Vaginal microbiota and persistence of human papillomavirus infection

Authors

DOI:

https://doi.org/10.33448/rsd-v11i6.29402

Keywords:

Bacterial vaginosis; Vaginal dysbiosis; Vaginal microbiota; Vaginal ecosystem; HPV; Human papillomavirus; Teaching.

Abstract

The vaginal microbiota is composed of a diversity of microorganisms that inhabit the vagina, either permanently or transiently. There are many questions about what could cause a disruption in the vaginal balance with regard to bacterial composition, inflammation, pH change and secretion of substances (cytokines and enzymes). In addition, it is already established that bacterial vaginosis can predispose to HPV infection, its persistence and the development of precursor lesions of cervical cancer. The aim of this study was to elucidate the correlation between the vaginal microbiota and the persistence of HPV infection. This is a comprehensive literature review using the Medline/PubMed and Web of Science Databases published from 2010 to 2021. It was identified that bacteria related to Bacterial Vaginosis (CST IV) and CST III, dominated by L. iners, had a greater dominance in HPV-positive women and may be related to HPV acquisition and persistence. The presence of Sneathia, found in the vaginal microbiota of HPV-positive women, suggests a relationship with viral persistence and cervical intraepithelial neoplasia (CIN).

References

Aguiar, P, V (2017). O ecossistema vaginal. Orientador: Dr. Joaquim Silva Neves. (2017). Trabalho final mestrado integrado em Medicina (Mestrado em Medicina) - Universidade de Lisboa.

Almeida, A. C. G.; Sakama, A. T. & Campos, R. G. (2006). A correlação do câncer do colo uterino com o Papilomavirus Humano. Revista APS, 2006; 9(2): 128-135

Brotman, R. M., Shardell, M. D., Gajer, P., Tracy, J. K., Zenilman, J. M., Ravel, J., & Gravitt, P. E. (2014). Interplay Between the Temporal Dynamics of the Vaginal Microbiota and Human Papillomavirus Detection. Journal of Infectious Diseases, 210(11), 1723–1733. https://doi.org/10.1093/infdis/jiu330

Carvalho, N. S. de, Silva, R. J. de C. da, Val, I. C. do, Bazzo, M. L., & Silveira, M. F. da. (2021). Protocolo Brasileiro para Infecções Sexualmente Transmissíveis 2020: infecção pelo papilomavírus humano (HPV). Epidemiologia E Serviços de Saúde, 30(spe1). https://doi.org/10.1590/s1679-4974202100014.esp1

Castanheira, C., Sallas, M., Nunes, R., Lorenzi, N., & Termini, L. (2020). Microbiome and Cervical Cancer. Pathobiology, 88(2), 187–197. https://doi.org/10.1159/000511477

Cheng, L., Norenhag, J., Hu, Y. O. O., Brusselaers, N., Fransson, E., Ährlund-Richter, A., Guðnadóttir, U., Angelidou, P., Zha, Y., Hamsten, M., Schuppe-Koistinen, I., Olovsson, M., Engstrand, L., & Du, J. (2020). Vaginal microbiota and human papillomavirus infection among young Swedish women. NPJ Biofilms and Microbiomes, 6(1), 39. https://doi.org/10.1038/s41522-020-00146-8

de Sanjosé, S., Brotons, M., & Pavón, M. A. (2018). The natural history of human papillomavirus infection. Best Practice & Research Clinical Obstetrics & Gynaecology, 47, 2–13. https://doi.org/10.1016/j.bpobgyn.2017.08.015

Di Paola, M., Sani, C., Clemente, A. M., Iossa, A., Perissi, E., Castronovo, G., Tanturli, M., Rivero, D., Cozzolino, F., Cavalieri, D., Carozzi, F., De Filippo, C., & Torcia, M. G. (2017). Characterization of cervico-vaginal microbiota in women developing persistent high-risk Human Papillomavirus infection. Scientific Reports, 7(1). https://doi.org/10.1038/s41598-017-09842-6

Fedrizzi, E. (2011). Infecção pelo Papilomavírus Humano (HPV) em Mulheres HIV-Positivo de Florianópolis, Santa Catarina. Jornal Brasileiro de Doenças Sexualmente Transmissíveis, 23(4), 205–209. https://doi.org/10.5533/2177-8264-201123410

