Effects of Passion Fruit (Passiflora edulis) on the Glycemic Management of Diabetes Mellitus

Authors

DOI:

https://doi.org/10.33448/rsd-v11i5.28296

Keywords:

Passiflora; Diabetes Mellitus; Glycemic control; Health teaching.

Abstract

Diabetes Mellitus (DM) is a chronic and progressive disease, characterized by persistent hyperglycemia, which can result in disabling and even fatal micro and macrovascular complications. Passiflora edulis, whose fruit is passion fruit, is an abundant plant in Brazil and has hypoglycemic potential, which can help in the treatment of DM. The aim of this article is to investigate the effects of P. edulis parts on the glycemic control of individuals with DM. This is an integrative literature review with the following research question: “Does passion fruit (P. edulis) have an impact on glycemic parameters in individuals with Diabetes Mellitus?”. The data search was performed in the Bireme, Cochrane Library, Scielo and Pubmed databases in January 2022. Fourteen articles were found, five of which made up the final sample. Three of the studies were randomized controlled trials, while two were experimental studies. Among the pharmaceutical forms were: flour from the peel and albedo, seed extract and ethanolic extract from the leaves of P. edulis. Most studies have shown effects such as lowering fasting blood glucose and glycated hemoglobin. It is possible to conclude that the passion fruit (P. edulis) parts, such as seeds, leaves and peel, contain substances that can help in the glycemic control of patients with DM, however, more studies are needed to ensure their use.

References

American Diabetes Association (ADA). (2022). Standards of Medical Care in Diabetes – 2022. Diabetes Care, 45 (Supplement 1).

Agra, M. de F., Freitas, P. F. de, & Barbosa-Filho, J. M. (2007). Synopsis of the plants known as medicinal and poisonous in Northeast of Brazil. Revista Brasileira de Farmacognosia, 17(1), 114–140. https://doi.org/10.1590/s0102-695x2007000100021.

Birdee, G. S., & Yeh, G. (2010). Complementary and Alternative Medicine Therapies for Diabetes: A Clinical Review. Clinical Diabetes, 28(4), 147–155. https://doi.org/10.2337/diaclin.28.4.147.

Cao, Q., Teng, J., Wei, B., Huang, L., & Xia, N. (2021). Phenolic compounds, bioactivity, and bioaccessibility of ethanol extracts from passion fruit peel based on simulated gastrointestinal digestion. Food Chemistry, 356, 129682. https://doi.org/10.1016/j.foodchem.2021.129682.

Cazarin, C. B. B., Silva, J. K. da, Colomeu, T. C., Zollner, R. de L., & Maróstica Junior, M. R. (2014). Capacidade antioxidante e composição química da casca de maracujá (Passiflora edulis). Ciência Rural, 44(9), 1699–1704. https://doi.org/10.1590/0103-8478cr20131437.

de Araújo, M. F. M., Veras, V. S., de Freitas, R. W. J. F., de Paula, M. do L., de Araújo, T. M., Uchôa, L. R. A., Gaspar, M. W. G., Cunha, M. da C. do S. O., Serra, M. A. A. de O., Carvalho, C. M. de L., Costa, E. C., & Damasceno, M. M. C. (2017). The effect of flour from the rind of the yellow passion fruit on glycemic control of people with diabetes mellitus type 2: a randomized clinical trial. Journal of Diabetes & Metabolic Disorders, 16(1). https://doi.org/10.1186/s40200-017-0300-z.

de Faveri, A., De Faveri, R., Broering, M. F., Bousfield, I. T., Goss, M. J., Muller, S. P., Pereira, R. O., de Oliveira e Silva, A. M., Machado, I. D., Quintão, N. L. M., & Santin, J. R. (2020). Effects of passion fruit peel flour (Passiflora edulis f. flavicarpa O. Deg.) in cafeteria diet-induced metabolic disorders. Journal of Ethnopharmacology, 250, 112482. https://doi.org/10.1016/j.jep.2019.112482.

de Queiroz, M. do S. R., Janebro, D. I., da Cunha, M. A. L., Medeiros, J. dos S., Sabaa-Srur, A. U., Diniz, M. de F. F., & dos Santos, S. C. (2012). Effect of the yellow passion fruit peel flour (Passiflora edulis f. flavicarpa deg.) in insulin sensitivity in type 2 diabetes mellitus patients. Nutrition Journal, 11(1). https://doi.org/10.1186/1475-2891-11-89.

