Ozone therapy in dentistry: a systematic review of literature
DOI:
https://doi.org/10.33448/rsd-v11i4.27474Keywords:
Ozone; Dentistry; Teeth; Tooth; Enamel; Mouth.Abstract
The aim of this study was to perform a systematic review to assess the effects of ozone therapy in dentistry. The databases used were Pubmed, Embase, Web of Science, and OpenGrey. The keyword: “Ozone” combined with one of the following keywords: “Dentistry”, “Teeth”, “Tooth”, “Enamel” and “Mouth” were used to search, only randomized clinical trials were included. The ROB2.0 tool was used to assess the risk of bias. 36 articles were included, 7 were classified as a low risk of bias, 17 as an uncertain risk and 12 as a high risk. For the most part, the articles dispelled results in the most diverse areas of dentistry and ozone has broadly broad applicability, however the large number of articles classified as having a high risk of bias or uncertain risk may be a limiting factor in the evidence found. Ozone therapy shows satisfactory results in its application in dentistry, however, due to the large number of articles with high or uncertain risk of bias, our evidence is limited. More randomized clinical trials are needed to assess the real benefits of ozone therapy in dentistry.
References
ABOZ - Associação Brasileira de Ozonioterapia - NOTA DE ESCLARECIMENTO SOBRE A OZONIOTERAPIA - Notícias - 2017). https://www.aboz.org.br/noticias/nota-de-esclarecimento-sobre-a-oz%20onioterapia/74/.
Aguiar, L. J. P., Báez, O. G., González, C. R. & Cepero, S. M. (2010). Ozonoterapia y electroestimulación en retinosis pigmentaria. Revista Cubana de Oftalmología, 23(1), 57-66. de http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-21762010000100006&lng=es&tlng=es.
Ajeti, N. N., Pustina-Krasniqi, T., & Apostolska, S. (2018). The Effect of Gaseous Ozone in Infected Root Canal. Open access Macedonian journal of medical sciences, 6(2), 389–396. doi.org/10.3889/oamjms.2018.102.
Al Habashneh, R., Alsalman, W., & Khader, Y. (2015). Ozone as an adjunct to conventional nonsurgical therapy in chronic periodontitis: a randomized controlled clinical trial. Journal of periodontal research, 50(1), 37–43. doi.org/10.1111/jre.12177.
Al-Omiri, M. K., Al Nazeh, A. A., Kielbassa, A. M., & Lynch, E. (2018). Randomized controlled clinical trial on bleaching sensitivity and whitening efficacy of hydrogen peroxide versus combinations of hydrogen peroxide and ozone. Scientific reports, 8(1), 2407. doi.org/10.1038/s41598-018-20878-0.
Al-Omiri, M. K., Hassan, R. S., AlZarea, B. K., & Lynch, E. (2016). Effects of combining ozone and hydrogren peroxide on tooth bleaching: A clinical study. Journal of dentistry, 53, p.88–93. doi.org/10.1016/j.jdent.2016.08.002.
Amaral, A., Medeiros, M., & Parada, A. (2013). Feridas não são doenças do corpo, são doenças da alma. https://www.revistasuninter.com/revistasaude/index.php/revista-praticas-interativas/article/view/249.
Atabek, D., & Oztas, N. (2011). Effectiveness of Ozone with or without the Additional Use of Remineralizing Solution on Non-Cavitated Fissure Carious Lesions in Permanent Molars. European journal of dentistry, 5(4), 393–399.
Buliés, C. J. C. E. (2005). Oxígeno-ozonoterapia como coadyuvante en el tratamiento de las infecciones óseas. Revista Cubana de Ortopedia y Traumatología, 19(1) http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-215X2005000100002&lng=es&tlng=es.
Celakil, T., Muric, A., Gökcen Roehlig, B., & Evlioglu, G. (2019). Management of pain in TMD patients: Bio-oxidative ozone therapy versus occlusal splints. Cranio the journal of craniomandibular practice, 37(2), 85–93. doi.org/10.1080/08869634.2017.1389506.
Chandra, S. P., Chandrasekhar, R., Uloopi, K. S., Vinay, C., & Kumar, N. M. (2014). Success of root fillings with zinc oxide-ozonated oil in primary molars: preliminary results. European archives of paediatric dentistry: official journal of the European Academy of Paediatric Dentistry, 15(3), 191–195. doi.org/10.1007/s40368-013-0094-8.
