Mastocytosis Colitis in 54 year old woman: A rare case report
DOI:
https://doi.org/10.33448/rsd-v11i13.32410Keywords:
Mastocytosis systemic; Mastocytosis colitis; Mast cell; Chronic diarrhea.Abstract
Introduction: Mastocytosis is a rare disorder occurring due to neoplastic clonal proliferation of mast cells accumulating in one or more organ systems. Systemic mastocytosis is generally diagnosed after the second decade of life, reported male-to-female ratios range from 1:1 to 1:1.5. Case description : A 54-year-old woman came complaining weakness and diarrhea for the last 2 months. Symptoms are watery stools for 2-4 times a day and nausea. Physical examination found that the body temperature was 37.60C, tachycardia, increased bowel sounds, and tenderness on stomach. An endoscopic examination was performed with results: transverse colon appears with polyps with a size of 3 mm, with a mosaic pattern of mucosa. The mucosa of the ascending colon and caecum also appears to be a mosaic pattern. Biopsy was sent for histopathological examination. Morphological features show significant increase of eosinophils & mast cells, differentially diagnosed with Mastocytosis colitis, Eosinophilic colitis, systemic mastocytosis with GI involvement. Methodology : Descriptive study of the case report type, data were obtained from the patient's record. Discussion and Conclusion : To rule out the differential diagnosis, an immunohistochemical examination and clinical correlation were performed. On histopathological examination, microscopic features showed the proliferation of mast cells in the aggregate only in the colon, without any other systemic manifestations, an increase in the number of mast cells >20/HPF was found in the colonic mucosa. The staining of CD117 on cells in the superficial (1/3 top) of the lamina propria suspected of being a mastocyte, supporting mastocytosis colitis.
References
Cancer.net. (2022). Statistics. Asco - Cancer.net. https://www.cancer.net/cancer-types/mastocytosis/statistics
Castells, M. C. & Akin, C. (2021). Mastocytosis (cutaneous and systemic) in children: Epidemiology, clinical manifestations, evaluation, and diagnosis. https://www.uptodate.com/contents/mastocytosis-cutaneous-and-systemic-in-children-epidemiology-clinical-manifestations-evaluation-and-diagnosis/print.
Horny, A. P., Akin, C., Arber, D. A., Peterson, L. C. et al. (2017). Mastocytosis, 4th ed. International Agency for Research on Cancer. P : 62-8.
Hyungil Seo, Park S H, Byeon J S, Woo C G, Hong S M, Chang K, et al. (2016). Chronic Intractable Diarrhea Caused by Gastrointestinal Mastocytosis. Diunduh pada 2 maret 2022, dari : http://dx.doi.org/10.5217/ir.2016.14.3.280.
Kirsch R., Geboes K., Shepherd N. A., Hertogh G., Nicola N., et al. (2008). Systemic Mastocytosis Involving the Gastrointestinal Tract: clinicopathologic and Molecular Study of Five Cases. Diunduh pada 4 maret 2022, dari : https://www.nature.com/articles/modpathol2008158.pdf?origin=ppub
Lee, J. K., Whittaker, S. J., Enns, R. A. & Zetler, P. (2008). Gastrointestinal manifestations of systemic mastocytosis. Diunduh pada 14 April 2022, dari : DOI:10.3748/wjg.14.7005
Pereira, A.S. et al. (2018). Metodologia da pesquisa cientifica. UFSM.
Ramsay D. B., Stephen S., Borum M., Voltaggio L. & Donam D. B. (2010). Mast Cells in Gastrointestinal Disease. Diunduh pada 14 Mei 2022, dari : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033552/
Reggiania S., Cossoa L., Adriania A., Pantaleonia S., Rissoa A., Vittoneb F., Chiusab L., Saponea N. & Astegianoa M. (2015). A Case of Intestinal Mastocytosis Misdiagnosed as Crohn’s Disease. DOI: 10.1159/000430946.
Sokol H., Lavialle S. G., Canioni D., Barette S., Damaj G., et al. (2013). Gastrointestinal manifestations in Mastocytosis : A study of 83 Patients. Diunduh pada 2 maret 2022, dari : http://dx.doi.org/10.1016/j.jaci.2013.05.026.
Srivastava A. (2016). Mastocytosis in Diagnostic Pathology Gastrointestinal. 2nd ed. Elsevier, Philadelphia. P : 514-7.
Sunkara T., Rawla P., Yarlagadda K. S. & Gaduputi V. (2019). Eosinophilic Gastroenteritis : Diagnosis and Clinical Perspectives. Diunduh pada 4 maret 2022, dari : https://www.dovepress.com/getfile.php?fileID=50324.
Yin., Robert K. (2017). Case Study Research and Application : desgin and method. 5th ed. SAGE, Los Angeles.
Zanelli M., Pizzi M., Saguedolce F., & Zizzo M. (2021). Gastrointestinal Menifestations in Systemic Mastocytosis : The Need of a Multidiciplinary Approach. Diunduh pada 22 mei 2022 dari : https://pubmed.ncbi.nlm.nih.gov/34282774/ .
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Herman Saputra ; Ni Putu Sriwidyani ; Putu Erika Paskarani; Dandy Citra
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
