The use of larval therapy in wound treatment: an integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i6.28627

Keywords:

Wounds and injuries; Larva; Therapeutics; Teaching.

Abstract

Due to the increasing number and prevalence of antibiotic-resistant microorganisms, our arsenal of antibiotics is no longer effective in controlling skin and soft tissue infections. Faced with this, many doctors and researchers begin to look back at the history of medicine, in the incessant search for alternative treatments, re-examining previous technologies with advanced tools and the wisdom of the 21st century, when faced with larval therapy. To analyze the scientific production on the use of larval therapy in the treatment of wounds. This is a scientific research of the integrative literature review type, in which it was used to generate the guiding question of this integrative literature review: “What does the scientific evidence show regarding the use of larval therapy in the treatment of wounds?” To locate the relevant studies that answered the research question, indexed and non-indexed descriptors (keywords) in Portuguese, English and Spanish were used. The results suggest that larvotherapy could have the potential to synergistically improve wound healing and result in shorter hospital stays, given the low cost of breeding worms, the technology is likely to be cost effective compared to other therapies. Finally, it is still estimated the development of more studies on the subject, deepening and improving knowledge, to strengthen the results to be obtained in the treatments.

References

Brambilla, P. B. T. (2018). Terapia larval e divulgação científica no Brasil: até quando serão negligenciadas?. Trabalho de conclusão de curso (Graduação em Ciências Biológicas) , Curso de Ciências Biológicas. Centro de Biociências. Universidade Federal do Rio Grande do Norte, Natal.

Bork, A. M. T. (2011). Enfermagem baseada em evidências. Rio de Janeiro: Guanabara Koogan.

Contreras-Ruiz, J., Fuentes-Suárez, A., Arroyo-Escalante, S., Moncada-Barron, D., Sosa-De-Martínez, M. C., Maravilla-Franco, E., & Domínguez-Cherit, J. G. (2016). Estudio comparativo de la eficacia de la larvoterapia (LT) para desbridar y controlar la carga bacteriana en úlceras venosas comparado con desbridamiento quirúrgico y aplicación de un antimicrobiano tópico. Gaceta medica de Mexico, 152(Suppl 2), 78–87.

Ercole, F. F., Melo, L. S., Alcoforado, C. L. G. C. (2014). Integrative review versus systematic review. Revista Mineira de Enfermagem, 18(1), 9-11.

Franco, L. C., Franco, W. C., Barros, S. B. L., Araújo, C. M., & Rezende, H. H. A. (2016). Aceitabilidade da terapia larval no tratamento de feridas. Revista Recien. Revista Científica de Enfermagem, 6(17), 2071-2079.

Linger, R. J., Belikoff, E. J., Yan, Y., Li, F., Wantuch, H. A.,& Fitzsimons, H. L., Scott, M. l. J. (2016). Towards next generation maggot debridement therapy: transgenic lucilia sericata larvae that produce and secrete a human growth factor. Bmc Biotechnology, 16( 1), 1-12.

Malekian, A., Djavid, G. E., Akbarzadeh, K., Soltandallal, M., Rassi, Y., Rafinejad, J., ... & Totonchi, M. (2019). Efficacy of Maggot Therapy on Staphylococcus aureus and Pseudomonas aeruginosa in Diabetic Foot Ulcers. Journal Of Wound, Ostomy & Continence Nursing, 46( 1), 25-29.

Masiero, F. S., Martins, D. S., & Thyssen, P. J. (2015). Terapia Larval e a aplicação de larvas para cicatrização: revisão e estado da arte no Brasil e no mundo. Revista Thema, 12(1), 4-14.

Masiero, F. S., Silva, D. G., Luchese, M., Estércio, T., PÉRSIO, N.V., & Thyssen, P. J. (2019). In vitro evaluation of the association of medicinal larvae (Insecta, Diptera, Calliphoridae) and topical agents conventionally used for the treatment of wounds. Acta Tropica, 190, 68-72.

Mirabzadeh, A., Ladani, M.J., Imani, B., Rosen, S.A.B., & Sherman, R.A. (2017). Maggot therapy for wound care in Iran: a case series of the first 28 patients. Journal Of Wound Care, 26(3), 137-143.

Nishijima, A., Gosho, M., Yoshida, R., Yanagibayashi, S., Takikawa, M., Nishijima, J., … & Yamamoto, N. (2017). Effective wound bed preparation using maggot debridement therapy for patients with critical limb ischaemia. Journal of Wound Care, 26(8), 483–489.

Oliveira, A. C. D., Rocha, D. D.M., Bezerra, M. M. G., Andrade, E. L. M. R., Santos, A. R. M. D., & Nogueira, L. T. (2019). Qualidade de vida de pessoas com feridas crônicas. Acta Paulista de Enfermagem [online], 32(2), 194-201.

Oliveira, F. B. M., Costa, A. C. A. L., Alves, D. L., França, J. F., Macedo, M. S., & Santos, R. D. (2016). Relação entre a sobrecarga de trabalho e erros de administração de medicação na assistência hospitalar. Revista Ciências & Saberes, 2(2), 325-334.

Potter, P. A., Perry, A. G. (2013). Enfermagem na Prevenção e Controle da Infecção Hospitalar. Rio de Janeiro: Elsevier.

Sherman, R. A. (2009). Maggot Therapy Takes Us Back to the Future of Wound Care: new and improved maggot therapy for the 21st century. Journal Of Diabetes Science And Technology, 3(2), 336-344.

Singorenko, P. D., Rosario, R., Windsor, J. A. P., Anthony R., & BLENKIRON, C. (2017). The transcriptional responses of cultured wound cells to the excretions and secretions of medicinal Lucilia sericata larvae. Wound Repair And Regeneration, 25(1), 51-61.

Siribumrungwong, B., Wilasrusmee, C., & Rerkasem, K. (2018). Maggot Therapy in Angiopathic Leg Ulcers: a systematic review and meta-analysis. The International Journal Of Lower Extremity Wounds, 17(4), 227-235.

Von Beckerath, O., Kanya, S., Gäbel, G., Kröger, K., & Juntermanns, B. (2020). Use of maggot debridement therapy in hospitalised patients in Germany. International wound journal, 17(1), 10–15.

Wang, P. H., Huang, B. S., Horng, H. C., Yeh, C. C., & Chen, Y. J. (2018). Wound healing. Journal Of The Chinese Medical Association, 81(2), 94-101.

Zubir, M. Z. M., Holloway, S.; Noor, N. (2020). Maggot Therapy in Wound Healing: a systematic review. International Journal Of Environmental Research And Public Health, 17(17), 6103.

Published

23/04/2022

How to Cite

SILVA, K. K. de A.; RABÊLO, M. T. S. .; ALMEIDA, R. de F. F. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .; SILVA , E. B. da .; SILVA , S. de J. de M. .; SILVA, J. S. da .; SANTOS, M. B. L. dos .; SANTANA, A. C. .; RAMOS, J. da S. .; OLIVEIRA, S. A. . The use of larval therapy in wound treatment: an integrative review . Research, Society and Development, [S. l.], v. 11, n. 6, p. e12611628627, 2022. DOI: 10.33448/rsd-v11i6.28627. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/28627. Acesso em: 28 may. 2022.

Issue

Section

Review Article