Use of vasoactive drugs in the management of shock: a literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i10.32453

Keywords:

Shock; vasoactive drugs; Vasoactive drugs; management; Management.

Abstract

Acute diseases are often characterized by alterations in cardiovascular homeostasis. Underlying mechanisms may include multiple factors that alter blood volume (actual or effective), cardiac function (diastolic and/or systolic), or vessels (large vessels and/or microvasculature). The present study aims to analyze which vasoactive drugs are used in the management of shock. This is a study with a qualitative approach, where the integrative literature review was adopted, which according to Galvão (2012), is a construction of a broad analysis of the literature with pre-defined steps. Conducted through the Virtual Health Library (BVS) in the Pubmed databases, using the crossings of the English descriptors “Vasoactive Drug”, “Catecholamines”. Vasoactive agents are classified into sympathomimetics, vasopressin analogues and angiotensin II. Catecholamines are subdivided into indirect-acting, mixed-acting, and direct-acting categories. Only direct action agents have a role in the shock. Direct agents are further delineated by their selective nature (eg, dobutamine, phenylephrine) or non-selective activity (eg, epinephrine, norepinephrine) at α1, α2, β1, β2, and β3 receptors. Catecholamines are most often associated with clinical improvement in shock states. Vasoactive drugs are part of the treatment of shock and must be chosen according to the patient's need, so it is essential that health professionals have adequate knowledge of these drugs to better serve each case.

References

Russell, J. A., Gordon, A. C., Williams, M. D., Boyd, J. H., Walley, K. R., & Kissoon, N. (2021) Vasopressor Therapy in the Intensive Care Unit. Semin Respir Crit Care Med. 42(1):59-77.

Galvão, C. M., et al. Revisão integrativa: método de revisão para sintetizar as evidências disponíveis na literatura. In: Brevidelli MM, Sertório SCM. Trabalho de conclusão de curso: guia prático para docentes e alunos da área da saúde. 105-26, 2012.

Bosch, N. A., Teja, B., Wunsch, H., & Walkey, A. J. (2021) Practice Patterns in the Initiation of Secondary Vasopressors and Adjunctive Corticosteroids during Septic Shock in the United States. Ann Am Thorac Soc.18(12):2049-2057.

Jentzer, J. C., Coons, J. C., Link, C. B., & Schmidhofer, M. (2015) Pharmacotherapy update on the use of vasopressors and inotropes in the intensive care unit. J Cardiovasc Pharmacol Ther.20(3):249-60.

Annane, D., Ouanes-Besbes, L., de Backer, D. D. U. B., Gordon, A. C., Hernández, G., Olsen, K. M., Osborn, T. M., Peake, S., Russell, J. A., & Cavazzoni, S. Z. (2018) A global perspective on vasoactive agents in shock. Intensive Care Med.44(6):833-846.

Jentzer, J. C., Ahmed, A. M., Vallabhajosyula, S., Burstein, B., Tabi, M., Barsness, G. W., Murphy, J. G., Best, P. J., & Bell, M. R. (2021) Shock in the cardiac intensive care unit: Changes in epidemiology and prognosis over time. Am Heart J.232:94-104.

Meresse, Z., Medam, S., Mathieu, C., Duclos, G., Vincent, J. L., & Leone, M. (2020) Vasopressors to treat refractory septic shock. Minerva Anestesiol. 86(5):537-545.

Israelsen, M., Krag, A., Allegretti, A. S., Jovani, M., Goldin, A. H., Winter, R. W., & Gluud, L. L. (2017) Terlipressin versus other vasoactive drugs for hepatorenal syndrome. Cochrane Database Syst Rev. 9(9).

Lobo, M. D., Sobotka, P. A., & Pathak, A. (2017) Interventional procedures and future drug therapy for hypertension. Eur Heart J. 14;38(15):1101-1111.

Seilitz, J, Grafver, I, Kiszakiewicz, L, Oikonomakis, I, Jansson, K, Axelsson, B, & Nilsson, K. F. (2021) A Randomized Porcine Study in Low Cardiac Output of Vasoactive and Inotropic Drug Effects on the Gastrointestinal Tract. Shock. 56(2):308-317.

