Risk prediction for HPV-induced lesions in early sexual intercourse
DOI:
https://doi.org/10.33448/rsd-v11i11.33571Keywords:
Sexual intercourse; Sexual behavior; Papillomavirus infection; Sexually transmitted infection.Abstract
Objective: This study aims to compare the effects of age at first sexual intercourse (sexarche) and menarche-sexarche interval in predicting the incidence of human papillomavirus (HPV)-induced lesions. Material & Methods: This is a cross-sectional study of 698 women with normal or HPV-induced lesions, diagnosed cytologically or histologically. Results: After multivariate analysis, the probability of developing HPV-induced lesions increased by 63% for those with menarche-sexarche interval of 3 years or less. Additionally, smoking, parity, and age were relevant in prediciting the risk. Conclusion: Sexarche within the first 3 years from menarche was associated with the occurrence of HPV-induced lesions as an independent factor, unlike sexarche, indicating that menarche-sexarche interval of less than 3 years may be an important parameter for the definition of early sexual intercourse.
References
Adebamowo, S. N., Befano, B., Cheung, L. C., Rodriguez, A. C., Demarco, M., Rydzak, G., Chen, X., Porras, C., Herrero, R., Kim, J. J., Castle, P. E., Wentzensen, N., Kreimer, A. R., Schiffman, M., & Campos, N. G. (2022). Different human papillomavirus types share early natural history transitions in immunocompetent women. International Journal of Cancer. Journal International Du Cancer, 151(6), 920–929.
Adhikari, I., Eriksson, T., Luostarinen, T., Apter, D., & Lehtinen, M. (2019). Is the risk of cervical atypia associated with the interval between menarche and the start of sexual activity? A population-based cohort study. BMJ Open, 9(9), e030091.
Amo-Adjei, J., & Tuoyire, D. A. (2018). Timing Of Sexual Debut Among Unmarried Youths Aged 15-24 Years In Sub-Saharan Africa. Journal of Biosocial Science, 50(2), 161–177.
Brinton, L. A., Hamman, R. F., Huggins, G. R., Lehman, H. F., Levine, R. S., Mallin, K., & Fraumeni, J. F., Jr. (1987). Sexual and reproductive risk factors for invasive squamous cell cervical cancer. Journal of the National Cancer Institute, 79(1), 23–30.
Doorbar, J., & Griffin, H. (2019). Refining our understanding of cervical neoplasia and its cellular origins. Papillomavirus Research (Amsterdam, Netherlands), 7, 176–179.
Hwang, L. Y., Ma, Y., Benningfield, S. M., Clayton, L., Hanson, E. N., Jay, J., Jonte, J., Godwin de Medina, C., & Moscicki, A.-B. (2009). Factors that influence the rate of epithelial maturation in the cervix in healthy young women. The Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine, 44(2), 103–110.
Hwang, L. Y., Scott, M. E., Ma, Y., & Moscicki, A.-B. (2011). Higher levels of cervicovaginal inflammatory and regulatory cytokines and chemokines in healthy young women with immature cervical epithelium. Journal of Reproductive Immunology, 88(1), 66–71.
Kops, N. L., Bessel, M., Horvath, J. D. C., Domingues, C., de Souza, F. M. A., Benzaken, A. S., Mendes Pereira, G. F., Maranhão, A. G. K., Villa, L. L., Mello, B., & Wendland, E. M. (2019). Factors associated with HPV and other self-reported STI coinfections among sexually active Brazilian young adults: cross-sectional nationwide study. BMJ Open, 9(6), e027438.
Louie, K. S., de Sanjose, S., Diaz, M., Castellsagué, X., Herrero, R., Meijer, C. J., Shah, K., Franceschi, S., Muñoz, N., Bosch, F. X., & International Agency for Research on Cancer Multicenter Cervical Cancer Study Group. (2009). Early age at first sexual intercourse and early pregnancy are risk factors for cervical cancer in developing countries. British Journal of Cancer, 100(7), 1191–1197.
Mekuria, M., Edosa, K., Endashaw, M., Bala, E. T., Chaka, E. E., Deriba, B. S., & Tesfa, B. (2021). Prevalence of Cervical Cancer and Associated Factors Among Women Attended Cervical Cancer Screening Center at Gahandi Memorial Hospital, Ethiopia. Cancer Informatics, 20, 11769351211068431.
Pereira Filho, J. L., Azevedo, G. C. A., Theodoro, T. F., Bonfim, B. F., Monteiro, P. de M., Arouche, R., Anunciação, R. K. L., Pereira, C. L., Buna, S. dos S. S., Silva, Á. L. S. da, Araújo, Á. W. M. da S., Lima, L. A., Arruda, A. C. P., Santos, T. dos, Silva, A. Z., Abreu, I. C., & Silva, S. do N. (2021). Câncer do colo do útero: Análise epidemiológica e citopatológica no Município de São Luís, Estado do Maranhão, Brasil. Research, Society and Development, 10(8), e33010817074.
Plummer, M., Peto, J., Franceschi, S., & International Collaboration of Epidemiological Studies of Cervical Cancer. (2012). Time since first sexual intercourse and the risk of cervical cancer. International Journal of Cancer. Journal International Du Cancer, 130(11), 2638–2644.
Roman Lay, A. A., Fujimori, E., Simões Duarte, L., & Vilela Borges, A. L. (2021). Prevalence and correlates of early sexual initiation among Brazilian adolescents. PloS One, 16(12), e0260815.
Ruiz, Á. M., Ruiz, J. E., Gavilanes, A. V., Eriksson, T., Lehtinen, M., Pérez, G., Sings, H. L., James, M. K., Haupt, R. M., & FUTURE I and II Study Group. (2012). Proximity of first sexual intercourse to menarche and risk of high-grade cervical disease. The Journal of Infectious Diseases, 206(12), 1887–1896.
Setia, M. S. (2016). Methodology Series Module 3: Cross-sectional Studies. Indian Journal of Dermatology, 61(3), 261–264.
Sichero, L., Picconi, M. A., & Villa, L. L. (2020). The contribution of Latin American research to HPV epidemiology and natural history knowledge. Brazilian Journal of Medical and Biological Research = Revista Brasileira de Pesquisas Medicas E Biologicas / Sociedade Brasileira de Biofisica ... [et Al.], 53(2), e9560.
Soares, L. C., Braz, F. L. T. A., Araújo, A. R., & Oliveira, M. A. P. (2019). Association of Sexually Transmitted Diseases With Cervical Ectopy: A Systematic Review. Sexually Transmitted Diseases, 46(7), 452–457.
Thakur, A., Gupta, B., Gupta, A., & Chauhan, R. (2015). Risk factors for cancer cervix among rural women of a hilly state: a case-control study. Indian Journal of Public Health, 59(1), 45–48.
Xavier-Júnior, J. C. C., Dufloth, R. M., Vale, D. B., Lima, M. T. de, & Zeferino, L. C. (2017). Early Age at First Sexual Intercourse is Associated with Higher Prevalence of High-grade Squamous Intraepithelial Lesions (HSIL). Revista Brasileira de Ginecologia E Obstetricia: Revista Da Federacao Brasileira Das Sociedades de Ginecologia E Obstetricia, 39(2), 80–85.
Yaya, S., & Bishwajit, G. (2018). Age at First Sexual Intercourse and Multiple Sexual Partnerships Among Women in Nigeria: A Cross-Sectional Analysis. Frontiers of Medicine, 5, 171.
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