de Sousa, D. F., Araújo, M. F. M. de, de Mello, V. D., Damasceno, M. M. C., & Freitas, R. W. J. F. de. (2021). Cost-Effectiveness of Passion Fruit Albedo versus Turmeric in the Glycemic and Lipaemic Control of People with Type 2 Diabetes: Randomized Clinical Trial. Journal of the American College of Nutrition, 40(8), 679–688. https://doi.org/10.1080/07315724.2020.1823909.

dos Reis, L. C. R., Facco, E. M. P., Salvador, M., Flôres, S. H., & de Oliveira Rios, A. (2018). Antioxidant potential and physicochemical characterization of yellow, purple and orange passion fruit. Journal of Food Science and Technology, 55(7), 2679–2691. https://doi.org/10.1007/s13197-018-3190-2.

Faleiro, F. G., Junqueira, N. T. V., Braga, M. F., & Peixoto, J. R. (2008). Caracterização de germoplasma e melhoramento genético do maracujazeiro assistidos por marcadores moleculares resultados de pesquisa 2005-2008. Planaltina, DF: Embrapa Cerrados.

Franz, M. J., Boucher, J. L., & Evert, A. B. (2014). Evidence-based diabetes nutrition therapy recommendations are effective: the key is individualization. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 7, 65–72. https://doi.org/10.2147/DMSO.S45140.

Goss, M. J., Nunes, M., Machado, I. D., Merlin, L., Macedo, N. B., Silva, A., Bresolin, T., & Santin, J. R. (2018). Peel flour of Passiflora edulis Var. Flavicarpa supplementation prevents the insulin resistance and hepatic steatosis induced by low-fructose-diet in young rats. Biomedicine & Pharmacotherapy, 102, 848–854. https://doi.org/10.1016/j.biopha.2018.03.137.

International Diabetes Federation (IDF). (2021). IDF Atlas (10ª ed.). International Diabetes Federation.

Kitada, M., Ogura, Y., Maruki-Uchida, H., Sai, M., Suzuki, T., Kanasaki, K., Hara, Y., Seto, H., Kuroshima, Y., Monno, I., & Koya, D. (2017). The Effect of Piceatannol from Passion Fruit (Passiflora edulis) Seeds on Metabolic Health in Humans. Nutrients, 9(10), 1142. https://doi.org/10.3390/nu9101142.

Li, H., Zhou, P., Yang, Q., Shen, Y., Deng, J., Li, L., & Zhao, D. (2011). Comparative studies on anxiolytic activities and flavonoid compositions of Passiflora edulis 'edulis' and Passiflora edulis 'flavicarpa'. Journal of Ethnopharmacology, 133(3), 1085–1090. https://doi.org/10.1016/j.jep.2010.11.039.

Martins, C. F. R., Salles, B. C. C., Brigagão, M. R. P. L., Rodrigues, M. R., Ferreira, E. B., Duarte, S. M. da S., & Paula, F. B. de A. (2015). Ethanolic extract of Passiflora edulis Sims leaves inhibits protein glycation and restores the oxidative burst in diabetic rat macrophages after Candida albicans exposure. Brazilian Journal of Pharmaceutical Sciences, 51(4), 869–878. https://doi.org/10.1590/s1984-82502015000400013.

Maruki-Uchida, H., Kurita, I., Sugiyama, K., Sai, M., Maeda, K., & Ito, T. (2013). The protective effects of piceatannol from passion fruit (Passiflora edulis) seeds in UVB-irradiated keratinocytes. Biological & Pharmaceutical Bulletin, 36(5), 845–849. https://doi.org/10.1248/bpb.b12-00708.

Matsui, Y., Sugiyama, K., Kamei, M., Takahashi, T., Suzuki, T., Katagata, Y., & Ito, T. (2010). Extract of passion fruit (Passiflora edulis) seed containing high amounts of piceatannol inhibits melanogenesis and promotes collagen synthesis. Journal of Agricultural and Food Chemistry, 58(20), 11112–11118. https://doi.org/10.1021/jf102650d.

Minakawa, M., Miura, Y., & Yagasaki, K. (2012). Piceatannol, a resveratrol derivative, promotes glucose uptake through glucose transporter 4 translocation to plasma membrane in L6 myocytes and suppresses blood glucose levels in type 2 diabetic model db/db mice. Biochemical and Biophysical Research Communications, 422(3), 469–475. https://doi.org/10.1016/j.bbrc.2012.05.017.

