The modulatory effect of acupuncture on amygdala functional connectivity: narrative review of the clinical research

Authors

DOI:

https://doi.org/10.33448/rsd-v11i6.28870

Keywords:

Acupuncture; Functional magnetic resonance imaging; Clinical research.

Abstract

The amygdala is a brain area crucial for emotional, behavioural and visceral sensitivity/motor signals processing. To exert these functions, the amygdala is reciprocally connected with cortical and subcortical regions. Some studies have showed that acupuncture modulates the activity of the amygdala and its circuits. However, there is no literature review synthesizing and evidencing the actual research status about this subject. Thus, the aim of this paper is to present and discuss the newest evidence about the effect of acupuncture on the amygdala resting-state functional connectivity (rsFC) in the context of clinical research. The narrative review of clinical research was focused on published clinical trials (controlled and randomized) designed to analyze the effect of acupuncture on the modulation of the amygdala rsFC in clinical conditions. The search was conducted on Pubmed, ScienceDirect and Scielo databases up to March, 2022. The studies found were about patients with major depressive disorder, functional dyspepsia and premenstrual syndrome, which demonstrated that acupuncture significantly decreases its symptoms. In addition, this therapeutic effect were correlated with the modulation of the amygdala rsFC with a range of brain regions. According to the data reviewed, it can be concluded that the brain action’s mechanisms of acupuncture is related, at least in part for the clinical conditions analyzed, to its modulatory effect on the amygdala network. However, the studies about this theme are rare, and more studies should be done to clarify the amygdala involvement in the effect of the acupuncture.

References

Aminoff, E. M., (2013). The role of the parahippocampal cortex in cognition. Trends Cogn Sci, 17(8), 379–390.

Andresen, V. et al. (2005). Brain activation responses to subliminal or supraliminal rectal stimuli and to auditory stimuli in irritable bowel syndrome.

Neurogastroenterol Motil, 17(6), 827–837.

Aziz, Q. et al. (2000). Functional neuroimaging of visceral sensation. J Clin Neurophysiol, 17(6), 604–612.

Bayer, J. et al. (2014). Menstrual-cycle dependent fluctuations in ovarian hormones affect emotional memory. Neurobiol Learn Mem, 110:55–63.

Bernardo, W.M. et al (2004). A prática clínica baseada em evidências. Parte II: buscando as evidências em fontes de informação. Rev Assoc Med

Bras, 50(1), 104-108.

Biswal, B. et al. (1995). Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med, 34(4), 537–541.

Brewer, J. et al. (2011). Meditation experience is associated with differences in default mode network activity and connectivity. Proc Nat Acad Scie U S A, 108(50), 20254–20259.

Cai, R. L. et al. (2018). Brain functional connectivity network studies of acupuncture: a systematic review on resting-state fMRI. J Integr Med, 16(1), 26-33.

Connolly, C. et al. (2017). Resting-state functional connectivity of the amygdala and longitudinal changes in depression severity in adolescent depression. J Affect Disord, 207, 86–94.

Corbit, L. H. & Balleine, B. W. (2005). Double dissociation of basolateral and central amygdala lesions on the general and outcome-specific forms of pavlovian-instrumental transfer. J Neurosci, 25(4), 962–970.

Deng, D. et al. (2018) Larger volume and different functional connectivity of the amygdala in women with premenstrual syndrome. Eur Radiol, 28(5):1900–1908.

Duan, G. et al. (2020). Altered amygdala resting-state functional connectivity following acupuncture stimulation at BaiHui (GV20) in first-episode drug-Naïve major depressive disorder. Brain Imaging Behav; 14(6), 2269-2280

Fox, M.D. et al. (2005). The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Natl Acad Sci U S A, 102(27), 9673–9678.

Greene, R. & Dalton, K. (1953). The premenstrual syndrome. Br Med J, 1(4818):1007–1014.

Gusnard, D. A. et al. (2001). Searching for a baseline: functional imaging and the resting human brain. Nat Rev Neurosci, 2(10):685–694.

He, Y. et al. (2016). Lifespan anxiety is reflected in human amygdala cortical connectivity. Hum Brain Mapp, 37(3), 1178–1193.

Heuvel, M. P. V. D. (2010). Exploring the brain network: a review on resting-state fMRI functional connectivity. Eur Neurophychopharmacol, 20(8), 519-534.

Hwang, J. W. et al. (2015). Subthreshold depression is associated with impaired resting-state functional connectivity of the cognitive control network. Transl Psychiatry, 5, e683.

Janak, P. H. & Tye, K. M. (2015). From circuits to behaviour in the amygdala. Nature, 517(7534), 284-292.

