Anxiety and depression symptoms in patients with tinnitus: systematic review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i10.33168

Keywords:

Tinnitus; Depression; Anxiety.

Abstract

Objective: to compare tinnitus sufferers to non-sufferers, regarding the presence of symptoms of anxiety and depression. Methodology: PubMed and Lilacs databases were searched for cross-sectional, cohort or case-control studies, with adult humans. The studies have been selected through a two-step process (title/abstract screening and full text reading). The study selection, data extraction and assessment of study quality were made independently by two reviewers. Results: 29 studies were included, totalizing 1,208,435 participants. 78% and 76% of the studies found a significant (p < 0,05) positive association between tinnitus and depression and anxiety, respectively. All the studies that compared the non-annoying tinnitus subgroup to controls found a significant (p < 0,05) positive association between non-annoying tinnitus and depression. All the studies that assessed the correlation between tinnitus-related annoyance and anxiety or depression levels found a significant (p < 0,05) positive correlation. Conclusion: tinnitus sufferers have greater odds of anxiety and depression symptoms than non-sufferers, and such finding is independent of hearing loss. The more annoying the tinnitus, the greater the prevalence and severity of the negative emotional symptoms; however, even not annoying tinnitus is associated with greater odds of depression.

References

Aazh, H., & Moore, B. C. (2017). Factors associated with depression in patients with tinnitus and hyperacusis. American Journal of Audiology, 26(4), 562–569. https://doi.org/10.1044/2017_aja-17-0008

Andersson, G., Eriksson, J., Lundh, L.-G., & Lyttkens, L. (2000). Tinnitus and cognitive interference. Journal of Speech, Language, and Hearing Research, 43(5), 1168–1173. https://doi.org/10.1044/jslhr.4305.1168

Baguley, D., McFerran, D., & Hall, D. (2013). Tinnitus. The Lancet, 382(9904), 1600–1607. https://doi.org/10.1016/s0140-6736(13)60142-7

Ban, M. J., Kim, W. S., Park, K. N., Kim, J. W., Lee, S. W., Han, K., Chang, J. W., Byeon, H. K., Koh, Y. W., & Park, J. H. (2018). Korean survey data reveals an association of chronic laryngitis with tinnitus in men. PLOS ONE, 13(1). https://doi.org/10.1371/journal.pone.0191148

Blaesing, L., & Kroener-Herwig, B. (2012). Self-reported and behavioral sound avoidance in tinnitus and hyperacusis subjects, and association with Anxiety Ratings. International Journal of Audiology, 51(8), 611–617. https://doi.org/10.3109/14992027.2012.664290

Bonett, D. G., & Price, R. M. (2020). Confidence intervals for ratios of means and medians. Journal of Educational and Behavioral Statistics, 45(6), 750–770. https://doi.org/10.3102/1076998620934125

Brännström, K. J., & Waechter, S. (2018). Reading comprehension in quiet and in noise: Effects on immediate and delayed recall in relation to tinnitus and high-frequency hearing thresholds. Journal of the American Academy of Audiology, 29(06), 503–511. https://doi.org/10.3766/jaaa.16174

Granjeiro, R. C., Kehrle, H. M., Oliveira, T. S. C., Sampaio, A. L. L., & Oliveira, C. A. C. P. (2013). Is the degree of discomfort caused by tinnitus in normal-hearing individuals correlated with psychiatric disorders? Otolaryngology–Head and Neck Surgery, 148(4), 658–663. https://doi.org/10.1177/0194599812473554

Danioth, L., Brotschi, G., Croy, I., Friedrich, H., Caversaccio, M.-D., & Negoias, S. (2020). Multisensory environmental sensitivity in patients with chronic tinnitus. Journal of Psychosomatic Research, 135, 110155. https://doi.org/10.1016/j.jpsychores.2020.110155

Durai, M., & Searchfield, G. (2016). Anxiety and depression, personality traits relevant to tinnitus: A scoping review. International Journal of Audiology, 55(11), 605–615. https://doi.org/10.1080/14992027.2016.1198966

Fuller, T., Cima, R., Langguth, B., Mazurek, B., Vlaeyen, J. W. S., & Hoare, D. J. (2020). Cognitive behavioural therapy for tinnitus. Cochrane Database of Systematic Reviews, 2020(1). https://doi.org/10.1002/14651858.cd012614.pub2

