The occurrence of myocarditis after the administration of vaccines against COVID-19: Systematic review
DOI:
https://doi.org/10.33448/rsd-v11i8.31473Keywords:
SARS-CoV-2; Covid-19; Myocarditis; Vaccine; Adverse effects.Abstract
Introduction: COVID-19, a disease whose etiological agent is the SARS-CoV-2 virus, is a disease that, in addition to causing respiratory complications, also causes other complications, such as cardiovascular and thromboembolic diseases. And, after the use of vaccines produced and launched in record time, there were several reports of myocarditis related to vaccination campaigns in several countries around the world. Objective: To investigate the possible relationship between vaccination against COVID-19 and the occurrence of cases of myocarditis. Methods: Systematic review, search in the Pubmed database for articles published between January 2020 and March 2022. Articles from clinical and observational studies with humans were included. Articles that related adverse reactions to the vaccine other than myocarditis, and those that did not specifically relate the vaccine to myocarditis were excluded. Results: 19 articles were selected. The total number of patients was 63, of which 60 were men, aged between 12 and 60 years, with chest pain as the main symptom and, in the majority, with onset 2 to 60 years old. 3 days after administration of the second dose of COVID-19 mRNA vaccine. The course of the disease was mostly mild and with rapid resolution of symptoms. Conclusion: Even with the search for evidence of the pathophysiological mechanism involved after vaccine administration and the development of acute myocarditis, there is still no evidence to prove this cause-effect relationship, beyond temporality. However, it is possible to confirm the temporal relationship between the mRNA vaccine and the development of myocarditis as adverse effects.
References
Abbate, A., Gavin, J., Madanchi, N., Kim, C., Shah, P.R., Klein, K. et al (2021). Fulminant myocarditis and systemic hyperinflammation temporally associated with BNT162b2 mRNA COVID-19 vaccination in two patients. International Journal of Cardiology. 340: 119–21. 10.1016/j.ijcard.2021.08.018
Abu Mouch, S., Roguin, A., Hellou, E., Ishai, A., Shoshan, U., Mahamid, L., et al (2021). Myocarditis following COVID-19 mRNA vaccination. Vaccine. 39(29):3790–3. 10.1016/j.vaccine.2021.05.087
Azir, M., Inman, B., Webb, J., & Tannenbaum, L (2021). STEMI Mimic: Focal Myocarditis in an Adolescent Patient After mRNA COVID-19 Vaccine. The Journal of Emergency Medicine, 61(6):e129–32. 10.1016/j.jemermed.2021.09.017.
Bozkurt, B., Kamat, I. & Hotez P. J (2021). Myocarditis With COVID-19 mRNA Vaccines. Circulation, 144(6):471–84. https://doi.org/10.1161/CIRCULATIONAHA.121.056135
Cocker, M. S., Abdel-Aty, H., Strohm, O., & Friedrich, M.G (2009). Age and gender effects on the extent of myocardial involvement in acute myocarditis: a cardiovascular magnetic resonance study. Heart, 95(23):1925–30. 10.1136/hrt.2008.164061
Cooper, L. T., Mather, P. J., Alexis, J. D., Pauly, D. F., Torre-Amione, G., Wittstein, I. S., et al (2012). Myocardial Recovery in Peripartum Cardiomyopathy: Prospective Comparison With Recent Onset Cardiomyopathy in Men and Nonperipartum Women. Journal of Cardiac Failure, 18(1):28–33. 10.1016/j.cardfail.2011.09.009
Dickey, J. B., Albert, E., Badr, M., Laraja, K. M., Sena, L. M., Gerson, D.S., Saucedo, J. E., Qureshi, W., & Aurigemma, G. P (2021). A Series of Patients With Myocarditis Following SARS-CoV-2 Vaccination With mRNA-1279 and BNT162b2. JACC: Cardiovascular Imaging, 14(9):1862–3. 10.1016/j.jcmg.2021.06.003
Fairweather, D., Cooper, L. T., & Blauwet, L. A (2013). Sex and Gender Differences in Myocarditis and Dilated Cardiomyopathy. Current Problems in Cardiology. 38(1):7–46. 10.1016/j.cpcardiol.2012.07.003
Frisancho-Kiss, S., Davis, S. E., Nyland, J. F., Frisancho, J. A., Cihakova, D., Barrett, M. A., Rose, N. R., & Fairwether, D (2007). Cutting Edge: Cross-Regulation by TLR4 and T cell Ig Mucin-3 Determines Sex Differences in Inflammatory Heart Disease. The Journal of Immunology, 178(11):6710–4. 10.4049/jimmunol.178.11.6710
Friedrich, M. G., Sechtem, U., Schulz-Menger, J., Holmvang, G., Alakija, P., Cooper, L. T. et al (2009). Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper. J Am Coll Cardiol, 53(17):1475–87. 10.1016/j.jacc.2009.02.007.
