Relationship between hematological and biochemical tests and senility in dogs

Authors

DOI:

https://doi.org/10.33448/rsd-v11i7.29568

Keywords:

Biochemistry; Dogs; Elderly; Geriatric; Hematology.

Abstract

Morphological and functional changes during senility give rise to changes to organs and tissues. Even in healthy dogs, laboratory parameters may differ, thus making preventive treatment difficult. The aim of this study was to evaluate hematological and biochemical parameters in elderly and geriatric dogs and to compare them for follow-up and possible worsening of prognosis. Thirty-four apparently healthy dogs living in the city of Ribeirão Pires, SP, were included in this study, divided into two groups: elderly (8-11,9 years) and geriatric (12 years or more). Two blood samples were taken with an interval of 20 days between them, to determine blood counts and urea, creatinine, alkaline phosphatase, alanine aminotransferase and blood glucose levels. The statistical analysis showed that this was a homogeneous group, since the only difference found between the elderly and geriatric dogs was in urea values (elderly > geriatric, p = 0.010), while in the hematological tests there were no differences between the groups or collection times. Even so, changes in test results occurred: 53% in hematological tests and 74% in biochemical tests, respectively. This highlights the importance of laboratory evaluations for prognoses and, consequently, improves the quality of life and wellbeing of dogs.

References

Bellows, J., Colitz, C. M., Daristotle, L., Ingram, D. K., Lepine, A., Marks, S. L., Sanderson, S. L., Tomlinson, J., & Zhang, J. (2015). Common physical and functional changes associated with aging in dogs. Journal of the American Veterinary Medical Association, 246(1), 67–75. https://doi.org/10.2460/javma.246.1.67

Cowell, R. L. (2004). Veterinary Clinical Pathology Secrets. Mosby Elsevier, St Louis, 408p.

Creevy, K. E., Grady, J., Little, S. E., Moore, G. E., Strickler, B. G., Thompson, S., & Webb, J. A. (2019). 2019 AAHA Canine Life Stage Guidelines. Journal of the American Animal Hospital Association, 55(6), 267–290. https://doi.org/10.5326/JAAHA-MS-6999

Dell'Osa, D., & Jaensch, S. (2016). Prevalence of clinicopathological changes in healthy middle-aged dogs and cats presenting to veterinary practices for routine procedures. Australian veterinary journal, 94(9), 317–323. https://doi.org/10.1111/avj.12481

Fernandes, T. R., Risso, D. F. A., Marini, M. R. & Manhoso, F. F. R. (2013). Proncipais afecções diagnosticadas em pacientes caninos geriátricos atendidos no município de Marília/SP no período de 2008 a 2012. Unimar Ciências, 22(1-2), 41–47.

Galvão, A. L. B., & Carvalho, M. B. (2015). Perfil hematológico de cães idosos sadios ou com doença renal crônica tratados com n-acetilcisteína. Nucleus Animalium, 7(2), 63–74. https://doi.org/10.3738/1982.2278.1470

Gates, M. C., Hinds, H. J., & Dale, A. (2017). Preliminary description of aging cats and dogs presented to a New Zealand first-opinion veterinary clinic at end-of-life. New Zealand veterinary journal, 65(6), 313–317. https://doi.org/10.1080/00480169.2017.1360161

Hall, J. A., Chinn, R. M., Vorachek, W. R., Gorman, M. E., & Jewell, D. E. (2010). Aged Beagle dogs have decreased neutrophil phagocytosis and neutrophil-related gene expression compared to younger dogs. Veterinary immunology and immunopathology, 137(1-2), 130–135. https://doi.org/10.1016/j.vetimm.2010.05.002

Jain, N. C. (1993). Essencials of Veterinary Hematology. Lea & Febiger, Philadelphia, 417p.

Lecheta, D. R., Silva, D. K. M., Santos, G. A., Cunha, M. S., Gaspar, T. T., Lopes, B. A., Deboleto, S. G. C., & Braz P. H. (2020). Effect of preanesthetic fasting on gastric emptying andplasma glucose in healthy dogs of different age groups. Pesquisa Veterinária Brasileira, 40(4),:289-292. https://doi.org/10.1590/1678-5150-pvb-6260

Lee, S. H., Kim, J. W., Lee, B. C., & Oh, H. J. (2020). Age-specific variations in hematological and biochemical parameters in middle- and large-sized of dogs. Journal of veterinary science, 21(1), e7. https://doi.org/10.4142/jvs.2020.21.e7

Lowseth, L. A., Gillett, N. A., Gerlach, R. F., & Muggenburg, B. A. (1990). The effects of aging on hematology and serum chemistry values in the beagle dog. Veterinary clinical pathology, 19(1), 13–19. https://doi.org/10.1111/j.1939-165x.1990.tb00535.x

Marotti, J., Galhardo, A. P. M., Furuyama, R. J., Pigozzo, M. N., Campos, N. T., & Laganá, D. C. (2008). Amostragem em Pesquisa Clínica: Tamanho da Amostra. Revista de Odontologia Da Universidade Cidade de São Paulo, 20(2), 186–194.

