Diabetes mellitus and its association with oral squamous cell carcinoma: a review of the literature
DOI:
https://doi.org/10.33448/rsd-v11i6.29382Keywords:
Diabetes Mellitus; Oral squamous cell carcinoma; Oral cancer; Insulin-like growth factor-1; Metformin.Abstract
Oral squamous cell carcinoma is a malignant tumor characterized by the uncontrollable, excessive, and irreversible proliferation of squamous cells of the oral epithelium, representing most of all oral cancers. Interestingly, despite advances on therapeutic procedures such as radiotherapy, chemotherapy, and surgical techniques, the survival rate has not improved in recent decades. On the other hand, diabetes mellitus is a chronic disease with clinical presentations and metabolic disorders characterized by increased blood glucose levels. Various studies suggest a possible relationship between these two entities; evidencing that a person with diabetes and, in addition, poorly controlled, may have many oral manifestations, such as the possible development of oral malignant lesions. This manuscript aims to present and discuss the updated scientific evidence on the relationship between diabetes mellitus and oral squamous cell carcinoma.
References
Abhinav, R. P., Williams, J., Livingston, P., Anjana, R. M., & Mohan, V. (2020). Burden of diabetes and oral cancer in India. J Diabetes Complications, 34(11), 107670. 10.1016/j.jdiacomp.2020.107670
Auluck, A. (2007). Diabetes mellitus: an emerging risk factor for oral cancer? J Can Dent Assoc, 73(6), 501-503.
Bosch-Barrera, J., Hernández, A., & Abella, L. E. (2009). La vía de la insulina y el factor de crecimiento similar a la insulina, una nueva diana terapéutica en oncología %J Anales del Sistema Sanitario de Navarra. 32, 413-421.
Brady, G., Crean, S. J., Naik, P., & Kapas, S. J. I. j. o. o. (2007). Upregulation of IGF-2 and IGF-1 receptor expression in oral cancer cell lines. 31(4), 875-881.
Brady, G., O’Regan, E., Miller, I., Ogungbowale, A., Kapas, S., Crean, S. J. I. j. o. o., & surgery, m. (2007). Serum levels of insulin-like growth factors (IGFs) and their binding proteins (IGFBPs),-1,-2,-3, in oral cancer. 36(3), 259-262.
care, A. D. A. J. D. (2019). 2. Classification and diagnosis of diabetes: standards of medical care in diabetes—2019. 42(Supplement 1), S13-S28.
Chi, A. C., Day, T. A., & Neville, B. W. (2015). Oral cavity and oropharyngeal squamous cell carcinoma--an update. CA Cancer J Clin, 65(5), 401-421. 10.3322/caac.21293
Cignarelli, A., Genchi, V. A., Caruso, I., Natalicchio, A., Perrini, S., Laviola, L., Practice, c. (2018). Diabetes and cancer: pathophysiological fundamentals of a ‘dangerous affair’. 143, 378-388.
Conget, I. J. R. e. d. c. (2002). Diagnóstico, clasificación y patogenia de la diabetes mellitus. 55(5), 528-535.
Dikshit, R. P., Ramadas, K., Hashibe, M., Thomas, G., Somanathan, T., & Sankaranarayanan, R. J. I. j. o. c. (2006). Association between diabetes mellitus and pre‐malignant oral diseases: A cross sectional study in Kerala, India. 118(2), 453-457.
Du, Y., Li, Y., Lv, H., Zhou, S., Sun, Z., & Wang, M. (2015). miR-98 suppresses tumor cell growth and metastasis by targeting IGF1R in oral squamous cell carcinoma. Int J Clin Exp Pathol, 8(10), 12252-12259.
Duarte, M., Romero, F., Espinosa, L., & Sánchez, R. J. M. I. d. M. (2016). diabetes y cáncer¿ es real la asociación? , 32(3).
Durruty, P., Sanzana, M., & Sanhueza, L. (2019). Pathogenesis of type 2 diabetes mellitus. In Type 2 Diabetes-From Pathophysiology to Modern Management: IntechOpen.
El-Naggar, A. K., Chan, J. K. C., Rubin Grandis, J., Takata, T., Slootweg, P. J., & International Agency for Research on, C. (2017). WHO classification of head and neck tumours.
Farrill, L. C. L. O., Fernández, L. A. O. F., & de Santelices Cuervo, A. M. J. A. M. d. C. (2017). Interacción genoma-ambiente en la génesis de la diabetes mellitus tipo 2. 11(4), 70-80.
