Ozonetherapy as a supporting in the treatment of periodontitis: literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v10i15.22961

Keywords:

Periodontitis; Ozone therapy; Ozone; Inflammation; Therapeutics.

Abstract

Introduction: Periodontitis is characterized as a chronic and multifactorial inflammation that is related to biofilm imbalance. The gold standard in therapy is through periodontal scaling, generally supported by an association of common and systemic antibiotics. However, drugs can lead to the development of bacterial resistance or patient discomfort. Thus, ozone therapy has stood out as a form of adjuvant intervention for the disease and the inflammatory process. Objective: To demonstrate, based on the literature, the efficiency of ozone therapy as an adjunct in the treatment of periodontitis. Methodology: A search in Pubmed, Embase, Scopus, Web of Science (all databases), and Cochrane Library databases was performed using a search strategy based on the MeSH terms “periodontitis”, “ozone” and “inflammation” and their corresponding input terms. No additional search filters were added. Only articles with their full text published and dealing with periodontitis as the primary focus of the study were included. Data were obtained through a qualitative synthesis of the results. Results and Discussion: 21 articles were selected and similar designs varied. All articles are emphatic about the safe use of ozone therapy, however, they differ as to its real practical effect in the clinic. Studies are still not conclusive about the expected effect. Conclusion: Despite its anti-inflammatory effects, ozone therapy does not seem to have a significant effect as periodontal treatment, but it can be used as an auxiliary measure in difficult-to-control cases in which periodontal scaling alone does not present satisfactory results.

References

Ameyaroy, D. K., Ramabhadran, B. K., Emmatty, R., Paul, T. P., & Jose, P. (2020). Comparative evaluation of the effect of Ozone therapy and Photodynamic therapy in non-surgical management of Chronic periodontitis: A split mouth longitudinal study. Journal of Indian Society of Periodontology, 24(5), 447–453. https://doi.org/10.4103/jisp.jisp_381_19

Anzolin, A. P., da Silveira-Kaross, N. L., & Bertol, C. D. (2020). Ozonated oil in wound healing: what has already been proven?.

Medical gas research, 10(1), 54–59. https://doi.org/10.4103/2045-9912.279985

Deas, D. E., Moritz, A. J., Sagun, R. S., Jr, Gruwell, S. F., & Powell, C. A. (2016). Scaling and root planing vs. conservative surgery in the treatment of chronic periodontitis. Periodontology 2000, 71(1), 128–139. https://doi.org/10.1111/prd.12114

Deepthi, R., & Bilichodmath, S. (2020). Ozone Therapy in Periodontics: A Meta-analysis. Contemporary clinical dentistry, 11(2), 108–115. https://doi.org/10.4103/ccd.ccd_79_19

Domb W. C. (2014). Ozone therapy in dentistry. A brief review for physicians. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 20(5), 632–636. https://doi.org/10.15274/INR-2014- 10083

Fischer, R., Lira Junior, R., Retamal-Valdes, B., Figueiredo, L., Malheiros, Z., Stewart, B., & Feres, M. (2020). Periodontal disease and its impact on general health in Latin America. Section V: Treatment of periodontitis. Brazilian Oral Research, 34(suppl 1). doi: 10.1590/1807-3107bor-2020.vol34.0026

Graziani, F., Karapetsa, D., Alonso, B., & Herrera, D. (2017). Nonsurgical and surgical treatment of periodontitis: how many options for one disease?. Periodontology 2000, 75(1), 152–188. https://doi.org/10.1111/prd.12201

Gupta, G., & Mansi, B. (2012). Ozone therapy in periodontics. Journal of medicine and life, 5(1), 59–67.