Galvão, T. F., & Pereira, M. G. (2014). Revisões Sistemáticas da Literatura: Passos para sua elaboração. Epidemiologia e Serviços De Saúde, 23(1), 183–184. https://doi.org/10.5123/s1679-49742014000100018

Genç, G. A., Muluk, N. B., & Belgin, E. (2013). The effects of tinnitus and/or hearing loss on the symptom checklist-90-revised test. Auris Nasus Larynx, 40(2), 154–161. https://doi.org/10.1016/j.anl.2012.06.002

Geocze, L., Mucci, S., Abranches, D. C., Marco, M. A., & Penido, N. de. (2013). Systematic review on the evidences of an association between tinnitus and Depression. Brazilian Journal of Otorhinolaryngology, 79(1), 106–111. https://doi.org/10.5935/1808-8694.20130018

Gibrin, P. C., Ciquinato, D. S., Gonçalves, I. C., Marchiori, V. de, & Marchiori, L. L. (2019). Tinnitus and its relationship with anxiety and depression in the elderly: A systematic review. Revista CEFAC, 21(4). https://doi.org/10.1590/1982-0216/20192147918

Gomaa, M. A., Elmagd, M. H., Elbadry, M. M., & Kader, R. M. (2013). Depression, anxiety and stress scale in patients with tinnitus and hearing loss. European Archives of Oto-Rhino-Laryngology, 271(8), 2177–2184. https://doi.org/10.1007/s00405-013-2715-6

Gopinath, B., McMahon, C. M., Rochtchina, E., Karpa, M. J., & Mitchell, P. (2010). Risk factors and impacts of incident tinnitus in older adults. Annals of Epidemiology, 20(2), 129–135. https://doi.org/10.1016/j.annepidem.2009.09.002

Granjeiro C. R. (2011). Relação do Incômodo do Zumbido com a Função das Células Ciliadas Externas e os Transtornos de Ansiedade e Depressão em Indivíduos com Limiar Auditivo Normal. [Tese de doutorado, Universidade de Brasília]. Biblioteca Digital Brasileira de Teses e Dissertações. http://repositorio.unb.br/handle/10482/10413

Gu, J. W., Halpin, C. F., Nam, E.-C., Levine, R. A., & Melcher, J. R. (2010). Tinnitus, diminished sound-level tolerance, and elevated auditory activity in humans with clinically normal hearing sensitivity. Journal of Neurophysiology, 104(6), 3361–3370. https://doi.org/10.1152/jn.00226.2010

Halford, J. B. S., & Anderson, S. D. (1991). Anxiety and depression in tinnitus sufferers. Journal of Psychosomatic Research, 35(4-5), 383–390. https://doi.org/10.1016/0022-3999(91)90033-k

Han, K.-M., Ko, Y.-H., Shin, C., Lee, J.-H., Choi, J., Kwon, D.-Y., Yoon, H.-K., Han, C., & Kim, Y.-K. (2018). Tinnitus, depression, and suicidal ideation in adults: A nationally representative general population sample. Journal of Psychiatric Research, 98, 124–132. https://doi.org/10.1016/j.jpsychires.2018.01.003

Honório, H. M., & Santiago, J. F., Jr. (2021a) Planejamento das revisões sistemáticas. In Honório, H. M., & Santiago, J. F., Jr. (Eds.) Fundamentos das revisões sistemáticas em saúde. (pp. 35-64) Santos Publicações.

Honório, H. M., & Santiago, J. F., Jr. (2021b) Revisões sistemáticas: definição, importância e limitações. In Honório, H. M., & Santiago, J. F., Jr. (Eds.) Fundamentos das revisões sistemáticas em saúde. (pp. 3-22) Santos Publicações.

