Effect of diet on DNA damage: critical review

Authors

DOI:

https://doi.org/10.33448/rsd-v9i6.3364

Keywords:

Nutrients; DNA; Comet assay; Nutrigenetics.

Abstract

Dietary intake involves complex interactions between nutrients and non-nutrients. Moreover, dietary components can influence gene activity and influence human health, because they are directly related to DNA synthesis and maintenance. DNA integrity and stability are essential for life, while, DNA damage contributes mainly to disease development. The present study aimed to review the literature about the influence of dietary factors and the presence of DNA damage through the comet assay in the last decade. The literature review was performed using PubMed, LILACS and Scielo databases, with the terms "comet assay", "diet" and "dietetic" in Portuguese and English. The review identified 647 studies, after applying the inclusion and exclusion criteria, 28 articles were included in the review. It was observed high methodological quality in the included studies and a few studies that evaluated the dietary pattern and DNA damage. In general, fruit and vegetable intake and dietary supplementation or multivitamin compounds had higher positive impact on DNA damage.

Author Biographies

Marina dos Santos, Universidade Federal do Rio Grande

Programa de Pós Graduação em Ciências da Saúde – Faculdade de Medicina

Júlia Oliveira Penteado, Universidade Federal do Rio Grande

Programa de Pós Graduação em Ciências da Saúde – Faculdade de Medicina

Caroline Lopes Feijo Fernandes, Universidade Federal do Rio Grande

Programa de Pós Graduação em Ciências da Saúde – Faculdade de Medicina

Flavio Manoel Rodrigues da Silva Júnior, Universidade Federal do Rio Grande

Laboratório de Ensaios Farmacológicos e Toxicológicos - LEFT, Instituto de Ciências Biológicas

Programa de Pós Graduação em Ciências da Saúde – Faculdade de Medicina

References

Academy, F. T. H. E. (2014). Position of the Academy of Nutrition and Dietetics: Nutritional Genomics, 299–312. https://doi.org/10.1016/j.jand.2013.12.001

Bakuradze, T., Boehm, N., Janzowski, C., Lang, R., Hofmann, T., Baum, M., & Eisenbrand, G. (2011). Antioxidant-rich coffee reduces DNA damage , elevates glutathione status and contributes to weight control : Results from an intervention study, 793–797. https://doi.org/10.1002/mnfr.201100093

Bakuradze, T., Lang, R., Hofmann, T., Eisenbrand, G., Schipp, D., Galan, J., & Richling, E. (2014). Consumption of a dark roast coffee decreases the level of spontaneous DNA strand breaks : a randomized controlled trial. https://doi.org/10.1007/s00394-014-0696-x

Barnes, J. L., Zubair, M., John, K., Poirier, M. C., & Martin, F. L. (2018). Carcinogens and DNA damage, 46, 1213–1224.

Bhattacharya, S. (2011). Natural Antimutagens: A review. Research Journal of Medicinal Plant, 5(2), 116–126.

Bo, C. Del, Marino, M., Martini, D., Tucci, M., Ciappellano, S., Riso, P., & Porrini, M. (2019). Overview of Human Intervention Studies Evaluating the Impact of the Mediterranean Diet on Markers of DNA Damage. https://doi.org/10.3390/nu11020391

Bohn, S. K., Blomhoff, R., & Paur, I. (2013). Coffee and cancer risk , epidemiological evidence,. Molecular Nutrition Food Research, 1–16. https://doi.org/10.1002/mnfr.201300526

Braakhuis, A. J., Campion, P., & Bishop, K. S. (2016). Reducing Breast Cancer Recurrence : The Role of Dietary Polyphenolics. Nutrients, 8(547), 1–15. https://doi.org/10.3390/nu8090547

Brevik, A., Gaivão, I., Medin, T., Jørgenesen, A., Piasek, A., Elilasson, J., Collins, A. R. (2011). Supplementation of a western diet with golden kiwifruits ( Actinidia chinensis var . ’ Hort 16A ’ :) effects on biomarkers of oxidation damage and antioxidant protection, 1–9. https://doi.org/10.1186/1475-2891-10-54