Conselho Federal de Odontologia. (Brasil). Portaria n° 702, de 13 de março de 2018. Inclusão da ozonioterapia, e de mais nove tratamentos, chamados de Práticas Integrativas e Complementares no Sistema Único de Saúde. Ministério da Saúde. https://bvsms.saude.gov.br/bvs/saudelegis/gm/2018/prt0702_22_03_2018.html.
Cosola, S., Giammarinaro, E., Genovesi, A. M., Pisante, R., Poli, G., Covani, U., & Marconcini, S. (2019). A short-term study of the effects of ozone irrigation in an orthodontic population with fixed appliances. European journal of paediatric dentistry, 20(1), 15–18. doi.org/10.23804/ejpd.2019.20.01.03.
Doğan, M., Ozdemir Doğan, D., Düger, C., Ozdemir Kol, I., Akpınar, A., Mutaf, B., & Akar, T. (2014). Effects of high-frequency bio-oxidative ozone therapy in temporomandibular disorder-related pain. Medical principles and practice: International journal of the Kuwait University, Health Science Centre, 23(6), 507–510. doi.org/10.1159/000365355.
Domb W. C. (2014). Ozone therapy in dentistry. A brief review for physicians. Interventional neuroradiology: Journal of peritherapeutic neuroradiology surgical procedures and related neurosciences, 20(5), 632–636. doi.org/10.15274/INR-2014-10083.
Gandhi, K.K., Cappetta, E.G. & Pavaskar, R. (2019). Effectiveness of the adjunctive use of ozone and chlorhexidine in patients with chronic periodontitis. BDJ Open 5, 17 doi.org/10.1038/s41405-019-0025-9.
Glória, J., Douglas-de-Oliveira, D. W., E Silva, L., Falci, S., & Dos Santos, C. (2020). Influence of ozonized water on pain, oedema, and trismus during impacted third molar surgery: a randomized, triple blind clinical trial. BMC oral health, 20(1), 41. doi.org/10.1186/s12903-020-1029-5.
Grocholewicz, K., Matkowska-Cichocka, G., Makowiecki, P., Droździk, A., Ey-Chmielewska, H., Dziewulska, A., Tomasik, M., Trybek, G., & Janiszewska-Olszowska, J. (2020). Effect of nano-hydroxyapatite and ozone on approximal initial caries: a randomized clinical trial. Scientific reports, 10(1), 11192. doi.org/10.1038/s41598-020-67885-8.
Hayakumo, S., Arakawa, S., Mano, Y., & Izumi, Y. (2013). Clinical and microbiological effects of ozone nano-bubble water irrigation as an adjunct to mechanical subgingival debridement in periodontitis patients in a randomized controlled trial. Clinical oral investigations, 17(2), 379–388. doi.org/10.1007/s00784-012-0711-7.
Isler, S. C., Uraz, A., Guler, B., Ozdemir, Y., Cula, S., & Cetiner, D. (2018). Effects of Laser Photobiomodulation and Ozone Therapy on Palatal Epithelial Wound Healing and Patient Morbidity. Photomedicine and laser surgery, 36(11), 571–580. doi.org/10.1089/pho.2018.4492.
Johansson, E., van Dijken, J. W., Karlsson, L., & Andersson-Wenckert, I. (2014). Treatment effect of ozone and fluoride varnish application on occlusal caries in primary molars: a 12-month study. Clinical oral investigations, 18(7), 1785–1792. doi.org/10.1007/s00784-013-1160-7.
Jorge, R. A., Rodríguez, Y.L., Rodríguez, A. C., & Ruiz, J. A.A. (2006). Producción científica sobre aplicaciones terapéuticas del ozono en el Web of Science. ACIMED, 14(1) de http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1024-94352006000100007&lng=es&tlng=es.
Kazancioglu, H. O., & Erisen, M. (2015). Comparison of Low-Level Laser Therapy versus Ozone Therapy in the Treatment of Oral Lichen Planus. Annals of dermatology, 27(5), 485–491. doi.org/10.5021/ad.2015.27.5.485.
Kazancioglu, H. O., Ezirganli, S., & Demirtas, N. (2014a). Comparison of the influence of ozone and laser therapies on pain, swelling, and trismus following impacted third-molar surgery. Lasers in medical science, 29(4), 1313–1319. doi.org/10.1007/s10103-013-1300-y.
Kazancioglu, H. O., Kurklu, E., & Ezirganli, S. (2014b). Effects of ozone therapy on pain, swelling, and trismus following third molar surgery. International journal of oral and maxillofacial surgery, 43(5), 644–648. doi.org/10.1016/j.ijom.2013.11.006.
