Susceptibilidade do eixo hipotalâmico-hipofisário-tireoidiano às isoflavonas de soja
DOI:
https://doi.org/10.33448/rsd-v11i9.32089Palavras-chave:
Isoflavonas; Disruptores endócrinos; Hormônios tireóideos; Glândula tireoide.Resumo
O aumento do consumo de produtos à base de soja pode estar relacionado com problemas de saúde, uma vez que o teor de isoflavonas consumidos diariamente, passa a representar níveis capazes de interferir na homeostase corporal, agindo como um desregulador endócrino químico. A interferência causada pelas isoflavonas no eixo hipotalâmico-hipofisário-tireoideano (HHT) pode afetar a produção dos hormônios tireoidianos ao interagir com receptores de estrógenos localizados na tireoide, além de influenciar na ação das desiodases para a conversão hormonal nos tecidos periféricos. Desta forma, o objetivo desta revisão foi evidenciar as possíveis alterações causadas pelo consumo de isoflavonas e o seu impacto sobre a produção dos hormônios tireoidianos. Para isto foram utilizadas plataformas de busca como PubMed, Science Direct e Google Acadêmico. Filtros de busca limitando o ano de publicação dos artigos utilizados como referência não foram aplicados nesta pesquisa devido a relevância que estudos iniciais que abordam a relação entre isoflavonas/soja e desregulação endócrina apresentam. Foram evidenciados efeitos da exposição as isoflavonas de soja (ISOF), sobre as funções tireoidianas relacionadas ao hipotireoidismo subclínico.
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