Gargano, J. W., Wallace, M., Hadler, S. C., Langley, G., Su, J. R., Oster, M. E. et al (2021). Use of mRNA COVID-19 Vaccine After Reports of Myocarditis Among Vaccine Recipients: Update from the Advisory Committee on Immunization Practices - United States, June 2021. MMWR Morb Mortal Wkly Rep, 70(27):977–82. Disponível em: https://www.cdc.gov/mmwr/volumes/70/wr/pdfs/mm7027e2-H.pdf. Acessado em 03 mai 2022.
Golpour, A., Patriki, D., Hanson, PJ., McManus, B., Heidecker, B (2021). Epidemiological Impact of Myocarditis. Journal of Clinical Medicine, 5,10(4):603. 10.3390/jcm10040603.
Habedank, D., Lagast, A., Novoa-Usme, M., & Atmowihardjo, I. A case of myocarditis in a 60-year-old man 48 h after mRNA vaccination against SARS-CoV2. Clinical Research in Cardiology, 2022,111(2):230–2. DOI:10.1007/s00392-021-01946-4
Hasnie, A. A., Hasnie, U. A., Patel, N., Aziz, M. U., Xie, M., Lloyd, S. G., & Prabhu, S. D (2021). Perimyocarditis following first dose of the mRNA-1273 SARS-CoV-2 (Moderna) vaccine in a healthy young male: a case report. BMC Cardiovascular Disorders. 21(1):375. 10.1186/s12872-021-02183-3
King, W. W., Petersen, M. R., Matar, R. M., Budweg, J. B., Pardo, L. C. & Petersen, J. W (2021). Myocarditis following mRNA vaccination against SARS-CoV-2, a case series. Am Hear J Plus, 8(100042). 10.1016/j.ahjo.2021.100042.
Larson, K. F., Ammirati, E., Adler, E. D., Cooper, L. T., Hong, K. N., Saponara, G., et al (2021). Myocarditis After BNT162b2 and mRNA-1273 Vaccination. Circulation, 144(6):506–8. 10.1161/CIRCULATIONAHA.121.055913.
Mendes, S. C., Oliveira, J. V., Ferrari, A. C., Gois, K. C., Nicolau, L. D., Oliveira, M. P., Menezes-Rodrigues, F. S., Packer, M. L. T., F. L. A. & GEHRKE, F.S (2020). COVID-19: viral characterization, pathophysiology and prevention. Research, Society and Development, 9(9):1-31. 10.33448/rsd-v9i9.7768.
Muthukumar, A., Narasimhan, M., Li, Q-Z., Mahimainathan, L., Hitto, I., Fuda, F. et al (2021). In-Depth Evaluation of a Case of Presumed Myocarditis After the Second Dose of COVID-19 mRNA Vaccine. Circulation, 144(6):487–98. 10.1161/CIRCULATIONAHA.121.056038
Minocha, P. K., Better, D., Singh, R. K., & Hoque, T. (2021). Recurrence of Acute Myocarditis Temporally Associated with Receipt of the mRNA Coronavirus Disease 2019 (COVID-19) Vaccine in a Male Adolescent. The Journal of Pediatrics, 238:321–3. 10.1016/j.jpeds.2021.06.035.