Kist, S., Kollmuss, M., Jung, J., Schubert, S., Hickel, R., & Huth, K. C. (2017). Comparison of ozone gas and sodium hypochlorite/chlorhexidine two-visit disinfection protocols in treating apical periodontitis: a randomized controlled clinical trial. Clinical oral investigations, 21(4), 995–1005. doi.org/10.1007/s00784-016-1849-5.
Krunić, J., Stojanović, N., Đukić, L., Roganović, J., Popović, B., Simić, I., & Stojić, D. (2019). Clinical antibacterial effectiveness and biocompatibility of gaseous ozone after incomplete caries removal. Clinical oral investigations, 23(2), 785–792. doi.org/10.1007/s00784-018-2495-x.
Kshitish D, Laxman VK. The use of ozonated water and 0.2% chlorhexidine in the treatment of periodontitis patients: A clinical and microbiologic study. Indian J Dent Res 2010; 21:341-8.
Martins, A., Silva, J. T. da,Graciola, L., Fréz, A. R., Ruaro, J. A., & Marquetti, M. da G. K. (2012). Efeito bactericida do gerador de alta frequência na cultura de Staphylococcus aureus. Fisioterapia E Pesquisa, 19(2), 153-157. doi.org/10.1590/S1809-29502012000200011.
Matys, J., Jaszczak, E., Flieger, R., Kostrzewska-Kaminiarz, K., Grzech-Leśniak, K., & Dominiak, M. (2020). Effect of ozone and diode laser (635 nm) in reducing orthodontic pain in the maxillary arch-a randomized clinical controlled trial. Lasers in medical science, 35(2), 487–496. doi.org/10.1007/s10103-019-02896-0.
McKenna, D. F., Borzabadi-Farahani, A., & Lynch, E. (2013). The effect of subgingival ozone and/or hydrogen peroxide on the development of peri-implant mucositis: a double-blind randomized controlled trial. The International journal of oral & maxillofacial implants, 28(6), 1483–1489. doi.org/10.11607/jomi.3168.
Mese, M., Tok, Y. T., Kaya, S., & Akcay, M. (2020). Influence of ozone application in the stepwise excavation of primary molars: a randomized clinical trial. Clinical oral investigations, 24(10), 3529–3538. doi.org/10.1007/s00784-020-03223-6.
Moraschini, V., Kischinhevsky, I., Calasans-Maia, M. D., Shibli, J. A., Sartoretto, S. C., Figueredo, C. M., & Granjeiro, J. M. (2020). Ineffectiveness of ozone therapy in nonsurgical periodontal treatment: a systematic review and metaanalysis of randomized clinical trials. Clinical oral investigations, 24(6), 1877–1888. doi.org/10.1007/s00784-020-03289-2.
Mostafa, B., & Zakaria, M. (2018). Evaluation of Combined Topical Ozone and Steroid Therapy in Management of Oral Lichen Planus. Open access Macedonian journal of medical sciences, 6(5), 879–884. doi.org/10.3889/oamjms.2018.219.
Nicolini, A. C., Rotta, I., Langa, G., Friedrich, S. A., Arroyo-Bonilla, D. A., Wagner, M. C., Weidlich, P., Rösing, C. K., & Cavagni, J. (2021). Efficacy of ozonated water mouthwash on early plaque formation and gingival inflammation: a randomized controlled crossover clinical trial. Clinical oral investigations, 25(3), 1337–1344. doi.org/10.1007/s00784-020-03441-y.
Nogales, C. G., Ferrari, P. H., Kantorovich, E. O., & Lage-Marques, J. L. (2008). Ozone therapy in medicine and dentistry. The journal of contemporary dental practice, 9(4), 75–84.
Nuvolone, D., Petri, D., & Voller, F. (2018). The effects of ozone on human health. Environmental science and pollution research international, 25(9), 8074–8088. doi.org/10.1007/s11356-017-9239-3.
Oliveira, J. T. C. (2007). Revisão sistemática de literatura sobre o uso terapêutico do ozônio em feridas. Dissertação de Mestrado, Escola de Enfermagem, Universidade de São Paulo, São Paulo. doi:10.11606/D.7.2007.tde-20122007-094050. www.teses.usp.br.
Patel, P. V., Kumar, V., Kumar, S., Gd, V., & Patel, A. (2011). Therapeutic effect of topical ozonated oil on the epithelial healing of palatal wound sites: a planimetrical and cytological study. Journal of investigative and clinical dentistry, 2(4), 248–258. doi.org/10.1111/j.2041-1626.2011.00072.x.
