Herpes virus associated with other infections and the risk for the development of cervical cancer





Herpes virus; Cervical cancer; HPV; Teaching.


Introduction: Cervical cancer is one of the main diseases that affect the female population. Its main causative agent is the Human Papillomavirus (HPV) that affects the cervical region causing lesions that can later develop into cancer. There are some risk factors that contribute to the development of this pathology, among them is the infection caused by the Herpes virus. There are some risk factors such as multiparity, smoking, multiple sexual partners and STIs such as herpes simplex virus that acts as a cofactor in the development of this pathology. The work aims to verify in the databases articles that address the relationship of herpes virus and cervical cancer, as well as to determine other pathologies associated with HPV and to verify the prevalence of infections caused by herpes. Methodology: A search was performed in the Pubmed, Scielo and ScienceDirect databases, in which the data of interest were divided into: Sample size, mean age, type of study, form of diagnosis, infections associated with HPV and results obtained. Results and Discussion: At the end of the search, 14 articles were found that dealt with the proposed topic, addressing various aspects of herpes infection along with HPV and the development of cervical cancer. Conclusion: Although there is no evidence that herpes virus causes cervical cancer, it is remarkable that its association with HPV generates the appearance of precancerous lesions, which can become cancer. It was also observed that herpes virus infection has been growing steadily in different regions and that most cases are caused by type 1 of the disease.


Abdolmaleki, M., & Sohrabi, A. (2018). Characterization of JAK2 V617F (1849 G> T) mutation in cervical cancer related to human papillomavirus and sexually transmitted infections. Journal of Cancer Prevention, 23(2), 82.

Alotaibi, H. J., Almajhdi, F. N., Alsaleh, A. N., Obeid, D. A., Khayat, H. H., Al-Muammer, T. A., & Alhamlan, F. S. (2020). Association of sexually transmitted infections and human papillomavirus co-infection with abnormal cervical cytology among women in Saudi Arabia. Saudi Journal of Biological Sciences, 27(6), 1587-1595.

Atencio, R., Bracho, A., Porto, L., Callejas, D., Gotera, J., Pirela, N., ... & Atencio, M. (2013). Determinación del virus papiloma humano y virus herpes simple y su posible relación con la presencia y tipo de lesiones preinvasivas del cuello uterino. Kasmera, 41(2), 145-153.

Britto, A. M. A., Policarpo, C., Pezzuto, P., Meirelles, A. R. I., Furtado, Y. L., Almeida, G., & Machado, E. S. (2018). Detection of sexually transmitted infections at a Brazilian gynecology center: high prevalence of co-infections. Jornal Brasileiro de Patologia e Medicina Laboratorial, 54, 393-400.

Carvalho, P. G. D., & Rodrigues, N. C. P. (2018). Trajetórias assistenciais de mulheres entre diagnóstico e início de tratamento do câncer de colo uterino. Saúde em Debate, 42, 687-701.

Castellsague, X., Pawlita, M., Roura, E., Margall, N., Waterboer, T., Bosch, F. X., & Riboli, E. (2014). Prospective seroepidemiologic study on the role of Human Papillomavirus and other infections in cervical carcinogenesis: evidence from the EPIC cohort. International journal of cancer, 135(2), 440-452.

Confessor, M. V. A. (2020). Fisiopatologia das Doenças:: Dos Aspectos Moleculares do Câncer de Colo do Útero às Novas Perspectivas dos Biomarcadores da Doença de Alzheimer. Editora Appris.

Costa, M. C., Bornhausen-Demarch, E., Azulay, D. R., Périssé, A. R. S., Dias, M. F. R. G., & Nery, J. A. C. Doenças sexualmente transmissíveis na gestação: uma síntese de particularidades. Anbras dermatol [Internet]. 2010 [cited 2013 Aug 20]; 85 (6): 767-85.

Chattopadhyay, K., Williamson, A. L., Hazra, A., & Dandara, C. (2015). The combined risks of reduced or increased function variants in cell death pathway genes differentially influence cervical cancer risk and herpes simplex virus type 2 infection among black Africans and the Mixed Ancestry population of South Africa. BMC cancer, 15(1), 1-7.

Dahlström, L. A., Andersson, K., Luostarinen, T., Thoresen, S., Ögmundsdottír, H., Tryggvadottír, L., & Dillner, J. (2011). Prospective seroepidemiologic study of human papillomavirus and other risk factors in cervical cancer. Cancer Epidemiology and Prevention Biomarkers, 20(12), 2541-2550.

De Oliveira Silva, B. L. A., de Andrade Barros, R. A, & Lopes, I. M. R. S. (2021). O impacto da pandemia da COVID-19 no rastreamento do câncer de colo uterino em Teresina–PI. Pesquisa, Sociedade e Desenvolvimento , 10 (10), e2091010118768-e2091010118768.

