Photobiomodulation as auxiliary treatment of oral mucositis in patients submitted to antineoplastic treatments: integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i8.30827

Keywords:

Stomatitis; Mouth neoplasms; Low-level light therapy.

Abstract

Objective: To investigate e effectiveness of inserted laser therapy in the treatment and prevention of oral mucositis. Methodology: Is low-level laser therapy effective in the treatment of oral mucositis in cancer patients? An integrative qualitative review was performed. Using PubMed and SciELO databases, as keywords: low-level laser, laser therapy, American cancer society, cancer, neoplasia, head and neck neoplasms, mucositis and stomatitis. As a Boolean “AND” operator. As inclusion criteria, Portuguese and English in the period from 2017 to 2022. Those that did not address the mentioned topic are excluded. In order to discuss laser therapy as an auxiliary preventive and curative alternative for oral mucositis. Results: 22 articles were selected, where the levels of clinical evidences ay that photodynamic therapy is associated with regression, in addition to the appearance of oral mucositis lesions when compared to those who did not have access to photobiomodulation. Conclusion: Laser therapy can be an adjuvant treatment to antineoplastic therapies, in addition to tissue repair and consequent analgesia in the region, and can be used in different age groups and degrees of oral mucositis.

References

Antunes, H. S., Herchenhorn, D., Small, I. A., Araújo, C. M. M., Viegas, C. M. P., Ramos, G. A. & Ferreira, C. G. (2017). Long-termsurvival of a randomizedphase III trial of head and neck cancer patients receivingconcurrentchemoradiation therapy withorwithout low-level laser therapy (LLLT) toprevent oral mucositis. Oral oncology, 71, 11-15.

Albuquerque, K. B. (2019). Laserterapia de baixa potência em mucosite oral. Revista Odontologia Planalto Central. Trabalho de Conclusão de Curso (Bacharel em Odontologia) – Centro Universitário do Planalto Central Aparecido dos Santos.

Albuquerque, M. E. C. A., Barros, V. S., Peixoto, F. B., Mendonça, I. C. G. & Peixoto, M. O. B. (2017). Abordagens terapêuticas da mucosite oral. Revista Acadêmica Brasileira de Odontologia, 26(2), 53 – 57.

Al-Rudayni, A. H. M., Gopinath, D., Maharajan, M. K., Veettil, S. K., & Menon, R. K. (2021). Efficacy of Photobiomodulation in the Treatment of Cancer Chemotherapy-Induced Oral Mucositis: A Meta-Analysis with Trial Sequential Analysis. Int J Environ RES Public Health, 18(14), 7418.

Araújo, B. A., Barros, J. N., Figueira, H. C., Jr., Gottardo, V. D., Salmeron, S., & Mariano, J. R. (2018). O impacto da laserterapia na mucosite oral. Revista UNINGÁ, 55(S3) 39-46.

Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin., 68(6), 394-424.

Campos, T. M., Silva, C. A. P. T., Sobral, A. P. T., Sobral, S. S., Rodrigues, M. F. S. D. Bussadori, S. K. & Motta, L. J. (2020). Photobiomodulation in oral mucositis in patients with head and neck cancer: a systematic review and meta-analysis followed by a cost-effectiveness analysis. SupportCareCancer, 28(12), 5649-5659.

Cicchelli, M. Q. Guerreiro, L., Costa, A. S., Marques, R. S. O., Carrera, M., Martins, G. B. & Medrado, A. P. (2017). Mucosite Oral induzida por terapia oncológica – Uma revisão de literatura. Revista de ciências médicas e biológicas, 16(1).

Conde, F. M., Cosano, L. C., Ilbanez, P., Figallo, M. A. S., Pérez, J. L. G., & Lagares, D. T. (2019). Photobiomodulation with low-level laser therapy reduces oral mucositis caused by head and neck radio-chemotherapy: prospective randomized controlled Trial. Int J Oral MaxillofacSurg, 48(7), 917-923.

Cunha, S. G. (2017). Aplicabilidade da laserterapia de baixa potência no tratamento da mucosite oral causada por quimioterápicos antineoplásicos. Trabalho de conclusão de curso (Bacharelado em Fisioterapia) – Faculdade de Educação e Meio Ambiente, FAEMA.