Nascimento, A. K. P. do, Santos, B. L. C. dos, Oliveira Filho, A. A. de, & Oliveira, H. M. B. F. de. (2020). Passiflora edulis: uma breve revisão dos efeitos antidiabéticos. Archives of Health Investigation, 9(2). https://doi.org/10.21270/archi.v9i2.3168.

Pandey, A., Tripathi, P., Pandey, R., Srivatava, R., & Goswami, S. (2011). Alternative therapies useful in the management of diabetes: A systematic review. Journal of Pharmacy & Bioallied Sciences, 3(4), 504–512. https://doi.org/10.4103/0975-7406.90103.

Salles, B., da Silva, M. A., Taniguthi, L., Ferreira, J. N., da Rocha, C. Q., Vilegas, W., Dias, P. H., Pennacchi, P. C., Duarte, S., Rodrigues, M. R., Brigagão, M., & Paula, F. (2020). Passiflora edulis Leaf Extract: Evidence of Antidiabetic and Antiplatelet Effects in Rats. Biological & Pharmaceutical Bulletin, 43(1), 169–174. https://doi.org/10.1248/bpb.b18-00952.

Salles, G. F., Bloch, K. V., & Cardoso, C. R. (2004). Mortality and predictors of mortality in a cohort of Brazilian type 2 diabetic patients. Diabetes Care, 27(6), 1299–1305. https://doi.org/10.2337/diacare.27.6.1299.

Santilli, F., Simeone, P., Liani, R., & Davì, G. (2015). Platelets and diabetes mellitus. Prostaglandins & Other Lipid Mediators, 120, 28–39. https://doi.org/10.1016/j.prostaglandins.2015.05.002.

Sociedade Brasileira de Diabetes (SBD). (2019). Diretrizes da Sociedade Brasileira de Diabetes 2019-2020. Clannad.

Sociedade Brasileira de Diabetes (SBD). (2022). Diretriz Oficial da Sociedade Brasileira de Diabetes. SBD. https://diretriz.diabetes.org.br/?utm_source=google-ads&utm_medium=search&gclid=CjwKCAjwlcaRBhBYEiwAK341jfZGUqd6vIOfxBgwQecD4g6FY1I5SI9tgTj3pU3-h2T53qHSdSvFQRoCHSsQAvD_BwE

Shane-McWhorter L. (2005). Botanical dietary supplements and the treatment of diabetes: what is the evidence?. Current Diabetes Reports, 5(5), 391–398. https://doi.org/10.1007/s11892-005-0099-8.

Shen, T., Wang, X. N., & Lou, H. X. (2009). Natural stilbenes: an overview. Natural Product Reports, 26(7), 916–935. https://doi.org/10.1039/b905960a.

Sierra, M., Garcia, J. J., Fernández, N., Diez, M. J., Calle, A. P., Sahagún, A. M., & Farmafibra Group (2001). Effects of ispaghula husk and guar gum on postprandial glucose and insulin concentrations in healthy subjects. European Journal of Clinical Nutrition, 55(4), 235–243. https://doi.org/10.1038/sj.ejcn.1601147.

Uchida-Maruki, H., Inagaki, H., Ito, R., Kurita, I., Sai, M., & Ito, T. (2015). Piceatannol lowers the blood glucose level in diabetic mice. Biological & Pharmaceutical Bulletin, 38(4), 629–633. https://doi.org/10.1248/bpb.b15-00009.

Zhang, A. J., Rimando, A. M., Mizuno, C. S., & Mathews, S. T. (2017). α-Glucosidase inhibitory effect of resveratrol and piceatannol. The Journal of Nutritional Biochemistry, 47, 86–93. https://doi.org/10.1016/j.jnutbio.2017.05.008.

Published

11/04/2022

How to Cite

MENDES, R. C. M.; SOUZA, M. P. G.; MARTINS , M. Y. P. T.; REIS, D. M. dos . Effects of Passion Fruit (Passiflora edulis) on the Glycemic Management of Diabetes Mellitus. Research, Society and Development, [S. l.], v. 11, n. 5, p. e42111528296, 2022. DOI: 10.33448/rsd-v11i5.28296. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/28296. Acesso em: 23 apr. 2024.

Issue

Section

Health Sciences