Occurrence of cholelithiasis in patients with sickle cell anemia: an integrative literature review





Sickle cell anemia; Cholelithiasis


Due to premature destruction of sickled erythrocytes, individuals with sickle cell anemia (SCA) are more likely to form gallstones through the accumulation of indirect bilirubin resulting from this hemolysis. Some risk factors, when present, may be associated with an increased prevalence and number of complications in the condition. In this sense, it is essential to recognize these relationships described, so that it is possible to avoid as much as possible the occurrence of cholelithiasis in SCA patients and to promote a better quality of life for them. Thus, the objective was to evaluate the risk factors and prevalence of cholelithiasis in SCA. This is an integrative literature review that searched for articles on the PubMed platform, using the descriptors "Sickle Cell Anemia" AND "Cholelithiasis" AND "Prevalence", in the time frame from 2010 to 2020. Of the 28 articles found, 16 were excluded by avoidance of the topic or impossibility of access to the full text. From the 12 selected articles, 2 thematic axes were identified: I) Risk factors for the development of cholelithiasis in SCA and II) Prevalence of cholelithiasis in SCA. relevance of risk factors and prevalence of cholelithiasis in SCA, it is essential to carry out prophylactic measures through an early diagnosis together with adequate guidance to the patient, in addition to further studies that enrich the knowledge already acquired on the subject in question.


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How to Cite

NASCIMENTO, B. M. R. do .; ROCHA, M. F. de A. .; UCHÔA, S. M. .; MONTENEGRO, I. O. .; BARBOSA, N. M. .; OLIVEIRA, K. A. de; BEZERRA, R. E. de A. .; MENDES, A. L. de A. C. .; NORÕES, M. E. de A. T. .; LUCENA, A. B. de . Occurrence of cholelithiasis in patients with sickle cell anemia: an integrative literature review. Research, Society and Development, [S. l.], v. 11, n. 3, p. e58911326868, 2022. DOI: 10.33448/rsd-v11i3.26868. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/26868. Acesso em: 14 jun. 2024.



Review Article