Photobiomodulation in the prevention and treatment of oral mucositis: case report

Authors

DOI:

https://doi.org/10.33448/rsd-v11i8.30921

Keywords:

Stomatitis; Radiotherapy; Low-level light therapy.

Abstract

Oral mucositis is a frequent complication of antineoplastic treatment in cases of head and neck tumors. The aim of this article was to report a clinical case of a patient diagnosed with malignant neoplasm of the oropharynx undergoing radiotherapy and chemotherapy and the effects of photobiomodulation in the prevention and treatment of oral mucositis. Photobiomodulation applied for preventive purposes was carried out two to three times a week with a diode laser, with a wavelength of 660nm, 100mW, 1J per point, in contact mode, on the entire oral mucosa. The associated red (660nm) and infrared (808nm) lasers, totaling 1 J per point, were applied for therapeutic purposes. Oral mucositis severity, pain and quality of life were assessed by the following means: WHO oral mucositis severity scale, visual analogue pain scale (VAS) and EOTRC-35 and OHIP 14 quality of life questionnaires. It was concluded that photobiomodulation showed a positive effect on the patient's quality of life and pain control. Photobiomodulation proved to be effective in preventing oral mucositis in a high degree of severity and promoted clinical remission of the lesions after approximately two sessions of application.

References

Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., & Takeda, F. (1993). The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. JNCI: Journal of the National Cancer Institute, 85(5), 365-376.

Beech, N., Robinson, S., Porceddu, S., & Batstone, M. (2014). Dental management of patients irradiated for head and neck cancer. Australian dental journal, 59(1), 20-28.

Bensadoun, R. J., & Nair, R. G. (2012). Low-level laser therapy in the prevention and treatment of cancer therapy-induced mucositis: 2012 state of the art based on literature review and meta-analysis. Current opinion in oncology, 24(4), 363-370.

Campos, L., Carvalho, D. L. C. D., Castro, J. R. D., & Simões, A. (2013). Laserterapia no tratamento da mucosite oral induzida por quimioterapia: relato de caso. Revista Da Associacao Paulista de Cirurgioes Dentistas, 67(2), 102-106.

Câncer de boca (2021) https://www.inca.gov.br/tipos-de-cancer/cancer-de-boca

Cancer today (2022) http://gco.iarc.fr/today/home.

Carneiro, V. R. T., & Júnior, R. D. A. V. (2022). Cuidados paliativos e manifestações orais em pacientes oncológicos: Revisão de literatura. Research, Society and Development, 11(6), e59911629768-e59911629768.

da Silva, F. K. V., de Assis Fursel, K., de Oliveira Neto, J. L., Boas, M. I. B. V., & Pereira, C. M. (2021a). Alterações bucais em pacientes submetidos a tratamento quimioterápico. Research, Society and Development, 10(6), e59510616562-e59510616562.

da Silva, J. K. M. C., Rios, T. L. B., & Guedes, C. D. C. F. V. (2021b). Cuidados odontológicos para pacientes submetidos a tratamentos antineoplásicos. Research, Society and Development, 10(12), e99101220231-e99101220231.

de Almeida Gonçalves, J. G., de Vasconcelos, M. C. S., Torres, J. L. M., Santos, L. G. P., de Sousa, J. N. L., de Brito Monteiro, B. V., & de Sena, L. S. B. (2020). Laserterapia aplicada ao tratamento da mucosite oral em pacientes oncológicos. Uma análise bibliométrica. Research, Society and Development, 9(7), e815974938-e815974938.

El Mobadder, M., Farhat, F., El Mobadder, W., & Nammour, S. (2018). Photobiomodulation therapy in the treatment of oral mucositis, dysgeusia and oral dryness as side-effects of head and neck radiotherapy in a cancer patient: a case report. Dentistry journal, 6(4), 64.

Elad, S., Cheng, K. K. F., Lalla, R. V., Yarom, N., Hong, C., Logan, R. M., & Zur, E. (2020). MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer, 126(19), 4423-4431.

Gondim, F. M. L., & Souza, B. D. (2021). The use of laser therapy in the prevention and treatment of oral mucositis: a literature review. Research, Society and Development,[S. l.], 10(1).

Hong, C. H., Gueiros, L. A., Fulton, J. S., Cheng, K. K. F., Kandwal, A., Galiti, D., & Elad, S. (2019). Systematic review of basic oral care for the management of oral mucositis in cancer patients and clinical practice guidelines. Supportive Care in Cancer, 27(10), 3949-3967.

