Canonical WNT signaling pathway in oral squamous cell carcinoma prognosis

Authors

DOI:

https://doi.org/10.33448/rsd-v11i2.25462

Keywords:

β-catenin; Oral squamous cell carcinoma; OSCC; Wnt signaling.

Abstract

The aim of the study was to demonstrate the immunohistochemical expression of the wnt/b-catenin pathway in oral carcinoma cells (OSCC), through a literature review. For this, a search was performed in the PubMed and SciELO databases with the keywords “β-catenin”, “oral squamous cell carcinoma”, “OSCC” and “Wnt signaling” with the Boolean AND operator. The inclusion criteria adopted were articles published in English, in vitro, in situ articles or clinical trials from 2010 to 2021 that relate the canonical WNT signaling pathway with oral squamous cell carcinoma and the exclusion criteria considered were duplicate articles, literature review and that did not address the issue. After reading the title, abstract, and full content of each of the studies, 110 articles were selected. IncRNA compounds, enzymes, hexachlorophene derivatives and lignin isolated from Taiwania were able to suppress growth and metastasis by inhibiting the WNT/β-catenin pathway. Cancer stem cells, PON2 type enzymes, nicotine intake, cytokine TNF-α and FAD1 gene are able to increase growth and metastasis by inhibiting the same pathway. Therefore, the expression of these biomarkers can influence the prognosis of cancer cells and help practitioners to explore new possible therapeutic effects in OSSC by modulating the Wnt/β-catenin pathway.

References

Araújo, C., Dias, L. P., Ferreira, P. C., Mittmann, J., Pupin, B., Brancini, G., Braga, G., & Rangel, D. (2018). Responses of entomopathogenic fungi to the mutagen 4-nitroquinoline 1-oxide. Fungal biology, 122(6), 621–628. https://doi.org/10.1016/j.funbio.2018.03.007.

Avgeris, M., & Scorilas, A. (2016). Kallikrein-related peptidases (KLKs) as emerging therapeutic targets: focus on prostate cancer and skin pathologies. Expert opinion on therapeutic targets, 20(7), 801–818. https://doi.org/10.1517/14728222.2016.1147560.

Benetatos, L., Vartholomatos, G., & Hatzimichael, E. (2011). MEG3 imprinted gene contribution in tumorigenesis. International journal of cancer, 129(4), 773–779. https://doi.org/10.1002/ijc.26052

Bernard, J. J., Cowing-Zitron, C., Nakatsuji, T., Muehleisen, B., Muto, J., Borkowski, A. W., Martinez, L., Greidinger, E. L., Yu, B. D., & Gallo, R. L. (2012). Ultraviolet radiation damages self non coding RNA and is detected by TLR3. Nature medicine, 18(8), 1286–1290. https://doi.org/10.1038/nm.2861

Beroukhim, R., Mermel, C. H., Porter, D., Wei, G., Raychaudhuri, S., Donovan, J., Barretina, J., Boehm, J. S., Dobson, J., Urashima, M., Mc Henry, K. T., Pinchback, R. M., Ligon, A. H., Cho, Y. J., Haery, L., Greulich, H., Reich, M., Winckler, W., Lawrence, M. S., Weir, B. A., … Meyerson, M. (2010). The landscape of somatic copy-number alteration across human cancers. Nature, 463(7283), 899–905. https://doi.org/10.1038/nature08822

Cabrera, M. C., Hollingsworth, R. E., & Hurt, E. M. (2015). Cancer stem cell plasticity and tumor hierarchy. World journal of stem cells, 7(1), 27–36. https://doi.org/10.4252/wjsc.v7.i1.27.

Cai, Y., He, J., & Zhang, D. (2015). Long noncoding RNA CCAT2 promotes breast tumor growth by regulating the Wnt signaling pathway. OncoTargets and therapy, 8, 2657–2664. https://doi.org/10.2147/OTT.S90485

Calin, G. A., Liu, C. G., Ferracin, M., Hyslop, T., Spizzo, R., Sevignani, C., Fabbri, M., Cimmino, A., Lee, E. J., Wojcik, S. E., Shimizu, M., Tili, E., Rossi, S., Taccioli, C., Pichiorri, F., Liu, X., Zupo, S., Herlea, V., Gramantieri, L., Lanza, G., … Croce, C. M. (2007). Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer cell, 12(3), 215–229. https://doi.org/10.1016/j.ccr.2007.07.027

Carloni, V., Mazzocca, A., Mello, T., Galli, A. & Capaccioli, S. Cell fusion promotes chemoresistance in metastatic colon carcinoma. Oncogene2013;32(21):2649-2660. https://doi.org/10.1038/onc.2012.268.

Cekaite, L., Rantala, J. K., Bruun, J., Guriby, M., Agesen, T. H., Danielsen, S. A., Lind, G. E., Nesbakken, A., Kallioniemi, O., Lothe, R. A., & Skotheim, R. I. (2012). MiR-9, -31, and -182 deregulation promote proliferation and tumor cell survival in colon cancer. Neoplasia (New York, N.Y.), 14(9), 868–879. https://doi.org/10.1593/neo.121094.

Chang, N. W., Pei, R. J., Tseng, H. C., Yeh, K. T., Chan, H. C., Lee, M. R., Lin, C., Hsieh, W. T., Kao, M. C., Tsai, M. H., & Lin, C. F. (2010). Co-treating with arecoline and 4-nitroquinoline 1-oxide to establish a mouse model mimicking oral tumorigenesis. Chemico-biological interactions, 183(1), 231–237. https://doi.org/10.1016/j.cbi.2009.10.005.