Gao, W., Weng, J., Gao, Y., & Chen, X. (2013). Comparison of the vaginal microbiota diversity of women with and without human papillomavirus infection: a cross-sectional study. BMC Infectious Diseases, 13(1). https://doi.org/10.1186/1471-2334-13-271

Gillet, E., Meys, J. F., Verstraelen, H., Bosire, C., De Sutter, P., Temmerman, M., & Broeck, D. V. (2011). Bacterial vaginosis is associated with uterine cervical human papillomavirus infection: a meta-analysis. BMC Infectious Diseases, 11(1). https://doi.org/10.1186/1471-2334-11-10

Kyrgiou, M., Mitra, A., & Moscicki, A.-B. (2017). Does the vaginal microbiota play a role in the development of cervical cancer? Translational Research, 179, 168–182. https://doi.org/10.1016/j.trsl.2016.07.004

Kwasniewski, W., Wolun‑Cholewa, M., Kotarski, J., Warchol, W., Kuzma, D., Kwasniewska, A., & Gozdzicka‑Jozefiak, A. (2018). Microbiota dysbiosis is associated with HPV‑induced cervical carcinogenesis. Oncology Letters. https://doi.org/10.3892/ol.2018.9509

Kovachev, S. M. (2019). Cervical cancer and vaginal microbiota changes. Archives of Microbiology. https://doi.org/10.1007/s00203-019-01747-4

Łaniewski, P., Barnes, D., Goulder, A., Cui, H., Roe, D. J., Chase, D. M., & Herbst-Kralovetz, M. M. (2018). Linking cervicovaginal immune signatures, HPV and microbiota composition in cervical carcinogenesis in non-Hispanic and Hispanic women. Scientific Reports, 8(1), 7593. https://doi.org/10.1038/s41598-018-25879-7

Lee, J. E., Lee, S., Lee, H., Song, Y.-M., Lee, K., Han, M. J., Sung, J., & Ko, G. (2013). Association of the Vaginal Microbiota with Human Papillomavirus Infection in a Korean Twin Cohort. PLoS ONE, 8(5), e63514. https://doi.org/10.1371/journal.pone.0063514

Liang, Y., Chen, M., Qin, L., Wan, B., & Wang, H. (2019). A meta-analysis of the relationship between vaginal microecology, human papillomavirus infection and cervical intraepithelial neoplasia. Infectious Agents and Cancer, 14(1). https://doi.org/10.1186/s13027-019-0243-8

Linhares, I. M., Giraldo, P. C., & Baracat, E. C. (2010). Novos conhecimentos sobre a flora bacteriana vaginal. Revista Da Associação Médica Brasileira, 56(3), 370–374. https://doi.org/10.1590/S0104-42302010000300026

Liu, J., Luo, M., Zhang, Y., Cao, G., & Wang, S. (2020). Association of high-risk human papillomavirus infection duration and cervical lesions with vaginal microbiota composition. Annals of Translational Medicine, 8(18), 1161–1161. https://doi.org/10.21037/atm-20-5832

Lv, P., Zhao, F., Xu, X., Xu, J., Wang, Q., & Zhao, Z. (2019). Correlation between Common Lower Genital Tract Microbes and High-Risk Human Papillomavirus Infection. Canadian Journal of Infectious Diseases and Medical Microbiology, 2019, 1–6. https://doi.org/10.1155/2019/9678104

Mitra, A., MacIntyre, D. A., Lee, Y. S., Smith, A., Marchesi, J. R., Lehne, B., Bhatia, R., Lyons, D., Paraskevaidis, E., Li, J. V., Holmes, E., Nicholson, J. K., Bennett, P. R., & Kyrgiou, M. (2015). Cervical intraepithelial neoplasia disease progression is associated with increased vaginal microbiome diversity. Scientific Reports, 5(1). https://doi.org/10.1038/srep16865

Nelson Valente Martins, & Julisa C L Ribalta. (2005). Patologia do trato genital inferior diagnóstico e tratamento, colposcopia, cito-histopatologia, Biologia molecular, CAF-LASER. São Paulo Roca.

