Dietary and supplementary management in the pathophysiology of polycystic ovary syndrome
DOI:
https://doi.org/10.33448/rsd-v10i15.22975Keywords:
Polycystic ovary syndrome; Insulin resistance; Diet therapy; PCOS Supplementation; PCOS; Pathophysiology of PCOS.Abstract
Introduction: Polycystic Ovary Syndrome (PCOS) is a gynecological endocrine disorder that interferes with the process of ovulation and female fertility. Women with PCOS have the highest circulating androgen requirements related to Insulin Resistance (IR), dyslipidemia, obesity, gestational diabetes, Type 2 Diabetes Mellitus (DM II), Cardiovascular Disease (CVD) and Arterial Hypertension (SAH) and infertility. Objective: The aim of the present study was to address the beneficial effects of nutritional and supplemental therapy on PCOS and describe its pathogenesis, clinical manifestations and diagnosis. Materials and Methods: This is a non-systematic literature review of articles related to the topic of PCOS from the SciELO and Pubmed databases. Results and Discussion: The intervention in the lifestyle of the patient with PCOS is the most efficient form of treatment, especially in overweight women, with dietary management and inclusion of physical activity. And in this context, nutritional supplementation can be beneficial. Conclusion: Food plans with glycemic control and glycemic load control Insulin Resistance (IR), regressing the PCOS picture. In addition, nutritional supplementation of myoinusitol and vitamin D may contribute to the control of PCOS signs and symptoms.
References
Abbott, D. H., Barnett, D. K., Bruns, C. M. et al. (2005). Androgen excesso fetal programming of female reproduction: a developmental aetiology for polycyr polycystic ovary syndrome? Hum Reprod Update. 11, 357–374.
Azzi, R. (20016). PCOS in 2015: New insights into the genetics of polycistics ovary syndrome. Nat Rev Endocrinol, 12(2), 74-5.
Baillargeon, J. P., Nestler, J. E., Ostlund, R. E., Apridonidze, T., & Diamanti, E. K. (2008). Greek hyperinsulinemic women, with or without polycystic ovary syndrome, display altered inositol metabolism. Hum Reprod, 24, 139–44.
Balen, A.H. (2013). Ovulation induction in the management of anovulatory polycystic ovary syndrome. Mol Cell Endocrinol, 373, 77–82.
Barber, T.M., et al. (2015). Polycystic ovary syndrome: insight into pathogenesis and a common association with insulin resistance. Clinical Medicine. 15(6), 72-76.
Cavalcante, I. dos S. et al. (2021). Síndrome dos ovários policísticos: aspectos clínicos e impactos na saúde da mulher. Research, Society and Development, 10(2), e23810212398. https://doi.org/10.33448/rsd-v10i2.12398.
Child, T. J., Abdul-Jail, A. K., & Gulekli, B. et al. (2001). In vitro maturation and fertilization of oocytes from unstimulated normal ovaries, polycystic ovaries, and women with polycystic ovary syndrome. Fertil Steril, 76, 936–942.
Clements, R., & Darnell, B. (1980). Myo-inositol content of common foods: development of a high-myo-inositol diet. Am J Clin Nutr. 33, 1954–67.
Connolly, F., Era, M.T., Spath, K., Boswell, L. Mcneilly, A. S., & Duncan, W.C. (2015). In a Ovine Model of Polycystic Ovary Syndrome (PCOS) prenatal androgens suppress female renal gluconeogenesis. PLos One. 10(7), e0132113
Costa, E. C., Soares, E. M. M., Lemos, T. M., Maranhão, T. M. O., & Azevedo, G. D. Índices de obesidade central e fatores de risco cardiovascular na síndrome dos ovários policísticos. Arq Bras Cardiol. 2010; 94(5):633-8.
Deslauriers, J. P. (1991). Recherche qualítative - Guide pratique. Montreal: McGraw~Hill.
Ding, C., Gao, D., Wilding, J., Trayhurn, P., & Bing, C. (2012). Vitamin D signalling in adipose tissue. Br J Nutr, 108(11), 1915–192.
Dunaif, A. (1997). Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Ver. 18, 774–800.
Duncan, W. C. (2014). A guide to understanding polycystic ovary syndrome (PCOS). Journal of Family planning and reproductive health care, 217-225.
Foster, G. D., & Wyatt, H. R. et al. (2003). A randomized trial of a low-carbohydrate diet for obesity. N engl J Med. 2082-90.