Chen M., Sun, X., Wang, Y., Ling, K., Chen, C., Cai, X., Liang, X., & Liang, Z. (2019). FAT1 inhibits the proliferation and metastasis of cervical cancer cells by binding β-catenin. International journal of clinical and experimental pathology, 12(10), 3807–3818.

Chen, D., Li, S. G., Chen, J. Y., & Xiao, M. (2018). MiR-183 maintains canonical Wnt signaling activity and regulates growth and apoptosis in bladder cancer via targeting AXIN2. European review for medical and pharmacological sciences, 22(15), 4828–4836. https://doi.org/10.26355/eurrev_201808_15618

Chen, J., Hu, L., Chen, J., Pan, Q., Ding, H., Xu, G., Zhu, P., Wen, X., Huang, K., & Wang, Y. (2016). Detection and Analysis of Wnt Pathway Related lncRNAs Expression Profile in Lung Adenocarcinoma. Pathology oncology research: POR, 22(3), 609–615. https://doi.org/10.1007/s12253-016-0046-9

Chen, L. L., Gao, G. X., Shen, F. X., Chen, X., Gong, X. H., & Wu, W. J. (2018). SDC4 Gene Silencing Favors Human Papillary Thyroid Carcinoma Cell Apoptosis and Inhibits Epithelial Mesenchymal Transition via Wnt/β-Catenin Pathway. Molecules and cells, 41(9), 853–867. https://doi.org/10.14348/molcells.2018.0103

Choe, Y., & Pleasure, S. J. (2012). Wnt signaling regulates intermediate precursor production in the postnatal dentate gyrus by regulating CXCR4 expression. Developmental neuroscience, 34(6), 502–514. https://doi.org/10.1159/000345353.

Cui, X., Yi, Q., Jing, X., Huang, Y., Tian, J., Long, C., Xiang, Z., Liu, J., Zhang, C., Tan, B., Li, Y., & Zhu, J. (2018). Mining Prognostic Significance of MEG3 in Human Breast Cancer Using Bioinformatics Analysis. Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology, 50(1), 41–51. https://doi.org/10.1159/000493956

Cui, Z., Cui, Y., Yang, S., Luo, G., Wang, Y., Lou, Y., & Sun, X. (2017). KLK4 silencing inhibits the growth of oral squamous cell carcinoma through Wnt/β-catenin signaling pathway. Cell biology international, 41(4), 392–404. https://doi.org/10.1002/cbin.10736.

Dasgupta, S., Demirci, F. Y., Dressen, A. S., Kao, A. H., Rhew, E. Y., Ramsey-Goldman, R., Manzi, S., Kammerer, C. M., & Kamboh, M. I. (2011). Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus. BMC medical genetics, 12, 7. https://doi.org/10.1186/1471-2350-12-7

Derrien, T., Johnson, R., Bussotti, G., Tanzer, A., Djebali, S., Tilgner, H., Guernec, G., Martin, D., Merkel, A., Knowles, D. G., Lagarde, J., Veeravalli, L., Ruan, X., Ruan, Y., Lassmann, T., Carninci, P., Brown, J. B., Lipovich, L., Gonzalez, J. M., Thomas, M., … Guigó, R. (2012). The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome research, 22(9), 1775–1789. https://doi.org/10.1101/gr.132159.111

Ding, J., Jin, W., Chen, C., Shao, Z., & Wu, J. (2012). Tumor associated macrophage × cancer cell hybrids may acquire cancer stem cell properties in breast cancer. PloS one, 7(7), e41942. https://doi.org/10.1371/journal.pone.0041942.

Eberhart, C. G., & Argani, P. (2001). Wnt signaling in human development: beta-catenin nuclear translocation in fetal lung, kidney, placenta, capillaries, adrenal, and cartilage. Pediatric and developmental pathology: the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 4(4), 351–357. https://doi.org/10.1007/s10024001-0037-y

Fan, Y., Shen, B., Tan, M., Mu, X., Qin, Y., Zhang, F., & Liu, Y. (2014). Long non-coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling. The FEBS journal, 281(7), 1750–1758. https://doi.org/10.1111/febs.12737

Fang, Z., Zhao, J., Xie, W., Sun, Q., Wang, H., & Qiao, B. (2017). LncRNA UCA1 promotes proliferation and cisplatin resistance of oral squamous cell carcinoma by sunppressing miR-184 expression. Cancer medicine, 6(12), 2897–2908. https://doi.org/10.1002/cam4.1253

Fracalossi, A. C., Silva, M., Oshima, C. T., & Ribeiro, D. A. (2010). Wnt/beta-catenin signalling pathway following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. Experimental and molecular pathology, 88(1), 176–183. https://doi.org/10.1016/j.yexmp.2009.11.004.

Freitas, R., Silveira, E. J., Silveira, J. P., Silva, F. M., & Amorim, R. F. (2010). Correlation of β-catenin expresssion and metastasis in tongue squamous cell carcinoma. Acta cirurgica brasileira, 25(6), 513–517. https://doi.org/10.1590/s0102-86502010000600010.

Furlong, C. E., Marsillach, J., Jarvik, G. P., & Costa, L. G. (2016). Paraoxonases-1, -2 and -3: What are their functions? Chemico-biological interactions, 259(Pt B), 51–62. https://doi.org/10.1016/j.cbi.2016.05.036.