Kavoussi, B. & Ross, B. E. (2007). The neuroimmune basis of anti-inflammatory acupuncture. Integr Cancer Ther, 6(3), 251–257.

Lalitha, V. et al. (2016). Gender difference in the role of Posterodorsal amygdala on the regulation of food intake, adiposity and immunological responses in albino Wistar rats. Ann Neurosci, 23(1), 6–12.

Lehtinen, V. & Joukamaa, M. (1994). Epidemiology of depression: prevalence, risk factors and treatment situation. Acta Psychiatr Scand Suppl, 377, 7–10.

McDonald, A. J. (1998). Cortical pathways to the mammalian amygdala. Prog Neurobiol, 55(3), 257–332.

Murray, E. A. (2007). The amygdala, reward and emotion, Trends Cogn. Sci, 11(11), 489–497.

Nan, J. et al. (2015). Brain-based correlations between psychological factors and functional dyspepsia. J Neurogastroenterol Motil, 21(1), 103–110.

Northoff, G. et al. (2006). Self-referential processing in our brain – a meta-analysis of imaging studies on the self. Neuroimage, 31(1), 440–457.

Pang, Y. et al. (2021). Regulated aberrant amygdala functional connectivity in premenstrual syndrome via electro-acupuncture stimulation at sanyinjiao acupoint (SP6). Gynecol Endocrinol, 37(4):315-319.

Phillips, M. L. et al., (2015). Identifying predictors, moderators, and mediators of antidepressant response in major depressive disorder: neuroimaging approaches. Am J Psychiatry, 172(2), 124–138.

Quin, W. et al (2008). FMRI connectivity analysis of acupuncture effects on an amygdala-associated brain network. Mol Pain, 4:55.

Salvadore, G. et al., 2010. Anterior cingulate desynchronization and functional connectivity with the amygdala during a working memory task predict rapid antidepressant response to ketamine. Neuropsychopharmacology, 35 (7), 1415–1422.

Schweinhardt P. & Bushnell, M.C. (2010). Pain imaging in health and diseasehow far have we come? J Clin Invest, 120(11), 3788–3797.

Sheline, Y. I. et al. (2010). Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus. Proc Natl Acad Sci U S A, 107(24), 11020–11025.

Shimamura, A.P. (2000). The role of the prefrontal cortex in dynamic filtering. Psychobiology, 28(2), 207–218.

Sun, L. et al. (2012). Abnormal functional connectivity between the anterior cingulate and the default mode network in drug-naïve boys with attention deficit hyperactivity disorder. Psychiatry Res, 201(2), 120–127.

Sun, R. et al. (2021). The participation of basolateral amygdala in the efficacy of acupuncture with deqi treating for functional dyspepsia. Brain Imaging Behav, 15(1):216-230.

Tack, J. & Talley, N. J. (2013). Functional dyspepsia–symptoms, definitions and validity of the Rome III criteria. Nat Rev Gastroenterol Hepatol, 10(3), 134–141.

Truini, A. et al. (2016). Abnormal resting state functional connectivity of the periaqueductal grey in patients with fibromyalgia. Clin Exp Rheumatol, 34(2 Suppl 96), S129–S133.

Wang, G. et al. (2008). Gastric distention activates satiety circuitry in the human brain. Neuroimage, 39(4), 1824–1831.

Wang, X. et al. (2016). Repeated acupuncture treatments modulate amygdala resting state functional connectivity of depressive patients. Neuroimage Clin, 12, 746-752.

Yu, H. et al. (2019). Modulation Effect of Acupuncture on Functional Brain Networks and Classification of Its Manipulation With EEG Signals. IEEE Trans Neural Syst Rehabil Eng, 27(10), 1973-1984.

Yu, R. et al. (2014). Disrupted functional connectivity of the periaqueductal gray in chronic low back pain. Neuroimage Clin, 6(100), 108.

Zeng, F. et al. (2019). Altered functional connectivity of the amygdala and sex differences in functional dyspepsia. Clin Transl Gastroenterol, 10(6), e00046.

Zhuo, M. (2016). Contribution of synaptic plasticity in the insular cortex to chronic pain. Neuroscience, 338, 220–229.

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Published

19/04/2022

How to Cite

ALMEIDA, M. dos S. de . The modulatory effect of acupuncture on amygdala functional connectivity: narrative review of the clinical research. Research, Society and Development, [S. l.], v. 11, n. 6, p. e4011628870, 2022. DOI: 10.33448/rsd-v11i6.28870. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/28870. Acesso em: 18 may. 2022.

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Review Article