Granulomatous dermatitis by Halicephalobus gingivalis in a horse in northeastern Brazil

Authors

DOI:

https://doi.org/10.33448/rsd-v11i3.26818

Keywords:

Equine disease; Dermatopathology; Parasitic dermatitis; Nematode.

Abstract

The clinical and anatomopathological findings of a case of granulomatous dermatitis by Halicephalobus gingivalis in a horse in northeastern Brazil, are described. The animal presented multifocal, non-pruritic and painless cutaneous nodules, predominantly arranged in the abdominal, thoracic, cervical and facial regions, and on the lateral surface of the thoracic and pelvic limbs. Skin fragments were collected, fixed in 10% buffered formalin, cleaved, routinely processed for histopathology and sent for anatomopathological evaluation. Macroscopically, well-delimited exophytic nodules with an alopecic, multilobulated and crusted surface, measuring 0.5 to 1 cm in diameter, were observed. When cut, the nodules were soft, with a yellowish, compact and smooth surface. Histopathology revealed a focally extensive, accentuated nodular and granulomatous dermatitis associated with rhabditiform nematode parasites, morphologically compatible with H. gingivalis. H. gingivalis infections should be included in the differential diagnosis of granulomatous dermatitis in horses. Treatment with ivermectin associated with surgical excision of the nodules proved to be efficient.

References

Avila, V. A., López-Garcia, Y., Hernández-Castro, R., Salas-Garrido, C. G., Ramírez-Lezama, J., Calderón-Vila, R. & Martínez-Chavarría, L. C. (2020). First case of fatal equine meningoencephalitis caused by Halicephalobus gingivalis in Mexico. Veterinary Parasitoly: Regional Studies and Reports, 20, 100399.

Cunha, B. M., França, T. N., Miranda, I. C., Santos, A. M., Seixas, J. N., Pires, A. P., Santos, B. B. & Peixoto, P. V. (2016). Granulomatous myocarditis in a horse by Halicephalobus gingivalis (H. deletrix) - Case report. Brazilian Journal of Veterinary Medicine, 38(Supl.2), 113-116.

Dunn, D. G., Gardiner, C. H., Dralle, K. R. & Thilsted, J. P. (1993). Nodular granulomatous posthitis caused by Halicephalobus (syn. Micronema) sp. in a horse. Veterinary Pathology, 30(2), 207-208.

Enemark, H. L., Hansen, M. S., Jensen, T. K., Larsen, G. & Al-Sabi, M. N. S. (2016). An outbreak of bovine meningoencephalomyelitis with identification of Halicephalobus gingivalis. Veterinary Parasitology, 218, 82-86.

Eydal, M., Bambir, S. H., Sigurdarson, S., Gunnarsson, E., Svansson, V., Fridriksson, S. & Sigurdardóttir, Ó. G. (2012). Fatal infection in two Icelandic stallions caused by Halicephalobus gingivalis (Nematoda: Rhabditida). Veterinary Parasitology, 186(3), 523-527.

Ferguson, R., Dreumel, T. V., Keystone, J. S., Manning, A., Malatestinic, A., Caswell, J. L. & Peregrine, A. S. (2008). Unsuccessful treatment of a horse with mandibular granulomatous osteomyelitis due to Halicephalobus gingivalis. The Canadian Veterinary Journal, 49(11), 1099-1103.

Fonderie, P., Vries, C. D., Verryken, K., Ducatelle, R., Moens, T., Loon, G. & Bert, W. (2013). Maxillary granulomatous inflammation caused by Halicephalobus gingivalis (Nematoda) in a Connemara mare in Belgium. Journal of Equine Veterinary Science, 33(3),186–190.

Gardiner, C. H. & Poynton, S. (1999). An Atlas of Metazoan Parasites in Animal Tissues. Washington, D.C.: Armed Forces Institute of Pathology, pp. 30-35.

Gracia-Calvo, L. A., Martín-Cuervo, M. Durán, M. E., Vieítez, V., Serrano, F., Jiménez, J. & Ezquerra, L. J. (2014). Maxillary osteomyelitis due to Halicephalobus gingivalis and fatal dissemination in a horse. Archivos de Medicina Veterinaria, 46(3), 407-411.

Greiner, E. C., Mays, M. B. C., Smart Jr, G. C. & Weisbrode, S. E. (1991). Verminous mastitis in a mare caused by a free-living nematode. The Journal of Parasitology, 77(2), 320-322.

Henneke, C., Jespersen, A., Jacobsen, S., Nielsen, M. K., McEvoy, F. & Jensen H. E. (2014). The distribution pattern of Halicephalobus gingivalis in a horse is suggestive of a haematogenous spread of the nematode. Acta Veterinaria Scandinavica, 56(1), 56.

Hoogstraten, J. & Young, W. G. (1975). Meningoencephalomyelitis due to the saprophagous nematode, Micronema deletrix. The Canadian of Jounal Neurologic Sciences, 2(2), 121-126.