Hayakumo, S., Arakawa, S., Mano, Y., & Izumi, Y. (2013). Clinical and microbiological effects of ozone nano-bubble water irrigation as an adjunct to mechanical subgingival debridement in periodontitis patients in a randomized controlled trial. Clinical oral investigations, 17(2), 379–388. https://doi.org/10.1007/s00784-012-0711-7

Herrera, D., Alonso, B., León, R., Roldán, S., & Sanz, M. (2008). Antimicrobial therapy in periodontitis: the use of systemic antimicrobials against the subgingival biofilm. Journal of clinical periodontology, 35(8 Suppl), 45–66. https://doi.org/10.1111/j.1600- 051X.2008.01260.x

Hiyari, S., Wong, R. L., Yaghsezian, A., Naghibi, A., Tetradis, S., Camargo, P. M., & Pirih, F. Q. (2018). Ligature-induced peri- implantitis and periodontitis in mice. Journal of clinical periodontology, 45(1), 89–99. https://doi.org/10.1111/jcpe.12817

Honório, H., & Santiago Júnior, J. (2021). Fundamentos das revisões sistemáticas em saúde (1st ed.). Santos Publicações.

Huth, K. C., Saugel, B., Jakob, F. M., Cappello, C., Quirling, M., Paschos, E., Ern, K., Hickel, R., & Brand, K. (2007). Effect of aqueous ozone on the NF-kappaB system. Journal of dental research, 86(5), 451–456. https://doi.org/10.1177/154405910708600512

Kaur, A., Bhavikatti, S. K., Das, S. S., Khanna, S., Jain, M., & Kaur, A. (2019). Efficacy of Ozonised Water and 0.2% Chlorhexidine Gluconate in the Management of Chronic Periodontitis when Used as an Irrigant in Conjugation with Phase I Therapy. The journal of contemporary dental practice, 20(3), 318–323.

Kubyshkina K. P.., Podoprigora A. V., Oleynik O.I., Kharitonov Y. M. & Belenova I. A. (2018). Statistical Evaluation Of Antimicrobial Influence Of Medical Ozone As A Part Of Inflammatory Prevention Of Periodontal Diseases. RJPBCS, 9(6), 690-696

Nardi, G. M., Cesarano, F., Papa, G., Chiavistelli, L., Ardan, R., Jedlinski, M., Mazur, M., Grassi, R., & Grassi, F. R. (2020). Evaluation of Salivary Matrix Metalloproteinase (MMP-8) in Periodontal Patients Undergoing Non-Surgical Periodontal Therapy and Mouthwash Based on Ozonated Olive Oil: A Randomized Clinical Trial. International journal of environmental research and public health, 17(18), 6619. https://doi.org/10.3390/ijerph17186619

Niveda R. & Malaiappan S. (2019). Comparison of the amount of bacterial microcolonies formed on using distilled water and ozonated water as an irrigating agent. Drug invention today, 11(4), 1605-1609.

Oliveira, J. K. S. de, Carvalho, J. M. de, Silva, C. A., Lima, M. B. de, Cavalcante, P. M. F., & Paiva, D. F. F. (2020). Relação entre a exposição ao pesticida Rotenona e o desenvolvimento de sintomas motores e não-motores da doença de Parkinson . Research, Society and Development, 9(9), e706997917. https://doi.org/10.33448/rsd-v9i9.7917

Papapanou, P. N., et al. (2018). Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. Journal of clinical periodontology, 45 Suppl 20, S162–S170. https://doi.org/10.1111/jcpe.12946

Penteado, L. A. M., Awabdi, T. W. M., Auto, V. C., Rodrigues, E. D. O., Oliveira, D. P.& Santos, N. B. (2010). Avaliação da padronização das sondas periodontais utilizadas em uma instituição de ensino superior de Maceió-AL. Int J Dent, 9(3), 120-127.

Rapone, B., Ferrara, E., Corsalini, M., Converti, I., Grassi, F. R., Santacroce, L., Topi, S., Gnoni, A., Scacco, S., Scarano, A., & Delvecchio, M. (2020). The Effect of Gaseous Ozone Therapy in Conjunction with Periodontal Treatment on Glycated Hemoglobin.

