Association between COVID-19 and Type 2 Diabetes Mellitus: systematic review




COVID-19; Type 2 Diabetes Mellitus; Pandemic; Health teaching.


People with Type 2 Diabetes Mellitus are more likely to develop COVID-19 compared to people with other comorbidities. These factors are partly due to the fact that the ACE-2 receptor, through which the coronavirus enters cells, affects the body's glucose metabolism, which can exacerbate the symptoms of both diseases. To analyze the association between COVID-19 and Type 2 Diabetes Mellitus in order to elucidate the main factors associated with the profile of these patients. Observational, retrospective cohort and cross-sectional studies were selected using the criteria according to Prisma - Preferred Reporting Items for Systematic Reviews and Meta-Analyses, published between 2019-2021 on the following data platforms: SciELO, Virtual Health Library (BVS) and PubMed. The results suggest an association between predominantly mild COVID-19 disease and newly diagnosed type 2 diabetes mellitus. However, it cannot be completely ruled out that factors other than the viral infection itself influence the manifestation of type 2 diabetes. The change in the predominantly sedentary lifestyle, especially during confinement, and the change in eating habits may have increased body weight and , therefore, the risk of type 2 diabetes. Patients with type 2 Diabetes Mellitus (DM2) are more vulnerable to the worsening of COVID-19 due to the peculiarities of their immune status and immune response to a viral attack, high virus activity in conditions of hyperglycemia, in the presence of comorbidity and obesity and in the elderly, which often accompany the course of T2DM.


Albuquerque, A. C. B., Albuquerque, J. B., Gomes, V. M. D. O., Martins, D. R., & Watanabe, A. S. A. (2021). A Tempestade De Citocinas Na Covid-19: Uma Revisão Narrativa. Revista Multidisciplinar em Saúde, 2(2), 23-23.

Al‐Ozairi, E., Brown, R., Hamdan, Y., Alabdullah, L., Voase, N., Al Kandari, J., ... & Welsh, P. (2021). Risk of mortality among inpatients with COVID‐19 and type 2 diabetes: National data from Kuwait. Endocrinology, Diabetes & Metabolism, 4(4), e00287. /doi/abs/10.1002/edm2.287

Arruda, D. É. G., Martins, D. D. S., da Silva, I. F. M., & de Sousa, M. N. A. (2020). Prognóstico de pacientes com COVID-19 e doenças crônicas: uma revisão sistemática. Comunicação em Ciências da Saúde, 31(03), 79-88.

Barron, E., Bakhai, C., Kar, P., Weaver, A., Bradley, D., Ismail, H., ... & Valabhji, J. (2020). Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study. The lancet Diabetes & endocrinology, 8(10), 813-822.

Boye, K. S., Erdemir, E. T., Zimmerman, N., Reddy, A., Benneyworth, B. D., Dabora, M. C., ... & Etemad, L. (2021). Risk factors associated with COVID-19 hospitalization and mortality: a large claims-based analysis among people with type 2 diabetes mellitus in the United States. Diabetes Therapy, 12(8), 2223-2239.

da Silva, C. R. (2021). Covid-19: diabetes mellitus como fator agravante. In Anais Da Mostra De Iniciação Científica Do Cesuca-ISSN 2317-5915, (15).

de Brito, V. P., Carrijo, A. M. M., & de Oliveira, S. V. (2020). Associação da Diabetes Mellitus com a gravidade da COVID-19 e seus potenciais fatores mediadores: uma revisão sistemática. Revista Thema, 18, 204-217.

Dennis, J. M., Mateen, B. A., Sonabend, R., Thomas, N. J., Patel, K. A., Hattersley, A. T., ... & Vollmer, S. J. (2021). Type 2 diabetes and COVID-19–Related mortality in the critical care setting: a national cohort study in England, March–July 2020. Diabetes care, 44(1), 50-57.

Duarte, P. M. (2020). COVID-19: Origem do novo coronavírus. Brazilian Journal of Health Review, 3(2), 3585-3590. https://www.brazilianjournals. com/index.php/BJHR/article/view/9131

Felix, H. C., Andersen, J. A., Willis, D. E., Malhis, J. R., Selig, J. P., & McElfish, P. A. (2021). Control of type 2 diabetes mellitus during the COVID-19 pandemic. Primary care diabetes, 15(5), 786-792. https://

Ferreira, L. L., & Andricopulo, A. D. (2020). Medicamentos e tratamentos para a Covid-19. Estudos avançados, 34, 7-27. gnxzKMshkcpd7kgRQy3W7bP/abstract/?lang=pt

Han, M., Ma, K., Wang, X., Yan, W., Wang, H., You, J., ... & Luo, X. (2021). Immunological characteristics in type 2 diabetes mellitus among COVID-19 patients. Frontiers in endocrinology, 12, 158.

Lima, B. S., Frota, M. C. M., Ramos, S. P., Júnior, J. L. P., & Neto, A. D. P. R. N. (2021). Diabetes mellitus e sua relação com a COVID-19: um panorama atual proveniente de uma revisão sistemática. Research, Society and Development, 10(15), e384101522598-e384101522598. index.php/rsd/article/view/22598

Marinho, F. P., de Loyola, I. S., Monteiro, I. D. O. F., Castro, T. M., Carvalho, M. D. G. S., Garcia, J. A. D., ... & Santos, G. B. (2021). Inter-relação entre COVID-19 e diabetes mellitus: uma revisão sistemática. Research, Society and Development, 10(2), e4810212191-e4810212191. index.php/rsd/article/view/12191

SBD, Sociedade Brasileira de Diabetes. (2021). Autocuidado E Diabetes Em Tempos De Covid-19. São Paulo: Editora SBD.

Souza, A. S. R., Amorim, M. M. R., Melo, A. S. D. O., Delgado, A. M., Florêncio, A. C. M. C. D., Oliveira, T. V. D., ... & Katz, L. (2021). Aspectos gerais da pandemia de COVID-19. Revista Brasileira de Saúde Materno Infantil, 21, 29-45. qVhzjfsr/abstract/?lang=pt

You, J. H., Lee, S. A., Chun, S. Y., Song, S. O., Lee, B. W., Kim, D. J., & Boyko, E. J. (2020). Clinical outcomes of COVID-19 patients with type 2 diabetes: a population-based study in Korea. Endocrinology and Metabolism, 35(4), 901.

Zhang, Q., Wei, Y., Chen, M., Wan, Q., & Chen, X. (2020). Clinical analysis of risk factors for severe COVID-19 patients with type 2 diabetes. Journal of Diabetes and its Complications, 34(10), 107666.

Zheng, M., Wang, X., Guo, H., Fan, Y., Song, Z., Lu, Z., ... & Ye, S. (2021). The cytokine profiles and immune response are increased in COVID-19 patients with type 2 diabetes mellitus. Journal of diabetes research, 2021.

Zhu, L., She, Z. G., Cheng, X., Qin, J. J., Zhang, X. J., Cai, J., ... & Li, H. (2020). Association of blood glucose control and outcomes in patients with COVID-19 and pre-existing type 2 diabetes. Cell metabolism, 31(6), 1068-1077.



How to Cite

NASCIMENTO, A. K. A.; CUNHA, A. da S.; VIEIRA, D. do S. R. . Association between COVID-19 and Type 2 Diabetes Mellitus: systematic review. Research, Society and Development, [S. l.], v. 11, n. 7, p. e50111730338, 2022. DOI: 10.33448/rsd-v11i7.30338. Disponível em: Acesso em: 3 mar. 2024.



Health Sciences