Seroprevalence of the Human T Lymphotropic Virus (HTLV 1 and HTLV 2) in Blood Donor Candidates in the State of Pará, Northern Brazil

Authors

DOI:

https://doi.org/10.33448/rsd-v11i4.27082

Keywords:

HTLV infection; Blood donors; Soroprevalência.

Abstract

The present study describes HTLV seroprevalence in potential blood donors from the Brazilian state of Pará, and the sociodemographic characteristics of the infection in this state. This descriptive, retrospective, and cross-sectional study is based on secondary serological and sociodemographic data on potential blood donors who were rejected for presenting reactive results in the serological HTLV screening between January 2010 and December 2020. The mean HTLV seroprevalence was 0.2%. The highest frequency of reactivity was recorded in first-time donors, women, individuals over 30 years old that were single and had a relatively low level of  education. There have been many advances since the discovery of HTLV, although it is still considered to be a neglected etiological agent in Brazil. Further research on data from hematological services will be necessary to refine regional infection profiles, which will be fundamental for the development of adequate prophylactic practises to control and prevent infection, as well the dissemination of information on the dangers of HTLV to the general population.

References

Bandeira, L. M., Uehara, S. N. O., Puga, M. A. M., Rezende, G. R., Vicente A. C. P., Domingos, J. A., Lago, B. V., Niel, C., & Castro, A. R. C. M. (2017). HTLV-1 intrafamilial transmission among Japanese immigrants in Brazil. J Med Virol, 90 (2), 351-357.

Blatyta, P. F., Custer B., Gonçalez, T. T., Birch, R., Lopes, M. E., & Ferreira, M. I. L. (2013). Undisclosed human immunodeficiency virus risk factors identified through a computer-based questionnaire program among blood donors in Brazil. Transfusion, 53 (11), 2734-43.

Catalan-Soares, B., Carneiro-Proietti, A. B. D. F., & Proietti, F. A. (2005). Heterogeneous geographic distribution of human T-cell lymphotropic viruses I and II (HTLV-I/II): serological screening prevalence rates in blood donors from large urban areas in Brazil. Cad Saude Publica, 21 (3), 926–31.

Costa, G. B., Oliveira, M.C., Gadelha, S.R., Albuquerque, G.R., Teiceira. M., Raiol M. R. S., Sousa, S. M. B., & Marin, L. J. (2018). Infectious diseases during pregnancy in Brazil: seroprevalence and risk factors. J Infect Dev Ctries, 12 (8), 657-665.

Dourado, I., Alcântara, L. C. J., Barreto, M. L., Teixeira, M. G., & Castro Filho, B. G. (2003). HTLV- I in the general population of Salvador, Brazil: a city with African ethnic and sociodemographic characteristics. J Acquir Immune Defic Syndr, 34 (5), 527–531

Eshima, N., Iwata, O., Iwata, S., Tabata, M., Higuchi, Y., Matsuishi T., & Karukaya, S. (2009). Age and gender specific prevalence of HTLV-1. J Clin Virol, 45 (2), 135-138.

Eusebio-Ponce, E., Anguita, E., Paulino-Ramirez, R., & Candel, F. J. (2019). HTLV-1 infection: an emerging risk. pathogenesis, epidemiology, diagnosis and associated diseases. Rev Esp Quimioter, 32 (6), 485-496.

Futsch, N., Mahieux, R., & Dutartre, H. (2018). HTLV-1, the Other Pathogenic Yet Neglected Human Retrovirus: from transmission to therapeutic treatment. Viruses, 10 (1), 1-25.

Galvão-Castro, B., Loures, L., Rodrigues, L. G. M., Sereno, A., Ferreira Junior, O. C., Franco, L. G. P., Muller, M., Sampaio, D. A., Santana, A., Passos, L. M., & Proietti, F. (1997). Distribution of human T-lymphotropic virus type I among blood donors: a nationwide Brazilian study. Transfusion, 37 (2), 242-243.

Gessain, A., & Cassar, O. (2012). Epidemiological aspects and world distribution of HTLV-1 infection. Front Microbiol, 3 (388), 1-23.

Glória, L. M., Damasceno, S.A., Rodrigues, L. R., Santos, M. S. B., Medeiros, R., Dias, G. A. S., Pinto, D. S. (2015). Perfil clínico-epidemiológico de pacientes infectados pelo HTLV-1 em Belém/Pará. Cad Saúde Colet, 23 (2), 157-162.

Guerra, A. B., Siravenha, L. Q., Laurentino, R. V., Feitosa, R. N. M., Azevedo, V. N., Vallinoto, A. C. R., Ishak, R., Machado, L. F. A. (2018). Seroprevalence of HIV, HTLV, CMV, HBV and rubella virus infections in pregnant adolescents who received care in the city of Belém, Pará, Northern Brazil. Bmc Pregnancy And Childbirth, 18 (1), 1-7.

ICTV—International Committee on Taxonomy of Viruses. Taxonomy history: primate T-lymphotropic virus 1; 2019. https://talk.ictvonline.org/taxonomy/p/taxonomy-history?taxnode_id=201904999. Accessed on 16 Fev 2022.

Maneschy, C. A., Barile, K. A. S., Castro, J. A. A., Palmeira, M. K., Castro, R. B. H., & Amaral, C. E. M. (2021). Epidemiological and molecular profile of blood donors infected with HTLV‐1/2 in the state of Pará, northern Brazil. Braz J Microbiol, 52 (4), 2001-2006.

Martinez, M. P., Al-Saleem, J., & Green, P. L. (2019). Comparative virology of HTLV-1 and HTLV-2. Retrovirology, 16 (21), 1-12.

