Ocular hypertension in pediatrics patients with acute lymphoblastic leukemia

Authors

DOI:

https://doi.org/10.33448/rsd-v11i7.29960

Keywords:

Acute lymphoblastic leukemia; Corticosteroids; Intraocular pressure; Glaucoma; Children.

Abstract

Objectives: To evaluate the frequency and associated factors with ocular hypertension (OH) in patients with acute lymphoblastic leukemia (ALL) using glucocorticoids (GC), in order to determine intraocular pressure (IOP) at four times along the treatment (first day – D0, after eight days – D8, after twenty-eight days – D28 and after 6 months – D6m) and to identify association of OH with IOP, age group, cerebrospinal fluid (CSF) infiltration, immunophenotyping (IMP), sex and death. Methodology: Prospective descriptive study design enrolling children with ALL under chemotherapy at a public and specialized in pediatric oncology ward from January/2013 until December/2017. IOP was measured on D0, D8, D28 and D6m of treatment. Measurements above 21 mmHg were considered HO. Results: Of the 58 patients included (aged between 1.4 and 19.2 years), 17.2% (10 patients) had OH, with higher blood pressure increases on D8 (p<0.001), and the two more cases on D28. No patient had symptoms and the pressures normalized after cessation of GC on D6m. The variables sex, age, IMP and CSF infiltration were not a risk for OH. It was not possible to predict mortality and CSF infiltration related to IOP values. Conclusion: Data analysis identified 17.2% of HO in the sample, the highest IOP means were concentrated on D8 and two other cases occurred on D28. Pre-treatment clinical and laboratory features were not associated with IOP elevation or CSF blast infiltration and death.

References

Badriyah, I. N., Irfani, I., & Rakhmilla, L.E. (2015). Characteristics of Childhood Steroid-Induced Glaucoma patients in National Eye Center, Cicendo Eye Hospital, Bandung, Indonesia from 2007 to 2011. Althea Medical Journal, 2(3). https://doi.org/10.15850/amj.v2n3.558

Barcelos R., Roisman, L., Tochetto, L. B., Tochetto, B. B., Fontoura, T. P. D., & Kohler, L. I. A. (2021). Alterações retinianas em pacientes com leucemia linfocítica aguda (IIa): discussão de tema a partir de relato de caso. Revista Brasileira de Oftalmologia, 80(1):33-41. https://doi.org/10.5935/0034-7280.20210007

de Espinosa, M. M., Pérez, R. P., Schiattino, P. M., Cossío, M. I., & Ponce, J. (2017). Juvenile glaucoma: Long-term development of ocular hypertension in children. New Front Ophthalmol, 3(1):1-4.

de Farias, J. V. M., Chaves, R. G. R., & Albuquerque, M. T. F. (2021). Perfil clínico-epidemiológico das crianças e adolescentes em leucemia linfoide aguda atendidas em um hospital de referência de Imperatriz-MA. Facit Business and Tecnology Journal, 23(1)85-98. ISSN: 2526-4281.

Halfon-Domenech, C. Leucemia linfoblástica aguda del niño y el adolescente. EMC-Pediatria. 56(1), 1-9. https://doi.org/10.1016/S1245-1789(21)44720-7

Hayasaka, Y., Hayasaka, S., & Matsukura H. (2006). Ocular Findings in Japanese Children with Nephrotic Syndrome Receiving Prolonged Corticosteroid Therapy. Ophthalmologica, 220(3):181-5. https://doi.org/10.1159/000091762

Herbert, H. M., Viswanathan, A., Jackson, H., & Lightman, S. L. (2004). Risk Factors for Elevated Intraocular Pressure in Uveitis. Journal of Glaucoma, 13(2):96-9. https://doi.org/10.1097/00061198-200404000-00003

Inaba H., & Pui, C. H. (2010). Glucocorticoid use in acute lymphoblastic leukaemia. The Lancet Oncology, 11(11):1096-106. https://doi.org/10.1016/s1470-2045(10)70114-5

Kawaguchi, E., Ishikura, K., Hamada, R., Nagaoka, Y., Morikawa, Y., Sakai, T., Hamasaki, Y., Hataya, H., Noda, E., Miura, M., Ando, T., & Honda, M. (2014). Early and frequent development of ocular hypertension in children with nephrotic syndrome. Pediatric Nephrology, 29(11):2165-71. https://doi.org/10.1007/s00467-014-2848-x

Krag, S., Larsen, D., Albertsen, B. K., & Glerup, M. (2021). Risk of ocular hypertension in children treated with systemic glucocorticoid. Acta Ophthalmologica, 99(8), e1430-e1434.

Lam, C. S., Kalthum, M. U., Norshamsiah., M. D., & Bastion, M. L. C. (2018). Case series of children with steroid-Induced glaucoma. Malaysian family physician: the official journal of the Academy of Family Physicians of Malaysia [online], 13(3), 32. http://www.ncbi.nlm.nih.gov/pubmed/30800232

Mendonca C. de Q., de Souza, C. P., Martins-Filho, P. R., Viana, S. S., Leal, B. C., & Cipolotti, R. (2014). Steroid-induced ocular hypertensive response in children and adolescents with acute lymphoblastic leukemia and non-hodgkin lymphoma. Pediatric Blood & Cancer, 61(11):2083-5. https://doi.org/10.1002/pbc.25070

