Intraoral peripheral giant cell granuloma
DOI:
https://doi.org/10.33448/rsd-v11i10.32954Keywords:
Mouth; Peripheral giant cell granuloma; Surgery, oral.Abstract
Introduction: Intraoral peripheral giant cell granuloma is considered a reactional lesion. Although its etiology is not clearly established, trauma and local irritants are associated with its occurrence. It commonly presents as a nodular lesion, which may present with superficial ulceration. The most frequent intraoral location is in the mandible, between the fifth and sixth decades of life. The lesion does not have specific imaging criteria for diagnosis. Histologically, it is composed of mononuclear cells and multinucleated giant cells in a stroma of fibrous connective tissue with different degrees of inflammation. Objective and case report: The article aims to present a case report of a patient with peripheral giant cell lesion in the large mandible. Surgical treatment for excision of the lesion was performed in a hospital environment, under the effect of general anesthesia. Final considerations: The control of local irritating agents and the complete excision of the lesion, associated with an adjuvant therapy, such as peripheral osteotomy, guarantee an effective treatment, reducing the possibility of recurrence.
References
Abofoul, S., Hurvitz, A. Z., Grienstein, O. K., Shuster, A., Vered, M., Edel, J., & Kaplan, I. (2022). Peripheral giant cell granuloma associated with dental implants: Case-series. Clinical implant dentistry and related research, 24(1), 133–137.
Ahmed, A., & Naidu, A. (2021). Towards better understanding of giant cell granulomas of the oral cavity. Journal of clinical pathology, 74(8), 483–490.
Ahmed, W. M. S., & Haggag, M. A. (2022). HAS Carnoy's solution a role in the management of recurrent peripheral giant cell granuloma? Journal of Stomatology, Oral and Maxillofacial Surgery, 123(1), 37-43.
Alsaywid, B. S., & Abdulhaq, N. M. (2019). Guideline on writing a case report. Urology annals, 11(2), 126–131.
Assadat Hashemi Pour, M., Rad, M., & Mojtahedi, A. (2008). A survey of soft tissue tumor-like lesions of oral cavity: A clinicopathological study. Iranian Journal of Pathology, 3(2), 81-87.
Baesso, R., de Lima Jacy Monteiro Barki, M. C., de Souza Azevedo, R., da Costa Fontes, K., Pereira, D. L., Tucci, R., Pires, F. R., & Picciani, B. (2019). Peripheral giant cell granuloma associated with a dental implant. BMC oral health, 19(1), 283.
Bodhankar, K., Bansal, S., Jashnani, K., & Desai, R. S. (2020). Immunohistochemical expression of stem cell markers OCT-4 and SOX-2 in giant cell tumor, central giant cell granuloma, and peripheral giant cell granuloma. Oral surgery, oral medicine, oral pathology and oral radiology, 130(1), 78–84.
Chapple, I., Mealey, B. L., Van Dyke, T. E., Bartold, P. M., Dommisch, H., Eickholz, P., Geisinger, M. L., Genco, R. J., Glogauer, M., Goldstein, M., Griffin, T. J., Holmstrup, P., Johnson, G. K., Kapila, Y., Lang, N. P., Meyle, J., Murakami, S., Plemons, J., Romito, G. A., Shapira, L., … Yoshie, H. (2018). Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. Journal of periodontology, 89 Suppl 1, S74–S84.
Chrcanovic, B. R., Gomes, C. C., & Gomez, R. S. (2018). Peripheral giant cell granuloma: An updated analysis of 2824 cases reported in the literature. Journal of oral pathology & medicine: official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 47(5), 454–459.
Chrcanovic, B. R., Gomes, C. C., & Gomez, R. S. (2019). Peripheral giant cell granuloma associated with dental implants: a systematic review. Journal of stomatology, oral and maxillofacial surgery, 120(5), 456-461.
Ekici, Ö., Ay, S., Açıkalın, M. F., & Paşaoğlu, Ö. (2022). Immunohistochemical evaluation of IL-1β, IL-6, TNF-α and IL-17 cytokine expression in peripheral giant cell granuloma and peripheral ossifying fibroma of the jaws. Archives of oral biology, 136, 105385.
Estrela, C. (2018). Metodologia científica: Ciência, ensino e pesquisa. Arte Med.
Jindal, D. G., Kushwaha, S. S., Joshi, S., Sepolia, N., Jindal, V., & Jain, K. (2019). Peripheral giant cell granuloma: a case report with review on its histogenesis and recurrence. Dental Journal of Advance Studies, 7(02), 095-098.
Katsikeris, N., Kakarantza-Angelopoulou, E., & Angelopoulos, A. P. (1988). Peripheral giant cell granuloma. Clinicopathologic study of 224 new cases and review of 956 reported cases. International journal of oral and maxillofacial surgery, 17(2), 94–99.
Lee, J. C., & Huang, H. Y. (2020). Soft Tissue Special Issue: Giant Cell-Rich Lesions of the Head and Neck Region. Head and neck pathology, 14(1), 97–108.
Lester, S. R., Cordell, K. G., Rosebush, M. S., Palaiologou, A. A., & Maney, P. (2014). Peripheral giant cell granulomas: a series of 279 cases. Oral surgery, oral medicine, oral pathology and oral radiology, 118(4), 475–482.
Mighell, A. J., Robinson, P. A., & Hume, W. J. (1995). Peripheral giant cell granuloma: a clinical study of 77 cases from 62 patients, and literature review. Oral diseases, 1(1), 12–19.
Moreno Rodríguez, J. A. (2019). Peripheral giant cell granuloma associated with periodontal intrabony defect. Clinical Advances in Periodontics, 9(3), 142-146.
Motamedi, M. H., Eshghyar, N., Jafari, S. M., Lassemi, E., Navi, F., Abbas, F. M., Khalifeh, S., & Eshkevari, P. S. (2007). Peripheral and central giant cell granulomas of the jaws: a demographic study. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 103(6), e39–e43.
Nagar, S. R., Bansal, S., Jashnani, K., Sinha, A., & Desai, R. S. (2020). A Comparative Analysis of p63 Expression in Giant Cell Tumour (GCT), Central Giant Cell Granuloma (CGCG) and Peripheral Giant Cell Granuloma (PGCG). Head and neck pathology, 14(3), 733–741.
Patil, C. L., Gaikwad, R. P., Banodkar, A. B., Attar, N. B., & Sethna, G. D. (2018). Peripheral giant cell granuloma manifestation in pregnancy. Indian Journal of Dental Research, 29(5), 678.
Sánchez-Torres, A., Pérez-Amate, B., Javier, A. N., Cercadillo-Ibarguren, I., Figueiredo, R., & Valmaseda-Castellón, E. (2021). Peripheral giant cell granuloma associated with a dental implant: A case report. Journal of clinical and experimental dentistry, 13(10), e1049–e1052.
Shadman, N., Ebrahimi, S. F., Jafari, S., & Eslami, M. (2009). Peripheral giant cell granuloma: a review of 123 cases. Dental research journal, 6(1), 47–50.
Sharma, N., Rana, S., & Jetley, S. (2022). Peripheral giant cell granuloma of maxilla. Journal of Indian Society of Periodontology, 26(1), 75.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Deise Ponzoni; Érica Bugone; Jadson Lisboa da Silva; Alexandre Silva de Quevedo; Fernanda Visioli; Edela Puricelli
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.