House, L., Bishop, C. E., Spankovich, C., Su, D., Valle, K., & Schweinfurth, J. (2017). Tinnitus and its risk factors in African Americans: The Jackson Heart Study. The Laryngoscope, 128(7), 1668–1675. https://doi.org/10.1002/lary.26964

Jackson, J. G., Coyne, I. J., & Clough, P. J. (2013). A preliminary investigation of potential cognitive performance decrements in non-help-seeking tinnitus sufferers. International Journal of Audiology, 53(2), 88–93. https://doi.org/10.3109/14992027.2013.846481

Joo, Y.-H., Han, K.-do, & Park, K. H. (2015). Association of Hearing Loss and tinnitus with health-related quality of life: The Korea National Health and Nutrition Examination Survey. PLOS ONE, 10(6). https://doi.org/10.1371/journal.pone.0131247

Kao, L.-T., Shih, J.-H., Yeh, C.-B., Wang, C.-H., Chen, H.-C., Chien, W. C., & Li, I.-H. (2020). Association between major depressive disorder and subsequent tinnitus: A population-based study. Journal of Affective Disorders, 263, 367–372. https://doi.org/10.1016/j.jad.2019.11.141

Krog, N. H., Engdahl, B., & Tambs, K. (2010). The association between tinnitus and mental health in a general population sample: Results from the hunt study. Journal of Psychosomatic Research, 69(3), 289–298. https://doi.org/10.1016/j.jpsychores.2010.03.008

Langguth, B. (2011). A review of tinnitus symptoms beyond ‘ringing in the ears’: A call to action. Current Medical Research and Opinion, 27(8), 1635–1643. https://doi.org/10.1185/03007995.2011.595781

Langguth, B., Landgrebe, M., Kleinjung, T., Sand, G. P., & Hajak, G. (2011). Tinnitus and depression. The World Journal of Biological Psychiatry, 12(7), 489–500. https://doi.org/10.3109/15622975.2011.575178

Lin, C.-E., Chen, L.-F., Chou, P.-H., & Chung, C.-H. (2018). Increased prevalence and risk of anxiety disorders in adults with tinnitus: A population-based study in Taiwan. General Hospital Psychiatry, 50, 131–136. https://doi.org/10.1016/j.genhosppsych.2017.11.006

Loprinzi, P. D., Maskalick, S., Brown, K., & Gilham, B. (2013). Association between depression and tinnitus in a nationally representative sample of US older adults. Aging & Mental Health, 17(6), 714–717. https://doi.org/10.1080/13607863.2013.775640

Malakouti S., Mahmoudian M., Alifattahi N., & Salehi M. (2011). Comorbidity of chronic tinnitus and mental disorders. International Tinnitus Journal, 16(2):118-122. https://www.tinnitusjournal.com/articles/comorbidity-of-chronic-tinnitus-and-mental-disorders.pdf

Mamani. M. P., Honório, H. M., & Santiago J. F., Jr. (2021) Seleção e extração de dados. In Honório, H. M., & Santiago, J. F., Jr. (Eds.) Fundamentos das revisões sistemáticas em saúde. (pp. 191-212) Santos Publicações.

McCormack, A., Edmondson-Jones, M., Fortnum, H., Dawes, P. D., Middleton, H., Munro, K. J., & Moore, D. R. (2015). Investigating the association between tinnitus severity and symptoms of depression and anxiety, while controlling for neuroticism, in a large middle-aged UK population. International Journal of Audiology, 54(9), 599–604. https://doi.org/10.3109/14992027.2015.1014577

McKenzie J. E., & Brennan S. E. (2021). Chapter 12: Synthesizing and presenting findings using other methods. In Higgins J. P. T., Thomas J., Chandler J., Cumpston M., Li T., Page M. J., & Welch V. A. (Eds.) Cochrane Handbook for Systematic Reviews of Interventions. Cochrane. https://training.cochrane.org/handbook/current/chapter-12

Michikawa, T., Nishiwaki, Y., Saito, H., Mizutari, K., & Takebayashi, T. (2013). Tinnitus preceded depressive symptoms in community-dwelling older Japanese: A prospective cohort study. Preventive Medicine, 56(5), 333–336. https://doi.org/10.1016/j.ypmed.2013.01.016

Moola S., Munn Z., Tufanaru C., Aromataris E., Sears K., Sfetcu R., Currie M., Qureshi R., Mattis P., Lisy K., & Mu P.-F. (2020) Checklist for Analytical Cross Sectional Studies. https://jbi.global/sites/default/files/2021-10/Checklist_for_Analytical_Cross_Sectional_Studies.docx

