Influence of drugs on laboratory results of blood tests: a biomedical look

Authors

DOI:

https://doi.org/10.33448/rsd-v11i8.30508

Keywords:

Drugs; Clinical Laboratory Techniques; Hematologic Tests; Health teaching.

Abstract

Within current clinical practice, the concomitant association of multiple drugs for the treatment of chronic pathologies is a common procedure in the therapeutic drug experience. In which the complex and diverse clinical laboratory routine can be influenced by the existence of drug interference. From this perspective, through a bibliographic research of the integrative review type in the databases of the Virtual Health Library, using the insertion of the DeCS: Pharmaceutical Preparations/Pharmaceutical Preparations, Drugs, (Hematological test), combined with the help of the Boolean operator "AND", the present study sought to describe, based on the current literature, the laboratory changes caused by the use of medicines in the results of blood tests of patients. From the interpretation of the data, synthesized by the review, it was observed that the three drugs with the highest numbers of repressions in the results of blood test parameters were Methylphenidate, Capecitabine and Clozapine. Therefore, during clinical practice, biomedical professionals become fundamental pieces for carrying out an adequate analysis of changes in biochemical markers caused by medications.

References

Brasil. Agência Nacional de Vigilância Sanitária (ANVISA). (2013). Conceitos Técnicos. Brasília, DF. http://www.anvisa.gov.br/medicamentos/conceito.htm#1.2.

Charach, G., Karniel, E., Grosskopf, I., Rabinovich, A., & Charach, L. (2020). Methylphenidate has mild hyperglycemic and hypokalemia effects and increases leukocyte and neutrophil counts. Medicine, 99(27), Artigo e20931. https://doi.org/10.1097/md.0000000000020931

Donnelly, L. A., Dennis, J. M., Coleman, R. L., Sattar, N., Hattersley, A. T., Holman, R. R., & Pearson, E. R. (2020). Risk of anemia with metformin use in type 2 diabetes: A MASTERMIND study. Diabetes Care, 43(10), 2493–2499. https://doi.org/10.2337/dc20-1104

Ferreira, B., Santos, K., Rudolph, S., Alcanfor, J., & Cunha, L. (2009). Estudo dos medicamentos utilizados pelos pacientes atendidos em laboratório de análises clínicas e suas interferências em testes laboratoriais: Uma revisão da literatura. Revista Eletrônica de Farmácia, 6(1). https://doi.org/10.5216/ref.v6i1.5859

Freitas, A. V., Freitas, M. V., Oliveira, C. G. A., Oliveira, W. D., Kashima, Y. M. P., & Barreto, J. G. (2018). Estudo da variabilidade de bilirrubina total e direta expostas à luz ambiente. Acta Biomédica Brasiliensia, 9(3), 72. https://doi.org/10.18571/acbm.187

Gharab, K. M., Onmaz, D. E., Abusoglu, S., Aydin, M., Sivrikaya, A., Tok, O., Abusoglu, G., & Unlu, A. (2020). The relationship between serum clozapine concentrations and hematological parameters by a validated mass spectrometric method. Journal of Pharmaceutical and Biomedical Analysis, 180, 113056. https://doi.org/10.1016/j.jpba.2019.113056

Junqueira, D. R. G. (2012). Desafios metodológicos em epidemiologia: uma abordagem com foco na reação adversa da trombocitopenia induzida por heparina e na condição clínica da dor lombar. [Tese de Doutorado, Universidade Federal de Minas Gerais].

Kortekaas-Rijlaarsdam, A. F., Luman, M., Sonuga-Barke, E., & Oosterlaan, J. (2018). Does methylphenidate improve academic performance? A systematic review and meta-analysis. European Child & Adolescent Psychiatry, 28(2), 155–164. https://doi.org/10.1007/s00787-018-1106-3

Leitoles, P. J. N. C., Lenhardt, M. M., Silva, B. K. F., & Tenfen, A. (2021). Interações fisiológicas causadas por medicamentos em exames bioquímicos de perfil renal e hepático/ physiological interactions caused by drugs in biochemical tests of renal and hepatic profile. Brazilian Journal of Development, 7(1), 10329–10348. https://doi.org/10.34117/bjdv7n1-702

Maduell, F., Belmar, L., Ugalde, J., Laguno, M., Martínez-Rebollar, M., Ojeda, R., Arias, M., Rodas, L., Rossi, F., Llovet, L.-P., González, L. N., Mallolas, J., & Londoño, M.-C. (2019). Elimination of hepatitis C virus infection from a hemodialysis unit and impact of treatment on the control of anemia. Gastroenterología y Hepatología (English Edition), 42(3), 164–170. https://doi.org/10.1016/j.gastre.2019.02.029

