Pharmacoeconomic study of antimicrobial control flow adoption by clinical pharmacy of a university hospital

Authors

DOI:

https://doi.org/10.33448/rsd-v11i8.30875

Keywords:

Antimicrobial management; Pharmacoeconomics; Antibiotic resistance.

Abstract

Currently antimicrobial resistance is a serious threat to public health. The increase in the incidence of infections by multidrug-resistant organisms has become a focus of concern regarding patient safety throughout the care cycle. The aim of this study was to evaluate the impact of the implementation of a new flow of antimicrobial dispensing and control in a university hospital. An observational and retrospective descriptive study was conducted with a quantitative approach, characterized as a pharmacoeconomic analysis, in one of the hospitalization posts of the University Hospital (HU) of the Federal University of Piauí (UFPI), located in Teresina, Piauí. A reduction in consumption was observed in 9 of the 12 most prescribed antimicrobials after the implementation of the dispensing flow, except for three antimicrobials, Ciprofloxacin 2mg/ml, Metronidazole 500mg/100ml and Vancomycin 500mg. Before the implementation of the flow, the 12 most prescribed antimicrobials implied 93% of the ATB consumed in the hospital, representing only 76% after the appropriate pharmaceutical interventions, demonstrating efficiency of the methodology adopted. The 12 tMDs most prescribed represented a cost of 98% of the hospital's expenses with antimicrobials, which now represents only 51% of the expenses with these. The reduction in costs observed in the period 2021 compared to 2020 may be directly related to the performance of hospital pharmacists in partnership with multidisciplinary teams and CCIH. The relationship between pharmacoeconomics and the rational use of antimicrobials is evident, so that the consumption of antimicrobials directly affects the costs generated in the hospital.

References

Agência Nacional de Vigilância Sanitária (ANVISA). (2017). Diretriz Nacional para Elaboração de Programa de Gerenciamento do Uso de antimicrobianos em Serviços de Saúde.

Barbosa, J. A. A., Belém, L. D. F., Sette, I. M. F., Farias, T. D., Pereira, G. D. S., & Júnior, E. D. S. (2009). Utilização de antimicrobianos em pacientes oncológicos hospitalizados. Rev. Bras. Farm, 90(1), 69-74.

Capita, R., & Alonso-Calleja, C. (2013). Antibiotic-resistant bacteria: a challenge for the food industry. Critical reviews in food science and nutrition, 53(1), 11-48.

Centers for Disease Control and Prevention. (2010). About antimicrobial resistance: A brief overview. USA: Centers for Disease Control and Prevention.[Online] Available from: http://www. cdc. gov/drugresistance/about. html [Accessed on 20th May 2014].

De Sousa, P. C. P., de Paula Rocha, M. V. A., de Sousa, F. S. P., & Nogueira, N. A. P. (2015). Utilização de antibacterianos em Unidade de Terapia Intensiva. InterSciencePlace, 1(18).

DE SOUZA, F. C., BARONI, M. M. F., & ROESE, F. M. (2017). Perfil de utilização de antimicrobianos na unidade de terapia intensiva de um hospital público. Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde, 8(4).

Santos, P. D., Silva, G. D. A., Coêlho, T. D. S., Oliveira, R. D., & Neto, M. P. L. (2020). Análise farmacoeconômica dos antimicrobianos na unidade de terapia intensiva em um hospital terciário. Research, Society and Development, 9(5), 14.

FERNANDES, I. D. Q., DE SOUSA, H. F., DE BRITO, M. A. M., TAVARES, S. N., DE MATOS, V. C., & DE SOUZA, M. D. O. B. (2012). Impacto farmacoeconômico da racionalização do uso de antimicrobianos em unidades de terapia intensiva. Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde, 3(4).

Ferri, M., Ranucci, E., Romagnoli, P., & Giaccone, V. (2017). Antimicrobial resistance: A global emerging threat to public health systems. Critical reviews in food science and nutrition, 57(13), 2857-2876.