Murakami, Y., Shinohara, M., Oka, Y., Wada, R., Noike, R., Ohara, H., Fujino, T. & Ikeda, T (2022). Myocarditis Following a COVID-19 Messenger RNA Vaccination: A Japanese Case Series. Internal Medicine, 61(4):8731–21. 10.2169/internalmedicine.8731-21
Patel, Y. R., Louis, D. W., Atalay, M., Agarwal, S., Shah, N. R (2021). Cardiovascular magnetic resonance findings in young adult patients with acute myocarditis following mRNA COVID-19 vaccination: a case series. Journal of Cardiovascular Magnetic Resonance, 23(1):101. 10.1186/s12968-021-00795-4
Patrignani, A., Schicchi, N., Calcagnoli, F., Falchetti, E., Ciampani, N., Argalia, G. & Mariani, A (2021). Acute myocarditis following Comirnaty vaccination in a healthy man with previous SARS-CoV-2 infection. Radiology Case Reports, 16(11):3321–5. 10.1016/j.radcr.2021.07.082
Pepe, S., Gregory, A. T. & Denniss, A. R (2021). Myocarditis, Pericarditis and Cardiomyopathy After COVID-19 Vaccination. Hear Lung Circ. 30(10):1425–9. 10.1016/j.hlc.2021.07.011.
Rosner, C. M., Genovese, L., Tehrani, B. N., Atkins, M., Bakhshi, H., Chaudhri, S. et al (2021). Myocarditis Temporally Associated With COVID-19 Vaccination. Circulation, 144(6):502–5. https://doi.org/10.1161/CIRCULATIONAHA.121.055891
Schauer, J., Buddhe, S., Colyer, J., Sagiv, E., Law, Y., Mallenahalli Chikkabyrappa, S., & Portman, M. A (2021). Myopericarditis After the Pfizer Messenger Ribonucleic Acid Coronavirus Disease Vaccine in Adolescents. The Journal of Pediatrics, 238:317–20. 10.1016/j.jpeds.2021.06.083
Singh, B., Kaur, P., Cedeno, L., Brahimi, T., Patel, P., Virk, H., Shamoon, F. & Bikkina, M (2021). COVID-19 mRNA Vaccine and Myocarditis. Eur J Case Rep Intern Med, 8(6):002681. 10.12890/2021_002681. eCollection 2021
Schmitt, P., Demoulin, R., Poyet, R., Capilla, E., Rohel, G., Pons, F., et al (2021). Acute Myocarditis after COVID-19 vaccination: A case report. Rev Med Interne, 42(11):797–800. 10.1016/j.revmed.2021.10.003
Tailor, P. D., Feighery, A. M., El-Sabawi, B., & Prasad, A (2021). Case report: acute myocarditis following the second dose of mRNA-1273 SARS-CoV-2 vaccine. European Heart Journal Case Reports, 5(8). 10.1093/ehjcr/ytab319
Tschöpe, C., Ammirati, E., Bozkurt, B., Caforio, A. L. P., Cooper, L. T., Felix, S. B., et al (2021). Myocarditis and inflammatory cardiomyopathy: current evidence and future directions. Nature Reviews Cardiology, 18(3):169–93. 10.1038/s41569-020-00435-x
Watkins, K., Griffin, G., Septaric, K., & Simon, E. L (2021). Myocarditis after BNT162b2 vaccination in a healthy male. Am J Emerg Med, 50:815.e1-815.e2. 10.1016/j.ajem.2021.06.051
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Copyright (c) 2022 Mariana Nicolella Abdalla; Carlos Alejandro Alzamora Bordini; Débora Driemeyer Wilbert; Francisco Sandro Menezes-Rodrigues
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