Brunner, E., & Witte, D. R. (2008). Dietary patterns and 15-y risks of major coronary events , diabetes. The American Journal of Clinical Nutrition, 87, 1414–1421. https://doi.org/10.1093/ajcn/87.5.1414

Caple, F., Williams, E. A., Spiers, A., Tyson, J., Burtle, B., Daly, A. K., Hesketh, J. E. (2010). Inter-individual variation in DNA damage and base excision repair in young , healthy non-smokers : effects of dietary supplementation and genotype, 1585–1593. https://doi.org/10.1017/S0007114509993540

Cemeli, E., Baumgartner, A., & Anderson, D. (2009). Mutation Research / Reviews in Mutation Research Antioxidants and the Comet assay, 681, 51–67. https://doi.org/10.1016/j.mrrev.2008.05.002

Chang, J., Chen, G., Ulrich, C. M., Bigler, J., King, I. B., Schwarz, Y., Lampe, J. W. (2010). DNA Damage and Repair : Fruit and Vegetable Effects in a Feeding Trial DNA Damage and Repair : Fruit and Vegetable Effects in a Feeding Trial, (January 2015), 37–41. https://doi.org/10.1080/01635580903407106

Charron, C. S., Clevidence, B. A., Albaugh, G. A., Kramer, M. H., Vinyard, B. T., Milner, J. A., & Novotny, J. A. (2013). Assessment of DNA damage and repair in adults consuming allyl isothiocyanate or Brassica vegetables. The Journal of Nutritional Biochemistry, 24(5), 894–902. https://doi.org/10.1016/j.jnutbio.2012.06.004

Collins, A. R. (2014). Biochimica et Biophysica Acta Measuring oxidative damage to DNA and its repair with the comet assay. BBA - General Subjects, 1840(2), 794–800. https://doi.org/10.1016/j.bbagen.2013.04.022

Damiani, A. P., Garcez, M. L., Abreu, L. L. De, Tavares, T. H., Boeck, C. R., & Andrade, V. M. De. (2017). A reduction in DNA damage in neural tissue and peripheral blood of old mice treated with caffeine, 7394. https://doi.org/10.1080/15287394.2017.1286901

Del, C., Riso, P., Campolo, J., Møller, P., Loft, S., Klimis-zacas, D., Porrini, M. (2013). A single portion of blueberry ( Vaccinium corymbosum L ) improves protection against DNA damage but not vascular function in healthy male volunteers. Nutrition Research, 33(3), 220–227. https://doi.org/10.1016/j.nutres.2012.12.009

Fenech, M., & Bonassi, S. (2011). The effect of age, gender, diet and lifestyle on DNA damage measured using micronucleus frequency in human peripheral blood lymphocytes. Mutagenesis, 26(1), 43–49. https://doi.org/10.1093/mutage/geq050

Fikrová, P., Št, R., Hronek, M., Hyšpler, R., & Tichá, A. (2011). Wiener klinische Wochenschrift Application of the comet assay method in clinical studies, 693–699. https://doi.org/10.1007/s00508-011-0066-0

Goon, A. J., Azman, N. H. E. N., Ghani, S. M. A., Hamid, Z., & Ngah, W. Z. W. (2017). Comparing palm oil tocotrienol rich fraction with a -tocopherol supplementation on oxidative stress in healthy older adults. Clinical Nutrition ESPEN, 1–12. https://doi.org/10.1016/j.clnesp.2017.07.004

Habermann, N., Makar, K. W., Abbenhardt, C., Xiao, L., Wang, C., Utsugi, H. K., Ulrich, C. M. (2014). No Effect of Caloric Restriction or Exercise on. MEDICINE & SCIENCE IN SPORTS & EXERCISE, (32), 896–905. https://doi.org/10.1249/MSS.0000000000000480

Heger, A., Ferk, F., Nersesyan, A., Szekeres, T., Kundi, M., Wagner, K. H., Knasmüller, S. (2012). Mutation Research / Genetic Toxicology and Environmental Mutagenesis Intake of a resveratrol-containing dietary supplement has no impact on DNA stability in healthy subjects, 749, 82–86. https://doi.org/10.1016/j.mrgentox.2012.07.005

