Neurological changes in individuals with post-traumatic stress disorder secondary to childhood sexual abuse: a scope review
DOI:
https://doi.org/10.33448/rsd-v11i4.27125Keywords:
Neurological Manifestations; Post-Traumatic Stress Disorder; Childhood sexual abuse.Abstract
The post-traumatic stress disorder is one of the main consequences in victims of childhood sexual abuse, and it’s symptoms are involved in many cognitive-behavioral implications for those subjects. Reseachs suggest that these symptoms are the expression of morphological and physiological modifications in the brain structure of the victims, compared to people who didn’t suffer this trauma. The present scoping review aims to answer which are the most relevant alterations studied in the current literature. Methods: A scoping review was conducted by searching the Capes Periodicals and PubMed databases. Seven texts that answered the guiding were selected and used as the basis for this review, which met the following selection criteria: publications dated from 2016 to 2021, deletion of duplicate articles and those that did not address the relationship between post-traumatic stress disorder, childhood sexual abuse and the associated neurological consequences. Results: 7 publications were included in our study. Individuals who have suffered abuse in childhood, including sexual abuse, presented some alteration in brain regions, such as changes in volume, functional connectivity and biochemical composition. Conclusion: Substantial structural and chemical modifications can be observed in the brain of individuals with PTSD that had childhood sexual abuse as the motivation to the trauma.
References
APA. (2014). Manual Diagnóstico e Estatístico de Transtornos Mentais - DSM-5: DSM-5. 5. American Psycatric Association. 5ed. Ed. Artmed, 2014. ISBN 978-85-8271-089-0
Azevedo, M. A. N., & Guerra, V. N. A. (1995). Violência doméstica na infância e na adolescência. Repositorio.usp.br. https://repositorio.usp.br/item/000884520
Brasil. (2021). Abuso sexual contra crianças e adolescentes - abordagem de casos concretos em uma perspectiva multidisciplinar e interdisciplinar e interinstitucional - Brasilia. https://www.gov.br/mdh/pt-br/assuntos/noticias/2021/maio/CartilhaMaioLaranja2021.pdf
Boccadoro, S., Siugzdaite, R., Hudson, A. R., Maeyens, L., Van Hamme, C., & Mueller, S. C. (2019). Women with early maltreatment experience show increased resting-state functional connectivity in the theory of mind (ToM) network. European Journal of Psychotraumatology, 10(1), 1647044. https://doi.org/10.1080/20008198.2019.1647044
Borges, J. L., & Dell’Aglio, D. D. (2008). Relações entre abuso sexual na infância, transtorno de estresse pós-traumático (TEPT) e prejuízos cognitivos. Psicologia Em Estudo, 13(2), 371–379. https://doi.org/10.1590/s1413-73722008000200020
Chung, M. C., & Chen, Z. S. (2016). Child Abuse and Psychiatric Co-morbidity Among Chinese Adolescents: Emotional Processing as Mediator and PTSD from Past Trauma as Moderator. Child Psychiatry & Human Development, 48(4), 610–618. https://doi.org/10.1007/s10578-016-0687-7
Cobos-Cali, M., Ladera, V., Perea, M. V., & García, R. (2018). Language disorders in victims of domestic violence in children’s homes. Child Abuse & Neglect, 86, 384–392. https://doi.org/10.1016/j.chiabu.2017.02.028
Damasio, H., Grabowski, T., Frank, R., Galaburda, A., & Damasio, A. (1994). The return of Phineas Gage: clues about the brain from the skull of a famous patient. Science, 264(5162), 1102–1105. https://doi.org/10.1126/science.8178168
