Epidemiology of patients with breast cancer assisted in a hospital unit in Maceió-AL submitted to neoadjuvant chemotherapy
DOI:
https://doi.org/10.33448/rsd-v11i7.29754Keywords:
Neoadjuvant therapy; Breast neoplasms; Margins of excision.Abstract
Introduction: Breast cancer is the second leading cause of disease and death in the world, with a wide variation in incidence and mortality between countries due to socioeconomic status and exposure to risk factors related to social conditions and lifestyle. The objective of this work is to trace the profile of women with breast cancer treated in an oncology unit in Maceió (Alagoas) undergoing neoadjuvant chemotherapy. Methodology: Cross-sectional analytical observational study with data collection from medical records of patients diagnosed with breast cancer assisted in a cancer hospital unit in Maceió-AL for the years 2019 and 2020. Results: It was found that there is a predominance of diagnosis of breast cancer treated with neoadjuvant chemotherapy at ages between 50 and 70 years and that comorbidities had a high correlation with this neoplasm, with 60% of the participants being obese, 29.09% smokers and 21.81% alcoholics. Neoadjuvant therapy was performed with the doxorubicin, cyclophosphamide and paclitaxel therapy in 96.36% of the participants, of which 56.36% had a complete pathological response. Conclusion: Maintaining healthy lifestyle habits and periodic screening for the early diagnosis of breast cancer are essential for a good prognosis of this disease, allowing greater chances of a complete pathological response after treatment.
References
Bertoni, N., de Souza, M. C., Crocamo, S., Szklo, M., & de Almeida, L. M. (2019). Is a Family History of the Breast Cancer Related to Women's Cancer Prevention Behaviors?. International journal of behavioral medicine, 26(1), 85–90. https://doi.org/10.1007/s12529-018-9737-9.
Bronsveld, H. K., Jensen, V., Vahl, P., De Bruin, M. L., Cornelissen, S., Sanders, J., Auvinen, A., Haukka, J., Andersen, M., Vestergaard, P., & Schmidt, M. K. (2017). Diabetes and Breast Cancer Subtypes. PloS one, 12(1), e0170084. https://doi.org/10.1371/journal.pone.0170084.
Early Breast Cancer Trialists' Collaborative Group (EBCTCG) (2018). Long-term outcomes for neoadjuvant versus adjuvant chemotherapy in early breast cancer: meta-analysis of individual patient data from ten randomised trials. The Lancet. Oncology, 19(1), 27–39. https://doi.org/10.1016/S1470-2045(17)30777-5.
Hamajima, N., Hirose, K., Tajima, K., Rohan, T., Calle, E. E., Heath, C. W., Jr, Coates, R. J., Liff, J. M., Talamini, R., Chantarakul, N., Koetsawang, S., Rachawat, D., Morabia, A., Schuman, L., Stewart, W., Szklo, M., Bain, C., Schofield, F., Siskind, V., Band, P., … Collaborative Group on Hormonal Factors in Breast Cancer (2002). Alcohol, tobacco and breast cancer--collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. British journal of cancer, 87(11), 1234–1245. https://doi.org/10.1038/sj.bjc.6600596.
Gravena, A., Romeiro Lopes, T. C., Demitto, M. O., Borghesan, D., Dell’ Agnolo, C. M., Brischiliari, S., Carvalho, M., & Pelloso, S. M. (2018). The Obesity and the Risk of Breast Cancer among Pre and Postmenopausal Women. Asian Pacific journal of cancer prevention : APJCP, 19(9), 2429–2436. https://doi.org/10.22034/APJCP.2018.19.9.2429.
Hamajima, N., Hirose, K., Tajima, K., Rohan, T., Calle, E. E., Heath, C. W., Jr, Coates, R. J., Liff, J. M., Talamini, R., Chantarakul, N., Koetsawang, S., Rachawat, D., Morabia, A., Schuman, L., Stewart, W., Szklo, M., Bain, C., Schofield, F., Siskind, V., Band, P., … Collaborative Group on Hormonal Factors in Breast Cancer (2002). Alcohol, tobacco and breast cancer--collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. British journal of cancer, 87(11), 1234–1245.
Han, H., Guo, W., Shi, W., Yu, Y., Zhang, Y., Ye, X., & He, J. (2017). Hypertension and breast cancer risk: a systematic review and meta-analysis. Scientific reports, 7, 44877. https://doi.org/10.1038/srep44877.