Martins, C. R., Noleto, P. G., Araújo, S. F., Miranda, R. L. & Mundim, A.V. (2013). Perfil hematológico de cães (Canis familiaris) obesos e senis. Vet. Not., 18(2) supl.,62–66.

Metzger, F. L., & Rebar, A. H. (2012). Clinical pathology interpretation in geriatric veterinary patients. The Veterinary clinics of North America. Small animal practice, 42(4), 615–v. https://doi.org/10.1016/j.cvsm.2012.04.004

Nabi, S.U., Dey, S., Gupta, G., Kumar, A., Vala, J. and Jan, M.H. (2010) A study of neuromuscular dysfunctions in geriatric dogs. Haryana Vet., 49, 73-74.

Pati, S., Panda, S. K., Acharya, A. P., Senapati, S., Behera, M., & Behera, S. S. (2015). Evaluation of geriatric changes in dogs. Veterinary world, 8(3), 273–278. https://doi.org/10.14202/vetworld.2015.273-278

Radakovich, L. B., Pannone, S. C., Truelove, M. P., Olver, C. S., & Santangelo, K. S. (2017). Hematology and biochemistry of aging-evidence of "anemia of the elderly" in old dogs. Veterinary clinical pathology, 46(1), 34–45. https://doi.org/10.1111/vcp.12459

Rofina, J. E., van Ederen, A. M., Toussaint, M. J., Secrève, M., van der Spek, A., van der Meer, I., Van Eerdenburg, F. J., & Gruys, E. (2006). Cognitive disturbances in old dogs suffering from the canine counterpart of Alzheimer's disease. Brain research, 1069(1), 216–226. https://doi.org/10.1016/j.brainres.2005.11.021

Sanjeeta, J., Patel, P. R., & Raval, S. K. (2013). Changes in haematological parameters in adult and geriatric dogs. Veterinary Pratitioner, 14(2), 230-231.

Santos, S. C. S., Meyer, R., & Costa, M. F. (2013). Variação dos parâmetros hematológicos de cães doadores regulares de sangue. Revista de Ciências Médicas e Biológicas, 12:472-477.

Srikala D., Ansar K., Nalini K.K., Ramesh P.T., Suguma R., & Yahiraj S. (2020). Studies on haematologica parameters in apparently healthy adult and sick geriatrics dogs. Journal of Entomology and Zoology Studies, 8(1), 209-211.

Stockhaus, C., Teske, E., Van Den Ingh, T., & Rothuizen, J. (2002). The Influence of Age on the Cytology of the Liver in Healthy Dogs. Veterinary Pathology, 39(1), 54-158. https://doi.org/10.1354/vp.39-1-154

Tesser, S., Cavagnolli, N. I., Torriani, T., & Rodrigues, A. D. (2016). Perfil hematológico de cães e gatos na cidade de Bento Gonçalves, Rio Grande do Sul, Brasil. Arq. Ciênc. Vet. Zool. Unipar, 19, 47-51. http://doi.org/10.25110/arqvet.v19i1.2016.5790

Thrall, M. A., Weiser, G., Allison, R. W. & Campbell, T. W. (2015). Hematologia e Bioquímica. Clínica Veterinária. 2nd.ed. Rio de Janeiro: Guanabara Koogan, 688p.

Willems, A., Paepe, D., Marynissen, S., Smets, P., Van de Maele, I., Picavet, P., Duchateau, L., & Daminet, S. (2017). Results of Screening of Apparently Healthy Senior and Geriatric Dogs. Journal of veterinary internal medicine, 31(1), 81–92. https://doi.org/10.1111/jvim.14587

Zangirolami-raimundo, J., Echeimberg, J. de O., & Leone, C. (2018). Tópicos de metodologia de pesquisa: Estudos de corte transversal. Journal of Human Growth and Development, 28(3), 356–360.http://doi.org/10.7322/jhgd.152198

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Published

18/05/2022

How to Cite

BRUNO, F.; BALBUENO, M. C. de S.; EMÍDIO, T. A.; RIOS, N.; PEREIRA, F. V.; SOUZA, M. L. B. de; COELHO, C. de P. Relationship between hematological and biochemical tests and senility in dogs. Research, Society and Development, [S. l.], v. 11, n. 7, p. e12611729568, 2022. DOI: 10.33448/rsd-v11i7.29568. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/29568. Acesso em: 18 nov. 2024.

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Agrarian and Biological Sciences