The complex epigenetic interaction in the predisposition to drug dependence: a systematic literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i7.30216

Keywords:

Illicit drugs; Epigenetics; Drug addiction; Mental health; Health teaching.

Abstract

This research aims to examine the issue of chemical dependence and the occurrences of epigenetic changes, highlighting its relevance in the clinical care of illegal drug users. For that, a systematic literature review was carried out, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) model. An electronic search for articles was performed in the databases: Cumulative Index to Nursing and Allied Health Literature (CINAHL); EBSCOhost, EMBASE; Latindex; Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS); Medical Literature Analysis and Retrieval System Online/PubMed (MEDLINE); Science Direct, Scientific Electronic Library Online (SciELO), SCOPUS, ISI Web of Science, with the descriptors "epigenetics AND illicit drugs AND addiction OR dependence AND mental disorders AND genetic predisposition OR genetic susceptibility”, chosen in consultation with DeCS and Medical Subject Heading (MeSH). A search strategy resulted in 532 studies. Following the inclusion and exclusion criteria, 22 articles published from 2008 to 2021 in national and international literature were analyzed. This review contributes to direct future research. A greater understanding of the complexities of the epigenome and the unravelling of the effects and contributions of disease states versus drugs of abuse is crucial to the development of new clinical therapies. Epigenetic therapy holds great promise for treating complex diseases and personalized interventions, including psychiatric illnesses.

Author Biographies

Cíntia da Silva Telles Nichele , Fundação Oswaldo Cruz

Lawyer. She holds a degree in Law from the Federal University of Rio de Janeiro. Master in Public Health from the Sérgio Arouca National School of Public Health of the Oswaldo Cruz Foundation (ENSP/FIOCRUZ), in the area of Health, Work and Environment. He is currently studying for a Doctorate in Public Health at ENSP/FIOCRUZ in the line of determination of health-disease processes: production/work, territories and human rights, developing research focused on the impact of International Human Rights Treaties on health. Professor of the Specialization Course in Human Rights and Health at the Department of Human Rights, Health and Cultural Diversity at ENSP/FIOCRUZ.

Jéssica Barreto dos Santos, Fundação Oswaldo Cruz

Psychologist, Master's student in Public Health at the National School of Public Health (ENSP/FIOCRUZ) and specialist in Psychoanalytic Clinic at the Federal University of Rio de Janeiro (IPUB/UFRJ). She currently works as a psychologist at the Municipality of Barra do Piraí and at the Amil Saúde Mental Health Program. She has experience in social work, mental health and clinical practice with an emphasis on psychoanalysis. Her research permeates the themes of gender, feminine clinic and mental health.

Maria José Cruz-Hernández, Comisión Nacional contra las Adicciones

Researcher at the Mexican Observatory of Mental Health and Drug Use, National Commission against Addictions (CONADIC).

References

Agrawal, A. & Lynskey, M. (2008). Are there genetic influences on addiction: evidence from family, adoption and twin studies. Addiction, 103(7),1069-1081. https://doi.org/10.1111/j.1360-0443.2008.02213.x

Amarante, P. & Nunes, M.O. (2018). A reforma psiquiátrica no SUS e a luta por uma sociedade sem manicômios. Ciência & Saúde Coletiva, 23(6), 2067-2074. https://doi.org/10.1590/1413-81232018236.07082018

American Psychiatric Association. (1994). Diagnostic and Statistical Manual of Mental Disorders – DSM. 4 ed. Washington D/C.

Bali, P., Im, H.I. & Kenny, P. (2011). Methylation, memory and addiction. Epigenetics. 6(6), 671-674. https://doi.org/10.4161/epi.6.6.15905

Berman, S.M., Kuczenski, R., McCracken, J.T. & London, E.D. (2009). Potential adverse effects of amphetamine treatment on brain and behavior: a review. Molecular Psychiatry, 14, 123-142.

Chen, L., Ru, Q., Xiong, Q., Yang, J., Xu, G., Wu, Y. & Veskoukis, A.S. (2022). Potential Effects of Nrf2 in exercise intervention of neurotoxicity caused by methamphetamine oxidative stress. Oxidative Medicine and Cellular Longevity, 4445734, 1-15. https://doi.org/10.1155/2022/4445734

Christophersen, A.S. (2000). Amphetamine designer drugs - an overview and epidemiology. Toxicology Letters, 112-113, 127-131. https://doi.org/10.1016/s0378-4274(99)00205-2

Cruickshank, C.C. & Dyer, K.R. (2009). A review of the clinical pharmacology of methamphetamine. Addiction, 104, 1085-1099.