Mendes, M. F. C., Lima, J. R. O., Melo, B. O., Pinto, C. M. F. S., Maia, H. S., Ferro, T. A. F., Monteiro, S. G., Stancioli, E. F. B., & Bomfim, M. R. Q. (2020). Molecular detection of human T cell lymphotropic virus type 1 in pregnant women from Maranhão state, Brazil. Braz J Microbiol, 51 (2), 637-645.

Morais, M. P. E., Gato, C. M., Maciel, L. A., Lalwani, P., Costa, C. A., & Lalwani, J. D. B. (2017). Prevalence of Human T-lymphotropic virus type 1 and 2 among blood donors in Manaus, Amazonas State, Brazil. Rev. Inst. Med. Trop. S. Paulo, 59 (80), 1-5.

Ngoma, A. M., Omokoko, M. D., Mutombo, P. B., Nollet, K. E., & Ohto, H. (2019). Seroprevalence of human T‐lymphotropic virus (HTLV) in blood donors in sub‐Saharan Africa: a systematic review and meta-analysis. Vox Sanguinis, 114 (5), 413-425.

Nunes, D., Boa-Sorte, N., Grassi, M. F. R., Taylor, G. P., Teixeira, G. P., & Barreto, M. L. et al. (2017). HTLV-1 is predominantly sexually transmitted in Salvador, the city with the highest HTLV-1 prevalence in Brazil. Plos One, 12 (2), 1-10.

Oliveira, E. H., Silva, F. L., & Silva, M. (2015). Perfil epidemiológico dos doadores de sangue infectados pelo vírus HTLV I/II, no Estado do Piauí. R. Interd, 8 (1), 149-156

Percher, F., Jeannin, P., Martin-Latil, S., Gessain, A., Afonso, P. V., Vidy-Roche, A., & Ceccaldi, P. E. (2016). Mother-to-child transmission of HTLV-1 epidemiological aspects, mechanisms and determinants of mother-to-child Transmission. Viruses, 8 (2), 40-49.

Pereira, G. C., & Bonafé, S. M. (2015). Soroprevalência para doenças infecto-contagiosas em doadores de sangue da cidade de Maringá, Paraná. Revista Uningá, 43 (1), 16-24.

Proietti, F. A., Carneiro-Proietti, A. B. F., Catalan-Soares, B. C., & Murphy, E. L. (2005). Global epidemiology of HTLV-I infection and associated diseases. Oncogene, 24 (39), 6058-6068.

Ribeiro, I. P., Kozlowski, A. G., Matos, M. A. D., Silva, A. M. C., Carneiro, M. A. S., Vicente, A. C. P., & Martins, R. M. B. (2018). HTLV-1 and -2 in a first-time blood donor population in Northeastern Brazil: prevalence, molecular characterization, and evidence of intrafamilial transmission. J Med Virol, 90 (10), 1651-1657.

Ribeiro-Lima, T. V., Wanzeller, A. L. M., Moura, A., & Linhares, A. C. (1999). Anticorpos para HTLV-1 e HTLV-II entre Doadores de Sangue em Belém, Brasil. Revista Paraense de Medicina, 13 (3), 8-13.

Rosadas, C., & Taylor, G. P. (2019). Mother-to-child HTLV-1 transmission: unmet research needs. Frontiers In Microbiology, 10 (999), 1-18.

Schierhout, G., McGregor, S., Gessain, A., Einsiedel, L., Martinello, M., & Kaldor, J. (2020). Association between HTLV-1 infection and adverse health outcomes: a systematic review and meta-analysis of epidemiological studies. The Lancet Infectious Diseases, 20 (1), 133-143.

Semeão, L. E. S., Roque, D. R., Sobrinho, T. F., Costa, C. K. F., Dodorico, M., & Yamaguchi, M. (2015). Soroprevalência do vírus linfotrópico de células T humanas (HTLV) entre doadores de sangue em hemocentros de Maringá-Paraná e Boa Vista-Roraima. Epidemiol. Serv. Saude, 24 (3), 523-529.

Silva, I. C., Pinheiro, B. T., Nobre, A. F. S., Coelho, J. L., Pereira, C. C. C., Ferreira, L. S. C., Almeida, C. P. S., Viana, M. N. S. A., Almeida, D. S., Falcão, J. R., Santos, Y. C. V., Araújo, M. W. L., Borges, M. S., Nascimento, L. D., Valentim, L. S., Casseb, J. S. R., Costa, C. A., & Sousa, M. S. (2018). Moderada endemicidade da infecção pelo vírus linfotrópico-T humano na região metropolitana de Belém, Pará, Brasil. Rev Bras Epidemiol, 21 (e180018), 1-14.

Veit, A. P. T., Mella, E. A. C., & Mella Junior, S. E. (2006). Soroprevalência do vírus linfotrópico de células T humanas (HTLV I/II) em indivíduos doadores de sangue do hemocentro da cidade de Maringá-Pr. Arq. Ciênc. Saúde Unipar, 10 (3), 123-126

Downloads

Published

09/03/2022

How to Cite

MANESCHY, C. de A.; BARILE, K. A. do S.; CASTRO, J. A. A. de; PALMEIRA, M. K.; CASTRO, R. B. H. de; AMARAL, C. E. de M. Seroprevalence of the Human T Lymphotropic Virus (HTLV 1 and HTLV 2) in Blood Donor Candidates in the State of Pará, Northern Brazil . Research, Society and Development, [S. l.], v. 11, n. 4, p. e1111427082, 2022. DOI: 10.33448/rsd-v11i4.27082. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/27082. Acesso em: 27 nov. 2024.

Issue

Section

Agrarian and Biological Sciences