Harbeck, N., & Gnant, M. (2017). Breast cancer. Lancet (London, England), 389(10074), 1134–1150.
Heil, J., Kuerer, H. M., Pfob, A., Rauch, G., Sinn, H. P., Golatta, M., Liefers, G. J., & Vrancken Peeters, M. J. (2020). Eliminating the breast cancer surgery paradigm after neoadjuvant systemic therapy: current evidence and future challenges. Annals of oncology : official journal of the European Society for Medical Oncology, 31(1), 61–71.
Instituto Nacional do Câncer (Brasil). Estimativa 2020. Incidência do Câncer no Brasil. https://www.inca.gov.br/publicacoes/livros/estimativa-2020-incidencia-de-cancer-no-brasil.
Jafari, S. H., Saadatpour, Z., Salmaninejad, A., Momeni, F., Mokhtari, M., Nahand, J. S., Rahmati, M., Mirzaei, H., & Kianmehr, M. (2018). Breast cancer diagnosis: Imaging techniques and biochemical markers. Journal of cellular physiology, 233(7), 5200–5213.
Jones, M. E., Schoemaker, M. J., Wright, L. B., Ashworth, A., & Swerdlow, A. J. (2017). Smoking and risk of breast cancer in the Generations Study cohort. Breast cancer research : BCR, 19(1), 118. https://doi.org/10.1186/s13058-017-0908-4.
Kang, C., LeRoith, D., & Gallagher, E. J. (2018). Diabetes, Obesity, and Breast Cancer. Endocrinology, 159(11), 3801–3812.
Leon-Ferre, R.A., Hieken, T.J, Boughey, J.C. The Landmark Series: Neoadjuvant Chemotherapy for Triple-Negative and HER2-Positive Breast Cancer. Ann Surg Oncol. 2021 Apr;28(4):2111-2119. doi: 10.1245/s10434-020-09480-9.
Medeiros, G. C., Thuler, L., & Bergmann, A. (2019). Delay in breast cancer diagnosis: a Brazilian cohort study. Public health, 167, 88–95. https://doi.org/10.1016/j.puhe.2018.10.012.
Ollila, D.W., Hwang, E.S., Brenin, D.R. et al. The Changing Paradigms for Breast Cancer Surgery: Performing Fewer and Less-Invasive Operations. Ann Surg Oncol 25, 2807–2812 (2018).
Panis, C., Kawasaki, A., Pascotto, C. R., Justina, E., Vicentini, G. E., Lucio, L. C., & Prates, R. (2018). Critical review of cancer mortality using hospital records and potential years of life lost. Einstein (Sao Paulo, Brazil), 16(1), eAO4018. https://doi.org/10.1590/s1679-45082018ao4018.
Rossi, L., Mazzara, C., & Pagani, O. (2019). Diagnosis and Treatment of Breast Cancer in Young Women. Current treatment options in oncology, 20(12), 86. https://doi.org/10.1007/s11864-019-0685-7.
Shien, T., Iwata, H. Adjuvant and neoadjuvant therapy for breast cancer. Jpn J Clin Oncol. 2020 Mar 9;50(3):225-229.
Silva, A.M., Silva, A.M., Guedes, G.W., Dantas, A.F.L.S. & Nóbrega, M.M. Perfil epidemiológico do câncer do colo do útero na Paraíba. Temas em Saúde, 17(3), 2447-2131.
Sun, Y., Liao, M., He, L., & Zhu, C. (2017). Comparison of breast-conserving surgery with mastectomy in locally advanced breast cancer after good response to neoadjuvant chemotherapy: A PRISMA-compliant systematic review and meta-analysis. Medicine, 96(43), e8367. https://doi.org/10.1097/MD.0000000000008367.
Varghese, F., & Wong, J. (2018). Breast Cancer in the Elderly. The Surgical clinics of North America, 98(4), 819–833. https://doi.org/10.1016/j.suc.2018.04.002.
Medeiros, G. C., Thuler, L., & Bergmann, A. (2019). Delay in breast cancer diagnosis: a Brazilian cohort study. Public health, 167, 88–95. https://doi.org/10.1016/j.puhe.2018.10.012.
Waks, A.G., Winer, E.P. Breast Cancer Treatment: A Review. JAMA. 2019 Jan 22;321(3):288-300. doi: 10.1001/jama.2018.19323.
Watkins, E.J. (2019). Overview of breast cancer. JAAPA : official journal of the American Academy of Physician Assistants, 32(10), 13–17.
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