Huttner, A., Harbarth, S., Carlet, J., Cosgrove, S., Goossens, H., Holmes, A., ... & Pittet, D. (2013). Antimicrobial resistance: a global view from the 2013 World Healthcare-Associated Infections Forum. Antimicrobial resistance and infection control, 2(1), 1-13.

Klein Klouwenberg, P., Cremer, O. L., van Vught, L. A., Ong, D. S., Frencken, J. F., Schultz, M. J., ... & van der Poll, T. (2015). Likelihood of infection in patients with presumed sepsis at the time of intensive care unit admission: a cohort study. Critical care, 19(1), 1-8.

Neves, C., & Colet, C. (2015). Perfil de uso de antimicrobianos e suas interações medicamentosas em uma UTI adulto do Rio Grande do Sul. Revista de Epidemiologia e Controle de Infecção, 5(2), 65-71.

Pan American Health Organization. (2018). Recommendations for implementing Antimicrobial Stewardship Programs in Latin America and the Caribbean: manual for public health decision-makers. Rodrigues, F. D. A., & Bertoldi, A. D. (2010). Perfil da utilização de antimicrobianos em um hospital privado. Ciência & Saúde Coletiva, 15, 1239-1247.

Rodrigues, R., Slomp, A. M., Carneiro, M. B., & Bernardi, E. A. T. (2014). Perfil de utilização de medicamentos anti-infecciosos sistêmicos em um hospital oncológico. Revista espaço para a saúde, 15(4), 42-52.

Santos, R. P. D., Nagel, F. M., Gastal, S. L., Sander, G. B., Jacoby, T. S., Konkewicz, L. R., ... & Ribeiro, S. P. (2010). Política de antimicrobianos do Hospital de Clínicas de Porto Alegre-2010: Comissão de Controle de Infecção Hospitalar. Revista HCPA. Vol. 30, n. 1 (2010), p. 13-21.

Seguro, M. L., Alovero, F., & Lamberghini, R. (2013). Consumo de antimicrobianos en un hospital privado: efecto de un programa para el uso racional.

Septimus, E. J. (2018). Antimicrobial resistance: an antimicrobial/diagnostic stewardship and infection prevention approach. Medical Clinics, 102(5), 819-829.

Stenehjem, E., Hersh, A. L., Sheng, X., Jones, P., Buckel, W. R., Lloyd, J. F., ... & Pavia, A. T. (2016). Antibiotic use in small community hospitals. Clinical Infectious Diseases, 63(10), 1273-1280.

Tabah, A., Bassetti, M., Kollef, M. H., Zahar, J. R., Paiva, J. A., Timsit, J. F., ... & Garnacho-Montero, J. (2020). Antimicrobial de-escalation in critically ill patients: a position statement from a task force of the European Society of Intensive Care Medicine (ESICM) and European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Critically Ill Patients Study Group (ESGCIP). Intensive care medicine, 46(2), 245-265.

Teshome, B. F., Vouri, S. M., Hampton, N., Kollef, M. H., & Micek, S. T. (2019). Duration of exposure to antipseudomonal β‐lactam antibiotics in the critically ill and development of new resistance. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 39(3), 261-270.

Webb, B. J., Sorensen, J., Jephson, A., Mecham, I., & Dean, N. C. (2019). Broad-spectrum antibiotic use and poor outcomes in community-onset pneumonia: a cohort study. European Respiratory Journal, 54(1).

Published

19/06/2022

How to Cite

PEREIRA, B. R. A. .; DIAS, L. M. F. .; BEZERRA, J. L. .; SÁ, L. L. F. de .; FERREIRA, W. F. de .; VIEIRA, J. F. P. do N. . Pharmacoeconomic study of antimicrobial control flow adoption by clinical pharmacy of a university hospital. Research, Society and Development, [S. l.], v. 11, n. 8, p. e30811830875, 2022. DOI: 10.33448/rsd-v11i8.30875. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/30875. Acesso em: 16 nov. 2024.

Issue

Section

Health Sciences