Evidence associated with the metabolic effect of carbohydrate restriction in patients with type II diabetes mellitus: An integrative literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i8.30333

Keywords:

Carbohydrate-restricted diet; Type 2 diabetes mellitus; Diet; Health Teaching.

Abstract

Type 2 Diabetes Mellitus (DM2) is one of the non-communicable pathologies that have a high prevalence, incidence in Brazil and in the world, and may be related to the development of cardiovascular diseases and other comorbidities. Evidence suggests that dietary management based on carbohydrate restriction has significant effects on the course of the disease, given that it is a nutrient that has the greatest impact on postprandial blood glucose. The aim of the study was to highlight the metabolic effects that carbohydrate restriction provides in individuals with type II diabetes mellitus. This is an integrative literature review carried out in the Virtual Health Library (VHL) and PubMed. Controlled and randomized clinical trials published in the last 6 years in English were prioritized, among the exclusion criteria, all studies that did not approach the selected methodology in question. The following Health Sciences Descriptors (DeCS) were used: “carbohydrate-restricted diet”, “type 2 diabetes mellitus” and diet, for this purpose, the Boolean operator “AND” was used. The results indicate that a low-carbohydrate diet results in a decrease in cardiometabolic indicators, such as: better control of metabolic parameters related to glycemic and lipid profiles, greater predisposition to reduce anthropometric measurements and less need for hypoglycemic drugs. Therefore, it is concluded that the dietary approach is fundamental in the treatment and prevention of this disorder, especially when based on carbohydrate restriction.

Author Biography

Priscylla Tavares Almeida, Centro Universitário de Juazeiro do Norte

Nutricionista especialista em nutrição e treinamento físico pela Faculdade de Juazeiro do Norte

References

Athinarayanan, S. J., Hallberg, S. J., McKenzie, A. L., Lechner, K., King, S., McCarter, J. P., Volek, J. S., Phinney, S. D., & Krauss, R. M. (2020). Impact of a 2-year trial of nutritional ketosis on indices of cardiovascular disease risk in patients with type 2 diabetes. Cardiovascular diabetology, 19(1), 208. https://doi.org/10.1186/s12933-020-01178-2

Barbosa-Yañez, R. L., Dambeck, U., Li, L., Machann, J., Kabisch, S., & Pfeiffer, A. (2018). Acute Endothelial Benefits of Fat Restriction over Carbohydrate Restriction in Type 2 Diabetes Mellitus: Beyond Carbs and Fats. Nutrients, 10(12), 1859. https://doi.org/10.3390/nu10121859

Chang, CR, François, ME, & Little, JP (2019). A restrição de carboidratos no café da manhã é suficiente para reduzir a exposição de 24 horas à hiperglicemia pós-prandial e melhorar a variabilidade glicêmica. The American Journal of Clinical Nutrition , 109 (5), 1302-1309. https://doi.org/10.1093/ajcn/nqy261

Ch'ng, L. Z., Barakatun-Nisak, M. Y., Wan Zukiman, W., Abas, F., & Wahab, N. A. (2019). Nutritional strategies in managing postmeal glucose for type 2 diabetes: A narrative review. Diabetes & metabolic syndrome, 13(4), 2339–2345. https://doi.org/10.1016/j.dsx.2019.05.026

Chen, CY., Huang, WS., Ho, MH. et ai. O potencial efeito prolongado em um ano de acompanhamento após 18 meses de ensaio clínico randomizado de uma dieta pobre em carboidratos de 90 g/dia em pacientes com diabetes tipo 2. Nutr. Diabetes 12, 17 (2022).

Dellis, D., Tsilingiris, D., Eleftheriadou, I., Tentolouris, A., Sfikakis, P. P., Jr, Dellis, G., Karanasiou, M., Meimari, A., Dimosthenopoulos, C., Lazarou, S., & Tentolouris, N. (2020). Carbohydrate restriction in the morning increases weight loss effect of a hypocaloric Mediterranean type diet: a randomized, parallel group dietary intervention in overweight and obese subjects. Nutrition (Burbank, Los Angeles County, Calif.), 71, 110578. https://doi.org/10.1016/j.nut.2019.110578

Dening, J., George, E. S., Ball, K., Mohebbi, M., & Shariful Islam, S. M. (2022). Randomised controlled trial of a web-based low carbohydrate diet intervention for adults with type 2 diabetes: the T2Diet study protocol. BMJ open, 12(2), e054594. https://doi.org/10.1136/bmjopen-2021-054594

Durrer, C., McKelvey, S., Singer, J., Batterham, A. M., Johnson, J. D., Gudmundson, K., Wortman, J., & Little, J. P. (2021). A randomized controlled trial of pharmacist-led therapeutic carbohydrate and energy restriction in type 2 diabetes. Nature communications, 12(1), 5367. https://doi.org/10.1038/s41467-021-25667-4

Francois, M. E., Myette-Cote, E., Bammert, T. D., Durrer, C., Neudorf, H., DeSouza, C. A., & Little, J. P. (2018). Carbohydrate restriction with postmeal walking effectively mitigates postprandial hyperglycemia and improves endothelial function in type 2 diabetes. American journal of physiology. Heart and circulatory physiology, 314(1), H105–H113. https://doi.org/10.1152/ajpheart.00524.2017

Han, Y., Cheng, B., Guo, Y., Wang, Q., Yang, N., & Lin, P. (2021). A Low-Carbohydrate Diet Realizes Medication Withdrawal: A Possible Opportunity for Effective Glycemic Control. Frontiers in endocrinology, 12, 779636. https://doi.org/10.3389/fendo.2021.779636