Dinc, B., Bozdayi, G., Biri, A., Kalkanci, A., Dogan, B., Bozkurt, N., & Rota, S. (2010). Molecular detection of cytomegalovirus, herpes simplex virus 2, human papillomavirus 16-18 in Turkish pregnants. Brazilian Journal of Infectious Diseases, 14, 569-574.

Ghosh, S., Shetty, R. S., Pattanshetty, S. M., Mallya, S. D., Pandey, D., Kabekkodu, S. P., ... & Satyamoorthy, K. (2019). Human papilloma and other DNA virus infections of the cervix: A population based comparative study among tribal and general population in India. PLoS One, 14(6), e0219173.

Muñoz, N., & Bravo, L. E. (2012). Epidemiology of cervical cancer in Colombia. Colombia Médica, 43(4), 298-304.

Okoye, J. O., Ngokere, A. A., & Erinle, C. A. (2018). Screening for cervical abnormalities associated with EBV, HPV and HSV-2 infections in South-West Nigeria: a tale between sex and non-sex workers. Journal of Oncological Sciences, 4(2), 85-95.

Patzi-Churqui, M., Terrazas-Aranda, K., Liljeqvist, J. Å., Lindh, M., & Eriksson, K. (2020). Prevalence of viral sexually transmitted infections and HPV high-risk genotypes in women in rural communities in the Department of La Paz, Bolivia. BMC infectious diseases, 20(1), 1-11.

Pereira, V. S., Moizeis, R. N., Fernandes, T. A., Araújo, J. M., Meissner, R. V., & Fernandes, J. V. (2012). Herpes simplex virus type 1 is the main cause of genital herpes in women of Natal, Brazil. European Journal of Obstetrics & Gynecology and Reproductive Biology, 161(2), 190-193.

Pérez Pérez, N., Tedesco, S., González, F., Jordi, J. M. L., & Rey, G. (2020). Prevalencia de los genotipos de HPV en lesiones pre invasoras de alto grado de malignidad y cáncer de cuello uterino en la población del Hospital de Clínicas. Montevideo-Uruguay. In Anales de la Facultad de Medicina (Vol. 7, No. 2). Universidad de la República. Facultad de Medicina.

Ramos, M. C., Sardinha, J. C., Alencar, H. D. R. D., Aragón, M. G., & Lannoy, L. H. D. (2021). Brazilian Protocol for Sexually Transmitted Infections, 2020: infections that cause genital ulcers. Revista da Sociedade Brasileira de Medicina Tropical, 54.

Roett, M. A., Mayor, M. T., & Uduhiri, K. A. (2012). Diagnosis and management of genital ulcers. American family physician, 85(3), 254-262.

Sauerbrei, A. (2016). Herpes genitalis: diagnosis, treatment and prevention. Geburtshilfe und Frauenheilkunde, 76(12), 1310-1317.

Shanehsazzadeh, M., Sharifi-Rad, J., Behbahani, M., & Pourazar, A. (2014). Analysis of human papillomavirus and herpes simplex virus genus-2 from patients with cervical cancer in isfahan, iran. Materia socio-medica, 26(4), 234.

Skeate, J. G., Porras, T. B., Woodham, A. W., Jang, J. K., Taylor, J. R., Brand, H. E., & Kast, W. M. (2016). Herpes simplex virus downregulation of secretory leukocyte protease inhibitor enhances human papillomavirus type 16 infection. The Journal of general virology, 97(Pt 2), 422.

Staykova, J., Belovska, T., Murad, A., Kakid, S., Nacheva, A., & Shikova, E. (2016). Cervical viral infections among asymptomatic Bulgarian women. Central European Journal of Public Health, 24(3), 176-179.

Wohlmeister, D., Vianna, D. R. B., Helfer, V. E., Gimenes, F., Consolaro, M. E. L., Barcellos, R. B., & Pilger, D. A. (2016). Association of human papillomavirus and Chlamydia trachomatis with intraepithelial alterations in cervix samples. Memórias do Instituto Oswaldo Cruz, 111, 106-113.



How to Cite

SOUSA, L. V. S. de; REIS, R. . de C.; LIMA, P. H. da F.; ARAÚJO, L. B. L. D.; SANTOS FILHO, A. L. dos; DUARTE , L. L.; LUZ, M. P. R.; QUINDERÉ, L. R. L.; SOUSA, I. C. B. de. Herpes virus associated with other infections and the risk for the development of cervical cancer. Research, Society and Development, [S. l.], v. 11, n. 6, p. e7711628620, 2022. DOI: 10.33448/rsd-v11i6.28620. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/28620. Acesso em: 28 may. 2022.



Health Sciences