Downhill esophageal varices associated with superior vena cava syndrome – A case report
DOI:
https://doi.org/10.33448/rsd-v11i10.33003Keywords:
Superior Vena Cava Syndrome; Esophageal varices; Gastrointestinal hemorrhage; Case report.Abstract
Objective: Esophageal varices are an important cause of digestive bleeding, with uphill varices secondary to portal hypertension being the most common cause. Downhill esophageal varices are rare, are related to superior vena cava obstruction, and require investigation as to their etiology, as appropriate treatment is related to the underlying cause and is essential to reduce the risk of complications. Methodology: A review of the patient's chart was carried out, as well as an extensive literature search on downhill esophageal varices, with a detailed study of their etiology, pathophysiology, diagnosis, and treatment. The correlations between the case and the findings in the literature are also presented. Case report: A 52-year-old patient presented with clinical manifestations of superior vena cava syndrome and endoscopic findings of downhill esophageal varices. A complementary investigation with computed tomography of the chest was performed, and chronic thrombosis of the superior vena cava with extensive collateral circulation was diagnosed. The investigation of thrombophilia was negative, and the etiology of the thrombosis was defined as idiopathic. Conclusion: The importance of recognizing, diagnosing downhill esophageal varices, and understanding their pathophysiology for adequate etiological investigation and early treatment, as well as reducing the risks of gastrointestinal bleeding, are highlighted in this case.
References
Ali, A. A. et al. (2021). Active bleeding from downhill varices: case report and management. VideoGIE, 6 (7): 305-307.
Ali, H. et al. (2021). Recurrent hematemesis from downhill esophageal varices: a therapeutic challenge for gastroenterologists. Cureus, 13 (3): e13840. doi: 10.7759/cureus.13840.
Areia, M. et al. (2006). “Downhill” varices: a rare cause of esophageal hemorrhage. Revista Española de Enfermedades Digestivas, 98 (5): 359-361.
Ayvaz, M. A. et al. (2018). Are downhill varices an overlooked entity of upper gastrointestinal bleedings? Gastroenterology Research and Practice. doi: 10.1155/2018/7638496. eCollection 2018.
Bellefqih, S. et al. (2014). Syndrome cave supérieur d’origine maligne. Revue de Pneumologie Clinique, 70: 343-352.
Berkowitz, J. C. et al. (2016). Downhill esophageal varices associated with central venous catheter-related thrombosis managed with endoscopic and surgical therapy. ACG Case Reports Journal, 3 (4): e102. doi: 10.14309/crj.2016.75
Chakinala, R. C. et al. (2018). Downhill esophageal varices: a therapeutic dilemma. Annals of Translational Medicine, 6 (23): 463. doi: 10.21037/atm.2018.11.13.
Ennaifer, R. et al. (2015). Downhill esophageal variceal bleeding: a rare complication in Behçet’s disease - related superior vena cava syndrome. Arab Journal of Gastroenterology, 16 (1):36-38.
Gessel, L., & Alcorn, J. (2015). Variants of varices: is it all “downhill” from here?. Digestive Disease and Sciences, 60(2): 316-319.
Gómez-Aldana, A.J., & Gómez-Zuleta, M.A. (2017). “Downhill” esophageal varices secondary to superior vena cava thrombosis and abnormal factor V. Revista de Gastroenterología de México, 82 (2): 179-180.
Gonzáles, J. L. et al. (2021). Hemorragia digestiva alta secundária a downhill varices: una complicación infrecuente y potencialmente mortal del síndrome de vena cava superior. Gastroenterología y Hepatología. https://doi.org/10.1016/j.gastrohep.2021.03.016
Harwani, Y. P. et al. (2014). Combined uphill and downhill varices as a consequence of rheumatic heart disease: a unique presentation. Journal of Clinical and Experimental Hepatology, 4 (1): 63-65.
Hussein, F. A. et al. (2008). Formation of downhill esophageal varices as a rare but serious complication of hemodialysis access: a case report and comprehensive literature review. Clinical and Experimental Nephrology, 12: 407-415.
Inoue, Y. et al. (2013). Downhill esophageal varices resulting from superior vena cava graft occlusion after resection of a thymoma. Interactive Cardiovascular and Thoracic Surgery, 17 (3): 598-600.
Kovacs, T. O. G., & Jensen, D.M (2019). Varices esophageal, gastric and rectal. Clinical Liver Disease, 23 (4): 625-642.
Loudin, M. et al. (2016). Bleeding “downhill' esophageal varices associated with benign superior vena cava obstruction: case report and literature review. BMC Gastroenterology, 16 (1): 134.
Nguyen, L. P. et al. (2016). A Rare but reversible cause of hematemesis: "downhill" esophageal varices. Case Reports in Critical Care. http://dx.doi.org/10.1155/2016/2370109
Siegel, Y. et al. (2015). Downhill esophageal varices: a prevalent complication of superior vena cava obstruction from benign and malignant causes. Journal of Computer Assisted Tomography, 39 (2): 149-152.
Tavakkoli, H. et al. (2006). Therapeutic approach to ‘downhill’ esophageal varices bleeding due to superior vena cava syndrome in Behcet’s disease: a case report. BMC Gastroenterology, 6, 43.
Uceda, P. V. et al. (2021). Management of superior vena cava occlusion causing bleeding "downhill" esophageal varices. Journal of Endovascular Therapy, 28(3): 469-473.
Van der Veldt, A. A. et al. (2006). An unusual cause of hematemesis: goiter. World Journal of Gastroenterology, 12 (33): 5412-5415.
Van J., & Singh, S. (2021). Hematemesis, a rare presentation for downhill esophageal varices. Case Reports in Gastroenterology, 15: 359-364.
Wan, J. F., & Bezjak, A. (2009). Superior vena cava syndrome. Emergency Medicine Clinics of North America, 27: 243-255.
Yasar, B., & Abut, E. (2015). A case of mediastinal fibrosis due to radiotherapy and ‘downhill’ esophageal varices: a rare cause of upper gastrointestinal bleeding. Clinical Journal of Gastroenterology, 8 (2): 73-76.
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Copyright (c) 2022 Mariana Almeida Hein; Danielle Duarte Silva; Otávio Romanini Lopes; Matheus Soares Braga ; Anderson Lubito Simoni; Bruno Doriguetto Couto Ferreira; Luís Ronan M. F. de Souza; Geisa Perez Medina Gomide; Ana Flávia Carrijo Chiovato
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