Marquito, A. B., Fernandes, N. M. S., Colugnati, F. A. B., & Paula, R. B. (2014). Identifying potential drug interactions in chronic kidney disease patients. Jornal Brasileiro de Nefrologia, 36(1), 26–34. https://doi.org/10.5935/0101-2800.20140006

Mijovic, A., & MacCabe, J. H. (2020). Clozapine-induced agranulocytosis. Annals of Hematology, 99(11), 2477–2482. https://doi.org/10.1007/s00277-020-04215-y

Ocanto, A., Debén, B., Rodríguez, I., Belinchón, B., Glaría, L., & Morera, R. (2020). Relación entre marcadores hematológicos y la respuesta patológica completa al tratamiento neoadyuvante en cáncer de recto localmente avanzado. Journal of Negative and No Positive Results, 5(11), 1356-1366.

Önder, S., & Ozturk, M. (2019). How does omalizumab affect the immunoinflammatory response in patients with chronic spontaneous urticaria? Cutaneous and Ocular Toxicology, 39(1), 31–35. https://doi.org/10.1080/15569527.2019.1684316

Pereira, J. P.,Faustino, S. M. M.; RODRIGUES, A. S. N. (2011). Análise dos problemas encontrados na execução do coagulograma em laboratórios da cidade de Macapá-Amapá. Ciência equatorial, 1(1).

Phukan, A., Mandal, P. K., & Dolai, T. K. (2020). Efficacy and safety profile of generic imatinib in patients with newly diagnosed chronic myeloid leukemia-chronic phase: Sharing experience of a hemato-oncology center from eastern India. Annals of Hematology, 100(1), 85–96. https://doi.org/10.1007/s00277-020-04289-8

Santos, S. L. F. d., Borges, R. N., & Barros, K. B. N. T. (2018). Drugs that interfere with the results of laboratory tests: An integrative review of the literature. Revista Brasileira de Análises Clínicas, 50(2). https://doi.org/10.21877/2448-3877.201800581

Siddiqui, N. S., Godara, A., Byrne, M. M., & Saif, M. W. (2019). Capecitabine for the treatment of pancreatic cancer. Expert Opinion on Pharmacotherapy, 20(4), 399–409. https://doi.org/10.1080/14656566.2018.1560422

Silva, R. S., Domingueti, C. P., Tinoco, M. S., Veloso, J. C., Pereira, M. L., Baldoni, A. O., & Rios, D. R. (2021). Interferência dos medicamentos nos exames laboratoriais. Jornal Brasileiro de Patologia e Medicina Laboratorial, 57.

Silva, N. A. T., Marcolino, K. G. A., Frade, R. I., & Alves, F. (2020). Análise Comparativa das Principais Alterações Hematológicas e Renais em Pacientes Adultos com Câncer Metastático Submetidos À Poliquimioterapia. NBC-Periódico Científico do Núcleo de Biociências, 10(20).

Souza, M. T., Silva, M. D., & Carvalho, R. (2010). Integrative review: What is it? How to do it? Einstein (São Paulo), 8(1), 102–106. https://doi.org/10.1590/s1679-45082010rw1134

Tamer, F. (2020). Omalizumab does not lead to a distinct alteration in hematological parameters and complete blood count-derived inflammation biomarkers except for basophil count. Cutaneous and Ocular Toxicology, 39(3), 229–232. https://doi.org/10.1080/15569527.2020.1766483

Wiciński, M., & Węclewicz, M. M. (2018). Clozapine-induced agranulocytosis/granulocytopenia. Current Opinion in Hematology, 25(1), 22–28. https://doi.org/10.1097/moh.0000000000000391

Zonozi, R., Wallace, Z. S., Laliberte, K., Huizenga, N. R., Rosenthal, J. M., Rhee, E. P., Cortazar, F. B., & Niles, J. L. (2020). Incidence, Clinical Features, and Outcomes of Late‐Onset Neutropenia From Rituximab for Autoimmune Disease. 27(2), 347–354. https://doi.org/10.1002/art.41501

Published

10/06/2022

How to Cite

PACHECO , M. V. de M. .; FREITAS, M. T. de S. . Influence of drugs on laboratory results of blood tests: a biomedical look. Research, Society and Development, [S. l.], v. 11, n. 8, p. e8411830508, 2022. DOI: 10.33448/rsd-v11i8.30508. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/30508. Acesso em: 26 apr. 2024.

Issue

Section

Health Sciences