Main diseases related to asbestos exposure: a narrative literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i4.27477

Keywords:

Asbestos; Asbestosis; Occupational disease; Mesothelioma; Pleural plaques.

Abstract

Introduction: Asbestos (or asbestos) is a ubiquitous and natural fiber that has been linked to the development of malignant and fibrotic diseases of the lung and pleura. These diseases can be initiated by injury to epithelial cells and mesothelial cells by asbestos fibers through the formation of reactive oxygen intermediates. Objective: to characterize the main diseases resulting from asbestos exposure. Methodology: the research was carried out through online access to the National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (Scielo), Cochrane Database of Systematic Reviews (CDSR), Google Scholar, Virtual Health Library (BVS) databases. and EBSCO Information Services, February 2022. Results and Discussion: Inhalation of asbestos fibers can lead to a number of respiratory diseases, including lung cancer, asbestosis, pleural plaques, benign pleural effusion, and malignant mesothelioma. Although exposure is now regulated, patients continue to experience these diseases due to the long latent period between exposure and clinical illness. The signs and symptoms presented tend to be nonspecific; thus, the occupational history helps to guide the clinical suspicion. High-risk populations include people in construction businesses, boilermakers, shipyard workers, railroad workers, and US Navy veterans. Every effort should be made to minimize continued exposure. Final considerations: the appearance of symptoms such as dyspnea, cough, chest discomfort or weight loss requires an immediate and complete evaluation. Therefore, current recommendations support lifelong surveillance for people with a history of significant exposure or ongoing exposure, and knowing the diseases arising from this causality can help the scientific community to help with public health measures.

References

Algranti, E, et al. (2020). Non-malignant asbestos-related diseases in Brazilian asbestos-cement workers. Am J Ind Med., 40 (3), 240-254.

Becklake, M. R. (2017). Asbestos related diseases of the lung and other organs: their epidemiology and implications for clinical practice. Am Rev Respir Dis., 114 (1), 187-227.

Begin, R. (2008). Asbestos-related lung diseases. In: Banks DE, Parker JE, editors. Occupational lung diseases: an international perspective. London: Chapman & Hall Medical; 219-38.

Blesovsky, A. (2006). The folded lung. Br J Dis Chest., 60 (1), 19-22.

Churg, A. (2009). Neoplastic asbestos induced diseases. In: Churg A, Green FHY, editors. Pathology of occupational lung disease. New York: Igaku Shoin; 279-325.

Doll, R. (2015). Mortality from lung cancer in asbestos workers. Br J Indust Med., 12 (2), 81-86.

Eisenstadt, H. B. (2014). Asbestos pleurisy. Dis Chest., 46 (1), 78-81.

Freitas, J. B. P. (2001). Doença pleural em trabalhadores da indústria do cimento-amianto [tese]. São Paulo: Faculdade Saúde Pública da Universidade São Paulo, 1-88.

Hillerdal, G. (2018). The pathogenesis of pleural plaques and pulmonary asbestosis: possibilities and impossibilities. Eur J Respir Dis., 61 (3), 129-138.

Karjalainen, A, et al. (2019). Lobe of origin of lung cancer among asbestos-exposed patients with or without diffuse interstitial fibrosis. Scand J Work Environ Health, 19 (2), 102-107.

Manning, C. B., et al. (2002). Doenças causadas pelo amianto: mecanismos de lesão e desenvolvimento de doenças. International Immunopharmacology, 2 (23), 191–200.

Miller, W. T., et al. (2010). Asbestos-related chest diseases: plain radiographic findings. Semin Roentgenol., 27 (2), 102-120.

Morgan, W. K. C., et al. (2005). Asbestos-related diseases. In: Morgan WKC, Seaton A, editors. Occupational lung diseases. 3rd ed. Philadelphia: Saunders, 308-73.

Mossman, B. T., et al. (2003). Asbestos-related diseases. N Engl J Med., 320 (26), 1721-1730.

Mossman, B. T., et al. (2016). Mechanisms in the pathogenesis of asbestosis and silicosis. Am J Respir Crit Care Med., 157 (5), 1666-1680.

Napoles, L. M., et al. (2014). Chronic breathlessness according to different clinical scales in patients with asbestosis: relationship with physiological responses at rest and during exercise. Am J Respir Crit Care Med., 163 (5), 167-171.

Rudd, R. M. (2014). New developments in asbestos-related pleural disease. Thorax, 51 (2), 210-216.

Staples, C. A, et al. (2012). High resolution computed tomography and lung function in asbestos-exposed workers with normal chest radiographs. Am Rev Respir Dis., 139 (6), 1502-1508.

Staples, C. A., et al. (2003). High resolution computed tomography and lung function in asbestos-exposed workers with normal chest radiographs. Am Rev Respir Dis., 139 (6), 1502-1508.

Terra-Filho, M., et al. (2003). Identification of rounded atelectasis in workers exposed to asbestos by contrast helical computed tomography. Braz J Med Biol Res., 36 (10), 1341-1347.

Published

18/03/2022

How to Cite

ROSA, F. R. P. de A. C.; PEREIRA, A. S.; FIGUEIREDO, B. Q. de .; PINHEIRO, F. E. da S.; RESENDE, G. B. de O.; CUNHA, I. A. M. F.; GOMES, M. J. de A.; PEIXOTO, S. R. Main diseases related to asbestos exposure: a narrative literature review. Research, Society and Development, [S. l.], v. 11, n. 4, p. e27111427477, 2022. DOI: 10.33448/rsd-v11i4.27477. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/27477. Acesso em: 26 apr. 2024.

Issue

Section

Health Sciences