Oral manifestations in pediatric patients with Acute Lymphoid Leukemia





Acute Lymphoblastic Leukemia; Oral Manifestations; Oncology; Health teaching.


Objective: To review the literature on the main oral alterations found in pediatric patients with Acute Lymphoblastic Leukemia, whether caused by the disease or by antineoplastic treatment. Methodology: This is an integrative literature review that used the PubMed, Lilacs and Scielo databases through the keywords registered in the Health Sciences Descriptors (DeCS), in which studies that addressed the proposed theme were included. in this work, available in the aforementioned databases, in English and Portuguese, between the years 2011 to 2021. Results: 514 articles were found, of these 178 were initially screened based on titles and abstracts and only 34 articles met the eligibility criteria. Conclusion: Acute Lymphoblastic Leukemia, in most cases, leads to the appearance of oral lesions resulting from the disease, especially in the gingival regions, buccal mucosa, floor of the mouth, hard and soft palate. Chemotherapy and radiotherapy for Acute Lymphoblastic Leukemia are effective antineoplastic therapies, however, their side effects affect the oral cavity, with the most recurrent oral complications being: mucositis, candidiasis and radiation caries. It is of great value that the dentist is inserted in the multidisciplinary context, at the hospital and oncological level, as part of the success of the treatment of this leukemia, whether as a preventive or therapeutic approach.

Author Biographies

Ana Clara Alves Santiago Silveira, Faculdade Independente do Nordeste

Undergraduate student in Dentistry, Faculdade Independente do Nordeste - FAINOR. Member of the PIVIC research group (2019-2022), with an emphasis on stomatology and hospital dentistry.

Luara Novaes Coutinho, Faculdade Independente do Nordeste

Student of the 10th semester of the Dentistry course at Faculdade Independente do Nordeste - FAINOR.

Gefter Thiago Batista Correa, Faculdade Independente do Nordeste

PhD in Molecular Medicine from the Federal University of Minas Gerais (2015). Master's in Health Sciences with emphasis on oral pathology from the State University of Montes Claros (2011). He is currently a professor of oral diagnosis at Faculdade Independente do Nordeste and professor of oral pathology at Faculdade Independente do Nordeste. Graduated in Dentistry from the State University of Montes Claros (2008).


Aggarwal, A., & Pai, K.M. (2018). Orofacial Manifestations of Leukemic Children on Treatment: A Descriptive Study. International Journal of Clinic Pediatric Dentistry, 11(3), 193-198.

Angst, P., Maier, J., Dos Santos Nogueira, R., Manso, I. S., & Tedesco, T. K. (2020). Oral health status of patients with leukemia: a systematic review with meta-analysis. Archives of oral biology, 120, 104948.

Antonini, M.F., Lemes, L.T.O., & Mozzini, C.B. (2016). Manifestações Orais da Leucemia no Momento do Diagnóstico. Revista Brasileira de Cancerologia, 64(2), 227-235.

Araújo, S. N., Luz, M. H. B. A., Almeida, L. H. R. B. de, Silva, G. R. F., Moita Neto, J. M., & Costa, A. C. M. M. A. (2013). Oncological patients and the nursing field: ration between the oral mucositis grade and the implemented therapeutic. Revista De Pesquisa Cuidado é Fundamental Online, 5(4), 386–395.

Arul, A. S., Verma, S., Ahmed, S., & Arul, A. S. (2012). A clinical and fine needle aspiration cytology study of gingiva in acute leukemia. Dental research journal, 9(1), 80–85. https://doi.org/10.4103/1735-3327.92954Azher, U., & Shiggaon, N. (2013). Oral health status of children with acute lymphoblastic leukemia undergoing chemotherapy. Indian Journal Dental Research, 24(4), 523-526.

Caldas, H. T. A., Ricarte, R. G., Souza, S. R. S., Néri, J. S. V., & Dantas, J. B. L. Alterações orais da quimioterapia em pacientes infantojuvenis com leucemia linfoide aguda: uma revisão de literatura. Revista Brasileira De Saúde Funcional, 9(1), 133 - 150.