Curra, M., Júnior Soares, L. A. V., Martins, M. D., & Santos P. S. S. (2018). Chemotherapy protocols and incidence of oral mucositis. Na integrative review. Einstein, 16(1).

Dantas, J. B. L., Martins, G. B., Lima, H. R., Carrera, M., Reis, S. R. A., & Medrado, A. R. A. P. (2020). Evaluation of preventive laser photobiomodulation in patients with head and neck cancerundergoingradiochemotherapy: Laser in patients with head and neck cancer. Space Care in Dentistry, 40, (4), 364-373.

Daugelaite, G., Užkuraitytė, K., Jagelavičienė, E., & Filipauskas, A. (2019).Prevention and Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis. Medicina (KAUNAS), 55(2), 25.

Gobbo, M., Verzegnassi, F., Ronfani, L., Zanon, D. , Melchionda, F. , Bagattoni, S. & Zanazzo, G. A. (2018). Multicenterrandomized, double-blind controlled Trial to evaluate the efficacy of laser therapy for the treatment of severe oral mucositis induced by chemotherapy in children: laMPO RCT. PediatrBloodCancer, 65(8).

Gonçalves, J. G. A., Vasconcelos, M. C. S., Torres, J. L. M., Santos, L. G. P., Sousa, J. N., Monteiro, B. V. B. & Sena, L. S. B. (2020). Laserterapia aplicada ao tratamento da mucosite oral em pacientes oncológicos. Uma revisão bibliométrica. Research, Society and Development, 9(7).

Guedes, C. C. F. V., Freitas, S. A. J., Fo., Faria, P. R., Loyola, A. M., & Silva, R. S., Cardoso, S. V. (2018). Variation of Energy in Photobiomodulation for theControl of Radiotherapy Induced Oral Mucositis: A Clinical Study in Head and Neck Cancer Patients. International Journal of Dentistry, 2018, 6.

Guimarães, D. M., Ota, T. M. N., Silva, D. A. C., Almeida, F. L. S., Schalch, T. D., Deana, A. M. & Fernandes, K. P. S. (2021). Low-level laser or LED photobiomodulation on oral mucositis in pediatric patients under high doses of methotrexate: prospective, randomized, controlledtrial. Support Care Cancer, 29(11), 6441-6447.

Hamblin, M. R. (2017). Mechanisms and applicatins of the anti – inflammatoryeffects of photobiomodulation. AIMS Biophys, 4(3), 337 – 361.

He, M., Zhang, B., Shen, N., Wu, N., & Sun, J. (2018). A systematic review and meta-analysis of theeffect of low-level laser therapy (LLLT) on chemotherapy-induced oral mucositis in pediatric and young patients. EuropeanJournalofPediatrics, 177, 7-17.

Instituto nacional do câncer (2020). Intervalo de tempo entre diagnóstico e o início do tratamento oncológico dos casos de câncer de lábio e cavidade oral. INCA.

Kusiak, A., & Fossa, B. A. J., Cichonska, D., & Alterio, D. (2020). Oncological Therapy Related Oral Mucositis as na Interdisciplinary Problem – Literature Review. International Journal of Environmental Research and Public Health, 17(2464).

Lavaee, F., Amanati, A., Ramzi, M., Naseri, S., & Sefatr, H. S. (2020). Evaluation of theeffect of photodynamic therapy on chemotherapy induced oral mucositis. PhotodiagnosisPhotodynTher, 30(101653).

Legouté, F., Bensadoun, R. J., Seegers, V., Pointreau, Y., Caron, D., Lang, P. & Jadaud, E. (2019). Low-level laser therapy in treatment of chemoradiotherapy-induced mucositis in head and neck cancer: results of a randomised, triple blind, multicentrephase III trial. RadiationOncology, 14(83).

Lima, V. H. S., & Neto, O. B. O., Sales, P. H. H., Torres, T. S., & Lima, F. J. C. (2019). Effectiveness of low-level laser therapy for oral mucositis prevention in patients undergoingchemoradiotherapy for thetreatment of head and neck cancer: A systematic review and meta-analysis. Oral Oncology, 102(104524).

