Folic acid supplementation in pregnancy related to the development of childhood neurological disorders
Keywords:Folicacid; Autism Spectrum Disorder; Pregnancy; Health teaching.
Thus, the present study aims to clarify the risk and benefit of using folic acid supplementation in the gestational period, and to clarify the consequences related to excessive use considered TEA as a psychopathology associated with high supplementation. This is an integrative review of the literature, which consists of broader methodological approaches among literature reviews. The preparation of a methodological survey for the research was carried out in the period of March 2022, the databases used were the Latin American and Caribbean Literature in Health Sciences (LILACS) and Medical Literature Analysis and Retrieval System Online (MEDLINE) 27 studies were submitted which went through the analysis of the abstracts and eligibility criteria. Studies have shown that folic acid supplementation adequately benefits both mother and baby, but current studies report that increased supplementation may generate an increased risk of developing TEA, although the research is still at an early stage in the scientific field, the field of study is developing rapidly and has provided this study with suggestive evidence on the importance of these nutrients. Thus, it was possible to identify the existence of a causal factor proven to lead to autism, believing that there are a set of factors, be it environmental, genetic, chemical or by pathologies acquired during the gestational phase.
Andrade, S. R. Ruoff, A. B., Piccoli, T., Schmitt, M. D., Ferreira, A., & Xavier, A. C. A. (2017). O estudo de caso como método de pesquisa em enfermagem: uma revisão integrativa. Texto & Contexto, 24(4). https://doi.org/10.1590/0104-07072017005360016
Di, Y. et al. (2021). Maternal folic acid supplementation prevents autistic behaviors in a rat model induced by prenatal exposure to valproic acid. Food e function, 12(10), 4544-4555. https://doi.org/10.1039/d0fo02926b
Friel, C. et al. (2021). Prenatal vitamins and the risk of offspring autismo spectrum disorder: systematic review and meta-analysis. Nutrients, 13(8), 25-58. https://doi.org/10.3390/nu13082558
Gogou, M., & Kolios, G. (2019). Nutritional Supplements During Gestation and Autism Spectrum Disorder: What Do We Really Know and How Far Have We Gone? Journal of the American College of Nutrition, 44(60), 1-11. https://doi.org/10.1080/07315724.2019.1635920
Goodrich, A. J. et al. (2017). Joint effects of prenatal air pollutant exposure and maternal folic acid supplementation on risk of autismo spectrum disorder. Austism research, 11(1), 69-80. https://doi.org/10.1002/aur.1885
Koren, G., Moser, S. S. (2019). Does high-dose gestational folic acid increase the risk for autismo? The birth order hypothesis. Medical Hypothesis, 132. https://doi.org/10.1016/j.mehy.2019.109350
Levine, S. Z., Kodesh, A., & Victorin, A. (2018). Association of Maternal Use of Folic Acid and Multivitamin Supplements in the Periods Before and During Pregnancy With the Risk of Autism Spectrum Disorder in Offspring. JAMA Psiquiatria, 75(2), 176-184. 10.1001/jamapsychiatry.2017.4050
Mendes, K. D. S., Silveira, R. C. C. P., & Galvão, C. M. (2008). Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & Contexto-Enfermagem, 17(4), 758-764.https://doi.org/10.1590/S0104-07072008000400018
Moser, S. S., Davidovitch, M., Rotem, R. S., Chodick, G., Shalev, V., Koren, G. (2019). High dose folic acid during pregnancy and the risk of autism; The birth order bias: A nested case-control study. Toxicologia Reprodutiva, 89, 173-177. https://doi.org/10.1016/j.reprotox.2019.07.083
Moura, A. V. (2022). Uso de ácido fólico na gestação. Revista Terra e Cultura: cadernos de ensino e pesquisa, 38(74). http://periodicos.unifil.br/index.php/Revistateste/article/view/2450/2067
Raghavan, R. et al. (2017). Maternal multivitamin intake, plasma folate and vitamin B12 levels and autismo spectrum disorder risk in offspring. Paediatric and perinatal epidemiology, 32(1), 100-111. https://doi.org/10.1111/ppe.12414
Ribeiro, A. C. A., Nave, C. R., Antonucci, A. T. & Batistella, V. A. (2021). Fatores etiológicos e riscos associados ao transtorno de espectro autista: revisão bibliográfica. Jornal Paranaense de Pediatria, 22(1), 1-12. https://doi.org/10.5935/1676-0166.20210016
Santos, F. P., Homem, C. S., Silva, J. O. M. & Amarante, J. (2019). Fatores gestacionais que podem influenciar no transtorno do espectro autista. Ciências biológicas e de saúde Unit, 5(3), 203-214. https://periodicos.set.edu.br/cadernobiologicas/article/view/6722/3628
Sousa, L. M. M. et al. (2017). Metodologia de Revisão Integrativa da Literatura em Enfermagem. Rev. Investigação em Enf. 17-26.
Souza, M. T., Silva, M. D. & Carvalho, R. Revisão integrativa: o que é e como fazer? Einstein. 8, 102-106. https://doi.org/10.1590/S1679-45082010RW1134
Tan, M. et al. (2020). Maternal folic acid and micronutrient supplementation is associated with vitamin levels and symptoms in children with autism spectrum disorders. Toxicologia Reprodutiva, 91, 109-115. https://doi.org/10.1016/j.reprotox.2019.11.009
Torres, K. S. et al. (2020). Suplementação individualizada de ferro e ácido fólico para gestantes adultas. Research Society and Development, 9(11), e2819119740. http://dx.doi.org/10.33448/rsd-v9i11.9740
Wang, M., Li, K., Zhao, D. & Li, L. (2017). The association between maternal use of folic acid supplements during pregnancy and risk of autismo spectrum disorders in children: a meta-analysis. Molecular autismo, 8(51). https://doi.org/10.1186/s13229-017-0170-8
Zhong, C., Tessing, J., Lee, B. K., & Lyall, K. (2020). Maternal dietary factors and the risk of autismo spectrum disorders: a systematc review of existing evidence. Austism Research, 13(10), 1634-1658.
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Copyright (c) 2022 Maria Letícia Cardoso da Silva Barbosa; Maria Eduarda Wanderley de Barros Silva; Izabely Galvão Menezes Dantas; Othon Luís Souza de Lucena; Lucas Emanuel de Aguiar Azevedo; Gabriella Avelino Montenegro ; Lindinês Pereira de Macêdo ; Césia Santos Jales ; Jeanyne Maria Santos Almeida Silva; Natália Valença Cavalcante ; Marcela Mayne de Almeida Sial; Felipe de Almeida Costa; Larissa Lima Soares
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