Deng, J.V., Rodriguiz, R.M., Hutchinson, A.N., Kim, I.H., Wetsel, W.C. & West, A.E. (2010). MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants. Nature Neuroscience, 13(9), 1128-1136. https://doi.org/10.1038/nn.2614

Ehrenber, A. (2004). Le sujet cerebral. Esprit, 309, 130-155. https://doi.org/10.1590/S0103-56652009000100013

Fantappié, M. (2013). Epigenética e Memória Celular. Revista Carbono, 3. http://revistacarbono.com/artigos/03-epigenetica-e-memoria-celular-marcelofantappie/

Ferreira, A.P. (2021). Dependência química e o cenário dos usuários de drogas atendidos nos Centros de Atenção Psicossocial Álcool e Drogas: A política de saúde na atenção integral aos idosos. Revista Interfaces: Saúde, Humanas e Tecnologia, 9, 1147-1157. https://doi.org/10.16891/950

Ferreira, A.P., Nichele, C.S.T., Wermuth, M.A.D. & Wermelinger, E.D. (2022). Uso y abuso de substancias en adultos mayores atendidos en Servicios de Salud Mental. Memorias de Instituto de Investigaciones en Ciencias de la Salud, 20, 73-84. https://doi.org/10.18004/mem.iics/1812-9528/2022.020.01.73

Ferreira, A.P., Wermelinger, E.D. & Silva, E.M. (2021). Consumption, risk factors, and the impact of psychoactive substances in road transport by professional drivers: A review. Acta Scientiarum. Human And Social Sciences, 43, e58057. https://doi.org/10.4025/actascihumansoc.v43i2.58057

Fischer, B., Blanken, P., Da Silveira, D., Gallassi, A., Goldner, E.M., Rehm, J., Tyndall, M. & Wood, E. (2015). Effectiveness of secondary prevention and treatment interventions for crack-cocaine abuse: A comprehensive narrative overview of English-language studies. International Journal of Drug Policy, 26(4), 352-363. https://doi.org/10.1016/j.drugpo.2015.01.002

Freeman, W.M., Nader, M.A., Nader, S.H., Robertson, D.J., Gioia, L., Mitchell, S.M., Daunais, J.B., Porrino, L.J., Friedman, D.P. & Vrana, K.E. (2001). Chronic cocaine-mediated changes in non-human primate nucleus accumbens gene expression. Journal of Neurochemistry, 77, 542–549. https://doi.org/10.1046/j.1471-4159.2001.00252.x

Freitas-Silva, L.R. & Ortega, F. (2016). A determinação biológica dos transtornos mentais: uma discussão a partir de teses neurocientíficas recentes. Cadernos de Saúde Pública, 32(8), e00168115. https://doi.org/10.1590/0102-311X00168115

Gajewski, P., Turecki, G. & Robison, A. (2016). Differential expression of FosB proteins and potential target genes in select brain regions of addiction and depression patients. PLoS One, 11(8):e0160355. https://doi.org/10.1371/journal.pone.0160355

Hamilton, P.J. & Nestler, E.J. (2019). Epigenetics and addiction. Current Opinion in Neurobiology, 59, 128-136. https://doi.org/10.1016/j.conb.2019.05.005

Jaenisch, R. & Bird, A. (2003). Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nature Genetics, 33, 245-254. https://doi.org/10.1038/ng1089

Jorde, L., Carey, J. & Bamshad, M. (2010). Genética médica. 4. ed. Rio de Janeiro: Elsevier.

Koob, G. & Volkow, N. (2010). Neurocircuitry of addiction. Neuropsychopharmacology, 35(1), 217-238. https://doi.org/10.1038/npp.2009

Longo, M., Wickes, W., Smout, M., Harrison, S., Cahill, S. & White, J.M. (2010). Randomized controlled trial of dexamphetamine maintenance for the treatment of methamphetamine dependence. Addiction, 105, 146-154. https://doi.org/10.1111/j.1360-0443.2009.02717.x

Malta, M., Cardoso, L.O., Bastos, F.I., Magnanini, M.M. & Silva, C.M. (2010). STROBE initiative: guidelines on reporting observational studies. Revista de Saúde Pública, 44(3), 559-565. https://doi.org/10.1590/s0034-89102010000300021

Marcon, C., Silva, L.A.M., Moraes, C.M.B., Martins, J.S. & Carpes, A.D. (2012). Uso de anfetaminas e substâncias relacionadas na sociedade contemporânea. Disciplinarum Scientia, 13(2), 247-263.