Franks, S. (2012). Polycystic ovary syndrome. N Engl J Med 1995, 333,835–861. 3
Motta, A. B. The role of obesity in the development of polycystic ovary syndrome. Curr Pharm Des, 18, 2482–2491.
Gambineri, A., Pelusi, C., et al. (2002). Obesity and the polycystic ovary syndrome. Int J Obes Relat Metab Disord, 883-96.
Heibronn, L. K., Coster, A. C., Campbell, L. V. et al. (2013). The effect of short term overfeeding on serum lipids in healthy humans. Obesity, 21, E649–E659.
Jafari, S. S., et al. (2017). The efect of vitamin D supplementation in combination with low‑calorie diet on anthropometric indices and androgen hormones in women with polycystic ovary syndrome: a double‑blind, randomized, placebo‑controlled trial. J Endocrinol Invest.
Lagunova, Z., Porojnicu, A. C., Lindberg, F, Hexeberg, S., & Monan, J. (2009). The dependency of vitamin D status on body mass index, gender, age and season. Anticancer Re, 29(9), 3713–3720.
Lima, T. C. S., & Mioto, R. C. T. (2007). Procedimentos metodológicos na construção do conhecimento científico: a pesquisa bibliográfica. Katál, Florianópolis, 10.
Legro, R. S. et al. (2013). Diagnostic and treatment of polycystic ovary syndrome: An Endrocrine Society practice guideline. The journal of clinical Endrocrinology & Metabolism, 4565-4592.
Mello, V. D., & Laaksonen, D. E. (2009). Fibras na dieta: tendências atuais e benefícios à saúde na síndrome metabólica e no diabetes melito tipo 2. Arq Bras Endocrinol Metab, 53.
Minegishi, T., Tano, M., & Igarashi, M. et al. (1997)). Expression of follicle-stimulating hormone receptor in human ovary. Eur J Clin Invest, 27, 469–474.
Motta, A. B. (2012). The role of obesity in the development of polycystic ovary syndrome. Curr Pharm Des. 18, 2482–2491.
Nahum, R., Thong, K. J., & Hillier, S. G. Metabolic regulation of androgen production by human thecal cells in vitro. Hum Reprod, 10, 75–81.
Reynolds, J. E. (1993). An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. Martindale-the Extra Pharmacopoeia, 30th ed. Pennsylvania: Rittenhouse Book Distributors, 1379
Rocha, M. P., Marcondes, J. A., Barcellos, C. R., Hayashida, S. A., Curi, D. D., Fonseca, A. M., da et al. (2011). Dyslipidemia in women with polycystic ovary syndrome: incidence, pattern and predictors. Gynecol Endocrinol. 814-9.
Santos, S. S., et al. (2019). Aspectos nutricionais e manejo alimentar em mulheres com síndrome dos ovários policísticos. Revista saúde em foco. Edição 11.
Thomson, R. L., Spedding, S., & Buckley, J. D. Vitamin D in the aetiology and management of polycystic ovary syndrome. Clin Endocrinol, 77(3), 343–350, 2012.
Tonetta, S. A., & Dizerega, G. S. (1989). Intragonadal regulation of follicular maturation. Endocr Ver, 10, 205–229.
Wehr, E. Pilz, S., Schweighofer, N., Giuliani, A., Kopera, D. Pieber, T., et al. (2009). Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome. Eur J Endocrinol, 161(4), 575–582.
Yildiz, B. O. (2008). Assessment, diagnosis and treatment of a patient with hirsutism. Nature Clinical Pratice Endocrinology & Metabolism.
Zeng, L., & Yang, K. (2017). Effectiveness of myoinositol for polycystic ovary syndrome: a systematic review and meta-analysis. Endocrine, 59 (1): 30-38.
Zhang, G., Garmey, J. C., & Veldhuis, J. D. (2000). Interactive stimulation by luteinizing hormone and insulin of the steroidogenic acute regulatory (StAR) protein and 17alpha-hydroxylase/17,20-lyase (CYP17) genes in porcine theca cells. Endocrinology, 141, 2735–2742.
Zuef, L. F. N., Marti, W. P., Vieira, C. S., & Ferriani, R. A. (2012). Ultrasonographic and laboratory markers of metabolic and cardiovascular disease risk in obese women with polycystic ovary syndrome. Ultrasound Obstet Gynecol., 39(3), 341-7.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Elen Chaves de Sousa Xavier; Francisca Marta Nascimento de Oliveira Freitas
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
