Clinical protocols for the application of dexamethasone in endodontic therapy: an integrative review
DOI:
https://doi.org/10.33448/rsd-v11i4.27230Keywords:
Corticosteroids; Dexamethasone; Postoperative pain; Pulpitis; Toothache.Abstract
The present study aims to analyze, by means of an integrative review, clinical protocols for the application of Dexamethasone to endodontic therapy reported in the scientific literature. To compose this review, national and international articles were included. The main online journal databases PubMed, Lilacs, and SciELO were searched using the following keywords/free terms: "Dexamethasone", "Endodontics", and "Preoperative", with the aid of the Boolean operator "AND". The inclusion criteria were articles in English, Portuguese and Spanish and clinical trials published in the last 10 years, while the exclusion criteria were articles that did not fulfill the information in the title, abstract, articles with years not between 2011 and 2021 and any other article that was not a clinical trial. The results showed that 10 studies presented in the present review showed in their results a significant efficacy of dexamethasone when applied to endodontic therapy. Thus, it is concluded that the painful symptomatology experienced by patients after endodontic therapy can be relieved with dexamethasone for up to 24 hours, which is the period in which most patients report experiencing pain.
References
Abdel, H. E., Abdel, A.S., Sadek, H. S., & Ibrahim, A. M. (2018). Effectiveness of triple antibiotic paste as an intra-canal medication for the root canal treatment of non-vital teeth with apical periodontitis: A systematic review. 7:1627.
Aggarwal, V., Singla, M., Rizvi, A., & Miglani, S. (2011). Comparative evaluation of local infiltration of articaine, articaine plus ketorolac, and dexamethasone on anesthetic efficacy of inferior alveolar nerve block with lidocaine in patients with irreversible pulpitis. J Endod. 37(4):445-9. 10.1016/j.joen.2011.01.016.
Aggarwal, V., Singla, M., Saatchi, M., Gupta, A., Hasija, M., Meena, B., & Kumar, U. (2020). Preoperative Intraligamentary Injection of Dexamethasone Can Improve the Anesthetic Success Rate of 2% Lidocaine during the Endodontic Management of Mandibular Molars with Symptomatic Irreversible Pulpitis. J Endod. 47(2):161-168.
Aksoy, F., Ege, B. (2020). The effect of pretreatment submucosal injections of tramadol and dexamethasone on post-endodontic pain in mandibular molar teeth with symptomatic irreversible pulpitis: a randomized controlled clinical trial. Int Endod J. 53(2):176-185. 10.1111/iej.13246
Alexander, R. E., & Throndson, R. R. (2008). Uma revisão do uso de corticosteroide préoperatório em cirurgia dentoalveolar. Oral Surg Oral Med Oral Pathol Oral RadiolEndod. 34: 1261–3.
Ali, F., Yousaf, A., Daud, Z., Hussain, S. M., Ullah, M., & Ahmed Rana, M. J. (2020). Comparison Of Two Intra-Canal Medicaments On The Incidence Of Post-Operative Endodontic Pain. J Ayub Med Coll Abbottabad. 2020 Jul-Sep;32(3):299-303.
Arash, G., Ajami, M., & Mohsen, A. (2019). The effect of diferent combinations of calcium hydroxide as intra-canal medicament on endodontic pain: a randomized clinical trial study. Iran Endod J 2019;14(1):1–6.
Attar, S., Bowles, W. R., Baisden, M. K., Hodges, J. S., & McClanahan, S. B. (2008). Avaliação da analgesia pré-tratamento e tratamento endodôntico para dor endodôntica pós operatória. J Endod. 34: 652–5.
Bidar, M., Mortazavi, S., Forghani, M., & Akhlaghi, S. (2017). Comparison of Effect of Oral Premedication with Ibuprofen or Dexamethasone on Anesthetic Efficacy of Inferior Alveolar Nerve Block in Patients with Irreversible Pulpitis: A Prospective, Randomized, Controlled, Double-blind Study. Bull Tokyo Dent Coll. 2017;58(4):231- 236.
Bml, N., Lg, S., & Crm, M., et al. (2018). Is the Use of Dexamethasone Effective in Controlling Pain Associated with Symptomatic Irreversible Pulpitis? A Systematic Review. J Endod 44:703-10.
Jorge-Araújo, A .C. A., Bortoluzzi, M. C., Baratto-Filho, F., Santos, F. A., & Pochapski, M. T. (2018). Effect of Premedication with Anti-inflammatory Drugs on Post-Endodontic Pain: A Randomized Clinical Trial. Braz Dent J. 29(3):254-260.
Kan, E., Coelho, M. S., Reside, J., Card, S. J., & Tawil, P. Z. (2016). Periapical microsurgery: the effects of locally injected dexamethasone on pain, swelling, bruising, and wound healing. Journal of Endodontics 42, 1608–12,2016.
Lapidus, D., Goldberg, J., Hobbs, E. H., Ram, S., Clark, G. T., & Enciso, R. (2016) Effect of premedication to provide analgesia as a supplement to inferior alveolar nerve block in patients with irreversible pulpitis. J Am Dent Assoc 147: 427–437.
Marshall, J. G. (2002). Consideração de esteróides para dor endodôntica. Endocrinol Top. 3: 41–5.