Gallenkamp, J., Spanier, G., Wörle, E., Englbrecht, M., Kirschfink, M., Greslechner, R., Braun, R., Schäfer, N., Bauer, R. J., & Pauly, D. (2017). A novel multiplex detection array revealed systemic complement activation in oral squamous cell carcinoma. Oncotarget, 9(3), 3001–3013. https://doi.org/10.18632/oncotarget.22963

Gao, F., Zhao, Z. L., Zhao, W. T., Fan, Q. R., Wang, S. C., Li, J., Zhang, Y. Q., Shi, J. W., Lin, X. L., Yang, S., Xie, R. Y., Liu, W., Zhang, T. T., Sun, Y. L., Xu, K., Yao, K. T., & Xiao, D. (2013). miR-9 modulates the expression of interferon-regulated genes and MHC class I molecules in human nasopharyngeal carcinoma cells. Biochemical and biophysical research communications, 431(3), 610–616. https://doi.org/10.1016/j.bbrc.2012.12.097.

Gast, C. E., Silk, A. D., Zarour, L., Riegler, L., Burkhart, J. G., Gustafson, K. T., Parappilly, M. S., Roh-Johnson, M., Goodman, J. R., Olson, B., Schmidt, M., Swain, J. R., Davies, P. S., Shasthri, V., Iizuka, S., Flynn, P., Watson, S., Korkola, J., Courtneidge, S. A., Fischer, J. M.,Wong, M. H. (2018). Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival. Science advances, 4(9), eaat7828. https://doi.org/10.1126/sciadv.aat7828.

Gottardi, C. J., & Gumbiner, B. M. (2004). Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes. The Journal of cell biology, 167(2), 339–349. https://doi.org/10.1083/jcb.200402153

Greife, A., Knievel, J., Ribarska, T., Niegisch, G., & Schulz, W. A. (2014). Concomitant downregulation of the imprinted genes DLK1 and MEG3 at 14q32.2 by epigenetic mechanisms in urothelial carcinoma. Clinical epigenetics, 6(1), 29. https://doi.org/10.1186/1868-7083-6-29

Gupta, B., Johnson, N. W., & Kumar, N. (2016). Global Epidemiology of Head and Neck Cancers: A Continuing Challenge. Oncology, 91(1), 13–23. https://doi.org/10.1159/000446117

Gupta, R. A., Shah, N., Wang, K. C., Kim, J., Horlings, H. M., Wong, D. J., Tsai, M. C., Hung, T., Argani, P., Rinn, J. L., Wang, Y., Brzoska, P., Kong, B., Li, R., West, R. B., van de Vijver, M. J., Sukumar, S., & Chang, H. Y. (2010). Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature, 464(7291), 1071–1076. https://doi.org/10.1038/nature08975

Guttman, M., Donaghey, J., Carey, B. W., Garber, M., Grenier, J. K., Munson, G., Young, G., Lucas, A. B., Ach, R., Bruhn, L., Yang, X., Amit, I., Meissner, A., Regev, A., Rinn, J. L., Root, D. E., & Lander, E. S. (2011). lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature, 477(7364), 295–300. https://doi.org/10.1038/nature10398

Hadzic, S., Gojkov-Vukelic, M., Pasic, E., & Dervisevic, A. (2017). Importance of Early Detection of Potentially Malignant Lesions in the Prevention of Oral Cancer. Materia socio-medica, 29(2), 129–133. https://doi.org/10.5455/msm.2017.29.129-133

Han, F., Zhang, M. Q., Liu, W. B., Sun, L., Hao, X. L., Yin, L., Jiang, X., Cao, J., & Liu, J. Y. (2018). SOX30 specially prevents Wnt-signaling to suppress metastasis and improve prognosis of lung adenocarcinoma patients. Respiratory research, 19(1), 241. https://doi.org/10.1186/s12931-018-0952-3

Han, Y., Yang, Y. N., Yuan, H. H., Zhang, T. T., Sui, H., Wei, X. L., Liu, L., Huang, P., Zhang, W. J., & Bai, Y. X. (2014). UCA1, a long non-coding RNA up-regulated in colorectal cancer influences cell proliferation, apoptosis and cell cycle distribution. Pathology, 46(5), 396–401. https://doi.org/10.1097/PAT.0000000000000125.

Hsieh, C. H., Hsu, H. H., Shibu, M. A., Day, C. H., Bau, D. T., Ho, C. C., Lin, Y. M., Chen, M. C., Wang, S. H., & Huang, C. Y. (2017). Down-regulation of β-catenin and the associated migration ability by Taiwanin C in arecoline and 4-NQO-induced oral cancer cells via GSK-3β activation. Molecular carcinogenesis, 56(3), 1055–1067. https://doi.org/10.1002/mc.22570. https://doi.org/10.1371/journal.pone.0066731.

Huang, J., Zhou, N., Watabe, K., Lu, Z., Wu, F., Xu, M., & Mo, Y. Y. (2014). Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1). Cell death & disease, 5(1), e1008. https://doi.org/10.1038/cddis.2013.541.

Hwang, J. T., & Kelly, G. M. (2012). GATA6 and FOXA2 regulate Wnt6 expression during extraembryonic endoderm formation. Stem cells and development, 21(17), 3220–3232. https://doi.org/10.1089/scd.2011.0492

Hydes, T. J., Burton, R., Inskip, H., Bellis, M. A., & Sheron, N. (2019). A comparison of gender-linked population cancer risks between alcohol and tobacco: how many cigarettes are there in a bottle of wine? BMC public health, 19(1), 316. https://doi.org/10.1186/s12889-019-6576-9.

Jin, Z., Zhao, C., Han, X., & Han, Y. (2012). Wnt5a promotes ewing sarcoma cell migration through upregulating CXCR4 expression. BMC cancer, 12, 480. https://doi.org/10.1186/1471-2407-12-480.

Kang, J. Y., He, J., & Duan, X. F. (2019) Shanghai kou qiang yi xue = Shanghai journal of stomatology, 28(4), 368–372.