Mendonca C. de Q., Freire, M. V., Viana, S. S., Tavares, M. K. S., Silva, W. M. A., & Cipolotti R. (2019). Ocular manifestations in acute lymphoblastic leukemia: A five-year cohort study of pediatric patients. Leukemia Research, 76:24-8. https://doi.org/10.1016/j.leukres.2018.11.017

Nuyen, B., Weinreb, R. N., & Robbins, S. L. (2017). Steroid-induced glaucoma in the pediatric population. Journal of American Association for Pediatric Ophthalmology and Strabismus, 21(1):1-6. https://doi.org/10.1016/j.jaapos.2016.09.026

Orhan, B., Malbora, B., Akça Bayar, S., Avcı, Z., Alioğlu, B., & Özbek, N. (2016). Ophthalmologic Findings in Children with Leukemia: A Single-Center Study. Türk Oftalmoloji Dergisi, 46(2):62-7. https://doi.org/10.4274/tjo.03880

Pereira A. S., Shitsuka D. M., Parreira F. J., & Shitsuka R. (2018). Metodologia da pesquisa científica. [free e-book]. Santa Maria/RS. Ed. UAB/NTE/UFSM.

Pilbeam, K., Salvi, S., & Havani, A. (2012). Corticosteroid-induced glaucoma as a complication of induction therapy in a child with acute lymphoblastic leukemia (ALL). ASPHO Abstracts. Pediatric Blood and Cancer, 58:1014-1097.

Pinto, S. S. (2019) Papel dos glicocorticoides no tratamento de neoplasias malignas. Revista Científica UNIFAGOC-Saúde [online], 4(1):40-16. https://revista.unifagoc.edu.br/index.php/saude/article/viewFile/414/417

Prakash, A., Dhasmana, R., Gupta, N., & Verma, S. (2016). Ocular manifestations in leukemia and myeloproliferative disorders and their association with hematological parameters. Annals of African Medicine, 15(3):97. https://doi.org/10.4103/1596-3519.188887

Remè, C., & Lalive d'Epinay, S. (1981). Periods of development of the normal human chamber angle. Documenta Ophthalmologica, 51(3):241-68. https://doi.org/10.1007/bf00143888

Roberti, G., Oddone, F., Agnifili, L., Katsanos, A., Michelessi, M., Mastropasqua, L., Quaranta, L., Riva, I., Tanga, L., & Manni, G. Steroid-induced glaucoma: Epidemiology, pathophysiology, and clinical management. (2020). Survey of Ophthalmology, 65(4):458-72. https://doi.org/10.1016/j.survophthal.2020.01.002

Schmid, K. E., Kornek, G. V., Scheithauer, W., & Binder, S. (2006). Update on Ocular Complications of Systemic Cancer Chemotherapy. Survey of Ophthalmology, 51(1):19-40. https://doi.org/10.1016/j.survophthal.2005.11.001

Sergeant, E. S. G. (2018). Epitools epidemiological calculators. Ausvet Pty Ltda. http://epitools.ausvet.com.au

Sharma, T., Grewal, J., Gupta, S., & Murray, P. I. (2004). Ophthalmic manifestations of acute leukaemias: the ophthalmologist's role. Eye, 18(7):663-72. https://doi.org/10.1038/sj.eye.6701308

Silva, D. D., Silva, I. E., Almeida, F. M., Souza, V. I., Nascimento, P. L., & Britto, L. R. (2021). Perfil infanto-juvenil e sobrevida de pacientes com leucemia linfóide aguda do semiárido brasileiro. Brazilian Journal of Development, 7(3):25085-93. https://doi.org/10.34117/bjdv7n3-286

Spaeth, G. L., Barros, D. S. M. de, & Fudemberg, S. J. (2009). Visual Loss Caused by Corticosteroid-Induced Glaucoma: How to Avoid It. Retina, 29(8):1057-61. https://doi.org/10.1097/iae.0b013e3181b32cfd

Tripathi, R. C., Kirschner, B. S., Kipp, M., Tripathi, B. J., Slotwiner, D., Borisuth, N. S., Karrison, T., & Ernest, J. T. (1992). Corticosteroid treatment for inflammatory bowel disease in pediatric patients increases intraocular pressure. Gastroenterology, 102(6):1957-61. https://doi.org/10.1016/0016-5085(92)90319-t

Viana, S. S., Lima L. M. de, Nascimento, J.B. do, Cardoso, C. A., Rosário, A. C., Mendonça, C. D., de Menezes-Neto, O. A., & Cipolotti, R. (2015). Secular trends and predictors of mortality in acute lymphoblastic leukemia for children of low socioeconomic level in Northeast Brazil. Leukemia Research, 39(10):1060-5. https://doi.org/10.1016/j.leukres.2015.07.007

Yamashita, T., Kodama, Y., Tanaka, M., Yamakiri, K., Kawano, Y., & Sakamoto, T. (2010). Steroid-induced Glaucoma in Children With Acute Lymphoblastic Leukemia. Journal of Glaucoma, (3):188-90. https://doi.org/10.1097/ijg.0b013e3181af321d

Published

18/05/2022

How to Cite

FREIRE, M. V.; CARVALHO, H. D. G.; CIPOLOTTI, R.; MENDONCA, C. de Q. Ocular hypertension in pediatrics patients with acute lymphoblastic leukemia . Research, Society and Development, [S. l.], v. 11, n. 7, p. e19811729960, 2022. DOI: 10.33448/rsd-v11i7.29960. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/29960. Acesso em: 23 feb. 2024.

Issue

Section

Health Sciences