Level in Subjects with Type 2 Diabetes Mellitus: An Unmasked Randomized Controlled Trial. International journal of environmental research and public health, 17(15), 5467. https://doi.org/10.3390/ijerph17155467

Saglam, E., Alinca, S., Celik, T., Hacisalihoglu, U., & Dogan, M. (2020). Evaluation of the effect of topical and systemic ozone application in periodontitis: an experimental study in rats. Journal Of Applied Oral Science, 28. doi: 10.1590/1678-7757-2019-0140

Seydanur Dengizek, E., Serkan, D., Abubekir, E., Aysun Bay, K., Onder, O., & Arife, C. (2019). Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial. Journal Of Applied Oral Science, 27. doi: 10.1590/1678-7757-2018-0108

Skurska, A., Pietruska, M. D., Paniczko-Drężek, A., Dolińska, E., Zelazowska-Rutkowska, B., Zak, J., Pietruski, J., Milewski, R., & Wysocka, J. (2010). Evaluation of the influence of ozonotherapy on the clinical parameters and MMP levels in patients with chronic and aggressive periodontitis. Advances in medical sciences, 55(2), 297–307. https://doi.org/10.2478/v10039-010-0048-x

Slots J. (2017). Periodontitis: facts, fallacies and the future. Periodontology 2000, 75(1), 7–23. https://doi.org/10.1111/prd.12221

Srikanth, A., Sathish, M., & Sri Harsha, A. V. (2013). Application of ozone in the treatment of periodontal disease. Journal of pharmacy & bioallied sciences, 5(Suppl 1), S89–S94. https://doi.org/10.4103/0975-7406.113304

Suh, Y., Patel, S., Kaitlyn, R., Gandhi, J., Joshi, G., Smith, N. L., & Khan, S. A. (2019). Clinical utility of ozone therapy in dental and oral medicine. Medical gas research, 9(3), 163–167. https://doi.org/10.4103/2045-9912.266997

Talmaç, A. C., & Çalişir, M. (2021). Efficacy of gaseous ozone in smoking and non-smoking gingivitis patients. Irish journal of medical science, 190(1), 325–333. https://doi.org/10.1007/s11845-020-02271-x

Tasdemir, Z., Oskaybas, M. N., Alkan, A. B., & Cakmak, O. (2019). The effects of ozone therapy on periodontal therapy: A randomized placebo-controlled clinical trial. Oral diseases, 25(4), 1195–1202. https://doi.org/10.1111/odi.13060

Uraz, A., Karaduman, B., Isler, S., Gönen, S., & Çetiner, D. (2019). Ozone application as adjunctive therapy in chronic periodontitis: Clinical, microbiological and biochemical aspects. Journal Of Dental Sciences, 14(1), 27-37. doi: 10.1016/j.jds.2018.06.005

Vasthavi, C., Babu, H. M., Rangaraju, V. M., Dasappa, S., Jagadish, L., & Shivamurthy, R. (2020). Evaluation of ozone as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A randomized clinico-microbial study. Journal of Indian Society of Periodontology, 24(1), 42–46. https://doi.org/10.4103/jisp.jisp_162_19

Wang, P., Tachi, Y., Masuno, K., Okusa, N., & Imamura, Y. (2018). The Study of Ozone Ointment on Human Gingival Fibroblasts Cell Proliferation Ability and Anti-Inflammatory. Journal Of Hard Tissue Biology, 27(3), 209-212. doi: 10.2485/jhtb.27.209

Yılmaz, S., Algan, S., Gursoy, H., Noyan, U., Kuru, B. E., & Kadir, T. (2013). Evaluation of the clinical and antimicrobial effects of the Er:YAG laser or topical gaseous ozone as adjuncts to initial periodontal therapy. Photomedicine and laser surgery, 31(6), 293– 298. https://doi.org/10.1089/pho.2012.3379

Published

26/11/2021

How to Cite

SILVA, T. D.; PAIVA, D. F. F.; SANTANA, D. C. Ozonetherapy as a supporting in the treatment of periodontitis: literature review. Research, Society and Development, [S. l.], v. 10, n. 15, p. e278101522961, 2021. DOI: 10.33448/rsd-v10i15.22961. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/22961. Acesso em: 5 nov. 2024.

Issue

Section

Health Sciences