Cavalcante, M. S., Rosa, I. S. S., & Torres, F. (2017). Leucemia linfóide aguda e seus principais conceitos. Revista Científica da Faculdade de Educação e Meio Ambiente, 8(2),151-164.

Costa, S. S., Silva, A. M., & Macedo, I. A. B. (2011). Conhecimento de manifestações orais da leucemia e protocolo de atendimento odontológico. Revista de Odontologia da Universidade Cidade de São Paulo, 23(1), 70-8.

Costa, S. S., Souza, H. R., Costa, I. S. (2017). O papel do cirurgião-dentista no diagnóstico precoce da leucemia e sua responsabilidade ética e legal – revisão de literatura. Revista Brasileira de Odontologia Legal, 4(2), 65-77.

Francisconi, C. F., Caldas, R. J., Oliveira Martins, L. J., Fischer Rubira, C. M., & da Silva Santos, P. S. (2016). Leukemic Oral Manifestations and their Management. Asian Pacific journal of cancer prevention: APJCP, 17(3), 911–915.

Gazzinelli, L., Costa, B., Gonçalves, C., Soares Júnior, L., & Santos, P. (2018). Manejo odontológico em crianças com leucemia aguda sob tratamento antineoplásico. Uningá Journal, 55(1), 121-133.

Gómez-Mercado, C., Segura-Cardona, A., Pájaro-Cantillo, D., & Mesa-Largo, M. (2020). Incidencia y determinantes demográficos de la leucemia linfoide aguda en pacientes con cáncer pediátrico, Antioquia. Universidad Y Salud, 22(2), 112-119.

Grando, L. J., Mello, A., Salvato, L., Brancher, A. P., Del Moral, J., & Steffenello-Durigon, G. (2015). Impact of leukemia and lymphoma chemotherapy on oral cavity and quality of life. Special care in dentistry: official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry, 35(5), 236–242.

Hasan, S., Khan, N. I., & Reddy, L. B. (2015). Leukemic gingival enlargement: Report of a rare case with review of literature. International Journal of Applied and Basic Medical Research, 5(1), 65-67.

Hegde, A.M., Joshi, S., Rai, K., Shetty, S. (2011). Evaluation of oral hygiene status, salivary characteristics and dental caries experience in acute lymphoblastic leukemic (ALL) children. Journal of Clinical Pediatric Dentistry, 35(3),319-23.

Instituto Nacional Do Câncer. (2020). Estimativa 2020: incidência de câncer no Brasil. Rio de Janeiro: Coordenação de prevenção e vigilância do câncer.

Jesus, L. G., Cicchelli, M., Martins, G. B., Pereira, M. C. C., Lima, H. S., & Medrado, A. R. S. P. (2016). Repercussões orais de drogas antineoplásicas: uma revisão de literatura. Revista da Faculdade de Odontologia-UFPE, 21(1), 130-135.

Joshi, S., Hegde, A. M., Rai, K., & Shetty, S. (2013). Evaluation of salivary sialic acid levels in acute lymphoblastic leukemic children and its correlation with dental caries experience. The Journal of clinical pediatric dentistry, 37(3), 309–313.

Leite, G. S., Bezerra, M. J. P. B., de Queiroz, V. K. P., Alves, D. J. P., da Nóbrega, L. P., & da Silva, W. E. (2020). Características buco-dentárias de pacientes leucêmicos: uma revisão sistemática. Revista Eletrônica Acervo Saúde, 12(11), 1-11.

Lopes, I. A., Nogueira, D. N., & Lopes, I. A. (2012). Manifestações Orais Decorrentes da Quimioterapia em Crianças de um Centro de Tratamento Oncológico. Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 12(1), 113-19.