Marinho, P. M. L., & Lima, R. B., Santos, J. C. O., Sobral, G. S., Vassilievitch, A. C., Amorim, B. F. & Sawada, N. O. (2021). Chemotherapy related oral mucositis in breast câncer patients: a brief review. Research, SocietyandDevelopment, 10(3).

Marinho, D. L. (2018). Prevenção e tratamento da mucosite oral induzida pela radioterapia exclusiva ou associada a quimioterapia em pacientes com câncer de cabeça e pescoço. Dissertação (Mestrado em Odontologia) – Faculdade de Ciências da Saúde, Universidade Fernando Pessoa.

Marques, E. C. P., Lopes, F. P., Nascimento, I. C., Morelli, J., Pereira, M. V., Meiken, V. M. M. & Pinheiro, S. L. (2020). Photobiomodulation and photodynamic therapy for thetreatment of oral mucositis in patients with câncer. PhotodiagnosisandPhotodynamicTherapy, 29(101621).

Martins, A. F. L., Nogueira, T. E., Morais, M. O., Sousa, S. S., Neto., Leite, A. F. O., & Mendonça, E. F. (2021). Cost – effectivenessrandomizedclinicaltrial on theeffect of photobiomodulation therapy for prevention of radiotherapy induced severe oral mucositis in a Brazilian câncer hospital selting. SupportCare Câncer, 29, 1245-1256.

Menezes, B. C., Thebit, M. M., Bonela, L. A. S., Oliveira, K. G., Gonçalves, W. L., Bissoli, N. S. & Gouvea, S. A. (2021). Laser Therapy as a Preventive Approach for oral Mucositis in Cancer Patients Undergoing Chemotherapy: The Potential Role of Superoxide Dismutase. Asian Pacific Journal of Cancer Prevention, 22(10), 3211-3217.

Oliveira, A. B., Ferrisse, T. M., Basso, F. G., Fontana, C. R., Giro, E. M. A., & Brighenti, F. L. (2021). A Systematic review and meta – analysis of theeffect of photodynamic therapy for thetretament of oral mucositis. PhotodiagnosisPhotodynTher, 34(02316).

Organização mundial da saúde (OMS) (2020). Estimativas Globais de Saúde 2020: Mortes por causa, idade, sexo, por país e por região, 2000 – 2019. Quem.

Paglioni, M. P., Alves, C. G. B., Fonte, E. K., Lopes, M. A., Ribeiro, A. C. P., Brandão, T. B. & Silva, A. R. S. (2019). Is photobiomodulation therapy effective in reducing pain caused by toxicities related to head and neck câncer treatment? A systematicreview. SupportiveCare in Cancer, 27(11), 4043 -4054.

Peralta, M. M., Silva, B. M., Pinto, A. C. S., &Bullen, I. R. F. R., Honório, H. M., Rubira, C. M. F. & Santos, P. S. S. (2019). Low-level laser therapy dosimetrymost used for oral mucositis duetoradiotherapy for head and neck cancer: a systematic review and meta-analysis. Crit. Ver. Oncol. Hematol., 38, 14-23.

Peng, J., Shi, Y. Wang, J., Wang, F., Dan, H., Xu, H. & Zeng, X. (2020). Low-level laser therapy in theprevention and treatment of oral mucositis: a systematic review and meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol, 130(4), 387-397.

Pereira, A. M. (2020). Impacto da fotobiomodulação no tratamento da mucosite em pacientes internados com câncer de cabeça e pescoço no HUB. Dissertação (Mestrado em ciências da saúde) – Faculdade de Ciências da Saúde, Universidade de Brasília.

Pulito, C., Cristaudo, A., La Porta, C., Zapperi, S., Blandino, G., Morrone, A. & Strano, S. (2020). Oral mucositis: the hidden side of cancer therapy. Journal of Experimental & Clinical Cancer Research, 39(1), 210.