Nondahl, D. M., Cruickshanks, K. J., Dalton, D. S., Klein, B. E. K., Klein, R., Schubert, C. R., Tweed, T. S., & Wiley, T. L. (2007). The impact of tinnitus on quality of life in older adults. Journal of the American Academy of Audiology, 18(03), 257–266. https://doi.org/10.3766/jaaa.18.3.7

Oosterloo, B. C., de Feijter, M., Croll, P. H., Baatenburg de Jong, R. J., Luik, A. I., & Goedegebure, A. (2021). Cross-sectional and longitudinal associations between tinnitus and mental health in a population-based sample of middle-aged and elderly persons. JAMA Otolaryngology–Head & Neck Surgery, 147(8), 708. https://doi.org/10.1001/jamaoto.2021.1049

Pajor, A. M., Ormezowska, E. A., & Jozefowicz-Korczynska, M. (2012). The impact of co-morbid factors on the psychological outcome of tinnitus patients. European Archives of Oto-Rhino-Laryngology, 270(3), 881–888. https://doi.org/10.1007/s00405-012-2079-3

Park, E., Kim, H., Choi, I. H., Han, H. M., Han, K., Jung, H. H., & Im, G. J. (2020). Psychiatric distress as a common risk factor for tinnitus and joint pain: A national population-based survey. Clinical and Experimental Otorhinolaryngology, 13(3), 234–240. https://doi.org/10.21053/ceo.2019.00563

Park, H.-M., Jung, J., Kim, J.-K., & Lee, Y.-J. (2020). Tinnitus and its association with mental health and health-related quality of life in an older population: A nationwide cross-sectional study. Journal of Applied Gerontology, 41(1), 181–186. https://doi.org/10.1177/0733464820966512

Park, S. Y., Han, J. J., Hwang, J. H., Whang, E. S., Yeo, S. W., & Park, S. N. (2017). Comparison of tinnitus and psychological aspects between the younger and older adult patients with tinnitus. Auris Nasus Larynx, 44(2), 147–151. https://doi.org/10.1016/j.anl.2016.04.007

Pattyn, T., Van Den Eede, F., Vanneste, S., Cassiers, L., Veltman, D. J., Van De Heyning, P., & Sabbe, B. C. G. (2016). Tinnitus and anxiety disorders: A Review. Hearing Research, 333, 255–265. https://doi.org/10.1016/j.heares.2015.08.014

Pinto, P. C., Marcelos, C. M., Mezzasalma, M. A., Osterne, F. J., de Melo Tavares de Lima, M. A., & Nardi, A. E. (2014). Tinnitus and its association with Psychiatric Disorders: Systematic Review. The Journal of Laryngology & Otology, 128(8), 660–664. https://doi.org/10.1017/s0022215114001030

Reis, A., Favoreto, M. W., Lauris, J. R. P., & Loguercio, A. D. (2021) Análise de dados em revisões sistemáticas. In Honório, H. M., & Santiago, J. F., Jr. (Eds.) Fundamentos das revisões sistemáticas em saúde. (pp. 214-246) Santos Publicações.

Rivera, M., Porras-Segovia, A., Rovira, P., Molina, E., Gutiérrez, B., & Cervilla, J. (2019). Associations of major depressive disorder with chronic physical conditions, obesity and medication use: Results from the Pisma-EP study. European Psychiatry, 60, 20–27. https://doi.org/10.1016/j.eurpsy.2019.04.008

Salazar, J. W., Meisel, K., Smith, E. R., Quiggle, A., McCoy, D. B., & Amans, M. R. (2019). Depression in patients with tinnitus: A systematic review. Otolaryngology–Head and Neck Surgery, 161(1), 28–35. https://doi.org/10.1177/0194599819835178

Salonen, J., Johansson, R., & Joukamaa, M. (2007). Alexithymia, depression and tinnitus in elderly people. General Hospital Psychiatry, 29(5), 431–435. https://doi.org/10.1016/j.genhosppsych.2007.05.002