Krüger, M., Amort, J., Wilgenbus, P., Helmstädter, J. P., Grechowa, I., Ebert, J., Tenzer, S., Moergel, M., Witte, I., & Horke, S. (2016). The anti-apoptotic PON2 protein is Wnt/β-catenin-regulated and correlates with radiotherapy resistance in OSCC patients. Oncotarget, 7(32), 51082–51095. https://doi.org/10.18632/oncotarget.9013.

Lazova, R., Laberge, G. S., Duvall, E., Spoelstra, N., Klump, V., Sznol, M., Cooper, D., Spritz, R. A., Chang, J. T., & Pawelek, J. M. (2013). A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer. PloS one, 8(6), e66731.

Leucci, E., Zriwil, A., Gregersen, L. H., Jensen, K. T., Obad, S., Bellan, C., Leoncini, L., Kauppinen, S., & Lund, A. H. (2012). Inhibition of miR-9 de-represses HuR and DICER1 and impairs Hodgkin lymphoma tumour outgrowth in vivo. Oncogene, 31(49), 5081–5089. https://doi.org/10.1038/onc.2012.

Li, C., Hong, Z., Ou, M., Zhu, X., Zhang, L., & Yang, X. (2021). Integrated miRNA-mRNA Expression Profiles Revealing Key Molecules in Ovarian Cancer Based on Bioinformatics Analysis. BioMed research international, 2021, 6673655. https://doi.org/10.1155/2021/6673655

Li, J., Zhuang, C., Liu, Y., Chen, M., Zhou, Q., Chen, Z., He, A., Zhao, G., Guo, Y., Wu, H., Cai, Z., & Huang, W. (2016). shRNA targeting long non-coding RNA CCAT2 controlled by tetracycline-inducible system inhibits progression of bladder cancer cells. Oncotarget, 7(20), 28989–28997. https://doi.org/10.18632/oncotarget.8259

Li, L., Liu, H. C., Wang, C., Liu, X., Hu, F. C., Xie, N., Lü, L., Chen, X., & Huang, H. Z. (2016). Overexpression of β-Catenin Induces Cisplatin Resistance in Oral Squamous Cell Carcinoma. BioMed research international, 2016, 5378567. https://doi.org/10.1155/2016/5378567.

Liang, S., Zhang, S., Wang, P., Yang, C., Shang, C., Yang, J., & Wang, J. (2017). LncRNA, TUG1 regulates the oral squamous cell carcinoma progression possibly via interacting with Wnt/β-catenin signaling. Gene, 608, 49–57. https://doi.org/10.1016/j.gene.2017.01.024

Ling, H., Spizzo, R., Atlasi, Y., Nicoloso, M., Shimizu, M., Redis, R. S., Nishida, N., Gafà, R., Song, J., Guo, Z., Ivan, C., Barbarotto, E., De Vries, I., Zhang, X., Ferracin, M., Churchman, M., van Galen, J. F., Beverloo, B. H., Shariati, M., Haderk, F., … Calin, G. A. (2013). CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome research, 23(9), 1446–1461. https://doi.org/10.1101/gr.152942.112

Liu, S., Kumar, S. M., Lu, H., Liu, A., Yang, R., Pushparajan, A., Guo, W., & Xu, X. (2012). MicroRNA-9 up-regulates E-cadherin through inhibition of NF-κB1-Snail1 pathway in melanoma. The Journal of pathology, 226(1), 61–72. https://doi.org/10.1002/path.2964.

Liu, Z., Wu, C., Xie, N., & Wang, P. (2017). Long non-coding RNA MEG3 inhibits the proliferation and metastasis of oral squamous cell carcinoma by regulating the WNT/β-catenin signaling pathway. Oncology letters, 14(4), 4053–4058. https://doi.org/10.3892/ol.2017.6682

Lu, Z., Xiao, Z., Liu, F., Cui, M., Li, W., Yang, Z., Li, J., Ye, L., & Zhang, X. (2016). Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1). Oncotarget, 7(1), 241–254. https://doi.org/10.18632/oncotarget.6280

Ma, Y., Hu, X., Shang, C., Zhong, M., & Guo, Y. (2017). Silencing of long non-coding RNA CCAT2 depressed malignancy of oral squamous cell carcinoma via Wnt/β-catenin pathway. Tumour biology: the journal of the International Society for Oncodevelopmental Biology and Medicine, 39(7), 1010428317717670. https://doi.org/10.1177/1010428317717670

Madathil, S. A., Rousseau, M. C., Wynant, W., Schlecht, N. F., Netuveli, G., Franco, E.L., & Nicolau, B. (2016). Nonlinear association between betel quid chewing and oral cancer: Implications for prevention. Oral oncology, 60, 25–31. https://doi.org/10.1016/j.oraloncology.2016.06.011.

Mavridis, K., & Scorilas, A. (2010). Prognostic value and biological role of the kallikrein-related peptidases in human malignancies. Future oncology (London, England), 6(2), 269–285. https://doi.org/10.2217/fon.09.149.

Meacham, C. E., & Morrison, S. J. (2013). Tumour heterogeneity and cancer cell plasticity. Nature, 501(7467), 328–337. https://doi.org/10.1038/nature12624.

Melton, C., Reuter, J. A., Spacek, D. V., & Snyder, M. (2015). Recurrent somatic mutations in regulatory regions of human cancer genomes. Nature genetics, 47(7), 710–716. https://doi.org/10.1038/ng.3332

Michalik, K. M., You, X., Manavski, Y., Doddaballapur, A., Zörnig, M., Braun, T., John, D., Ponomareva, Y., Chen, W., Uchida, S., Boon, R. A., & Dimmeler, S. (2014). Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth. Circulation research, 114(9), 1389–1397. https://doi.org/10.1161/CIRCRESAHA.114.303265

Miki, T., Yasuda, S. Y., & Kahn, M. (2011). Wnt/β-catenin signaling in embryonic stem cell self-renewal and somatic cell reprogramming. Stem cell reviews and reports, 7(4), 836–846. https://doi.org/10.1007/s12015-011-9275-1.