Morais, E. F., Lira, J. A. S., Macedo, R. A. P., Santos, K. S., Elias, C. T. V., & Morais, M. L. S. A. (2014). Oral manifestations resulting from chemotherapy in children with acute lymphoblastic leucemia. Brazilian Journal of Otorhinolaryngology, 80(1), 78-85.

Ponte-Torres, E., Ruiz-Rodriguez, M. D. S., Alejo-Gonzalez, F., Hernández-Sierra, J. F., & Pozos-Guillén, A. J. (2011). Oral manifestations in pediatric patients receiving chemotherapy for acute lymphoblastic leukemia. Journal of Clinical Pediatric Dentistry, 34(3), 275–9.

Ptasiewicz, M., Pawłowicz, A. K., & Borowicz, B. T. (2020). Chemotherapy and Oral Health in Leukemic Patients. Polish Journal of Environmental Studies, 29(5), 3263-3271.

Quispe, R. A., Aguiar, E. M., de Oliveira, C. T., Neves, A., & Santos, P. (2021). Oral manifestations of leukemia as part of early diagnosis. Hematology, transfusion and cell therapy, S2531-1379 (21) 01309-2.

Reenesh, M., Munishwar, S., & Rath, S. K. (2012). Generalised Leukaemic Gingival Enlargement: a Case Report. J Oral Maxillofac Res., 3(3), 5.

Resende, G. A. D., Gileno, M. C., Souza, H. M., Carlos, A. M., Leal, A. S., & Martins, P. R. J. (2017). The Role of Cytochemistry in the Diagnosis of Acute Leukemias. International Journal Of Health Sciences & Research, 7(8), 290-95.

Ruiz-Argüelles, G.J. (2016). Advances in the diagnosis and treatment of acute and chronic leukemia in Mexico. Salud pública Méx., 58(2), 291-5.

Sasada, I. N. V., Cancino, C. M. H., Petersen, R. C., Hellwing, I., & Dillenburg, C. S. (2015). Prevenção de intercorrências estomatológicas em oncologia pediátrica. Revista da Faculdade de Odontologia – UPF, 20(1), 105-109.

Silva, B. A., Siqueira, C., Castro, P., Araújo, S. S., & Volpato, L. (2012). Oral manifestations leading to the diagnosis of acute lymphoblastic leukemia in a young girl. J Indian Soc Pedod Prev Dent., 30, 166-8.

Sousa, L.M.M., Marques-Vieira, C.M.A, Severino, S.S.P., & Antunes, A.V. (2017). A metodologia de revisão integrativa da literatura em enfermagem. Revista Investigação em Enfermagem, 21(2), 17-26.

Wang, Y., Zeng, X., Yang, X., Que, J., Du, Q., Zhang, Q., & Zou, J. (2021). Oral Health, Caries Risk Profiles, and Oral Microbiome of Pediatric Patients with Leukemia Submitted to Chemotherapy. BioMed research international, 2021, 6637503.

Watson, E., Wood, R. E., Maxymiw, W. G., & Schimmer, A. D. (2018). Prevalence of oral lesions in and dental needs of patients with newly diagnosed acute leukemia. Journal of the American Dental Association (1939), 149(6), 470–480.

Zimmermann, C., Meurer, M. I., Grando, L. J., Gonzaga Del Moral, J. Â., da Silva Rath, I. B., & Schaefer Tavares, S. (2015). Dental treatment in patients with leukemia. Journal of oncology, 2015, 571739.

Zocante, P. T., Silva, P. C. & Parizi, A. G. (2021). Abordagem odontológica em paciente portador de leucemia linfóide aguda: revisão de literatura. Colloquium Vitae, 12(2), 12–18.



How to Cite

SILVEIRA, A. C. A. S. .; COUTINHO, L. N. .; CORREA, G. T. B. . Oral manifestations in pediatric patients with Acute Lymphoid Leukemia . Research, Society and Development, [S. l.], v. 11, n. 7, p. e27711730119, 2022. DOI: 10.33448/rsd-v11i7.30119. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/30119. Acesso em: 6 jul. 2022.



Review Article