Mayes, R. & Horwitz, A. (2005). DSM-III and the revolution in the classification of mental illness. Journal of the history of the behavioral sciences, 41(3), 249-267. https://doi.org/10.1002/jhbs.20103

McCowan, T.J., Dhasarathy, A. & Carvelli, L. (2015). The epigenetic mechanisms of amphetamine. Journal of Addiction & Prevention, Suppl 1, 10. https://doi.org/10.13188/2330-2178.S100001

Muller, H.R. & Prado, K.B. (2008). Epigenética: um novo campo da genética. RUBS, 1(3), 61-69.

Nestler, E. (2008). Transcriptional mechanisms of addiction: role of Delta FosB. Philosophical Transactions of the Royal Society B, 363(1507), 3245-3255. https://doi.org/10.1098/rstb.2008.0067

Nestler, E. (2014). Epigenetic mechanisms of drug addiction. Neuropharmacology, 76 Pt B(0 0), 259-268. https://doi.org/10.1016/j.neuropharm.2013.04.004

Nielsen, D.A., Utrankar, A., Reyes, J.A., Simons, D.D. & Kosten, T.R. (2012). Epigenetics of drug abuse: predisposition or response. Pharmacogenomics, 13(10), 1149-1160. https://doi.org/10.2217/pgs.12.94

Nieratschker, V., Batra, A. & Fallgatter, A.J. (2013). Genetics and epigenetics of alcohol dependence. Molecular Psychiatry, 1(11). https://doi.org/10.1186/2049-9256-1-11

O’Brien, B.C., Harris, I.B., Beckman, T.J., Reed, D.A. & Cook, D.A. (2014). Standards for reporting qualitative research: a synthesis of recommendations. Academic Medicine, 89(9), 1245-1251. https://doi.org/10.1097/ACM.0000000000000388

Page, M.J., McKenzie, J.E., Bossuyt, P.M., Boutron, I., Hoffmann, T.C., Mulrow, C.D., Shamseer, L., Tetzlaff, J.M., Akl, E.A., Brennan, S.E., Chou, R., Glanville, J., Grimshaw, J.M., Hróbjartsson, A., Lalu, M.M., Li, T., Loder, E.W., Wilson, M., McDonald, S., McGuinness, L.A., Stewart, L.A., Thomas, J., Tricco, A.C., Welch, V.A., Whiting, P. & Moher, D. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. British Medical Journal, 372, 71. https://doi.org/10.1136/bmj.n71

Prescott, C. & Kendler, K. (1999). Genetic and environmental contributions to alcohol abuse and dependence in a population-based sample of male twins. American Journal of Psychiatry, 156, 34-40.

Renthal, W., Carle, T.L., Maze, I., Covington, H.E., Truong, H.T., Alibhai, I., Kumar, A., Montgomery, R.L., Olson, E.N. & Nestler, E.J. (2008). Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure. Journal of Neuroscience, 28(29), 7344-7349. https://doi.org/10.1523/JNEUROSCI.1043-08.2008

Richards, E. (2006). Inherited epigenetic variation — revisiting soft inheritance. Nature Reviews Genetics, 7:395-401.

Robison, A. & Nestler, E. (2011). Transcriptional and epigenetic mechanisms of addiction. Nature Reviews Neuroscience, 12(11), 623-637. https://doi.org/10.1038/nrn3111

Sadri-Vakili, G. (2015). Cocaine triggers epigenetic alterations in the corticostriatal circuit. Brain research, 1628(Pt A), 50–59. https://doi.org/10.1016/j.brainres.2014.09.069

Santos, C.M.C., Pimenta, C.A.M. & Nobre, M.R.C. (2007). A estratégia pico para a construção da pergunta de pesquisa e busca de evidência. Revista Latino-Americana de Enfermagem, 15(3), 508-511. https://doi.org/10.1590/S0104-11692007000300023

Shorter, J. & Lindquist, S. (2005). Prions as adaptive conduits of memory and inheritance. Nature Reviews Genetics, 6(6), 435-450. https://doi.org/10.1038/nrg1616

