Adrenal insufficiency: from concept to treatment




Health education; Adrenal insufficiency; Diagnosis.


Adrenal Insufficiency (AI) is a clinical condition resulting from the deficient synthesis of the hormone cortisol by the cortex of the glands located just above the kidneys. Cortisol performs several essential functions in the body, interfering with metabolism, blood pressure and inflammatory processes. AI can be classified as primary or secondary. The primary form occurs early on in the adrenal gland itself. Glandular inflammation, inherited enzyme deficits and infectious processes are the most common causes. The secondary form in this situation, the initial problem is in the hypothalamus or the pituitary gland, located at the base of the brain. Tumors in this portion or abrupt discontinuation of glucocorticoid therapy are the most frequently seen. The following article aimed to describe from concept to treatment of adrenal insufficiency. This is a narrative review of literature based on SciELO, MEDLINE, BVS, SBEM platforms, in the time frame of the last 5 years. There is a lot of information on the subject in the scientific literature. Possibly this underscores the importance of the topic, in which current data on the definition, classification, clinical picture, diagnosis and treatment of AI are made available in full. In view of the information collected, it can be clarified that AI is a syndrome with clinical implications that urge an early and differential diagnosis, investigation of the etiological cause and appropriate treatment according to the clinical condition of the patient and the form of presentation of AI.


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How to Cite

CARVALHO, L. do C. .; SILVA , M. de M. e .; REIS , O. G. dos .; SILVA , N. G. da .; MACHADO, D. O. Q. .; OLIVEIRA JUNIOR, V. D. de .; SILVA , L. da C.; MELO , A. M. de S. .; SILVA, S. C. M. .; SOLER, C. M. D. .; MENDES FILHO, E. B. . Adrenal insufficiency: from concept to treatment. Research, Society and Development, [S. l.], v. 11, n. 9, p. e29411931901, 2022. DOI: 10.33448/rsd-v11i9.31901. Disponível em: Acesso em: 3 oct. 2022.



Review Article