Cross-sectional study of patients with Trigeminal Neuralgia treated at the Walter Cantídio Hospital of the Federal University of Ceará

Authors

DOI:

https://doi.org/10.33448/rsd-v11i11.33640

Keywords:

Trigeminal Neuralgia; Carbamazepine; Drug therapy combination.

Abstract

Trigeminal Neuralgia is described as excruciating pain, similar to an electric shock that affects one or more branches of the trigeminal nerve. The treatment of Trigeminal Neuralgia (TN) remains a therapeutic challenge. Pharmacological treatment is the first choice, however many patients become intolerant to it, being referred to surgery. Thus, this study aimed to evaluate data from a group of patients diagnosed with trigeminal neuralgia (TN) treated at the Walter Cantídio University Hospital of the Federal University of Ceará, focusing on sociodemographic data, symptoms and treatment type. The following data were collected on age, sex, anamnesis, reported symptoms, diagnosis, comorbidities, treatment and evolution. Data from 62 patients obtained from medical records during the follow-up period were included. The results showed that the incidence in all age groups was primarily in females, the most reported symptom was unilateral shock pain. 25% of patients associated the onset of symptoms with a previous event such as tooth extraction, endodontic treatment or trauma. The drug of choice for treatment was carbamazepine in 74% of patients, 20% of patients did not control pain with treatment and underwent surgery. Therefore, more advances in scientific studies regarding pain mechanisms and the discovery of more precise drugs to control it will be the way to treat trigeminal neuropathic pain.

References

Araya, E. I., Claudino, R. F., Piovesan, E. J., & Chichorro, J. G. (2020). Trigeminal Neuralgia: Basic and Clinical Aspects. Current neuropharmacology, 18(2), 109–119. https://doi.org/10.2174/1570159X17666191010094350

Bendtsen, L., Zakrzewska, J. M., Abbott, J. A., Braschinsky, M., Di Stefano, G., Donnet, A., & Cruccu, G. (2019). European Academy of Neurology guideline on trigeminal neuralgia. European journal of neurology, 26(6), 831-849.

Cruccu, G., Biasiotta, A., Galeotti, F., Iannetti, G. D., Innocenti, P., Romaniello, A., & Truini, A. (2006). Diagnosis of trigeminal neuralgia: a new appraisal based on clinical and neurophysiological findings. In Supplements to Clinical Neurophysiology (Vol. 58, pp. 171-186). Elsevier.

Cruccu, G., Biasiotta, A., Galeotti, F., Iannetti, G. D., Innocenti, P., Romaniello, A., & Truini, A. (2006). Diagnosis of trigeminal neuralgia: a new appraisal based on clinical and neurophysiological findings. In Supplements to Clinical Neurophysiology (Vol. 58, pp. 171-186). Elsevier.

Cruccu, G., Di Stefano, G., & Truini, A. (2020). Trigeminal Neuralgia. The New England journal of medicine, 383(8), 754–762. https://doi.org/10.1056/NEJMra1914484

Edwards, J. W., & Shaw, V. (2021). Acupuncture in the management of trigeminal neuralgia. Acupuncture in Medicine, 39(3), 192-199.

Estrela, C. (2018). Metodologia Científica: Ciência, Ensino, Pesquisa. Editora Artes Médicas.

Fields, H. L., Rowbotham, M., & Baron, R. (1998). Postherpetic neuralgia: irritable nociceptors and deafferentation. Neurobiology of disease, 5(4), 209-227.

Han, K. R., Kim, C., Chae, Y. J., & Kim, D. W. (2008). Efficacy and safety of high concentration lidocaine for trigeminal nerve block in patients with trigeminal neuralgia. International journal of clinical practice, 62(2), 248-254.

Jensen, T. S., & Baron, R. (2003). Translation of symptoms and signs into mechanisms in neuropathic pain. Pain, 102(1), 1-8.

Jones, M. R., Urits, I., Ehrhardt, K. P., Cefalu, J. N., Kendrick, J. B., Park, D. J., & Viswanath, O. (2019). A comprehensive review of trigeminal neuralgia. Current pain and headache reports, 23(10), 1-7.

Jones, M. R., Urits, I., Ehrhardt, K. P., Cefalu, J. N., Kendrick, J. B., Park, D. J., & Viswanath, O. (2019). A comprehensive review of trigeminal neuralgia. Current pain and headache reports, 23(10), 1-7.

Leocádio, J. C. M., Santos, L. C., Sousa, M. C. A., Gonçalves, N. J. C., & Campos, I. C. (2014). Neuralgia do trigêmeo: uma revisão de literatura. Braz J Surg Clin Res, 7(2), 33-7.

Maarbjerg, S., Di Stefano, G., Bendtsen, L., & Cruccu, G. (2017). Trigeminal neuralgia - diagnosis and treatment. Cephalalgia : an international journal of headache, 37(7), 648–657. https://doi.org/10.1177/0333102416687280

Obermann, M. (2019). Recent advances in understanding/managing trigeminal neuralgia. F1000Research, 8.

Okeson, J. P. (2006). Dores Bucofaciais de Bell. Quintessence

Oomens, M. M., & Forouzanfar, T. (2015). Pharmaceutical management of trigeminal neuralgia in the elderly. Drugs & aging, 32(9), 717-726.

Rang, H. P., Dale, M. M., Ritter, J. M., & Flower, R. J. (2007). Farmacologia. Elsevier.

Rowbotham, M. C., Petersen, K. L., & Fields, H. L. (1998, December). Is postherpetic neuralgia more than one disorder?. In Pain Forum (7(4,) . 231-237). Churchill Livingstone.

Sabino, J. C. A., & de Brito Filho, A. P. (2018). Neuralgia Trigeminal: Um Breve Referencial Teórico. Caderno de Graduação-Ciências Biológicas e da Saúde-UNIT-PERNAMBUCO, 3(3), 83-83.

Spina, A., Mortini, P., Alemanno, F., Houdayer, E., & Iannaccone, S. (2017). Trigeminal neuralgia: toward a multimodal approach. World neurosurgery, 103, 220-230.

Woolf, C. J., & Max, M. B. (2001). Mechanism-based pain diagnosis: issues for analgesic drug development. The Journal of the American Society of Anesthesiologists, 95(1), 241-249.

Zakrzewska, J. M., Chaudhry, Z., Nurmikko, T. J., Patton, D. W., & Mullens, E. L. (1997). Lamotrigine (lamictal) in refractory trigeminal neuralgia: results from a double-blind placebo controlled crossover trial. Pain, 73(2), 223-230.

Published

24/08/2022

How to Cite

DA SILVA, A. M. .; DE ARRUDA, N. M. M.; DE ARRUDA, J. A. M. .; CAMPELO, C. M. B. .; PONTES, K. M. de F.; CUTRIM, R. C.; ARAÚJO , L. V. .; DIBAI, D. B.; TAVAREZ, R. R. de J. . Cross-sectional study of patients with Trigeminal Neuralgia treated at the Walter Cantídio Hospital of the Federal University of Ceará . Research, Society and Development, [S. l.], v. 11, n. 11, p. e353111133640, 2022. DOI: 10.33448/rsd-v11i11.33640. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/33640. Acesso em: 22 nov. 2024.

Issue

Section

Health Sciences