Isaza, R., Schiller, C. A., Stover, J. Smith, P. J. & Greiner, E. C. (2000). Halicephalobus gingivalis (Nematoda) infection in a Grevy's zebra (Equus grevyi). Journal of Zoo and Wildlife Medicine, 31(1), 77-81.

Kinde, H., Mathews, M., Ash, L. & St. Leger, J. (2000). Halicephalobus Gingivalis (H. Deletrix) Infection in two horses in Southern California. Journal of Veterinary Diagnostic Investigation, 12(2), 162-165.

Lim, C. K., Crawford, A., Moore, C. V., Gasser, R. B., Nelson, R., Koehler, A. V., Bradbury, R. S., Speare, R., Dhatrak, D. & Weldhagen, G. F. (2015). First human case of fatal Halicephalobus gingivalis meningoencephalitis in Australia. Journal of Clinical Microbiology, 53(5), 1768-1774.

Muller, S., Grzybowski, M., Sager, H., Bornad, V. & Brehm, W. A. (2008). Nodular granulomatous posthitis caused by Halicephalobus sp. in a horse. Veterinary Dermatology, 19(1), 44-48.

Pearce, S. G., Bouré, L. P., Taylor, J. A. & Peregrine, A. S. (2001). Treatment of a granuloma caused by Halicephalobus gingivalis in a horse. Journal of the American Veterinary Medical Association, 219(12), 1735-1738.

Rames, D. S., Miller, D. K., Barthel, R., Craig, T. M., Dziezyc, J., Helman, R. G. & Mealey, R. (1995). Ocular Halicephalobus (syn. Micronema) deletrix in a horse. Veterinary Pathology, 32(5), 540-542.

Ruggles, A. J., Beech, J., Gilette, D. M., Midla, L. T., Reef, V. B. & Freeman, D. E. (1993). Disseminated infection by Halicephalobus deletrix in a horse. Journal of American Veterinary Medical Association, 203(4), 550-552.

Sant’Ana, F. J., Júnior, J. A. F., Costa, Y. L., Resende, R. M. & Barros, C. S. (2012). Granulomatous meningoencephalitis due to Halicephalobus gingivalis in a horse. Brazilian Journal of Veterinary Research and Animal Science, 5(1), 12-15.

Santana, C. H., Oliveira, L. B., Pimentel, S. P., Mendes, B. L. L., Silva, A. P. R., Maranhão, R. P. A., Teixeira, R. B. C. & Ecco, R. (2019). Granulomatous lesions in multiple organs in a horse caused by Halicephalobus gingivalis. Brazilian Journal of Veterinary Pathology, 12(3), 111-116.

Schmitz, D. G. & Chaffin, M. K. (2004). What is your diagnosis? Halicephalobus gingivalis. Journal of the American Veterinary Medical Association, 225(11), 1667-1668.

Sousa, S., Teixeira, N. R., Leonardo, S. A., Camara, L. A. C. & Castro, B. M. (2018). Neurological changes in horses naturally infected with Halicephalobus gingivalis. Journal of Equine Veterinary Science, 60, 1-5.

Spalding, M. G., Greiner, E. C. & Green, S. L. (1990). Halicephalobus (Micronema) deletrix infections in two half-sibling foals. Journal of American Veterinary Medical Association, 196(7), 1127-1129.

Taulescu, M. A., Ionicã, A. M., Diugan, E., Pavaloiu, A., Cora, R., Amorim, I. & Roccabianca, P. (2016). First report of fatal systemic Halicephalobus gingivalis infection in two Lipizzaner horses from Romania: clinical, pathological, and molecular characterization. Parasitology Research, 115(3), 1097-1103.

Trostle, S. S., Wilson, D. G., Steinberg, H., Dzata, G. & Richard, R. (1993). Antemortem diagnosis and attempted treatment of (Halicephalobus) Micronema deletrix infection in a horse. The Canadian Veterinary Journal, 34(2), 117-118.

Vasconcelos, R. O., Lemos, K. R., Moraes, J. R. E. & Borges, V. P. (2007). Halicephalobus gingivalis (H. deletrix) no cérebro de um cavalo. Ciência Rural, Santa Maria, 37(4), 1185-1187.

Wilkins, P. A., Wacholder, S., Nolan, T. J., Bolin, D. C., Hunt, P., Bernard, W. & Piero, F. (2001). Evidence for transmission of Halicephalobus deletrix (H. gingivalis) from dam to foal. Journal of Veterinary Interne Medicine, 15(4), 412-417.

Published

07/03/2022

How to Cite

OLIVEIRA, A. M. de; SOUTO, E. P. F. de; NASCIMENTO, M. J. R. do; SILVEIRA, G. L. da; DINIZ, A. N. S.; DANTAS, A. F. M. .; GALIZA, G. J. N. de. Granulomatous dermatitis by Halicephalobus gingivalis in a horse in northeastern Brazil . Research, Society and Development, [S. l.], v. 11, n. 3, p. e54011326818, 2022. DOI: 10.33448/rsd-v11i3.26818. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/26818. Acesso em: 22 nov. 2024.

Issue

Section

Agrarian and Biological Sciences