Stewart, A.F., Fulton, S.L. & Maze, I. (2021). Epigenetics of drug addiction. Cold Spring Harbor Perspectives in Medicine, 11(7), a040253. https://doi.org/10.1101/cshperspect.a040253

Strauch, A.P., Visscher, P.M., Wray, N.R., Guo, X., Wiggins, K.L., Smith, A.K., Binder, E.B., Ressler, K.J., Irvin, M.R., Absher, D.M., Hernandez, D., Ferrucci, L., Bandinelli, S., Lohman, K., Ding, J., Trevisi, L., Gustafsson, S., Sandling, J.H., Stolk, L., Uitterlinden, A.G., Yet, I., Castillo-Fernandez, J.E., Spector, T.D., Schwartz, J.D., Vokonas, P., Lind, L., Li, Y., Fornage, M., Arnett, D.K., Wareham, N.J., Sotoodehnia, N., Ong, K.K., van Meurs, J.B.J., Conneely, K.N., Baccarelli, A.A., Deary, I.J., Bell, J.T., North, K.E., Liu, Y., Waldenberger, M., London, S.J., Ingelsson, E. & Levy, D. (2018). A DNA methylation biomarker of alcohol consumption. Molecular Psychiatry, 23, 422–443. https://doi.org/10.1038/mp.2016.192

Szutorisz, H. & Hurd, Y.L. (2016). Epigenetic effects of cannabis exposure. Biological Psychiatry. 79(7), 586-594. https://doi.org/10.1016/j.biopsych.2015.09.014

Szutorisz, H. & Hurd, Y.L. (2018). High times for cannabis: Epigenetic imprint and its legacy on brain and behavior. Neuroscience & Biobehavioral Reviews, 85, 93-101. https://doi.org/10.1016/j.neubiorev.2017.05.011

Tuesta, L.M. & Zhang, Y. (2014). Mechanisms of epigenetic memory and addiction. The EMBO Journal, 33(10), 1091-1103. https://doi.org/10.1002/embj.201488106

Umesh, S., Khess, C.R.J., Simlai, J. & Bose, S. (2015). The role of epigenetic mechanisms in substance use disorders: An overview. Hereditary Genetics, 4, 149. https://doi.org/10.4172/2161-1041.1000149

UNODC/WHO (2020). International standards for the treatment of drug use disorders. https://www.unodc.org/documents/drug-prevention-and-treatment/UNODC-WHO_International_Treatment_Standards_March_2020.pdf

Vandenbroucke, J.P., von Elm, E., Altman, D.G., Gotzsche, P.C., Mulrow, C.D. & Pocock, S.J. (2007). Strobe Initiative. Strengthening the reporting of observational studies in epidemiology (STROBE): explanation and elaboration. PLoS Medicine, 4(10), e297. https://doi.org/10.1016/j.ijsu.2014.07.014

Vassoler, F.M., White, S.L., Schmidt, H.D., Sadri-Vakili, G., & Pierce, R.C. (2013). Epigenetic inheritance of a cocaine-resistance phenotype. Nature neuroscience, 16(1), 42–47. https://doi.org/10.1038/nn.3280

Volkow, N., Wang, G.J., Fowler, J. & Tomasi, D. (2012). Addiction circuitry in the human brain. Annual Review of Pharmacology and Toxicology, 52, 321-336. https://doi.org/10.1146/annurev-pharmtox-010611-134625

Walker, D. & Nestler, E. (2018). Neuroepigenetics and addiction. Handbook of Clinical Neurology, 148, 747-765. https://doi.org/10.1016/B978-0-444-64076-5.00048-X

Wong, C., Mill, J. & Fernandes, C. (2011). Drugs and addiction: an introduction to epigenetics. Addiction, 106(3), 480-489. https://doi.org/10.1111/j.1360-0443.2010.03321.x

Zakhari, S. (2013). Alcohol metabolism and epigenetics changes. Alcohol research, 35(1), 6-16.

Published

03/06/2022

How to Cite

FERREIRA, A. P. .; NICHELE , C. da S. T.; SANTOS, J. B. dos .; CRUZ-HERNÁNDEZ, M. J. . The complex epigenetic interaction in the predisposition to drug dependence: a systematic literature review. Research, Society and Development, [S. l.], v. 11, n. 7, p. e51911730216, 2022. DOI: 10.33448/rsd-v11i7.30216. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/30216. Acesso em: 7 jul. 2022.

Issue

Section

Review Article