Functional and therapeutic properties of beta-hydroxy beta-methylbutyrate (HMB): an integrative review
DOI:
https://doi.org/10.33448/rsd-v9i3.2422Keywords:
Lipolysis; Anabolic effect; Dietary sources; Nutrition.Abstract
Betahydroxy-beta-methylbutyrate (HMB) is a branched-chain metabolite of the amino acid L-Leucine, synthesized in liver and muscle cells. It shows many functional properties observed as therapeutic effect in many deseases, highlighting those with proteic catabolism nd anticatabolic effect, being related to the increase of muscle strength and muscle mass, therefore, without treatment of sarcopenia. This study is a literature review not classified as PubMed, eduCAPES, ResearchGate database with keywords "beta-hydroxy-beta-methylbutyrate" or "HMB", "anabolic effect of HMB", "dietary sources" properties of HMB". The terms were designated, those that prevail are a factor of differentiation and the therapeutic and functional factors, standing out their anabolic effect, increase of the strength and reduction of the body fat.
References
Albert, F.J.; Morente-Sánchez, J.; Ortega, F.B.; Castillo, M.J.; Gutiérrez, Á. (2015). Usefulness of β-hydroxy-β-methylbutyrate (HMB) supplementation in different sports: an update and practical implications. Nutricion hospitalaria;
American Diabetes Association (2008). Diagnosis and classification of diabetes mellitus. Diabetes Care.
Brasil. (1999). Resolução nº 18, de 30 de abril de 1999. Aprova o Regulamento Técnico que Estabelece as Diretrizes Básicas para Análise e Comprovação de Propriedades Funcionais e ou de Saúde Alegadas em Rotulagem de Alimentos. Diário Oficial da República Federativa do Brasil. Brasília,03 nov. 1999.
Bruckbauer, A.; Zemel, M.B.; Thorpe, T.; Akula, M.R.; Stuckey, A.C.; Osborne, D.; Martin, E.B.; Kennel, S.; Wall, J.S. (2012). Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab.
David, N.; Hewitt, J.A.; Howatson, G. et al. (2006). HMB and KIC Supplementation Does Not Reduce Signs and Symptoms of Exercise-Induced Muscle Damage. Medicine & Science in Sports & Exercise. Vol. 38. Num. 5.
Eley, H.L.; Russell S.T.; Baxter, J.H.; Mukerji, P.; Tisdale, M.J. (2007). Signaling pathways initiated by beta-hydroxy-beta-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli. American Journal Physiology Endocrinology Metabolism.
Flakoll, P.; Sharp, R.; Baier, S.; Levenhagen, D.; Carr, C.; Nissen, S. (2004). Effect of beta-hydroxy-beta-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women. Nutrition,
Fuller, J.; Sharp, R.; Angus, H.; Baier, S.M.; Rathmacher, J.A. (2011). Free acid gel form of bhydroxy-b-methylbutyrate (HMB) improves HMB clearance from plasma in human subjects compared with the calcium HMB salt. Nutrition.
Fuller, J.; Sharp, R.; Angus, H.; Khoo, P.; Rathmacher, J. (2015). Comparison of availability and plasma clearance rates of b-hydroxy-b-methylbutyrate delivery in the free acid and calcium salt forms. Britsh Journal of Nutrition.
Holeček, M. (2017). Beta‐hydroxy‐beta‐methylbutyrate supplementation and skeletal muscle in healthy and muscle‐wasting conditions. Journal of cachexia, sarcopenia and muscle.
Lecker, S.H.; Goldberg, A.L.; Mitch, W.E. (2006). Protein Degradation by the Ubiquitin–Proteasome Pathway in Normal and Disease States. J Am Soc Nephrol.
Manjarrez, M.O.R.; Torres-Vaca, M.; González-Gallego, J.; Alvear-Ordenes, I. (2015). El β-hidroxi-β-metilbutirato (HMB) como suplemento nutricional (I): metabolismo y toxicidade. Nutrición Hospitalaria.