Morris, L. G., Kaufman, A. M., Gong, Y., Ramaswami, D., Walsh, L. A., Turcan, Ş., Eng, S., Kannan, K., Zou, Y., Peng, L., Banuchi, V. E., Paty, P., Zeng, Z., Vakiani, E., Solit, D., Singh, B., Ganly, I., Liau, L., Cloughesy, T. C., Mischel, P. S. Chan, T. A. (2013). Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. Nature genetics, 45(3), 253–261. https://doi.org/10.1038/ng.2538.

Nayak, A., Siddharth, S., Das, S., Nayak, D., Sethy, C., & Kundu, C. N. (2017). Nanoquinacrine caused apoptosis in oral cancer stem cells by disrupting the interaction between GLI1 and β catenin through activation of GSK3β. Toxicology and applied pharmacology, 330, 53–64. https://doi.org/10.1016/j.taap.2017.07.008

Nie, D., Wang, Z., Zhang, Y., Pang, D., Ouyang, H., & Li, L. I. (2016). Fat-1 gene inhibits human oral squamous carcinoma cell proliferation through downregulation of β-catenin signaling pathways. Experimental and therapeutic medicine, 11(1), 191–196. https://doi.org/10.3892/etm.2015.2847.

Nik-Zainal, S., Alexandrov, L. B., Wedge, D. C., Van Loo, P., Greenman, C. D., Raine, K., Jones, D., Hinton, J., Marshall, J., Stebbings, L. A., Menzies, A., Martin, S., Leung, K., Chen, L., Leroy, C., Ramakrishna, M., Rance, R., Lau, K. W., Mudie, L. J., Varela, I, Breast Cancer Working Group of the International Cancer Genome Consortium (2012). Mutational processes molding the genomes of 21 breast cancers. Cell, 149(5), 979–993. https://doi.org/10.1016/j.cell.2012.04.024.

Nishikawa Y, Miyazaki T, Nakashiro K, et al. Human FAT1 cadherin controls cell migration and invasion of oral squamous cell carcinoma through the localization of β-catenin. Oncol Rep. 2011;26(3):587–592. https://doi.org/10.3892/or.2011.1324.

Noubissi, F. K., Harkness, T., Alexander, C. M., & Ogle, B. M. (2015). Apoptosis-induced cancer cell fusion: a mechanism of breast cancer metastasis. FASEB journal: official publication of the Federation of American Societies for Experimental Biology, 29(9), 4036–4045. https://doi.org/10.1096/fj.15-271098

Ohno, R., Uozaki, H., Kikuchi, Y., Kumagai, A., Aso, T., Watanabe, M., Watabe, S., Muto, S., & Yamaguchi, R. (2016). Both cancerous miR-21 and stromal miR-21 in urothelial carcinoma are related to tumour progression. Histopathology, 69(6), 993–999. https://doi.org/10.1111/his.13032.

Pannone, G., Bufo, P., Santoro, A., Franco, R., Aquino, G., Longo, F., Botti, G., Serpico, R., Cafarelli, B., Abbruzzese, A., Caraglia, M., Papagerakis, S., & Lo Muzio, L. (2010). WNT pathway in oral cancer: epigenetic inactivation of WNT-inhibitors. Oncology reports, 24(4), 1035–1041. https://doi.org/10.3892/or.2010.1035

Pannone, G., Bufo, P., Santoro, A., Franco, R., Aquino, G., Longo, F., Botti, G., Serpico, R., Cafarelli, B., Abbruzzese, A., Caraglia, M., Papagerakis, S., & Lo Muzio, L. (2010). WNT pathway in oral cancer: epigenetic inactivation of WNT-inhibitors. Oncology reports, 24(4), 1035–1041. https://doi.org/10.3892/or.2010.1035.

Patel KJ, De Silva HL, Tong DC, Love RM. Concordance between clinical and histopathologic diagnoses of oral mucosal lesions. J Oral Maxillofac Surg. 2011; 69:125–133.

Petridis, C., Shinomiya, I., Kohut, K., Gorman, P., Caneppele, M., Shah, V., Troy, M., Pinder, S. E., Hanby, A., Tomlinson, I., Trembath, R. C., Roylance, R., Simpson, M. A., & Sawyer, E. J. (2014). Germline CDH1 mutations in bilateral lobular carcinoma in situ. British journal of cancer, 110(4), 1053–1057. https://doi.org/10.1038/bjc.2013.792

Quinn, J. J., Zhang, Q. C., Georgiev, P., Ilik, I. A., Akhtar, A., & Chang, H. Y. (2016). Rapid evolutionary turnover underlies conserved lncRNA-genome interactions. Genes & development, 30(2), 191–207. https://doi.org/10.1101/gad.272187.115.

Ren, W., Qiang, C., Gao, L., Li, S. M., Zhang, L. M., Wang, X. L., Dong, J. W., Chen, C., Liu, C. Y., & Zhi, K. Q. (2014). Circulating microRNA-21 (MIR-21) and phosphatase and tensin homolog (PTEN) are promising novel biomarkers for detection of oral squamous cell carcinoma. Biomarkers: biochemical indicators of exposure, response, and susceptibility to chemicals, 19(7), 590–596. https://doi.org/10.3109/1354750X.2014.955059.

Riley, B. T., Ilyichova, O., Costa, M. G., Porebski, B. T., de Veer, S. J., Swedberg, J. E., Kass, I., Harris, J. M., Hoke, D. E., & Buckle, A. M. (2016). Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics. Scientific reports, 6, 35385. https://doi.org/10.1038/srep35385.