Ferreira Mendes, J. M., de Faro Valverde, L., Torres Andion Vidal, M., Paredes, B. D., Coelho, P., Allahdadi, K. J., & Rocha, C. A. G. (2020). Effects of IGF-1 on Proliferation, Angiogenesis, Tumor Stem Cell Populations and Activation of AKT and Hedgehog Pathways in Oral Squamous Cell Carcinoma. Int J Mol Sci, 21(18). 10.3390/ijms21186487
Foreman, A., Lee, D. J., McMullen, C., de Almeida, J., Muhanna, N., Gama, R. R., & Goldstein, D. P. (2017). Impact of Type 2 Diabetes Mellitus on Survival in Head and Neck Squamous Cell Carcinoma. Otolaryngol Head Neck Surg, 157(4), 657-663. 10.1177/0194599817726756
Givony, S. J. M. m. M. s. K. V. L. s. m. t. c. (2020). Oral squamous cell carcinoma (OSCC) an overview. 8(13).
Gong, Y., Wei, B., Yu, L., & Pan, W. (2015). Type 2 diabetes mellitus and risk of oral cancer and precancerous lesions: a meta-analysis of observational studies. Oral Oncol, 51(4), 332-340. 10.1016/j.oraloncology.2015.01.003
Hayes Dorado, J. P. J. R. d. l. S. B. d. P. (2014). Diabetes mellitus en pediatría. 53(1), 54-59.
Hu, X., Xiong, H., Chen, W., Huang, L., Mao, T., Yang, L., & Su, T. (2020). Metformin reduces the increased risk of oral squamous cell carcinoma recurrence in patients with type 2 diabetes mellitus: A cohort study with propensity score analyses. Surg Oncol, 35, 453-459. 10.1016/j.suronc.2020.09.023
Hua, F., Yu, J. J., & Hu, Z. W. (2016). Diabetes and cancer, common threads and missing links. Cancer Lett, 374(1), 54-61. 10.1016/j.canlet.2016.02.006
Hua, H., Kong, Q., Yin, J., Zhang, J., & Jiang, Y. (2020). Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy. J Hematol Oncol, 13(1), 64. 10.1186/s13045-020-00904-3
Jia, T., Ren, Y., Wang, F., Zhao, R., Qiao, B., Xing, L., . . . Guo, B. J. B. r. (2020). MiR-148a inhibits oral squamous cell carcinoma progression through ERK/MAPK pathway via targeting IGF-IR. 40(4).
Kato, K., Gong, J., Iwama, H., Kitanaka, A., Tani, J., Miyoshi, H., . . . Masaki, T. (2012). The antidiabetic drug metformin inhibits gastric cancer cell proliferation in vitro and in vivo. Mol Cancer Ther, 11(3), 549-560. 10.1158/1535-7163.MCT-11-0594
Larry, J., Fauci, A., Kasper, D., Hauser, S., Longo, D., & Loscalzo, J. (2018). Harrison. Principios de Medicina Interna, 20e McGraw-Hill Medical. In: McGraw-Hill Medical.
Lee, J., Yesilkanal, A. E., Wynne, J. P., Frankenberger, C., Liu, J., Yan, J., . . . Rosner, M. R. (2019). Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism. Nature, 568(7751), 254-258. 10.1038/s41586-019-1005-x
Li, J., Liu, Y., Zhang, H., & Hua, H. J. O. d. (2020). Association between hyperglycemia and the malignant transformation of oral leukoplakia in China. 26(7), 1402-1413.
Lysne, D., Johns, J., Walker, A., Ecker, R., Fowler, C., & Lawson, K. R. (2014). P-cadherin potentiates ligand-dependent EGFR and IGF-1R signaling in dysplastic and malignant oral keratinocytes. Oncol Rep, 32(6), 2541-2548. 10.3892/or.2014.3545
Mekala, M. R., Bangi, B. B., N, J., Lebaka, R. R., Nadendla, L. K., & Ginjupally, U. (2020). Association of Diabetes with Oral Cancer- an Enigmatic Correlation. Asian Pac J Cancer Prev, 21(3), 809-814. 10.31557/APJCP.2020.21.3.809
Mozaffari, H. R., Sharifi, R., & Sadeghi, M. (2016). Prevalence of Oral Lichen Planus in Diabetes Mellitus: a Meta-Analysis Study. Acta Inform Med, 24(6), 390-393. 10.5455/aim.2016.24.390-393
Nazir, M. A., AlGhamdi, L., AlKadi, M., AlBeajan, N., AlRashoudi, L., & AlHussan, M. J. O. a. M. j. o. m. s. (2018). The burden of diabetes, its oral complications and their prevention and management. 6(8), 1545.
Organization, W. H. (2020). Noncommunicable diseases: Progress monitor 2020.
Otero Rey, E. M., Yanez-Busto, A., Rosa Henriques, I. F., Lopez-Lopez, J., & Blanco-Carrion, A. (2019). Lichen planus and diabetes mellitus: Systematic review and meta-analysis. Oral Dis, 25(5), 1253-1264. 10.1111/odi.12977
Ozougwu, J., Obimba, K., Belonwu, C., Unakalamba, C. J. J. o. p., & pathophysiology. (2013). The pathogenesis and pathophysiology of type 1 and type 2 diabetes mellitus. 4(4), 46-57.
