Analysis of the influence of β-TCP particle size on deagglomeration processes




β-tricalcium phosphate; particle size; high energy ball milling; agate mortar.


There are a class of material widely used in bone tissue repair. This material is calcium phosphate ceramics (CPCs)that can be used on two phases: α and β. However, β-TCP is more used in bone regeneration than α–TCP due to the biocompatible and bioactive properties.In the present work evaluate the influence of these two distinct processes to deagglomeration and the consequence in the particle size of the β-TCP obtained through solid-state reaction. Among all of the routes used in research and industry to reduce the particles size of different materials, the high energy ball milling is one of the most effective, due to the high rotation speed that this process achieves. The deagglomeration through agate mortar is considered a cheaper process when compared with the high energy ball milling. The characterization of both powders, deagglomerated in high energy ball milling and agate mortar, was realized through scanning electron microscopy, to analyze the powder morphology, and laser granulometry, to determine the size of the particles. Also, the forerunner powder was previously submitted to x-ray diffraction to confirm the formation of the β-TCP phase. The analysis through x-ray diffraction confirmed that the phase formed during the calcination process corresponded to the β-TCP. The results obtained after the deagglomeration processes indicated that the morphology was predominantly irregular for both powders. In relation to the granulometry, the deagglomeration performed through agate mortar showed to produce particles with smaller size (11,4µm e 0,9µm) and heterogeneous distribution, while the high energy ball milling process produced particles with larger size (11,4µm a 1,8µm) and higher homogeneity.


Hench L. L.; Polak J. M. (2002). Third-generation biomedical materials. Science, 295:1014–7.

Tang Z.; Li X.; Tan Y. et al. (2018). The material and biological characteristics of oste-oinductive calcium phosphate ceramics. Regen Biomater.;5(1):43-59, Feb.

Li X.; GUO B.; Xiao Y. et al. (2016). Influences of the steam sterilization on the proper-ties of calcium phosphate porous bioceramics. J Mater Sci Mater Med; 27:5–14.

Hong Y.; Fan H.; Li B. et al. (2010). Fabrication, biological effects, and medical applica-tions of calcium phosphate nanoceramics. Mater Sci Eng R Rep;70:225–42.

Wang J.; Chen Y.; Zhu X. et al. (2014). Effect of phase composition on protein adsorption and osteoinduction of porous calcium phosphate ceramics in mice. J Biomed Mater Res A; 102:4234–43.

Parent M.; Baradari H.; Champion E. et al. (2017). Design of calcium phosphate ceramics for drug delivery applications in bone diseases: a review of the parameters affecting the loading and release of the therapeutic substance. Journal of Controlled Release; v. 252, p. 1–17.

Dorozhkin S. V.; Epple M. (2002). Biological and medical significance of calcium phos-phates. Angewandte Chemie International Edition; v. 41, p. 3130–3146.

Wagoner-Johnson A. J.; Herschler B.A. (2011). A review of the mechanical behavior of CaPs and CaP/polymer composites for applications in bone repair and replacement. Acta Biomaterialia; 7:16–30.

Bohner M. (2000). Calcium orthophosphates in medicine: from ceramics to calcium phos-phate cements. Injury; 31, pp. S-D37-S-D47.

Vallet- Regi M.; Gonzalez- Calbet J. M. (2004). Calcium phosphates as substitution of bone tissues. Prog. Solid State Chem.; 32, pp. 1-3.

Lazar D. R. R. ; Cunha S. M. ; Ussui V. et al. (2006). Effect of calcination conditions on phase formation of calcium phosphates ceramics synthesized by homogeneous precipita-tion. Mater. Sci. Forum; 530–531, pp.612-617.

Cardoso H. A. I.; Motisuke M.; Zavaglia C. A. C. (2012). Análise da influência de dois processos distintos de moagem nas propriedades do pó precursor e do cimento de beta-TCP. Cerâmica; 58, 225-228.

Ruiz- Aguilar C.; Olivares- Pinto U.; Aguilar- Reyes E. et al. (2018). Characterization of -tricalcium phosphate powders synthesized by sol–gel and mechanosynthesis. Boletín de la Sociedad Española de Cerámica y Vidrio.

Thumer M. B.; Diehl C. E.; Dos Santos L. A. L. (2016). Calcium phosphate cements based on alpha-tricalcium phosphate obtained by wet method: synthesis and milling effects. Ceram. Int.; 42, 18094–18099.

Nasiri- Tabrizi B.; Fahami A. (2013). Mechanochemical synthesis and structural charac-terization of nano-sized amorphous tricalcium phosphate. Ceram. Int.; 39, 8657–8666.

Farzadi A.; Solati-Hashjin M.; Bakshshi F. (2011). Synthesis and characterization of hy-droxyapatite/-tricalcium phosphate nanocomposites using microwave irradiation. Ceram. Int.; 37, 65–71.

Sanosh K. P.; Chu M.; Balakrishnan A. et al. (2010). Sol–gel synthesis of pure nano sized -tricalcium phosphate crystalline powders. Curr. Appl. Phys.; 10, 68–71.

Duncan J.; Macdonald J. F.; Hanna J. V. et al. (2014). The role of the chemical composi-tion of monetite on the synthesis and properties of -tricalcium phosphate. Mater. Sci. Eng. C: Mater. Biol. Appl.; 34, 123–129.

Wang H.; Lee J. K.; Moursi A. et al. (2003). Ca/P ratio effects on the degradation of hy-droxyapatite in vitro. Journal of Biomedical Materials Research; v. 67 A, p. 599–608.




How to Cite

ALMEIDA, J. A. M.; KUFFNER, B. H. B.; SILVA, G.; CAPELLATO, P.; SACHS, D. Analysis of the influence of β-TCP particle size on deagglomeration processes. Research, Society and Development, [S. l.], v. 9, n. 4, p. e175943067, 2020. DOI: 10.33448/rsd-v9i4.3067. Disponível em: Acesso em: 21 sep. 2021.