Roadmap Epigenomics Consortium, Kundaje, A., Meuleman, W., Ernst, J., Bilenky, M., Yen, A., Heravi-Moussavi, A., Kheradpour, P., Zhang, Z., Wang, J., Ziller, M. J., Amin, V., Whitaker, J. W., Schultz, M. D., Ward, L. D., Sarkar, A., Quon, G., Sandstrom, R. S., Eaton, M. L., Wu, Y. C., … Kellis, M. (2015). Integrative analysis of 111 reference human epigenomes. Nature, 518(7539), 317–330. https://doi.org/10.1038/nature14248

Saba, N. F., Goodman, M., Ward, K., Flowers, C., Ramalingam, S., Owonikoko, T., Chen, A., Grist, W., Wadsworth, T., Beitler, J. J., Khuri, F. R., & Shin, D. M. (2011). Gender and ethnic disparities in incidence and survival of squamous cell carcinoma of the oral tongue, base of tongue, and tonsils: a surveillance, epidemiology and end results program-based analysis. Oncology, 81(1), 12–20. https://doi.org/10.1159/000330807

Sakurai, R., Cerny, L. M., Torday, J. S., & Rehan, V. K. (2011). Mechanism for nicotine-induced up-regulation of Wnt signaling in human alveolar interstitial fibroblasts. Experimental lung research, 37(3), 144–154. https://doi.org/10.3109/01902148.2010.490288.

Schlosser, K., Hanson, J., Villeneuve, P. J., Dimitroulakos, J., McIntyre, L., Pilote, L., & Stewart, D. J. (2016). Assessment of Circulating LncRNAs Under Physiologic and Pathologic Conditions in Humans Reveals Potential Limitations as Biomarkers. Scientific reports, 6, 36596. https://doi.org/10.1038/srep36596

Schweikert, E. M., Devarajan, A., Witte, I., Wilgenbus, P., Amort, J., Förstermann, U., Shabazian, A., Grijalva, V., Shih, D. M., Farias-Eisner, R., Teiber, J. F., Reddy, S. T., & Horke, S. (2012). PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death. Cell death and differentiation, 19(9), 1549–1560. https://doi.org/10.1038/cdd.2012.35.

Scorilas, A., & Mavridis, K. (2012). Kallikrein-related peptidases (KLKs) as novel potential biomarkers in gastric cancer: an open yet challenging road lies ahead. Journal of surgical oncology, 105(3), 223–224. https://doi.org/10.1002/jso.22041.

Selcuklu, S. D., Donoghue, M. T., Rehmet, K., de Souza Gomes, M., Fort, A., Kovvuru, P., Muniyappa, M. K., Kerin, M. J., Enright, A. J., & Spillane, C. (2012). MicroRNA-9 inhibition of cell proliferation and identification of novel miR-9 targets by transcriptome profiling in breast cancer cells. The Journal of biological chemistry, 287(35), 29516–29528. https://doi.org/10.1074/jbc.M111.335943

Shi, J., Liu, F., Zhang, W., Liu, X., Lin, B., & Tang, X. (2015). Epigallocatechin-3-gallate inhibits nicotine-induced migration and invasion by the suppression of angiogenesis and epithelial-mesenchymal transition in non-small cell lung cancer cells. Oncology reports, 33(6), 2972–2980. https://doi.org/10.3892/or.2015.3889

Sicard, F., Gayral, M., Lulka, H., Buscail, L., & Cordelier, P. (2013). Targeting miR-21 for the therapy of pancreatic cancer. Molecular therapy: the journal of the American Society of Gene Therapy, 21(5), 986–994. https://doi.org/10.1038/mt.2013.35.

Sotgia, F., Fiorillo, M., & Lisanti, M. P. (2019). Hallmarks of the cancer cell of origin: Comparisons with "energetic" cancer stem cells (e-CSCs). Aging, 11(3), 1065–1068. https://doi.org/10.18632/aging.101822.

Su, M. C., Chen, C. T., Huang, F. I., Chen, Y. L., Jeng, Y. M., & Lin, C. Y. (2014). Expression of LEF1 is an independent prognostic factor for patients with oral squamous cell carcinoma. Journal of the Formosan Medical Association = Taiwan yi zhi, 113(12), 934–939. https://doi.org/10.1016/j.jfma.2013.07.012.

Subapriya, R., Thangavelu, A., Mathavan, B., Ramachandran, C. R., & Nagini, S. (2007). Assessment of risk factors for oral squamous cell carcinoma in Chidambaram, Southern India: a case-control study. European journal of cancer prevention: the official journal of the European Cancer Prevention Organisation (ECP), 16(3), 251–256. https://doi.org/10.1097/01.cej.0000228402.53106.9e

Sun, Z., Han, Q., Zhou, N., Wang, S., Lu, S., Bai, C., & Zhao, R. C. (2013). MicroRNA-9 enhances migration and invasion through KLF17 in hepatocellular carcinoma. Molecular oncology, 7(5), 884–894. https://doi.org/10.1016/j.molonc.2013.04.007.

Takahashi-Yanaga, F., & Kahn, M. (2010). Targeting Wnt signaling: can we safely eradicate cancer stem cells? Clinical cancer research: an official journal of the American Association for Cancer Research, 16(12), 3153–3162. https://doi.org/10.1158/1078-0432.CCR-09-2943.

Tang, L., Wen, J. B., Wen, P., Li, X., Gong, M., & Li, Q. (2019). Long non-coding RNA LINC01314 represses cell migration, invasion, and angiogenesis in gastric cancer via the Wnt/β-catenin signaling pathway by down-regulating KLK4. Cancer cell international, 19, 94. https://doi.org/10.1186/s12935-019-0799-9.