Perisanidis, C., Wrba, F., Brandstetter, A., Kornek, G., Mitchell, D., Seemann, R., & Surgery, M. (2013). Impact of epidermal growth factor receptor, mesenchymal–epithelial transition factor, and insulin-like growth factor receptor 1 expression on survival of patients with oral and oropharyngeal cancer. 51(3), 234-240.
Ramos-Garcia, P., Roca-Rodriguez, M. D. M., Aguilar-Diosdado, M., & Gonzalez-Moles, M. A. (2021). Diabetes mellitus and oral cancer/oral potentially malignant disorders: A systematic review and meta-analysis. Oral Dis, 27(3), 404-421. 10.1111/odi.13289
Ujpal, M., Matos, O., Bibok, G., Somogyi, A., Szabo, G., & Suba, Z. (2004). Diabetes and oral tumors in Hungary: epidemiological correlations. Diabetes Care, 27(3), 770-774. 10.2337/diacare.27.3.770
Vairaktaris, E., Goutzanis, L., Kalokerinos, G., Yannopoulos, A., Yapijakis, C., Vassiliou, S., & Lazaris, A. C. J. i. v. (2007). Diabetes increases both N-ras and ets-1 expression during rat oral oncogenesis resulting in enhanced cell proliferation and metastatic potential. 21(4), 615-621.
Vairaktaris, E., Goutzanis, L., Nkenke, E., Spyridonidou, S., Vassiliou, S., Derka, S., & Strantzias, P. J. i. v. (2007). Diabetes does not influence oral oncogenesis through fibroblast growth factor receptors. 21(4), 623-628.
Vairaktaris, E., Goutzanis, L., Vassiliou, S., Spyridonidou, S., Nkenke, E., & Papageorgiou, G (2008). Enhancement of erbB2 and erbB3 expression during oral oncogenesis in diabetic rats. 134(3), 337-344.
Vairaktaris, E., Kalokerinos, G., Goutzanis, L., Spyridonidou, S., Vassiliou, S., Derka, S., & Lazaris, A. J. A. r. (2007). Diabetes alters expression of p53 and c-myc in different stages of oral oncogenesis. 27(3B), 1465-1473.
Vairaktaris, E., Kalokerinos, G., Goutzanis, L., Yapijakis, C., Derka, S., & Vassiliou, S. (2008). Diabetes enhances cell proliferation but not Bax/Bcl-2-mediated apoptosis during oral oncogenesis. 37(1), 60-65.
Velasco-Ortega, E., Delgado-Ruiz, R. A., & Lopez-Lopez, J. (2016). Dentistry and Diabetes: The Influence of Diabetes in Oral Diseases and Dental Treatments. J Diabetes Res, 2016, 6073190. 10.1155/2016/6073190
Wang, S.-H., Chen, Y.-L., Hsiao, J.-R., Tsai, F.-Y., Jiang, S. S., Lee, A. Y.-L., & Research, C. C. (2021). Insulin-like growth factor binding protein 3 promotes radiosensitivity of oral squamous cell carcinoma cells via positive feedback on NF-κB/IL-6/ROS signaling. 40(1), 1-18.
Wang, W., He, Q., Yan, W., Sun, J., Chen, Z., Liu, Z., & Wang, A. (2017). High glucose enhances the metastatic potential of tongue squamous cell carcinoma via the PKM2 pathway. Oncotarget, 8(67), 111770-111779. 10.18632/oncotarget.22907
Warnakulasuriya, S., Johnson, N. W., & van der Waal, I. (2007). Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med, 36(10), 575-580. 10.1111/j.1600-0714.2007.00582.x
Yen, Y.-C., Shiah, S.-G., Chu, H.-C., Hsu, Y.-M., Hsiao, J.-R., Chang, J.-Y., & Lu, Y.-C. J. M. c. (2014). Reciprocal regulation of microRNA-99a and insulin-like growth factor I receptor signaling in oral squamous cell carcinoma cells. 13(1), 1-16.
Zhang, B., Li, Y., Hou, D., Shi, Q., Yang, S., Li, Q. J. C. P., & Biochemistry. (2017). MicroRNA-375 inhibits growth and enhances radiosensitivity in oral squamous cell carcinoma by targeting insulin like growth factor 1 receptor. 42(5), 2105-2117.
Zhao, P., Wang, W., Yang, L., & Gaole, A. J. A. i. M. O. R. (2016). The expression and regulation of glucose transporters in tumor cells. 2(6), 318-322.
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Copyright (c) 2022 Marco Miguel Vega García; Andrea Margarita Martínez León; Diego Mauricio Bravo Calderón
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