Evidence about the anticarcinogenic potential of allium cepa: an integrative literature review
DOI:
https://doi.org/10.33448/rsd-v11i7.30414Keywords:
Allium cepa; Onion; Cancer; Oxidation.Abstract
Introduction: Onion (Allium cepa) is a widely used ingredient in Brazilian gastronomy, as well as being used medicinally for over 4000 thousand years as a treatment for a variety of diseases, including headaches, insect bites, intestinal worms and tumors. Objective: to elucidate the main evidence about the possible anticarcinogenic potential conferred on onions. Methodology: this is a descriptive research of the type narrative review of the literature, which sought to answer the main evidence about the anticarcinogenic potential of onion. The research was carried out through online access to the National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (Scielo), Cochrane Database of Systematic Reviews (CDSR), Google Scholar, Virtual Health Library (BVS) and EBSCO databases. Information Services. Results and Discussion: Onion intake may decrease the risk of sarcoma and carcinoma in various tissues and organs such as stomach, colon, esophagus, prostate, bladder, liver, lungs, breasts, skin and brain. Thus, it is possible to affirm that onion exerts its anticarcinogenic action indirectly through different mechanisms: alteration of carcinogenic metabolism or increasing the activity of detoxification enzyme systems that increases carcinogenic polarity, inhibition of oxidative damage due to its antioxidant action; inhibition of cell proliferation by inducing apoptosis and inhibition of cell division, prevention of chromosomal damage (anticlastogenic effect); and inhibition of lipoxygenase and cyclooxygenase activities (anti-inflammatory effect). Final Thoughts: While the minimum daily intake needed to reduce cancer risk is yet to be determined, onion intake may offer protection against cancer development.
References
Alzani, A. A., et al. (2021). Extrato de cebola encapsulado em nanoquitosana: um agente anticâncer promissor. Journal of Gastrointestinal Cancer, 8 (7), 67-71.
Arnault, I., et al. (2006). Seleno-compostos no alho e na cebola. Journal of Chromatography, 11 (23).
Bastaki, S. M. A., et al. (2021). Chemical constituents and medicinal properties of Allium species. Mol Cell Biochem, 5 (1), 1-9.
Bystrická, J., et al. (2013). Componentes bioativos da cebola (Allium cepa L.) Acta Aliment., 42 (4), 11-22.
Dorrigiv, M., et al. (2021). Onion (Allium cepa) and its Main Constituents as Antidotes or Protective Agents against Natural or Chemical Toxicities: a Comprehensive Review. Iran J Pharm Res., 20 (11), 3-26.
Elhassaneen, Y. A., et al. (2014). A casca de cebola em pó alivia a citotoxicidade e imunotoxicidade induzidas pela acrilamida em cultura de células hepáticas. Life Sci., 11 (4), 381-388.
Hassanpour, S. H., et al. (2017). Review of cancer from perspective of molecular. Journal of Cancer Research and Practice, 5 (9), 45-52.
Hosseini, S., et al. (2018). Efeitos de extratos de plantas e compostos bioativos na atenuação da fibrose pulmonar induzida por bleomicina. Biomed & Pharmacother., 107 (3), 1454-1465.
Instituto Nacional de Câncer (INCA). Posicionamento do Instituto Nacional de Câncer José Alencar Gomes da Silva Acerca dos Agrotóxicos. 2011. Disponivel em: <http://bvsms.saude.gov.br/bvs/publicacoes/abc_do_cancer.pdf>. Acesso em: 22 mar. 2022.
Ko, E. Y., et al. (2018). Potencial antioxidante e antiplaquetário de diferentes frações do metanol e flavonóis extraídos da cebola (Allium cepa L.). Biotech., 8 (2).
Lautraite, S., et al. (2002). Os flavonóides inibem a toxicidade genética produzida por carcinógenos em células que expressam CYP1A2 e CYP1A1. Mutagênese, 17 (1), 45-53.
Lee, B. K., et al. (2016). Allium cepa extract and quercetin protect neuronal cells from oxidative stress via PKC-ε inactivation/ERK1/2 activation. Oxid Med Cell Longev., 24 (9).
Masoli, M., et al. (2004). The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy, 59 (5), 469-478.
Nakagome, K., et al. (2011). Pathogenesis of airway inflammation in bronchial asthma. Auris Nasus Larynx, 38 (3), 555-563.
Nilo, A., et al. (2021). O espirosídeo extraído da casca da cebola roxa melhora a apoptose e exerce potentes efeitos antitumorais, antioxidantes e inibidores de enzimas. Food Chem Toxicol., 154 (11).
Ola-Mudathir, K. F., et al. (2014). Efeitos antioxidantes do extrato metanólico de Allium cepa linn na toxicidade renal induzida por cianeto em ratos wistar machos. Níger. J. Physiol. Sci., 29 (1), 147-151.
Parton, K. (2000). Toxicidade da cebola em animais de criação. NZ Vet. J., 48 (1).
Ritter, J. M., et al. (2020). Rang & Dale: Farmacologia. Guanabara Koogan, 9. ed.
Roldan, E., et al. (2008). Characterisation of onion (Allium cepa L.) by-products as food ingredients with antioxidant and antibrowning properties. Food Chem., 108 (1), 907-916.
Roldan-Marin, E., et al. (2009). Efeitos de um subproduto da cebola na bioatividade e marcadores de segurança em ratos saudáveis. Br. J. Nutr., 102 (4), 1574-1582.
Silva, A.E., et al. (2004). Carcinogênese Hormonal e neoplasias hormônio-dependentes. Revista Ciência Rural, 34 (2), 625-633.
Tang, X., et al. (2008). Um estudo experimental de hemólise induzida por envenenamento por cebola (Allium cepa) em cães. J. Vet. Pharmacol. Ther., 31 (4), 143-149.
Votto, A. P., et al. (2010). Mecanismos de toxicidade de extratos e compostos de cebola (Allium cepa) em linhagens de células eritroleucêmicas multirresistentes. Biol. Res., 43 (3), 429-437.
Ward, L. S. (2002). Entendendo o Processo Molecular da Tumorigênese. Arquivos Brasileiros de Endocrinologia & Metabologia, 46 (4), 351-360.
Zhao, X. X., et al. (2021). Recent Advances in Bioactive Compounds, Health Functions, and Safety Concerns of Onion (Allium cepa L.). Front Nutr., 8 (6), 1-9.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Bárbara Queiroz de Figueiredo; Amabille Dellalibera Simões; Bárbara Ferreira de Brito; Carlos Antônio da Silva Júnior; Diândria Mendonça Martins do Prado; Diego da Rocha; Luis Ferreira Neto; Milena Valdineia da Silva; Paulo da Costa Araújo; Tayná Lima Rodrigues
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
