Investigation of neurological manifestations in patients admitted with COVID-19 infection at Teresina Emergency Hospital

Authors

DOI:

https://doi.org/10.33448/rsd-v11i10.32047

Keywords:

Neurological manifestations; COVID-19.

Abstract

Objective: to analyze the frequency of neurological manifestations of COVID-19 in patients admitted to the Hospital de Urgência de Teresina, describing the different neurological manifestations and their correlations with age, gender, and history of hypertension and diabetes. Methodology: This is a cross-sectional, descriptive and quantitative study conducted during the months of June 2021 to April 2022. Data collection occurred in the medical record archiving service (SAME) at the Hospital de Urgência de Teresina (HUT) in Teresina-PI during the months of August and September 2021. For the research, we analyzed 253 medical records of patients diagnosed with COVID-19, randomly selected among the 736 seen at the HUT between March 1, 2020 and September 30, 2020. Variables analyzed: diagnosis of COVID-19, diagnostic test, age, gender, presence of neurological manifestations, diabetes, hypertension. Results: 50.2% of the analyzed medical records had neurological manifestations, and 40 different neurological symptoms were catalogued. It was not possible to establish a statistical relationship between age, gender and presence of hypertension with neurological symptoms, but there is evidence about diabetes mellitus influencing the presence of the catalogued symptoms. Conclusion: Neurological symptoms have considerable presence for the establishment of the disease and its evolution, with RNC, seizures, anosmia and ageusia being the most common. It was possible to correlate the presence of diabetes with the symptoms presented. The neurological symptoms show direct links with the neurological invasion of COVID-19.

References

Ahmed, M. U., Hanif, M., Ali, M. J., Haider, M. A., Kherani, D., Memon, G. M., Karim, A. H., & Sattar, A. (2020). Neurological Manifestations of COVID-19 (SARS-CoV-2): A Review. Frontiers in Neurology, 11, 518. https://doi.org/10.3389/fneur.2020.00518

Ali, L., Muhammad, A., Khan, A., Mohammed, I., Janjua, I., Zada, Y., Sharif, M., Naeem, M., Iqrar, A., & Haroon, K. H. ([s.d.]). Acute Neurological Manifestations of COVID-19 Patients From Three Tertiary Care Hospitals in Qatar. Cureus, 14(3), e23150. https://doi.org/10.7759/cureus.23150

Baj, J., Karakuła-Juchnowicz, H., Teresiński, G., Buszewicz, G., Ciesielka, M., Sitarz, R., Forma, A., Karakuła, K., Flieger, W., Portincasa, P., & Maciejewski, R. (2020). COVID-19: Specific and Non-Specific Clinical Manifestations and Symptoms: The Current State of Knowledge. Journal of Clinical Medicine, 9(6), 1753. https://doi.org/10.3390/jcm9061753

Carod Artal, F. J. (2020). Complicaciones neurológicas por coronavirus y COVID-19. Revista de Neurología, 70(09), 311. https://doi.org/10.33588/rn.7009.2020179

D, V., Sharma, A., Kumar, A., & Flora, S. J. S. (2021). Neurological Manifestations in COVID-19 Patients: A Meta-Analysis. ACS Chemical Neuroscience, acschemneuro.1c00353. https://doi.org/10.1021/acschemneuro.1c00353

Divani, A. A., Andalib, S., Biller, J., Di Napoli, M., Moghimi, N., Rubinos, C. A., Nobleza, C. O., Sylaja, P. N., Toledano, M., Lattanzi, S., McCullough, L. D., Cruz-Flores, S., Torbey, M., & Azarpazhooh, M. R. (2020). Central Nervous System Manifestations Associated with COVID-19. Current Neurology and Neuroscience Reports, 20(12), 60. https://doi.org/10.1007/s11910-020-01079-7

Ellul, M. A., Benjamin, L., Singh, B., Lant, S., Michael, B. D., Easton, A., Kneen, R., Defres, S., Sejvar, J., & Solomon, T. (2020). Neurological associations of COVID-19. The Lancet Neurology, 19(9), 767–783. https://doi.org/10.1016/S1474-4422(20)30221-0

Ge, H., Wang, X., Yuan, X., Xiao, G., Wang, C., Deng, T., Yuan, Q., & Xiao, X. (2020). The epidemiology and clinical information about COVID-19. European Journal of Clinical Microbiology & Infectious Diseases, 39(6), 1011–1019. https://doi.org/10.1007/s10096-020-03874-z

Jesuthasan, A., Massey, F., Manji, H., Zandi, M. S., & Wiethoff, S. (2021). Emerging potential mechanisms and predispositions to the neurological manifestations of COVID-19. Journal of the Neurological Sciences, 428, 117608. https://doi.org/10.1016/j.jns.2021.117608

Khatoon, F., Prasad, K., & Kumar, V. (2022). COVID-19 associated nervous system manifestations. Sleep Medicine, 91, 231–236. https://doi.org/10.1016/j.sleep.2021.07.005

Long, B., Carius, B. M., Chavez, S., Liang, S. Y., Brady, W. J., Koyfman, A., & Gottlieb, M. (2022). Clinical update on COVID-19 for the emergency clinician: Presentation and evaluation. The American Journal of Emergency Medicine, 54, 46–57. https://doi.org/10.1016/j.ajem.2022.01.028