Cacanyiova, S, Goals, S, Zemancikova, A, Majzunova, M, Cebova, M, Malinska, H, Hüttl, M, Markova, I, & Berenyiova, A. (2021) The Vasoactive Role of Perivascular Adipose Tissue and the Sulfide Signaling Pathway in a Nonobese Model of Metabolic Syndrome. Biomolecules. 11(1):108.

Udesen, N. L. J., Helgestad, O. K. L., Banke,. A .B S., Frederiksen, P. H., Josiassen, J., Jensen, L. O., Schmidt, H., Edelman, E. R., Chang, B. Y., Ravn, H. B., & Møller, J. E. (2020 )Impact of concomitant vasoactive treatment and mechanical left ventricular unloading in a porcine model of profound cardiogenic shock. Crit Care. 24(1):95.

Miller, L. E., Laughon, M. M., Clark, R. H., Zimmerman, K. O., Hornik, C. P., Aleem, S., Brian, S. P., & Greenberg, R G. (2021) Vasoactive medications in extremely low gestational age neonates during the first postnatal week. J Perinatol.41(9):2330-2336.

Cioccari, L, Luethi, N, Bailey, M, Shehabi, Y, Howe, B, Messmer, A. S., Proimos, H. K., Peck, L., Young , H., Eastwood, G. M., Merz, T. M., Takala, J., Jakob, S. M., & Bellomo, R. (2020). The effect of dexmedetomidine on vasopressor requirements in patients with septic shock: a subgroup analysis of the Sedation Practice in Intensive Care Evaluation [SPICE III] Trial. Crit Care. 24(1):441.

Lim, J. Y., Park, S. J., Kim, H. J., Kim, H. J., Choo, S. J., Chung, C. H., Lee, J. W., Park, D. W., & Kim, J. B. (2021) Comparison of dopamine versus norepinephrine in circulatory shock after cardiac surgery: A randomized controlled trial. J Card Surg. 36(10):3711-3718.

Chang, Y. T., Huang, W. C., Cheng, C. C., Ke, M. W., Tsai, J. S., Hung, Y. M., Huang, N. C., Huang, M. S., Wann, S. R. (2020) Efeitos da epinefrina na variabilidade da frequência cardíaca e citocinas em um modelo de sepse em ratos. Bosn J Basic Med Sci. 20(1):88-98.

Belletti, A., Benedetto, U., Biondi-Zoccai, G., Leggieri, C., Silvani, P., Angelini, G. D., Zangrillo, A., & Landoni, G. (2017) The effect of vasoactive drugs on mortality in patients with severe sepsis and septic shock. A network meta-analysis of randomized trials. J Crit Care. 37:91-98.

Birtan, D., Arslantas, M. K., Altun, G. T., Dincer, P. C., Gecegormez, S., Demirel, A., Ayanoglu, H. O. (2018). Effect of Vasoactive Therapy Used for Brain-Dead Donors on Graft Survival After Kidney Transplantation. Transplant Proc.50(5):1289-1291.

D'Souza, M., Pye, S., Randle, E., Ramnarayan, P., & Jones, A. J. (2022) Use of peripheral vasoactive drug infusions during the critical care transport of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 infection. Arch Dis Child. 107(3):e11

Lesur, O., Delile, E., Asfar, P., & Radermacher, P. (2018) Hemodynamic support in the early phase of septic shock: a review of challenges and unanswered questions. Ann Intensive Care. 29;8(1):102.

Published

26/07/2022

How to Cite

COSTA JUNIOR, V. A. da; BRANCO, A. L. G. C. .; CAVALCANTI, A. L. M. .; BARROS, B. S. .; MAPURUNGA VASCONCELOS, D.; NEGREIROS, F. da S. .; ROSA, Ícaro F. .; PORTELA, L. P. .; TEIXEIRA, L. N. A. . Use of vasoactive drugs in the management of shock: a literature review. Research, Society and Development, [S. l.], v. 11, n. 10, p. e149111032453, 2022. DOI: 10.33448/rsd-v11i10.32453. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/32453. Acesso em: 3 oct. 2022.

Issue

Section

Health Sciences