Mohammadi, Z. (2009). Systemic and local applications of steroids in endodontics: an updated review. International Dental Journal 59, 297–304, 2009.
Nagendrababu, V., et al. (2019). “Efficacy and Safety of Oral Premedication on Pain after Nonsurgical Root Canal Treatment: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials.” Journal of endodontics 45(4), 364-371, 2019
Nath, R., Daneshmand, A., Sizemore, D., Guo, J., & Enciso, R. (2018). Efficacy of corticosteroids for postoperative endodontic pain: A systematic review and meta-analysis. Journal of Dental Anesthesia and Pain Medicine 18:205.
Pochapski, M. T, Santos, F. A., de Andrade, E. D., & Sydney G B. (2009). Efeito da dexametasona pré- tratamento na dor pós-endodôntica. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 108: 790–5.
Praveen, R., et al. (2017). “Comparative Evaluation of Premedication with Ketorolac and Prednisolone on Postendodontic Pain: A Double blind Randomized Controlled Trial.” Journal of endodontics 43, (5) 667-673, 2017.
Ravi, K., et al (2019). Effect of pre-treatment medication on post-endodontic pain: a double endodontic pain: a double-blind, placebo-controlled study placebo controlled study J Conserv Dent. 2019 de janeiro a fevereiro; 22 (1): 54–58.
Scremin, A. et al. (2012). Histopathological analysis of corticosteroidantibiotic preparation and propolis paste formulation as intracanal medication after pulpectomy: an in vivo study. J Appl Oral Sci. 20 (1) 50-6, 2012.
Shahi, S., Mokhtari, H., Rahimi, S., Yavari, H. R., Narimani, S., Abdolrahimi, M., & Nezafati, S. (2013). Effect of premedication with ibuprofen and dexamethasone on success rate of inferior alveolar nerve block for teeth with asymptomatic irreversible pulpitis: a randomized clinical trial. J Endod. 39(2):160-2. 10.1016/j.joen.2012.10.011
Shamszadeh, S. et al. (2018). “Efficacy of Corticosteroids on Postoperative Endodontic Pain: A Systematic Review and Meta-analysis.” Journal of endodontics, 44, (7), 1057-1065.
Shantiaee Y, Mahjour F, & Dianat O. (2012). Efficacy comparison of periapical infiltration injection of dexamethasone, morphine and placebo for postoperative endodontic pain. Int Dent J. 62(2):74-8
Shantiaee, Y., Mahjour, F., & Dianat, O. (2012). Efficacy comparison of periapical infiltration injection of dexamethasone, morphine and placebo for postoperative endodontic pain. Int Dent J, 2, (62), 74-8, 2012.
Sousa, M.,Silva, M., & Carvalho, R. (2010). Revisão integrativa: o que é e como fazer. Einstein. 8(1), 102-6,2010
Suneelkumar, C. et al. (2018). “Effect of Preoperative Corticosteroids in Patients with Symptomatic Pulpitis on Postoperative Pain after Single-visit Root Canal Treatment: A Systematic Review and Meta-analysis.” Journal of endodontics 44 (9) 1347-1354.
Suneelkumar c. et al. (2018). “Effect of Preoperative Corticosteroids in Patients with Symptomatic Pulpitis on Postoperative Pain after Single-visit Root Canal Treatment: A Systematic Review and Meta-analysis.” Journal of endodontics 44, (9)1347-1354.
Suresh, N, Nagendrababu, V., Koteeswaran, V., Haritha, J. S., Swetha, S. D., & Varghese, A., (2021). Natanasabapathy, V. Effect of preoperative oral administration of steroids in comparison to an anti-inflammatory drug on postoperative pain following single-visit root canal treatment - a double-blind, randomized clinical trial. Int Endod J.54(2):198-209. 10.1111/iej.13416.
Tortamano, I. P., Siviero, M., Costa, C. G., Buscariolo, I. A., & Armonia, P. L. (2009). A comparison of the anesthetic efficacy of articaine and lidocaine in patients with irreversible pulpitis J Endod 35:165–8.
Yavari, H. R., Jafari, F., Jamloo, H., Hallaj-Nezhadi, S., & Jafari, S. (2019). The Effect of Submucosal Injection of Corticosteroids on Pain Perception and Quality of Life after Root Canal Treatment of Teeth with Irreversible Pulpitis: A Randomized Clinical Trial. J Endod. 2019 May;45(5):477-482. 10.1016/j.joen.2019.01.005.
Yavari, R. et al. (2019). “The Effect of Submucosal Injection of Corticosteroids on Pain Perception and Quality of Life after Root Canal Treatment of Teeth with Irreversible Pulpitis: A Randomized Clinical Trial.” Journal of endodontics 45, (5) ,477-482.
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Copyright (c) 2022 Maria Eduarda de Araujo Cruz; Alynne Correia de Andrade; Myllenna Nayara de França Alves; Niebla Bezerra de Melo; Fernanda Clotilde Mariz Suassuna; Luiza de Almeida Souto Montenegro; Amanda Lira Rufino de Lucena; Herrison Félix Valerino da Silva; Jussara da Silva Barbosa
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