publicações.
Huth, K. C., Saugel, B., Jakob, F. M., Cappello, C., Quirling, M., Paschos, E., Ern, K., Hickel, R., & Brand, K. (2007). Effect of aqueous ozone on the NF-kappaB system. Journal of dental research, 86(5), 451–456. https://doi.org/10.1177/154405910708600512
Kaur, A., Bhavikatti, S. K., Das, S. S., Khanna, S., Jain, M., & Kaur, A. (2019). Efficacy of Ozonised Water and 0.2% Chlorhexidine Gluconate in the Management of Chronic Periodontitis when Used as an Irrigant in Conjugation with Phase I Therapy. The journal of contemporary dental practice, 20(3), 318–323.
Kubyshkina K. P.., Podoprigora A. V., Oleynik O.I., Kharitonov Y. M. & Belenova I. A. (2018). Statistical Evaluation Of Antimicrobial Influence Of Medical Ozone As A Part Of Inflammatory Prevention Of Periodontal Diseases. RJPBCS, 9(6), 690-696
Nardi, G. M., Cesarano, F., Papa, G., Chiavistelli, L., Ardan, R., Jedlinski, M., Mazur, M., Grassi, R., & Grassi, F. R. (2020). Evaluation of Salivary Matrix Metalloproteinase (MMP-8) in Periodontal Patients Undergoing Non-Surgical Periodontal Therapy and Mouthwash Based on Ozonated Olive Oil: A Randomized Clinical Trial. International journal of environmental research and public health, 17(18), 6619. https://doi.org/10.3390/ijerph17186619
Niveda R. & Malaiappan S. (2019). Comparison of the amount of bacterial microcolonies formed on using distilled water and ozonated water as an irrigating agent. Drug invention today, 11(4), 1605-1609.
Oliveira, J. K. S. de, Carvalho, J. M. de, Silva, C. A., Lima, M. B. de, Cavalcante, P. M. F., & Paiva, D. F. F. (2020). Relação entre a exposição ao pesticida Rotenona e o desenvolvimento de sintomas motores e não-motores da doença de Parkinson . Research, Society and Development, 9(9), e706997917. https://doi.org/10.33448/rsd-v9i9.7917
Papapanou, P. N., et al. (2018). Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. Journal of clinical periodontology, 45 Suppl 20, S162–S170. https://doi.org/10.1111/jcpe.12946
Penteado, L. A. M., Awabdi, T. W. M., Auto, V. C., Rodrigues, E. D. O., Oliveira, D. P.& Santos, N. B. (2010). Avaliação da padronização das sondas periodontais utilizadas em uma instituição de ensino superior de Maceió-AL. Int J Dent, 9(3), 120-127.
Rapone, B., Ferrara, E., Corsalini, M., Converti, I., Grassi, F. R., Santacroce, L., Topi, S., Gnoni, A., Scacco, S., Scarano, A., & Delvecchio, M. (2020). The Effect of Gaseous Ozone Therapy in Conjunction with Periodontal Treatment on Glycated Hemoglobin.
Level in Subjects with Type 2 Diabetes Mellitus: An Unmasked Randomized Controlled Trial. International journal of environmental research and public health, 17(15), 5467. https://doi.org/10.3390/ijerph17155467
Saglam, E., Alinca, S., Celik, T., Hacisalihoglu, U., & Dogan, M. (2020). Evaluation of the effect of topical and systemic ozone application in periodontitis: an experimental study in rats. Journal Of Applied Oral Science, 28. doi: 10.1590/1678-7757-2019-0140
Seydanur Dengizek, E., Serkan, D., Abubekir, E., Aysun Bay, K., Onder, O., & Arife, C. (2019). Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial. Journal Of Applied Oral Science, 27. doi: 10.1590/1678-7757-2018-0108
Skurska, A., Pietruska, M. D., Paniczko-Drężek, A., Dolińska, E., Zelazowska-Rutkowska, B., Zak, J., Pietruski, J., Milewski, R., & Wysocka, J. (2010). Evaluation of the influence of ozonotherapy on the clinical parameters and MMP levels in patients with chronic and aggressive periodontitis. Advances in medical sciences, 55(2), 297–307. https://doi.org/10.2478/v10039-010-0048-x
Slots J. (2017). Periodontitis: facts, fallacies and the future. Periodontology 2000, 75(1), 7–23. https://doi.org/10.1111/prd.12221
Srikanth, A., Sathish, M., & Sri Harsha, A. V. (2013). Application of ozone in the treatment of periodontal disease. Journal of pharmacy & bioallied sciences, 5(Suppl 1), S89–S94. https://doi.org/10.4103/0975-7406.113304
Suh, Y., Patel, S., Kaitlyn, R., Gandhi, J., Joshi, G., Smith, N. L., & Khan, S. A. (2019). Clinical utility of ozone therapy in dental and oral medicine. Medical gas research, 9(3), 163–167. https://doi.org/10.4103/2045-9912.266997
Talmaç, A. C., & Çalişir, M. (2021). Efficacy of gaseous ozone in smoking and non-smoking gingivitis patients. Irish journal of medical science, 190(1), 325–333. https://doi.org/10.1007/s11845-020-02271-x
Tasdemir, Z., Oskaybas, M. N., Alkan, A. B., & Cakmak, O. (2019). The effects of ozone therapy on periodontal therapy: A randomized placebo-controlled clinical trial. Oral diseases, 25(4), 1195–1202. https://doi.org/10.1111/odi.13060
Uraz, A., Karaduman, B., Isler, S., Gönen, S., & Çetiner, D. (2019). Ozone application as adjunctive therapy in chronic periodontitis: Clinical, microbiological and biochemical aspects. Journal Of Dental Sciences, 14(1), 27-37. doi: 10.1016/j.jds.2018.06.005
Vasthavi, C., Babu, H. M., Rangaraju, V. M., Dasappa, S., Jagadish, L., & Shivamurthy, R. (2020). Evaluation of ozone as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A randomized clinico-microbial study. Journal of Indian Society of Periodontology, 24(1), 42–46. https://doi.org/10.4103/jisp.jisp_162_19
Wang, P., Tachi, Y., Masuno, K., Okusa, N., & Imamura, Y. (2018). The Study of Ozone Ointment on Human Gingival Fibroblasts Cell Proliferation Ability and Anti-Inflammatory. Journal Of Hard Tissue Biology, 27(3), 209-212. doi: 10.2485/jhtb.27.209
Yılmaz, S., Algan, S., Gursoy, H., Noyan, U., Kuru, B. E., & Kadir, T. (2013). Evaluation of the clinical and antimicrobial effects of the Er:YAG laser or topical gaseous ozone as adjuncts to initial periodontal therapy. Photomedicine and laser surgery, 31(6), 293– 298. https://doi.org/10.1089/pho.2012.3379
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Tainara Dutra Silva; Daniel Felipe Fernandes Paiva; Dilma Carvalho Santana
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.