Heidemann, C., Schulze, M. B., Franco, O. H., Dam, R. M. van, Mantzoros, C. S., & Frank B. Hu. (2008). Dietary Patterns and Risk of Mortality from Cardiovascular Disease, Cancer, and All-Causes in a Prospective Cohort of Women. Circulation, 118(3), 230–237. https://doi.org/10.1161/CIRCULATIONAHA.108.771881.Dietary

Herrero-Barbudo, C., Soldevilla, B., Perez-Sacristan, B., Blanco-Navarro, I., Mercedes, H., Granado-Lorencio, F., & Domınguez, G. (2013). Modulation of DNA-Induced Damage and Repair Capacity in Humans after Dietary Intervention with Lutein-Enriched Fermented Milk. PLOS ONE, 8(9). https://doi.org/10.1371/journal.pone.0074135

Hoelzl, C., & Knasm, S. (2010). Instant coffee with high chlorogenic acid levels protects humans against oxidative damage of macromolecules, 1722–1733. https://doi.org/10.1002/mnfr.201000048

Izquierdo-vega, J. A., Morales-gonzález, J. A., Sánchez-gutiérrez, M., Betanzos-cabrera, G., Sosa-delgado, S. M., Sumaya-martínez, M. T., Madrigal-Santillán, E. (2017). Evidence of Some Natural Products with Antigenotoxic Effects. Part 1: Fruits and Polysaccharides. Nutrients, 9(102), 1–27. https://doi.org/10.3390/nu9020102

Joray, M. L., Yu, T., Ho, E., Clarke, S. L., Stanga, Z., Gebreegziabher, T., Stoecker, B. J. (2015). ScienceDirect Zinc supplementation reduced DNA breaks in Ethiopian women. Nutrition Research, 35(1), 49–55. https://doi.org/10.1016/j.nutres.2014.10.006

Kadioglu, E., Kocabas, N. A., Demircigil, G. C., Coskun, E., Ozcagli, E., Durmaz, E., Sardas, S. (2012). Assessment of Individual Susceptibility to Baseline DNA and Cytogenetic Damage in a Healthy Turkish Population :, 16(10), 1157–1164. https://doi.org/10.1089/gtmb.2012.0038

Kim, Y. J., Ahn, Y. H., Lim, Y., Kim, J. Y., Kim, J., & Kwon, O. (2013). Daily Nutritional Dose Supplementation with Antioxidant Nutrients and Phytochemicals Improves DNA and LDL Stability: A Double-Blind, Randomized, and Placebo-Controlled Trial, 5218–5232. https://doi.org/10.3390/nu5125218

Ladeira, C., Carolino, E., Gomes, M. C., & Brito, M. (2017). Role of Macronutrients and Micronutrients in DNA Damage : Results From a Food Frequency Questionnaire. https://doi.org/10.1177/1178638816684666

Lamy, E., Garcia-ka, M., Prinzhorn, J., & Mersch-Sundermann, V. (2012). Antigenotoxic action of isothiocyanate-containing mustard as determined by two cancer biomarkers in a human intervention trial, 21, 400–406. https://doi.org/10.1097/CEJ.0b013e32834ef140

Lee, S. H., S, M., Kang, H. J., S, M., Lee, H., S, M. (2010). Six-week supplementation with Chlorella has favorable impact on antioxidant status in Korean male smokers. Nutrition, 26(2), 175–183. https://doi.org/10.1016/j.nut.2009.03.010

Louzada, M. L. da C., Martins, A. P. B., Canella, D. S., Baraldi, L. G., Levy, R. B., Claro, R. M., Monteiro, C. A. (2015). Ultra-processed foods and the nutritional dietary profile in Brazil. Revista de Saude Publica, 49, 1–11. https://doi.org/10.1590/S0034-8910.2015049006132

Nikitina, D., Chen, Z., Vallis, K., Poll, A., Ainsworth, P., Narod, S. A., & Kotsopoulos, J. (2015). Relationship between Caffeine and Levels of DNA Repair and Oxidative Stress in Women with and without a BRCA1 Mutation, 2, 174–184. https://doi.org/10.1159/000439110

Odongo, G. A., Skatchkov, I., Herz, C., & Lamy, E. (2019). Optimization of the alkaline comet assay for easy repair capacity quanti fi cation of oxidative DNA damage in PBMC from human volunteers using aphidicolin block. DNA Repair, 77(October 2018), 58–64. https://doi.org/10.1016/j.dnarep.2019.03.005

Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Ricardo, S. (2018). Metodologia da pesquisa científica.