Nunes, E. A. (2009). Efeitos do B-Hidroxi-B-Metilbutirato (HMB) sobre produção de citocinas e vias de sinalização de células imunitárias.
Paschoal, V. Neves, A. (2014). Tratado de nutrição esportiva funcional. Roca. São Paulo.
Pereira, A.S. et al. (2018). Metodologia da pesquisa científica. [e-book]. Santa Maria/RS. Ed.
UAB/NTE/UFSM.Disponívelm:https://repositorio.ufsm.br/bitstream/handle1/15824Lic_Com
putacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1. Acesso em 30 ago. 2019.
Rowlands, D.S.; Thomson, J.S. (2009). Effects of beta-hydroxy-beta-methylbutyrate supplementation during resistance training on strength, body composition, and muscle damage in trained and untrained young men: a meta-analysis. The Journal of Strength & Conditioning Research. Vol.23. Num.3.
Slater, G.J. Jenkins, D. Logan, P. Lee, H. Vukovich. M. Rathmacher J.A. (2001). Beta-hydroxy-betamethylbutyrate (HMB) supplementation does not affect changes in strength or body composition during resistance training in trained men. Int J Sport Nutr Exerc Metab.
Smith, H. J.; Mukerji, P.; Tisdale, M. J. (2005). Attenuation of proteasome-induced proteolysis in skeletal muscle by β-hydroxy-β-methylbutyrate in cancer-induced muscle loss. Cancer research.
Spiering, B.A.; Kraemer, W.J.; Anderson, J.M. et al. (2008). Resistance exercise biology: manipulation of resistance exercise programme variables determines the responses of cellular and molecular signalling pathways. Sports Medicine. Vol.38. Num.7.
Teixeira, F.J.; Matias, C.N.; Monteiro, C.P. et al. (2019) No effect of HMB or α-HICA supplementation on training-induced changes in body composition. European Journal of Sport Science. Vol. 19. Num. 6.
Vianna, D.; Teodoro, G. F. R.; Torres-Leal, F. L.; Tirapegui. J. (2010). Protein Synthesis Regutation by Leucine. Brazilian Journal of Pharmaceutical Sciences. São Paulo. Vol. 46. Num. 1.
Vukovich, M.D, Strubbs, N.B, Bohlken, R.M, Desch, M.F, Fuller, J.Rw. Jc, Rathmacher, J.A. (1997). The effect of dietary b-Hydroxy-b-Methylbutyrate (HMB) on strength gains and body composition changes in older adults. FASEB J.
Vukovich, M.D.; Slater, G.; Macchi, M.B.; Turner, M.J.; Fallon, K.; Boston, T.; Ratchmacher, J. (2001). β-hydroxy-β-methylbutyrate (HMB) kinetics and the influence of glucose ingestion in humans. J. Nutr. Biochem.
Wilkinson, D. J.; Hossain, T.; Limb, M.C.; Phillips, B.E.; Lund, J.; Williams, J.P.; Brook, M.S.; Cegielski, J.; Philp, A.; Ashcroft, S.; Rathmacher, J.A.; Szewczyk, N.J.; Smith, K.; Atherton, P.J. (2017). Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism. Clinical Nutrition.
Wilson, J. M.; Lowery, R.P.; Joy, J.M.; Andersen, J.C.; Wilson, S.M.; Stout, J.R.; Duncan, N.; Fuller, J.C.; Baier, S.M.; Naimo, M.A.; Rathmacher, J. (2014). The effects of 12 weeks of beta-hydroxy-beta-methylbutyrate free acid supplementation on muscle mass, strength, and power in resistance-trained individuals: a randomized, double-blind, placebo-controlled study. European journal of applied physiology.
Zanchi, N. E.; Nicastro, H.; Gualano, B.; Costa, A.S.; Lancha Junior, A.H. (2009). Suplementação de HMB: relevância clínica e mecanismos de ação. Revista Mackenzie de Educação Física e Esporte.
Zhang, Y.; Guo, K.; LeBlanc, R.E.; Loh, D.; Schwartz, G.J.; Yu, Y.H. (2007). Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms. Diabetes.
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