Bioactives Derived from Endophytic Fungi Isolated from Azadirachta Indica (Neem) and their Applications

Authors

DOI:

https://doi.org/10.33448/rsd-v11i9.32454

Keywords:

Bioprospecting; Secondary metabolites; Micro-organisms; Medicinal plants.

Abstract

Azadirachta indica A. Juss (Neen) has great ethnomedicinal importance, being known for its insecticidal power and for various therapeutic purposes as a folk medicine. Studies show that endophytes isolated from medicinal plants have potential as an alternative source of secondary metabolites. More than 400 compounds have been isolated from different parts of Neen, including important bioactive secondary metabolites such as azadirachtin, nimbidin, nimbin, nimbolide, gedunin, however, the metabolites of fungi already isolated and characterized showed that more than half of the molecules have antibacterial activity, antifungal and antitumor. Penicillin, cephalosporin, ergotrate and statins are fungal secondary metabolites. The present work aimed to carry out a review of the literature on bioactive products from endophytic fungi of Azadirachta indica and their applications. Activities from extracts of plant parts (leaves, stems, roots) or from cultivation and selection of endophytes other than the kingdom Fungi were excluded. 11 articles were found in the databases that present 12 different endophytic fungi, isolated from Azadirachta indica, with the production of different secondary metabolites and varied applications. Antimicrobial, antifungal, insecticidal and nematicidal activities and improvement in plant adaptation mechanisms. Thirty-four metabolites were identified and tested in different techniques and applications.

Author Biographies

José Celso Rocha Martins Júnior, Universidade Católica Dom Bosco

Postgraduate Program in Environmental Sciences and Agricultural Sustainability

Vanessa Pinto Oleques Pradebon, Universidade Católica Dom Bosco

Postgraduate Program in Environmental Sciences and Agricultural Sustainability

Laís Rezende Maia, Universidade Católica Dom Bosco

Postgraduate Program in Environmental Sciences and Agricultural Sustainability

Antonia Railda Roel, Universidade Católica Dom Bosco

Programa de Pós Graduação em Ciencias Ambientais e Sustentabilidade Agropecuária

Tiago Tognolli de Almeida, Universidade Católica Dom Bosco

Postgraduate Program in Environmental Sciences and Agricultural Sustainability

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Published

20/07/2022

How to Cite

RICCI, A. P.; MARTINS JÚNIOR, J. C. R.; PRADEBON, V. P. O.; MAIA, L. R.; LOOSLI , A. W. M. .; ROEL, A. R.; ALMEIDA, T. T. de. Bioactives Derived from Endophytic Fungi Isolated from Azadirachta Indica (Neem) and their Applications. Research, Society and Development, [S. l.], v. 11, n. 9, p. e13911932454, 2022. DOI: 10.33448/rsd-v11i9.32454. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/32454. Acesso em: 13 aug. 2022.

Issue

Section

Health Sciences