Glaser, D. (2000). Child abuse and neglect and the brain--a review. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 41(1), 97–116. https://pubmed.ncbi.nlm.nih.gov/10763678/
Hart, H., Lim, L., Mehta, M. A., Chatzieffraimidou, A., Curtis, C., Xu, X., Breen, G., Simmons, A., Mirza, K., & Rubia, K. (2017). Reduced functional connectivity of fronto-parietal sustained attention networks in severe childhood abuse. PLOS ONE, 12(11), e0188744. https://doi.org/10.1371/journal.pone.0188744
Hayes, J. P., Hayes, S. M., & Mikedis, A. M. (2012). Quantitative meta-analysis of neural activity in posttraumatic stress disorder. Biology of Mood & Anxiety Disorders, 2(1). https://doi.org/10.1186/2045-5380-2-9
Hein, T. C., & Monk, C. S. (2016). Research Review: Neural response to threat in children, adolescents, and adults after child maltreatment - a quantitative meta-analysis. Journal of Child Psychology and Psychiatry, 58(3), 222–230. https://doi.org/10.1111/jcpp.12651
Kelly, P. A., Viding, E., Puetz, V. B., Palmer, A. L., Samuel, S., & McCrory, E. J. (2016). The sexually dimorphic impact of maltreatment on cortical thickness, surface area and gyrification. Journal of Neural Transmission, 123(9), 1069–1083. https://doi.org/10.1007/s00702-016-1523-8
Milad, M. R., Pitman, R. K., Ellis, C. B., Gold, A. L., Shin, L. M., Lasko, N. B., Zeidan, M. A., Handwerger, K., Orr, S. P., & Rauch, S. L. (2009). Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder. Biological Psychiatry, 66(12), 1075–1082. https://doi.org/10.1016/j.biopsych.2009.06.026
Milani, A. C. C., Foerster, B., Cogo-Moreira, H., Farias, T. M. de B., Salido, F., Carrete, H., Mello, M. F., & Jackowski, A. P. (2018). A Longitudinal 1H-MRS Study of the Anterior Cingulate Gyrus in Child and Adolescent Victims of Multiple Forms of Violence. Chronic Stress (Thousand Oaks, Calif.), 2, 2470547018763359. https://doi.org/10.1177/2470547018763359
Morey, R. A., Haswell, C. C., Hooper, S. R., & De Bellis, M. D. (2015). Amygdala, Hippocampus, and Ventral Medial Prefrontal Cortex Volumes Differ in Maltreated Youth with and without Chronic Posttraumatic Stress Disorder. Neuropsychopharmacology, 41(3), 791–801. https://doi.org/10.1038/npp.2015.205
Perez, D. L., Matin, N., Barsky, A., Costumero-Ramos, V., Makaretz, S. J., Young, S. S., Sepulcre, J., LaFranceJr, W. C., Keshavan, M. S., & Dickerson, B. C. (2017). Cingulo-insular structural alterations associated with psychogenic symptoms, childhood abuse and PTSD in functional neurological disorders. Journal of Neurology, Neurosurgery & Psychiatry, 88(6), 491–497. https://doi.org/10.1136/jnnp-2016-314998
Peverill, M., Sheridan, M. A., Busso, D. S., & McLaughlin, K. A. (2019). Atypical Prefrontal–Amygdala Circuitry Following Childhood Exposure to Abuse: Links With Adolescent Psychopathology. Child Maltreatment, 24(4), 411–423. https://doi.org/10.1177/1077559519852676
van Hoof, M.-J., van den Bulk, B. G., Rombouts, S. A. R. B., Rinne-Albers, M. A. W., van der Wee, N. J. A., van IJzendoorn, M. H., & Vermeiren, R. R. J. M. (2017). Emotional face processing in adolescents with childhood sexual abuse-related posttraumatic stress disorder, internalizing disorders and healthy controls. Psychiatry Research: Neuroimaging, 264, 52–59. https://doi.org/10.1016/j.pscychresns.2017.04.006
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Isabelle Pereira Lima; Julia Costa Evangelista; Lara Cavalcante Assunção Bezerra; Maria Carolina Leal Silva; Mariana Lucena Loureiro; Pedro Cunto Goulart; Ylina Pereira de Mesquita
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
