Detection of SARS-CoV-2 in saliva and salivary glands – a systematic review
DOI:
https://doi.org/10.33448/rsd-v11i3.26673Keywords:
Covid-19; Salivary gland; Saliva and infection.Abstract
At the beginning of the COVID-19 pandemic, contact with the saliva infected was observed to represent a form of contagion possibly related to the anatomical proximity between the upper respiratory tract and the oral cavity. Studies seem to indicate that SARS-COV-2 can infect epithelial cells of the salivary glands, and impacts the clinical practice of dental surgeons. This study aimed to collect current evidence on the presence of SARS-CoV-2 in salivary glands, its detection through saliva, and discuss the relevance of this knowledge in clinical dental practice. A systematic review was conducted in the databases Pubmed, Lilacs, Google Schoolar, Scielo, Cochrane and Medline in the period from November/2020 to May/2021. PRISMA guidelines and the anagram PICO were adopted to characterize the selected studies according to the inclusion criteria, which comprised prospective studies, with full text available online in the English or Portuguese language and published from the year 2020. Among the 17 selected articles, 2 prospective studies evaluated the presence of SARS-CoV-2 in the parenchyma of salivary glands and all 16 papers found the presence of SARS-CoV-2 in saliva. The size of the studies varied according to the type of study, and the total number of participants was 3677. This study ratifies saliva as a route of transmission, and it is crucial that all health care workers use personal protective equipment and adhere strictly to biosafety regulations.
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Copyright (c) 2022 Lavínia Sampaio Bonfim; Bruna Carvalho Lopez Moreno; Anildo Alves de Brito Junior; Flávia Quadros Lima; Juliana Borges de Lima Dantas; Alena Ribeiro Alves Peixoto Medrado
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