López-Hortúa, M. A., Rodríguez-Hernández, P. A., Alviarez-Chaustre, K., Rivera-Hernández, S., Sánchez-Barrero, C. A., Valderrama-Mendoza, N., Miranda-Acosta, Y., & Torres-Bayona, S. (2022). Serious and infrequent neurological complications in hospitalized patients with COVID19. Interdisciplinary Neurosurgery, 28, 101493. https://doi.org/10.1016/j.inat.2022.101493

Mao, L., Jin, H., Wang, M., Hu, Y., Chen, S., He, Q., Chang, J., Hong, C., Zhou, Y., Wang, D., Miao, X., Li, Y., & Hu, B. (2020). Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurology, 77(6), 683. https://doi.org/10.1001/jamaneurol.2020.1127

Nepal, G., Rehrig, J. H., Shrestha, G. S., Shing, Y. K., Yadav, J. K., Ojha, R., Pokhrel, G., Tu, Z. L., & Huang, D. Y. (2020). Neurological manifestations of COVID-19: A systematic review. Critical Care, 24(1), 421. https://doi.org/10.1186/s13054-020-03121-z

Niazkar, H. R., Zibaee, B., Nasimi, A., & Bahri, N. (2020). The neurological manifestations of COVID-19: A review article. Neurological Sciences, 41(7), 1667–1671. https://doi.org/10.1007/s10072-020-04486-3

Noronha, K. V. M. de S., Guedes, G. R., Turra, C. M., Andrade, M. V., Botega, L., Nogueira, D., Calazans, J. A., Carvalho, L., Servo, L., & Ferreira, M. F. (2020). Pandemia por COVID-19 no Brasil: Análise da demanda e da oferta de leitos hospitalares e equipamentos de ventilação assistida segundo diferentes cenários. Cadernos de Saúde Pública, 36(6), e00115320. https://doi.org/10.1590/0102-311x00115320

Nogueira, R. G., Abdalkader, M., Qureshi, M. M., Frankel, M. R., Mansour, O. Y., Yamagami, H., Qiu, Z., Farhoudi, M., Siegler, J. E., Yaghi, S., Raz, E., Sakai, N., Ohara, N., Piotin, M., Mechtouff, L., Eker, O., Chalumeau, V., Kleinig, T. J., Pop, R., & Nguyen, T. (2021). Global impact of COVID-19 on stroke care. International Journal of Stroke, 16(5), 573–584. https://doi.org/10.1177/1747493021991652

Oliveira, B. A., Oliveira, L. C. de, Sabino, E. C., & Okay, T. S. (2020). SARS-CoV-2 and the COVID-19 disease: A mini review on diagnostic methods. Revista do Instituto de Medicina Tropical de São Paulo, 62, e44. https://doi.org/10.1590/s1678-9946202062044

Severino, A. J. (2017). Metodologia do trabalho científico (24th ed.). Editora Cortez

Taga, A., & Lauria, G. (2022). COVID-19 and the peripheral nervous system. A 2-year review from the pandemic to the vaccine era. Journal of the Peripheral Nervous System, 27(1), 4–30. https://doi.org/10.1111/jns.12482

Vakili, K., Fathi, M., Hajiesmaeili, M., Salari, M., Saluja, D., Tafakhori, A., Sayehmiri, F., & Rezaei-Tavirani, M. (2021). Neurological Symptoms, Comorbidities, and Complications of COVID-19: A Literature Review and Meta-Analysis of Observational Studies. European Neurology, 84(5), 307–324. https://doi.org/10.1159/000516258

Whittaker, A., Anson, M., & Harky, A. (2020). Neurological Manifestations of COVID‐19: A systematic review and current update. Acta Neurologica Scandinavica, 10.1111/ane.13266. https://doi.org/10.1111/ane.13266

WHO COVID-19 Dashboard. Geneva: World Health Organization, 2020. Available online: https://covid19.who.int/

Shi, Y., Wang, G., Cai, X., Deng, J., Zheng, L., Zhu, H., Zheng, M., Yang, B., & Chen, Z. (2020). An overview of COVID-19. Journal of Zhejiang University-SCIENCE B, 21(5), 343–360. https://doi.org/10.1631/jzus.B2000083

Yachou, Y., El Idrissi, A., Belapasov, V., & Ait Benali, S. (2020). Neuroinvasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: Understanding the neurological manifestations in COVID-19 patients. Neurological Sciences, 41(10), 2657–2669. https://doi.org/10.1007/s10072-020-04575-3

Yi, Y., Lagniton, P. N. P., Ye, S., Li, E., & Xu, R.-H. (2020). COVID-19: What has been learned and to be learned about the novel coronavirus disease. International Journal of Biological Sciences, 16(10), 1753–1766. https://doi.org/10.7150/ijbs.45134

Published

10/08/2022

How to Cite

PORTELA, D. M. M. C.; POLICARPO, M. E. G. . Investigation of neurological manifestations in patients admitted with COVID-19 infection at Teresina Emergency Hospital . Research, Society and Development, [S. l.], v. 11, n. 10, p. e542111032047, 2022. DOI: 10.33448/rsd-v11i10.32047. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/32047. Acesso em: 23 nov. 2024.

Issue

Section

Health Sciences