The proteomics behind clinical and temporal changes in Parkinson's Disease: a literature review

Valécia Natália Carvalho da  Silva; Francisco  Magalhães; Jacks Renan Neves  Fernandes; Antonio Thomaz de  Oliveira; Hoanna Izabely Rego  Castro; Thayaná Ribeiro Silva  Fernandes; Valéria de Fátima Veras de  Castro

doi:10.33448/rsd-v11i5.28475

Authors

Valécia Natália Carvalho da Silva Universidade Federal do Delta do Parnaíba https://orcid.org/0000-0001-5739-0722
Francisco Magalhães Universidade Federal do Delta do Parnaíba https://orcid.org/0000-0002-8542-4245
Jacks Renan Neves Fernandes Universidade Federal do Piauí https://orcid.org/0000-0001-7868-0673
Antonio Thomaz de Oliveira Universidade Federal do Delta do Parnaíba https://orcid.org/0000-0003-0277-6833
Hoanna Izabely Rego Castro Universidade Federal do Ceará https://orcid.org/0000-0001-5646-4902
Thayaná Ribeiro Silva Fernandes Universidade Federal do Delta do Parnaíba https://orcid.org/0000-0002-6590-4620
Valéria de Fátima Veras de Castro Universidade Federal do Delta do Parnaíba https://orcid.org/0000-0001-8281-3029

DOI:

https://doi.org/10.33448/rsd-v11i5.28475

Keywords:

Parkinson's Disease; PARK Proteins; Time perception.

Abstract

Parkinson's disease (PD) is characterized by the dopaminergic neuron's progressive neurodegeneration, which is chronic and results in movement and behavioral disorders. There are still many gaps in the PD etiology and pathogenesis. Thus, aiming to strengthen the evidence that serves as a tool for diagnostic aid and future treatments, this systematic review aims to relate and analyze studies on the PARK proteomics, that is, the class of expressed park proteins that are associated with pathogenesis, PD clinical changes, and temporal effects. 261 papers were selected for eligibility analysis based on their title and abstract, resulting in 56 papers, with a full reading, included in this study. The observed result leads to the understanding of gene expression for a class of proteins that participate in cellular metabolic pathways associated with the PD etiology. Genetic studies applied to proteomics investigated disease-linked loci of PARK genes and their gene expression to relate the cellular pathways that contribute to PD. It was observed that PARK proteins corroborate the PD pathogenesis, highlighting the hypothesis of change in perception over time. Therefore, exploratory, and systematic studies can guide future investigations and strengthen clinically applied evidence.

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The proteomics behind clinical and temporal changes in Parkinson's Disease: a literature review

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