Drug interaction between antiretrovirals and psychodrugs

Authors

DOI:

https://doi.org/10.33448/rsd-v11i11.32576

Keywords:

Drug interactions; Anti-HIV Drugs; Drug incompatibility.

Abstract

Introduction: The human immunodeficiency virus type 1 (HIV-1) is the agent that produces AIDS, a disease recognized for more than forty years, which has reached pandemic proportions. Its origin dates back to the transmission to humans of retroviruses that infected populations of chimpanzees in central Africa approximately 100 years ago. From this location, its expansion to the whole world has been enormous, mainly in the last decades. Objectives: to carry out a literature review on the drug interaction between antiretrovirals and psychotropic drugs, identifying the factors that influence the consumption of psychotropic drugs in people with HIV. Method: Qualitative research, such as an integrative literature review, with data collected through articles available on online platforms. Results: The results obtained already published may be controversial, since some authors interpret certain adverse reactions as not resulting from drug interaction, but caused by the antidepressant, antipsychotic and antiretroviral drug itself, that is, the observation of effects side effects, which may be related both to the interaction of different classes of antiretrovirals and to that of antidepressants and antipsychotics with antiretrovirals, make it difficult to characterize the interaction and, therefore, this observation is often neglected. Conclusion: Despite the studies analyzed demonstrate effects between drug interactions (retrovirals and psychotropic drugs, research with a greater number of individuals should be developed.

References

Amodeo, D. A., Yi, J., Sweeney, J. A. & Ragozzino, M. E. (2014) Oxotremorine treatment reduces repetitive behaviors in BTBR T+ tf/J mice. Front Synaptic Neurosci 6:17.

Baer, L., Trivedi, M. H., Huz, I., Rush, A. J, Wisniewski, S. R. & Fava, M. (2015). Prevalence and impact of obsessive-compulsive symptoms in depression. J Clin Psychiatry.

Brasil. (2018). Ministério da Saúde. Boletim de Aids e DST HIV/Aids 2018. Publ. 27/11/2018.

Galvão, C. M. (2002). A prática baseada em evidências: uma contribuição para a melhoria da assistência de enfermagem perioperatória. [livre-docência]. Ribeirão Preto (SP): Escola de Enfermagem de Ribeirão Preto/USP

Gonzalez-Torres, M. A., Salazar, M. A., Imaz, M. et al. (2014), Undertreatment of human immunodeficiency virus in psychiatric inpatients: a cross-sectional study of seroprevalence and associated factors. Neuropsychiatr Dis Treat

Goodlet, K. J., Zmarlicka, M. T. & Peckham, A. M. (2019). Drug-drug interactions and clinical considerations with co-administration of antiretrovirals and psychotropic drugs CNS

Hoefler R. (2015). Drug Interactions. Secr Ciência, Tecnol e Insumos Estratégicos/MS - FTN. 35(1):28–34

Kitchenham, B. A. (2020). Procedures for performing systematic reviews. Software Engineering Group – Keele University – United Kingdom and Empirical Software Engineering, National ICT Australia. 2004.

Lima, L. G. B. et al. (2020) Características de usuários com diagnóstico de Transtorno Depressivo atendidos em um Centro de Atenção Psicossocial. Rev. Eletrônica Saúde Mental Álcool Drog

Mills, J. C., Harman, J. S., Cook, R. L., Marlow, N. M., Harle, C. A., Duncan, R, P. et al. (2017). Comparative effectiveness of dual vs single-action antidepressants on HIV clinical outcomes in HIV-infected people with depression. AIDS

Moura C, Acurcio F, & Belo N. (2009) Drug-drug interactions associated with length of stay and cost of hospitalization. J Pharm Pharm Sci. 12(3):266–72. 88.

Ostad Haji E, Hiemke C, & Pfuhlmann B. (2012) Therapeutic drug monitoring for antidepressant drug treatment. Curr Pharm Des 2012; 18:5818–5827.

Oviedo-Joekes E, et al. (2009) Uso y valoración de los servicios sanitarios y de la medicación antirretroviral en personas diagnosticadas de infección por el virus de la inmunodeficiencia humana [Use and evaluation of the health care services and the antirretroviral medication in HIV diagnosed people]. 23(2):121-6.

Reis, H. P. L. C. (2014) Acompanhamento de pessoas com HIV sob terapia antirretroviral: adequação, aplicação e avaliação de indicadores clínico-laboratoriais, farmacoterapêuticos e humanísticos na atenção farmacêutica. 395 f. Tese (Doutorado) – Universidade Federal do Ceará, Departamento de Farmácia, Programa de Pós-Graduação em Ciências Farmacêuticas, Doutorado em Ciências Farmacêuticas, Fortaleza, 2014.

Sampieri, R. H., et al. (2013) Metodologia de Pesquisa. São Paulo: Mc-Graw-Hill, (5a ed.).

Santos, W. M.; Secoli, S. R.; & Padoin, S. M. M. (2016) Potenciais interações de drogas em pacientes de terapia antirretroviral. Revista Latino-Americana de Enfermagem, v. 24, n. 1, p. 1-9, 2016.

Thompson A, Silverman B, Dzeng L, & Treisman G. (2006) Psychotropic medications and HIV. Clin Infect Dis. 42(9):1305-10. 10.1086/501454.

Tseng, A.; et al. (2013) Association of age with polypharmacy and risk of drug interactions with antiretroviral medications in HIV-positive patients. Ann Pharmacother, 47, 1429-1439.

Van Mil, J. W. F.; et al. (2016) Medical Care and Drug – related problems: ¿do doctors and pharmacists speak the same language? Int J Clin Pharm, 38, 191-194

Whittemore R, Knafl K. The integrative review: update methodology. J Adv Nurs. 2005;52(5):546-53.

Zirulnik J. L. (2015) Actualización en el manejo de psicofármacos en pacientes VIH positivos [Management of psychotropic drugs in hiv-infected patients]. 2015 26(121):217-23. Spanish.

Published

03/09/2022

How to Cite

MOTA, A. R. .; SCHUELTER-TREVISOL , F. . Drug interaction between antiretrovirals and psychodrugs. Research, Society and Development, [S. l.], v. 11, n. 11, p. e02111132576, 2022. DOI: 10.33448/rsd-v11i11.32576. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/32576. Acesso em: 28 sep. 2022.

Issue

Section

Review Article