Ramos,M. B. R., Gusmão, T. P. L., Schimidt, J., Filho., Jaguar, G. C., Martins, M. D., & Alves, F. A. (2021). Intraoral versus extraoral photobiomodulation therapy in the prevention of oral mucositis in HSCT patients: a randomized, single-blind, controlled clinical Trial. SupportCareCancer, 29(11), 6495-6503.

Redman, M. G., Harris, K., & Phillips, B. S. (2022). Low-level laser therapy for oral mucositis in children with cancer. ArchDisChild, 107(2), 128-133.

Reolon, L. Z., Rigo, L., Conto, F., & Cé, L. C. (2017). Impacto da laserterapia na qualidade de vida de pacientes oncológicos portadores de mucosite oral. Revista de Odontologia da UNESP, 46(1), 19-27.

Shakar, A., Roy, S., Bhandari, M., Rath, G. K., Biswas, A. S., Kanodia, R. & Sachan, R. (2017). Current Trends in Management of Oral Mucositis in Cancer Treatment. Asian Pacific Journal of Cancer Prevention, 18(8), 2019-2026.

Salvador, D. R. N., Soave, D. F., Sacono, N. T., Castro, E. F., Silva, G. B. L., & Silva, L. P. & Batista, A. C. (2017). Effect of photobiomodulation therapy on reducing the chemo-induced oral mucositis severity and on salivarylevels of CXCL8/interleukin 8, nitrite, and myeloperoxidase in patients undergoing hematopoietic stem cell transplantation: a randomized clinical trial. Laser in Medical Science, 32, 1801-1810.

Silva, B. M., Prosdócimo, M. L., Gasparini, L. R., Silva, B. M., Araújo, M. R., & Amenábar, J. M. (2022). Most used photobiomodulation dosimetry parameters to treat oral mucositis after preconditioning for hematopoietic stem cell transplantation: systematic review and meta-analysis. SupportCareCancer, 30(5), 3721-3732.

Soares, G. A., Silva, J. S., Nascimento, E. F., Santos, J. P., & Mendes, J. R. (2018). Evidências da eficácia da laserterapia de baixa intensidade na prevenção e tratamento da mucosite oral. Revista Univap, 24(48).

Sppezia, S. (2020). Mucosite oral em pacientes cancerosos submetidos a tratamento quimioterápico. Revista Ciência e Odontologia, 4(1), 36-40.

Sung, H., Ferlay, J., Siegel, L. R., Laversanne, M., Soerjomataram, I., Jemal, A. & Bray, F. (2021). Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A CancerJournal for Clinicians, 71(3), 209-249.

Valduga, F., Oltramari, E., Lemes, L. T. O., Mattos, C. E., Stefenon, L., & Mozzini, B. (2018). Prevenção da mucosite oral em pacientes submetidos à quimioterapia. Revista Brasileira de Cancerologia, 64(2), 189 – 194.

Vigarios, E., Epstein, J. B., & Sibaud, V. (2017). Oral mucosal changes induced by anticâncer targeted therapies and imune checkpoint inhibitors. SupportCareCancer, 25(5), 1713-1739.

Whittemore, R., & Knafl, K. (2005). The integrative review: updated methodology. Journal of advanced nursing, 52(5), 546-553.

Zadik, Y., Arany, P. R., Fregnani, E. R. Bossi, P., Antunes, H. S., Bendadoun, R. –J. & Elad, S. (2019). Systematic review of photobiomodulation for the management of oral mucositis in câncer patients and clinicalpractice guidelines. SupportiveCare in Cancer, 27(10), 3696-3983.

Published

13/06/2022

How to Cite

AMARO, J. S. .; OLIVEIRA JÚNIOR, J. K. de .; OLIVEIRA, M. A. C. de .; SOUSA, R. V. de .; AMARO, J. B. S. .; BARNABÉ, L. Éverton G. .; MARINHO-VIEIRA, L. E. Photobiomodulation as auxiliary treatment of oral mucositis in patients submitted to antineoplastic treatments: integrative review. Research, Society and Development, [S. l.], v. 11, n. 8, p. e15511830827, 2022. DOI: 10.33448/rsd-v11i8.30827. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/30827. Acesso em: 15 nov. 2024.

Issue

Section

Review Article