Seo, J. H., Kang, J. M., Hwang, S. H., Han, K. D., & Joo, Y. H. (2016). Relationship between tinnitus and suicidal behaviour in Korean men and women: A cross-sectional study. Clinical Otolaryngology, 41(3), 222–227. https://doi.org/10.1111/coa.12500

Seydell-Greenwald, A., Leaver, A. M., Turesky, T. K., Morgan, S., Kim, H. J., & Rauschecker, J. P. (2012). Functional MRI evidence for a role of ventral prefrontal cortex in tinnitus. Brain Research, 1485, 22–39. https://doi.org/10.1016/j.brainres.2012.08.052

Snaith, R. P., & Zigmond, A. S. (1986). The hospital anxiety and depression scale. BMJ, 292(6516), 344–344. https://doi.org/10.1136/bmj.292.6516.344

Stevens, C., Walker, G., Boyer, M., & Gallagher, M. (2007). Severe tinnitus and its effect on selective and divided attention. International Journal of Audiology, 46(5), 208–216. https://doi.org/10.1080/14992020601102329

Trevis, K. J., McLachlan, N. M., & Wilson, S. J. (2016). Cognitive mechanisms in chronic tinnitus: Psychological markers of a failure to switch attention. Frontiers in Psychology, 7. https://doi.org/10.3389/fpsyg.2016.01262

Trevis, K. J., McLachlan, N. M., & Wilson, S. J. (2018). A systematic review and meta-analysis of psychological functioning in chronic tinnitus. Clinical Psychology Review, 60, 62–86. https://doi.org/10.1016/j.cpr.2017.12.006

Waechter, S. (2021). Association between hearing status and tinnitus distress. Acta Oto-Laryngologica, 141(4), 381–385. https://doi.org/10.1080/00016489.2021.1876919

Waechter, S., & Brännström, K. J. (2015). The impact of tinnitus on cognitive performance in normal-hearing individuals. International Journal of Audiology, 54(11), 845–851. https://doi.org/10.3109/14992027.2015.1055836

Waechter, S., Hallendorf, L., Malmstein, E., Olsson, A., & Brannstrom, K. J. (2018). The impact of tinnitus on N-back performance in normal hearing individuals. Journal of the American Academy of Audiology. https://doi.org/10.3766/jaaa.17048

Wells, G. A., Shea, B., O'Connell, D., Peterson, J., Welch, V., Losos, M., & Tugwell, P. (s.d.) Newcastle-Ottawa Quality Assessment Scale. http://www.ohri.ca/programs/clinical_epidemiology/nosgen.pdf

Worrall, D. M., & Cosetti, M. K. (2021) Tinnitus and Hyperacusis. In Flint P. W., Francis H. W., Haughey B. H., Lesperance M. M., Lund V. J., Robbins K. T., & Thomas, J. R. (Eds.) Cummings Otolaryngology – Head and Neck Surgery. (pp. 2328-2341) Elsevier.

Xu, Y., Yao, J., Zhang, Z., & Wang, W. (2016). Association between sleep quality and psychiatric disorders in patients with subjective tinnitus in China. European Archives of Oto-Rhino-Laryngology, 273(10), 3063–3072. https://doi.org/10.1007/s00405-016-3906-8

Yu, J.-N., Nam, G. E., Han, K., Kim, J.-su, Kim, Y.-H., Cho, K. H., Kang, G., & Roh, Y. K. (2019). Association between menstrual cycle irregularity and tinnitus: A nationwide population-based study. Scientific Reports, 9(1). https://doi.org/10.1038/s41598-019-50559-5

Ziai, K., Moshtaghi, O., Mahboubi, H., & Djalilian, H. R. (2017). Tinnitus patients suffering from anxiety and depression: A Review. The International Tinnitus Journal, 21(1). https://doi.org/10.5935/0946-5448.20170013

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09/08/2022

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PESARICO, J. P.; KOKUBO, L. C. P.; AZEREDO, L. M.; SILVA, P. B. da; GROTO, A. D. Anxiety and depression symptoms in patients with tinnitus: systematic review. Research, Society and Development, [S. l.], v. 11, n. 10, p. e533111033168, 2022. DOI: 10.33448/rsd-v11i10.33168. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/33168. Acesso em: 23 nov. 2024.

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Vol. 11 No. 10

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