Inchingolo, F., Santacroce, L., Ballini, A., Topi, S., Dipalma, G., Haxhirexha, K., & Charitos, I. A. (2020). Oral cancer: A historical review. International journal of environmental research and public health, 17(9), 3168.

Klausner, G., Troussier, I., Canova, C. H., & Bensadoun, R. J. (2022). Clinical use of photobiomodulation as a supportive care during radiation therapy. Supportive Care in Cancer, 30(1), 13-19.

Kuhn, A., Porto, F. A., Miraglia, P., & Brunetto, A. L. (2009). Low-level infrared laser therapy in chemotherapy-induced oral mucositis: a randomized placebo-controlled trial in children. Journal of pediatric hematology/oncology, 31(1), 33-37.

Lalla, R. V., Bowen, J., Barasch, A., Elting, L., Epstein, J., Keefe, D. M., & Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO). (2014). MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer, 120(10), 1453-1461.

Legouté, F., Bensadoun, R. J., Seegers, V., Pointreau, Y., Caron, D., Lang, P., & Jadaud, E. (2019). Low-level laser therapy in treatment of chemoradiotherapy-induced mucositis in head and neck cancer: results of a randomised, triple blind, multicentre phase III trial. Radiation Oncology, 14(1), 1-11.

Martins, A. F. L., Nogueira, T. E., Morais, M. O., Oton-Leite, A. F., Valadares, M. C., Batista, A. C., & Mendonça, E. F. (2019). Effect of photobiomodulation on the severity of oral mucositis and molecular changes in head and neck cancer patients undergoing radiotherapy: a study protocol for a cost-effectiveness randomized clinical trial. Trials, 20(1), 1-10.

Noirrit-Esclassan, E., Valera, M. C., Vignes, E., Munzer, C., Bonal, S., Daries, M., & Pasquet, M. (2019). Photobiomodulation with a combination of two wavelengths in the treatment of oral mucositis in children: the PEDIALASE feasibility study. Archives de Pédiatrie, 26(5), 268-274.

On behalf of the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology (MASCC/ISOO) (2021) OralOncology_HeadNeck_DuringRadiation_Portuguese.pdf. http://www.isoo.world/patient-education.html#sheets

Rezk-Allah, S. S., Abd Elshaf, H. M., Farid, R. J., Hassan, M. A. E., & Alsirafy, S. A. (2019). Effect of low-level laser therapy in treatment of chemotherapy induced oral mucositis. Journal of lasers in medical sciences, 10(2), 125.

Sasada, I. N. V., Munerato, M. C., & Gregianin, L. J. (2013). Mucosite oral em crianças com câncer-revisão de literatura. Revista da Faculdade de Odontologia-UPF, 18(3).

Sherman, A. C., Simonton, S., Adams, D. C., Vural, E., Owens, B., & Hanna, E. (2000). Assessing quality of life in patients with head and neck cancer: cross-validation of the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Head and Neck module (QLQ-H&N35). Archives of Otolaryngology–Head & Neck Surgery, 126(4), 459-467.

Wittekindt, C., Wagner, S., Sharma, S. J., Würdemann, N., Knuth, J., Reder, H., & Klußmann, J. P. (2018). HPV–Das andere Kopf-Hals-Karzinom. Laryngo-Rhino-Otologie, 97(S 01), S48-S113.

WHO, G. (1979). Handbook for reporting results of cancer treatment. WHO offset publication, 48, 1-41.

Zecha, J. A., Raber-Durlacher, J. E., Nair, R. G., Epstein, J. B., Elad, S., Hamblin, M. R., & Bensadoun, R. J. (2016). Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols. Supportive Care in Cancer, 24(6), 2793-2805.

Published

27/06/2022

How to Cite

SOUSA , M. M. de .; PRADO, M. do; MACHADO, M. P. S. .; FERREIRA, C. G. M. .; COELHO, T. M. .; MARSKI, S. R. de S. .; PACHECO , J. A. .; FRANÇA , B. de A. L. .; VASCONCELLOS, B. T. de . Photobiomodulation in the prevention and treatment of oral mucositis: case report. Research, Society and Development, [S. l.], v. 11, n. 8, p. e50811830921, 2022. DOI: 10.33448/rsd-v11i8.30921. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/30921. Acesso em: 20 apr. 2024.

Issue

Section

Health Sciences