Petrovi, J., Stani, D., Dmitrašinovi, G., Plecas-Solarovic, B., Ignjatovi, S., Batini, B., … Pešic, V. (2016). Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man, 2016. https://doi.org/10.1155/2016/2019643

Prado, R. P., Fornazari, B., Carvalho, R., Lombardi, C., Pinto, D. S., Assis, D., & Fa, D. M. (2010). Influence of diet on oxidative DNA damage , uracil misincorporation and DNA repair capability, 25(5), 483–487. https://doi.org/10.1093/mutage/geq030

Riso, P., Martini, D., Visioli, F., Martinetti, A., Porrini, M., Riso, P., & Martini, D. (2009). Effect of Broccoli Intake on Markers Related to Oxidative Stress and Cancer Risk in Healthy Smokers and Nonsmokers Effect of Broccoli Intake on Markers Related to Oxidative Stress and Cancer Risk in Healthy Smokers and Nonsmokers. Nutrition and Cancer, 61(2), 232–237. https://doi.org/10.1080/01635580802425688

Shaughnessy, D. T., Gangarosa, L. M., Schliebe, B., Umbach, D. M., Xu, Z., Knize, M. G., … Taylor, J. A. (2011). Inhibition of Fried Meat-Induced Colorectal DNA Damage and Altered Systemic Genotoxicity in Humans by Crucifera , Chlorophyllin , and Yogurt, 6(4). https://doi.org/10.1371/journal.pone.0018707

Song, B., Zeng, G., Gong, J., Liang, J., Xu, P., Liu, Z., Ren, X. (2017). Evaluation methods for assessing effectiveness of in situ remediation of soil and sediment contaminated with organic pollutants and heavy metals. Environment International, 105(January), 43–55. https://doi.org/10.1016/j.envint.2017.05.001

Song, Y., Chung, C. S., Bruno, R. S., Traber, M. G., Brown, K. H., King, J. C., & Ho, E. (2009). Dietary zinc restriction and repletion affects DNA integrity in healthy men, 90, 321–328. https://doi.org/10.3945/ajcn.2008.27300.1

Stevens, A. J., Rucklidge, J. J., Kennedy, M. A., Stevens, A. J., Rucklidge, J. J., Kennedy, M. A., Kennedy, M. A. (2017). Epigenetics , nutrition and mental health . Is there a relationship ? Nutritional Neuroscience, 1–12. https://doi.org/10.1080/1028415X.2017.1331524

Wahlqvist, M. L. (2016). Future food, 25(35), 706–715. https://doi.org/10.6133/apjcn.092016.01

Wlodarczyk, M., Jabłonowska-lietz, B., Olejarz, W., & Nowicka, G. (2018). Anthropometric and Dietary Factors as Predictors of DNA Damage in Obese Women, 1–12. https://doi.org/10.3390/nu10050578

Wu, J., Salisbury, C., Graham, R., Lyons, G., & Fenech, M. (2009). Increased Consumption of Wheat Biofortified With Selenium Does Not Modify Biomarkers of Cancer Risk , Oxidative Stress , or Immune Function in Healthy Australian Males, 50, 489–501. https://doi.org/10.1002/em

Yuan, L., Meng, L., Ma, W., Xiao, Z., Zhu, X., Feng, J. I. N. F., Xiao, R. (2011). Impact of apple and grape juice consumption on the antioxidant status in healthy subjects, 62(10), 844–850. https://doi.org/10.3109/09637486.2011.587399

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Published

12/04/2020

How to Cite

SANTOS, M. dos; PENTEADO, J. O.; FERNANDES, C. L. F.; SILVA JÚNIOR, F. M. R. da. Effect of diet on DNA damage: critical review. Research, Society and Development, [S. l.], v. 9, n. 6, p. e52963364, 2020. DOI: 10.33448/rsd-v9i6.3364. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/3364. Acesso em: 22 nov. 2024.

Issue

Vol. 9 No. 6

Section

Review Article

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