Norenhag, J., Du, J., Olovsson, M., Verstraelen, H., Engstrand, L., & Brusselaers, N. (2019). The vaginal microbiota, human papillomavirus and cervical dysplasia: a systematic review and network meta‐analysis. BJOG: An International Journal of Obstetrics & Gynaecology, 127(2), 171–180. https://doi.org/10.1111/1471-0528.15854

Onywera, H., Williamson, A.-L., Mbulawa, Z. Z. A., Coetzee, D., & Meiring, T. L. (2019). Factors associated with the composition and diversity of the cervical microbiota of reproductive-age Black South African women: a retrospective cross-sectional study. PeerJ, 7, e7488. https://doi.org/10.7717/peerj.7488

Onywera, H., Williamson, A.-L., Mbulawa, Z. Z. A., Coetzee, D., & Meiring, T. L. (2019). The cervical microbiota in reproductive-age South African women with and without human papillomavirus infection. Papillomavirus Research. https://doi.org/10.1016/j.pvr.2019.04.006

Ramos de Lima, Y. A., & Costa Alves, M. de F. (2009). O sistema imune da mucosa do trato genital feminino e o impacto das doenças sexualmente transmissíveis. Revista de Patologia Tropical, 37(4). https://doi.org/10.5216/rpt.v37i4.5661

Ravel, J., Gajer, P., Abdo, Z., Schneider, G. M., Koenig, S. S. K., McCulle, S. L., Karlebach, S., Gorle, R., Russell, J., Tacket, C. O., Brotman, R. M., Davis, C. C., Ault, K., Peralta, L., & Forney, L. J. (2010). Vaginal microbiome of reproductive-age women. Proceedings of the National Academy of Sciences, 108(Supplement_1), 4680–4687. https://doi.org/10.1073/pnas.1002611107

Redelinghuys, M. J., Geldenhuys, J., Jung, H., & Kock, M. M. (2020). Bacterial Vaginosis: Current Diagnostic Avenues and Future Opportunities. Frontiers in Cellular and Infection Microbiology, 10. https://doi.org/10.3389/fcimb.2020.00354

Ritu, W., Enqi, W., Zheng, S., Wang, J., Ling, Y., & Wang, Y. (2018). Evaluation of the Associations Between Cervical Microbiota and HPV Infection, Clearance, and Persistence in Cytologically Normal Women. Cancer Prevention Research, 12(1), 43–56. https://doi.org/10.1158/1940-6207.capr-18-0233

Shannon, B., Yi, T. J., Perusini, S., Gajer, P., Ma, B., Humphrys, M. S., Thomas-Pavanel, J., Chieza, L., Janakiram, P., Saunders, M., Tharao, W., Huibner, S., Shahabi, K., Ravel, J., Rebbapragada, A., & Kaul, R. (2017). Association of HPV infection and clearance with cervicovaginal immunology and the vaginal microbiota. Mucosal Immunology, 10(5), 1310–1319. https://doi.org/10.1038/mi.2016.129

Souza, M. T. de, Silva, M. D. da, & Carvalho, R. de. (2010). Integrative review: what is it? How to do it? Einstein (São Paulo), 8(1), 102–106. https://doi.org/10.1590/s1679-45082010rw1134

Vespero, E. C., Azevedo, E. M. M. de, Pelisson, M., & Perugini, M. R. E. (1999). Correlação entre critérios clínicos e critérios laboratoriais no diagnóstico de vaginose bacteriana. Semina: Ciências Biológicas E Da Saúde, 20(2), 57. https://doi.org/10.5433/1679-0367.1999v20n2p57

Wei, Z.-T., Chen, H.-L., Wang, C.-F., Yang, G.-L., Han, S.-M., & Zhang, S.-L. (2021). Depiction of Vaginal Microbiota in Women With High-Risk Human Papillomavirus Infection. Frontiers in Public Health, 8. https://doi.org/10.3389/fpubh.2020.587298

Published

07/05/2022

How to Cite

SCANAGATTA, V. C. .; FERRAZ, A. L. .; COSTA, H. V. C. C. .; GAMA , A. V. .; PERES, M. C. T. de S. . Vaginal microbiota and persistence of human papillomavirus infection. Research, Society and Development, [S. l.], v. 11, n. 6, p. e50111629402, 2022. DOI: 10.33448/rsd-v11i6.29402. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/29402. Acesso em: 29 may. 2022.

Issue

Section

Review Article