Morphometrical analysis of the coronary arteries in human fetuses

Authors

DOI:

https://doi.org/10.33448/rsd-v10i16.23725

Keywords:

Morphology; Anatomy; Coronary vessels; Heart.

Abstract

Coronary arteries anatomical variations in humans have presented great clinical interest for resulting in a better understanding of cardiac pathological processes. This study aimed to analyze the morphometry of the coronary arteries of human cadavers from the fourth to the ninth month of intrauterine life. A total of 62 hearts from formalin-fixed Brazilian fetuses, with gestational ages ranging from 16 to 36 weeks, equally distributed as to gender and fetal age in each group, were analyzed. The dissection procedure was performed by removing the heart with the lungs in “monoblocks”. The length of the arteries under study was determined using a flexible tape placed along the vessels and later measured with a pachymeter. Additionally, histological analysis of the coronary artery tissues was performed to quantify the elastic fibers. The data were analyzed through two-way ANOVA, followed by Student-Newman-Keuls post hoc analysis, considering p < 0.05. When comparing the length of the right coronary artery (RCA) in fetuses between the second and third trimester a statistically significant difference was found for both males (p = 0.04) and females (p = 0.04). No statistically significant difference was found when comparing the left coronary artery (LCA) length between second and third trimester in male (p = 0.07) and female (p = 0.09) fetuses. We noticed a similar growth pattern between male and female fetuses and early development of LCA in relation to RCA.

References

Akkaya, H., & Gunturk, E. E. (2020). Coronary artery anomalies and dominance: data from 7,858 patients in a single center in Turkey. Minerva Cardioangiologica. https://doi.org/10.23736/S0026-4725.20.05279-2

Alemañ, G. B., Burgos, A. A., Agüero, P. M. A., Rodríguez, S. C., Villoslada, J. C. P., & Ezquerra, E. A. (2008). Anatomía normal, variantes anatómicas y anomalías del origen y trayecto de las arterias coronaries por tomografía computarizada multicorte. Radiología, 50(3), 197–206.

Almeida, C., Dourado, R., Machado, C., Santos, E., Pelicano, N., Pacheco, M., Tavares, A., Melo, F., Matos, M., & Faria, J. V. (2012). Anomalias das artérias coronárias. Revista Portuguesa de Cardiologia, 31(7–8), 477–484.

Ballesteros, L. E., Ramirez, L. M., & Quintero, I. D. (2011). Anatomia da artéria coronária direita: análises anatômicas e morfométricas. Brazilian Journal of Cardiovascular Surgery, 26(2), 230–237.

Batista, A. V. de S., Porto, E. A., & Molina, G. P. (2011). Estudo da anatomia da artéria coronária esquerda e suas variações: perspectivas de nova classificação. Revista Saúde & Ciência Online, 2(1), 55–65.

Dodge Jr, J. T., Brown, B. G., Bolson, E. L., & Dodge, H. T. (1992). Lumen diameter of normal human coronary arteries. Influence of age, sex, anatomic variation, and left ventricular hypertrophy or dilation. Circulation, 86(1), 232–246.

Farias, D. C. C., Moreira, A. C. V., Tavares, J. M., Correia, J. N. F., Souza, R. S., & Silva Filho, A. R. da. (2013). Origem anômala da artéria coronária esquerda do seio de Valsalva direito. Revista Brasileira de Cardiologia Invasiva, 21, 82–84.

Fernandes, M., Pinheiro, N. M., Crema, V. O., & Mendonça, A. C. (2014). Effects of microdermabrasion on skin rejuvenation. Journal of Cosmetic and Laser Therapy, 16(1), 26–31.

Fiss, D. M. (2007). Normal coronary anatomy and anatomic variations. Applied Radiology, 14.

He, L., & Zhou, B. (2018). The Development and Regeneration of Coronary Arteries. Current Cardiology Reports, 20(7), 54. https://doi.org/10.1007/s11886-018-0999-2

Hutchins, G. M., Kessler-Hanna, A., & Moore, G. W. (1988). Development of the coronary arteries in the embryonic human heart. Circulation, 77(6), 1250–1257.

Lewis, D. A., Kamon, E., & Hodgson, J. L. (1986). Physiological differences between genders. Implications for sports conditioning. Sports Medicine, 3(5), 357–369. https://doi.org/10.2165/00007256-198603050-00005

Lima Júnior, R., Cabral, R. H., & Prates, N. E. V. B. de. (1993). Tipos de circulação e predominância das artérias coronárias em corações de brasileiros: morphometric study. Brazilian Journal of Cardiovascular Surgery, 8, 9–19.

Lourenço, M. L. G., & Machado, L. H. de A. (2013). Características do período de transição fetal-neonatal e particularidades fisiológicas do neonato canino. Revista Brasileira de Reprodução Animal, 303–308.

Martínez González, B., Theriot Girón, M. del C., López Serna, N., Morales Avalos, R., Quiroga Garza, A., Reyes Hernández, C. G., Villanueva Olivo, A., Leyva Villegas, J. I., Soto Domínguez, A., & De la Fuente Villarreal, D. (2015). Morphological analysis of major segments of coronary artery occlusion: Importance in myocardial revascularization surgery. International Journal of Morphology, 33(4), 1205–1212.

Santos, J. S., Luppi, C. H. B., Campos, É., & Alves, M. V. (2010). Insuficiência coronariana: perfil e fatores de risco relacionados às ocorrências. Revista Ciência Em Extensão, 6(2), 68–85.

Silva, A., Baptista, M. J., & Araújo, E. (2018). Anomalias congénitas das artérias coronárias. Revista Portuguesa de Cardiologia, 37(4), 341–350.

Singh, S., Ajayi, N., Lazarus, L., & Satyapal, K. S. (2017). Anatomic study of the morphology of the right and left coronary arteries. Folia Morphologica, 76(4), 668–674.

Xavier-Vidal, R. (1997). Uma breve revisão sobre alguns aspectos do desenvolvimento embrionário do coração com especial referência às artérias coronárias. Arquivos Brasileiros de Cardiologia, 68(4).

Yurtdas, M., & Gülen, O. (2012). Anomalous origin of the right coronary artery from the left anterior descending artery: review of the literature. Cardiology Journal, 19(2), 122–129.

Zamith, M. M., Tatani, S. B., Carvalho, A. C. C., Campos Filho, O., de Andrade, J. L., & Moises, V. A. (2005). Artérias Coronárias na Faixa Etária Pediátrica pela Ecocardiografia. CEP, 4320, 30.

Downloads

Published

13/12/2021

How to Cite

GARÇÃO, D. C.; SANTOS, M. B.; CARVALHO NETO, J. N. de .; CORREIA, A. G. da S.; PEREIRA, P. C.; ANDRADE, R. C. de; FRAGA, B. P.; MOREIRA, O. S. M.; OLIVEIRA, A. D. S. de; FEITOSA, V. L. C. Morphometrical analysis of the coronary arteries in human fetuses. Research, Society and Development, [S. l.], v. 10, n. 16, p. e340101623725, 2021. DOI: 10.33448/rsd-v10i16.23725. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/23725. Acesso em: 14 nov. 2024.

Issue

Vol. 10 No. 16

Section

Health Sciences

License

Copyright (c) 2021 Diogo Costa Garção; Matheus Boaventura Santos; José Nolasco de Carvalho Neto; Alisson Guilherme da Silva Correia; Pedro Costa Pereira; Roberta Coelho de Andrade; Byanka Porto Fraga; Olga Sueli Marques Moreira; Ana Denise Santana de Oliveira; Vera Lúcia Correia Feitosa

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.