Safwat, O., Elkateb, M., Dowidar, K., & El Meligy, O. (2017). Clinical Evaluation of Ozone on Dentinal Lesions in Young Permanent Molars using the Stepwise Excavation. The Journal of clinical pediatric dentistry, 41(6), 429–441. doi.org/10.17796/1053-4628-41.6.3.
Santos, G. M., Pacheco, R. L., Bussadori, S. K., Santos, E. M., Riera, R., Latorraca, C. O. C., Mota, P., Bellotto, E. F. B. C., & Martimbianco, A. L. C. (2020). Effectiveness and Safety of Ozone Therapy in Dental Caries Treatment: Systematic Review and Meta-analysis. The journal of evidence-based dental practice, 20(4), 101472. doi.org/10.1016/j.jebdp.2020.101472.
Seidler, V., Linetskiy, I., Hubálková, H., Stanková, H., Smucler, R., & Mazánek, J. (2008). Ozone and its usage in general medicine and dentistry. A review article. Prague medical report, 109(1), 5–13.
Seydanur Dengizek, E., Serkan, D., Abubekir, E., Aysun Bay, K., Onder, O., & Arife, C. (2019). Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial. Journal of applied oral science, 27, e20180108. doi.org/10.1590/1678-7757-2018-0108.
Silva, E., Prado, M. C., Soares, D. N., Hecksher, F., Martins, J., & Fidalgo, T. (2020). The effect of ozone therapy in root canal disinfection: a systematic review. International endodontic journal, 53(3), 317–332. doi.org/10.1111/iej.13229.
Sivalingam, V. P., Panneerselvam, E., Raja, K. V., & Gopi, G. (2017). Does Topical Ozone Therapy Improve Patient Comfort After Surgical Removal of Impacted Mandibular Third Molar? A Randomized Controlled Trial. Journal of oral and maxillofacial surgery: Journal of the American Association of Oral and Maxillofacial Surgeons, 75(1), 51.e1–51.e9. doi.org/10.1016/j.joms.2016.09.014.
Skurska, A., Pietruska, M. D., Paniczko-Drężek, A., Dolińska, E., Zelazowska-Rutkowska, B., Zak, J., Pietruski, J., Milewski, R., & Wysocka, J. (2010). Evaluation of the influence of ozonotherapy on the clinical parameters and MMP levels in patients with chronic and aggressive periodontitis. Advances in medical sciences, 55(2), 297–307. doi.org/10.2478/v10039-010-0048-x.
Sridharan, K., & Sivaramakrishnan, G. (2021). Interventions for oral lichen planus: A systematic review and network meta-analysis of randomized clinical trials. Australian dental journal, 10.1111/adj.12835. Advance online publication. doi.org/10.1111/adj.12835.
Taşdemir, Z., Alkan, B. A., & Albayrak, H. (2016). Effects of Ozone Therapy on the Early Healing Period of Deepithelialized Gingival Grafts: A Randomized Placebo-Controlled Clinical Trial. Journal of periodontology, 87(6), 663–671. doi.org/10.1902/jop.2016.150217.
Tasdemir, Z., Oskaybas, M. N., Alkan, A. B., & Cakmak, O. (2019). The effects of ozone therapy on periodontal therapy: A randomized placebo-controlled clinical trial. Oral diseases, 25(4), 1195–1202. doi.org/10.1111/odi.13060.
Unal, M., & Oztas, N. (2015). Remineralization Capacity of Three Fissure Sealants with and without Gaseous Ozone on Non-Cavitated Incipient Pit and Fissure Caries. The Journal of clinical pediatric dentistry, 39(4), 364–370. doi.org/10.17796/1053-4628-39.4.364.
Uraz, A., Karaduman, B., Isler, S. Ç., Gönen, S., & Çetiner, D. (2019). Ozone application as adjunctive therapy in chronic periodontitis: Clinical, microbiological and biochemical aspects. Journal of dental sciences, 14(1), 27–37. doi.org/10.1016/j.jds.2018.06.005.
Vasthavi, C., Babu, H. M., Rangaraju, V. M., Dasappa, S., Jagadish, L., & Shivamurthy, R. (2020). Evaluation of ozone as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A randomized clinico-microbial study. Journal of Indian Society of Periodontology, 24(1), 42–46. doi.org/10.4103/jisp.jisp_162_19.
Wang X. (2018). Emerging roles of ozone in skin diseases. Journal of Central South University, 43(2), 114–123. doi.org/10.11817/j.issn.1672-7347.2018.02.002.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Poliana Lima Bastos; Guilherme Salles Ottoboni; Alexandre Melo Karam; Marcelo Bonifácio da Silva Sampieri; Elane Fernandes de Araújo
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