Tseng, S. K., Chang, M. C., Su, C. Y., Chi, L. Y., Chang, J. Z., Tseng, W. Y., Yeung, S. Y., Hsu, M. L., & Jeng, J. H. (2012). Arecoline induced cell cycle arrest, apoptosis, and cytotoxicity to human endothelial cells. Clinical oral investigations, 16(4), 1267–1273. https://doi.org/10.1007/s00784-011-0604-1.

Wang, C., Moya, L., Clements, J. A., Nelson, C. C., & Batra, J. (2018). Mining human cancer datasets for kallikrein expression in cancer: the 'KLK-CANMAP' Shiny web tool. Biological chemistry, 399(9), 983–995. https://doi.org/10.1515/hsz-2017-0322.

Wang, C., Xu, X., Jin, H., & Liu, G. (2017). Nicotine may promote tongue squamous cell carcinoma progression by activating the Wnt/β-catenin and Wnt/PCP signaling pathways. Oncology letters, 13(5), 3479–3486. https://doi.org/10.3892/ol.2017.5899.

Wang, C., Yan, G., Zhang, Y., Jia, X., & Bu, P. (2015). Long non-coding RNA MEG3 suppresses migration and invasion of thyroid carcinoma by targeting of Rac1. Neoplasma, 62(4), 541–549. https://doi.org/10.4149/neo_2015_065

Wang, J., Qiu, M., Xu, Y., Li, M., Dong, G., Mao, Q., Yin, R., & Xu, L. (2015). Long noncoding RNA CCAT2 correlates with smoking in esophageal squamous cell carcinoma. Tumour biology: the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(7), 5523–5528. https://doi.org/10.1007/s13277-015-3220-x

Wang, P., Magdolen, V., Seidl, C., Dorn, J., Drecoll, E., Kotzsch, M., Yang, F., Schmitt, M., Schilling, O., Rockstroh, A., Clements, J. A., & Loessner, D. (2018). Kallikrein-related peptidases 4, 5, 6 and 7 regulate tumour-associated factors in serous ovarian cancer. British journal of cancer, 119(7), 1–9. https://doi.org/10.1038/s41416-018-0260-1.

Wang, P., Ren, Z., & Sun, P. (2012). Overexpression of the long non-coding RNA MEG3 impairs in vitro glioma cell proliferation. Journal of cellular biochemistry, 113(6), 1868–1874. https://doi.org/10.1002/jcb.24055

Wang, P., Ren, Z., & Sun, P. (2012). Overexpression of the long non-coding RNA MEG3 impairs in vitro glioma cell proliferation. Journal of cellular biochemistry, 113(6), 1868–1874. https://doi.org/10.1002/jcb.24055

Wang, Y., Chen, W., Yang, C., Wu, W., Wu, S., Qin, X., & Li, X. (2012). Long non-coding RNA UCA1a(CUDR) promotes proliferation and tumorigenesis of bladder cancer. International journal of oncology, 41(1), 276–284. https://doi.org/10.3892/ijo.2012.1443

Wei, G. H., & Wang, X. (2017). lncRNA MEG3 inhibit proliferation and metastasis of gastric cancer via p53 signaling pathway. European review for medical and pharmacological sciences, 21(17), 3850–3856.

Weiler, J., Mohr, M., Zänker, K. S., & Dittmar, T. (2018). Matrix metalloproteinase-9 (MMP9) is involved in the TNF-α-induced fusion of human M13SV1-Cre breast epithelial cells and human MDA-MB-435-pFDR1 cancer cells. Cell communication and signaling: CCS, 16(1), 14. https://doi.org/10.1186/s12964-018-0226-11.

Witte, I., Altenhöfer, S., Wilgenbus, P., Amort, J., Clement, A. M., Pautz, A., Li, H., Förstermann, U., & Horke, S. (2011). Beyond reduction of atherosclerosis: PON2 provides apoptosis resistance and stabilizes tumor cells. Cell death & disease, 2(1), e112. https://doi.org/10.1038/cddis.2010.91.

Witte, I., Foerstermann, U., Devarajan, A., Reddy, S. T., & Horke, S. (2012). Protectors or Traitors: The Roles of PON2 and PON3 in Atherosclerosis and Cancer. Journal of lipids, 2012, 342806. https://doi.org/10.1155/2012/342806.

Wu, L., Jin, L., Zhang, W., & Zhang, L. (2016). Roles of Long Non-Coding RNA CCAT2 in Cervical Cancer Cell Growth and Apoptosis. Medical science monitor: international medical journal of experimental and clinical research, 22, 875–879. https://doi.org/10.12659/msm.897754

Wu, S. W., Hao, Y. P., Qiu, J. H., Zhang, D. B., Yu, C. G., & Li, W. H. (2017). High expression of long non-coding RNA CCAT2 indicates poor prognosis of gastric cancer and promotes cell proliferation and invasion. Minerva medica, 108(4), 317–323. https://doi.org/10.23736/S0026-4806.17.04703-6.

Xia, Y., He, Z., Liu, B., Wang, P., & Chen, Y. (2015). Downregulation of Meg3 enhances cisplatin resistance of lung cancer cells through activation of the WNT/β-catenin signaling pathway. Molecular medicine reports, 12(3), 4530–4537. https://doi.org/10.3892/mmr.2015.3897

Xu, Y., & Lu, S. (2015). Regulation of β-catenin-mediated esophageal cancer growth and invasion by miR-214. American journal of translational research, 7(11), 2316–2325..