Kakoschke, N., Zajac, I. T., Tay, J., Luscombe-Marsh, N. D., Thompson, C. H., Noakes, M., Buckley, J. D., Wittert, G., & Brinkworth, G. D. (2021). Effects of very low-carbohydrate vs. high-carbohydrate weight loss diets on psychological health in adults with obesity and type 2 diabetes: a 2-year randomized controlled trial. European journal of nutrition, 60(8), 4251–4262. https://doi.org/10.1007/s00394-021-02587-z

McKenzie, A. L., Athinarayanan, S. J., McCue, J. J., Adams, R. N., Keyes, M., McCarter, J. P., Volek, J. S., Phinney, S. D., & Hallberg, S. J. (2021). Type 2 Diabetes Prevention Focused on Normalization of Glycemia: A Two-Year Pilot Study. Nutrients, 13(3), 749. https://doi.org/10.3390/nu13030749

Röhling, M., Kempf, K., Banzer, W., Berg, A., Braumann, K. M., Tan, S., Halle, M., McCarthy, D., Pinget, M., Predel, H. G., Scholze, J., Toplak, H., Martin, S., & Acoorh Study Group (2020). Prediabetes Conversion to Normoglycemia Is Superior Adding a Low-Carbohydrate and Energy Deficit Formula Diet to Lifestyle Intervention-A 12-Month Subanalysis of the ACOORH Trial. Nutrients, 12(7), 2022. https://doi.org/10.3390/nu12072022

Samkani, A., Skytte, MJ, Anholm, C. et ai. Os efeitos agudos da redução de carboidratos na dieta nas respostas pós-prandiais de ácidos graxos não esterificados e triglicerídeos: um estudo randomizado. Lipídios Saúde Dis 17, 295 (2018). https://doi.org/10.1186/s12944-018-0953-8

Saslow, L. R., Daubenmier, J. J., Moskowitz, J. T., Kim, S., Murphy, E. J., Phinney, S. D., Ploutz-Snyder, R., Goldman, V., Cox, R. M., Mason, A. E., Moran, P., & Hecht, F. M. (2017). Twelve-month outcomes of a randomized trial of a moderate-carbohydrate versus very low-carbohydrate diet in overweight adults with type 2 diabetes mellitus or prediabetes. Nutrition & diabetes, 7(12), 304. https://doi.org/10.1038/s41387-017-0006-9

Sato, J., Kanazawa, A., Makita, S., Hatae, C., Komiya, K., Shimizu, T., Ikeda, F., Tamura, Y., Ogihara, T., Mita, T., Goto, H., Uchida, T., Miyatsuka, T., Takeno, K., Shimada, S., Ohmura, C., Watanabe, T., Kobayashi, K., Miura, Y., Iwaoka, M., … Watada, H. (2017). A randomized controlled trial of 130 g/day low-carbohydrate diet in type 2 diabetes with poor glycemic control. Clinical nutrition (Edinburgh, Scotland), 36(4), 992–1000. https://doi.org/10.1016/j.clnu.2016.07.003

Skytte, M. J., Samkani, A., Petersen, A. D., Thomsen, M. N., Astrup, A., Chabanova, E., Frystyk, J., Holst, J. J., Thomsen, H. S., Madsbad, S., Larsen, T. M., Haugaard, S. B., & Krarup, T. (2019). A carbohydrate-reduced high-protein diet improves HbA1c and liver fat content in weight stable participants with type 2 diabetes: a randomised controlled trial. Diabetologia, 62(11), 2066–2078. https://doi.org/10.1007/s00125-019-4956-4

Souza, M. T. D., Silva, M. D. D., & Carvalho, R. D. (2010). Revisão integrativa: o que é e como fazer. Einstein (São Paulo), 8, 102-106.

Tay, J., Thompson, C. H., Luscombe-Marsh, N. D., Wycherley, T. P., Noakes, M., Buckley, J. D., Wittert, G. A., Yancy, W. S., Jr, & Brinkworth, G. D. (2018). Effects of an energy-restricted low-carbohydrate, high unsaturated fat/low saturated fat diet versus a high-carbohydrate, low-fat diet in type 2 diabetes: A 2-year randomized clinical trial. Diabetes, obesity & metabolism, 20(4), 858–871. https://doi.org/10.1111/dom.13164

Wang, L. L., Wang, Q., Hong, Y., Ojo, O., Jiang, Q., Hou, Y. Y., Huang, Y. H., & Wang, X. H. (2018). The Effect of Low-Carbohydrate Diet on Glycemic Control in Patients with Type 2 Diabetes Mellitus. Nutrients, 10(6), 661. https://doi.org/10.3390/nu10060661

Published

18/06/2022

How to Cite

ALMEIDA, P. T.; MORAIS, I. C. L. de .; HARTCOPFF, P. F. P. .; SILVA, M. R. R. B. da .; SOUSA, L. N. de .; BRITO, D. de .; SILVA, R. F. da .; CORREIA, A. K. G. de F. .; RUSSELL, E. S. .; SILVA, S. F. da .; DUTRA, L. M. S. . Evidence associated with the metabolic effect of carbohydrate restriction in patients with type II diabetes mellitus: An integrative literature review . Research, Society and Development, [S. l.], v. 11, n. 8, p. e27311830333, 2022. DOI: 10.33448/rsd-v11i8.30333. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/30333. Acesso em: 22 nov. 2024.

Issue

Section

Health Sciences