Yan, T. L., Wang, M., Xu, Z., Huang, C. M., Zhou, X. C., Jiang, E. H., Zhao, X. P., Song, Y., Song, K., Shao, Z., Liu, K., & Shang, Z. J. (2017). Up-regulation of syncytin-1 contributes to TNF-α-enhanced fusion between OSCC and HUVECs partly via Wnt/β-catenin-dependent pathway. Scientific reports, 7, 40983. https://doi.org/10.1038/srep40983.

Yang, F., Aubele, M., Walch, A., Gross, E., Napieralski, R., Zhao, S., Ahmed, N., Kiechle, M., Reuning, U., Dorn, J., Sweep, F., Magdolen, V., & Schmitt, M. (2017). Tissue kallikrein-related peptidase 4 (KLK4), a novel biomarker in triple-negative breast cancer. Biological chemistry, 398(10), 1151–1164. https://doi.org/10.1515/hsz-2017-0122.

Yang, Y. T., Wang, Y. F., Lai, J. Y., Shen, S. Y., Wang, F., Kong, J., Zhang, W., & Yang, H. Y. (2016). Long non-coding RNA UCA1 contributes to the progression of oral squamous cell carcinoma by regulating the WNT/β-catenin signaling pathway. Cancer science, 107(11), 1581–1589. https://doi.org/10.1111/cas.13058

Yao, H., Duan, M., Lin, L., Wu, C., Fu, X., Wang, H., Guo, L., Chen, W., Huang, L., Liu, D., Rao, R., Wang, S., & Ding, Y. (2017). TET2 and MEG3 promoter methylation is associated with acute myeloid leukemia in a Hainan population. Oncotarget, 8(11), 18337–18347. https://doi.org/10.18632/oncotarget.15440

Yokogi, S., Tsubota, T., Kanki, K., Azumi, J., Itaba, N., Oka, H., Morimoto, M., Ryoke, K., & Shiota, G. (2016). Wnt/Beta-Catenin Signal Inhibitor HC-1 Sensitizes Oral Squamous Cell Carcinoma Cells to 5-Fluorouracil through Reduction of CD44-Positive Population. Yonago acta medica, 59(2), 93–99.

Yoneyama, R., Aoshiba, K., Furukawa, K., Saito, M., Kataba, H., Nakamura, H., & Ikeda, N. (2016). Nicotine enhances hepatocyte growth factor-mediated lung cancer cell migration by activating the α7 nicotine acetylcholine receptor and phosphoinositide kinase-3-dependent pathway. Oncology letters, 11(1), 673–677. https://doi.org/10.3892/ol.2015.3930.

Yu, J., & Li, H. (2017). The expression of FAT1 is associated with overall survival in children with medulloblastoma. Tumori, 103(1), 44–52. https://doi.org/10.5301/tj.5000570.

Yu, T., Liu, K., Wu, Y., Fan, J., Chen, J., Li, C., Yang, Q., & Wang, Z. (2014). MicroRNA-9 inhibits the proliferation of oral squamous cell carcinoma cells by suppressing expression of CXCR4 via the Wnt/β-catenin signaling pathway. Oncogene, 33(42), 5017–5027. https://doi.org/10.1038/onc.2013.448.

Yuan, S. X., Yang, F., Yang, Y., Tao, Q. F., Zhang, J., Huang, G., Yang, Y., Wang, R. Y., Yang, S., Huo, X. S., Zhang, L., Wang, F., Sun, S. H., & Zhou, W. P. (2012). Long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma promotes angiogenesis and serves as a predictor for hepatocellular carcinoma patients' poor recurrence-free survival after hepatectomy. Hepatology (Baltimore, Md.), 56(6), 2231–2241. https://doi.org/10.1002/hep.25895

Zhao, Z., Wang, J., Wang, S., Chang, H., Zhang, T., & Qu, J. (2017). LncRNA CCAT2 promotes tumorigenesis by over-expressed Pokemon in non-small cell lung cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 87, 692–697. https://doi.org/10.1016/j.biopha.2016.12.122

Zhuo, H., Tang, J., Lin, Z., Jiang, R., Zhang, X., Ji, J., Wang, P., & Sun, B. (2016). The aberrant expression of MEG3 regulated by UHRF1 predicts the prognosis of hepatocellular carcinoma. Molecular carcinogenesis, 55(2), 209–219. https://doi.org/10.1002/mc.22270

Zou, W., Zou, Y., Zhao, Z., Li, B., & Ran, P. (2013). Nicotine-induced epithelial-mesenchymal transition via Wnt/β-catenin signaling in human airway epithelial cells. American journal of physiology. Lung cellular and molecular physiology, 304(4), L199–L209. https://doi.org/10.1152/ajplung.00094.2012

Downloads

Published

18/01/2022

How to Cite

FARRAPO, M. T. .; RIFANE, T. O. .; PINTO, D. N. .; RODRIGUES, R. E. A. .; OLIVEIRA, K. K. P. de .; MEDEIROS, S. T. C. B. .; SOUSA, L. M. de .; VASCONCELOS, L. V. .; FEITOSA , V. P. . Canonical WNT signaling pathway in oral squamous cell carcinoma prognosis. Research, Society and Development, [S. l.], v. 11, n. 2, p. e8411225462, 2022. DOI: 10.33448/rsd-v11i2.25462. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/25462. Acesso em: 20 apr. 2024.

Issue

Vol. 11 No. 2

Section

Review Article

License

Copyright (c) 2022 Manuela Timbó Farrapo; Tainah Oliveira Rifane; Diego Neves Pinto; Ranyele Elis Alexandre Rodrigues; Ketelyn Kerty Pereira de Oliveira; Samara Tabata Cavalcante Braga Medeiros; Luane Macedo de Sousa; Lorena Vieira Vasconcelos; Victor Pinheiro Feitosa

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.